ES8609308A1 - Un procedimiento para la preparacion de un derivado de indo-lina o de 2-indolinona - Google Patents
Un procedimiento para la preparacion de un derivado de indo-lina o de 2-indolinonaInfo
- Publication number
- ES8609308A1 ES8609308A1 ES543078A ES543078A ES8609308A1 ES 8609308 A1 ES8609308 A1 ES 8609308A1 ES 543078 A ES543078 A ES 543078A ES 543078 A ES543078 A ES 543078A ES 8609308 A1 ES8609308 A1 ES 8609308A1
- Authority
- ES
- Spain
- Prior art keywords
- indoline
- indolinone derivatives
- derivatives
- indolinone
- pharmaceutical formulations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1
- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical class OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 abstract 1
- 239000004041 inotropic agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61021084A | 1984-05-14 | 1984-05-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8609308A1 true ES8609308A1 (es) | 1986-09-01 |
| ES543078A0 ES543078A0 (es) | 1986-09-01 |
Family
ID=24444125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES543078A Expired ES8609308A1 (es) | 1984-05-14 | 1985-05-13 | Un procedimiento para la preparacion de un derivado de indo-lina o de 2-indolinona |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0161918B1 (h) |
| JP (1) | JPH0643417B2 (h) |
| KR (1) | KR870000274B1 (h) |
| AR (1) | AR241531A1 (h) |
| AT (1) | ATE54915T1 (h) |
| AU (1) | AU577372B2 (h) |
| CA (1) | CA1248099A (h) |
| DE (1) | DE3578822D1 (h) |
| DK (1) | DK207785A (h) |
| EG (1) | EG17342A (h) |
| ES (1) | ES8609308A1 (h) |
| GR (1) | GR851121B (h) |
| HU (1) | HU194873B (h) |
| IL (1) | IL75122A (h) |
| MY (1) | MY101520A (h) |
| NZ (1) | NZ212023A (h) |
| PH (1) | PH21862A (h) |
| PT (1) | PT80414B (h) |
| SU (1) | SU1486060A3 (h) |
| ZA (1) | ZA853440B (h) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4591591A (en) * | 1984-03-08 | 1986-05-27 | Eli Lilly And Company | Pyridazinone derivatives as inotropic agents |
| DE3631085A1 (de) * | 1986-09-12 | 1988-03-24 | Boehringer Mannheim Gmbh | Heterocyclisch substituierte indolinone, verfahren zu ihrer herstellung, arzneimittel sowie zwischenprodukte |
| DE3706427A1 (de) * | 1987-02-27 | 1988-09-08 | Boehringer Mannheim Gmbh | Neue substituierte 3h-indole, zwischenprodukte, verfahren zu ihrer herstellung sowie arzneimittel |
| ATE76584T1 (de) * | 1987-08-28 | 1992-06-15 | Lilly Co Eli | Die permeation verbessernde zusammensetzung. |
| US5196416A (en) * | 1987-08-28 | 1993-03-23 | Eli Lilly And Company | Transdermal flux-enhancing pharmaceutical compositions comprising azone, ethanol and water |
| DE68917485T2 (de) * | 1988-01-23 | 1995-02-09 | Kyowa Hakko Kogyo Kk | Pyridazinon-Derivate und diese enthaltende pharmazeutische Zubereitungen. |
| GB8816944D0 (en) * | 1988-07-15 | 1988-08-17 | Sobio Lab | Compounds |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| JP5546451B2 (ja) | 2007-06-04 | 2014-07-09 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| ES2627848T3 (es) | 2008-06-04 | 2017-07-31 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| EA201391254A1 (ru) | 2011-03-01 | 2014-02-28 | Синерджи Фармасьютикалз Инк. | Способ получения агонистов гуанилатциклазы c |
| JP6499591B2 (ja) | 2013-02-25 | 2019-04-10 | シナジー ファーマシューティカルズ インコーポレイテッド | 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト |
| EP2968439A2 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| PL3004138T3 (pl) | 2013-06-05 | 2024-07-29 | Bausch Health Ireland Limited | Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie |
| EP3030252B1 (en) | 2013-08-09 | 2018-11-07 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス， インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
| US20240308973A1 (en) * | 2023-03-10 | 2024-09-19 | Zoetis Services Llc | Phosphodiesterase 3 (pde3) inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8101067A1 (es) * | 1978-08-25 | 1980-12-01 | Thomae Gmbh Dr K | Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona |
| US4258185A (en) * | 1978-10-17 | 1981-03-24 | Yoshitomi Pharmaceutical Industries, Ltd. | Pyridazinone compounds |
| DE3124699A1 (de) * | 1981-06-24 | 1983-01-13 | Basf Ag, 6700 Ludwigshafen | Neue 2-aryl-3,4-diaza-bicyclo(4.n.0.)alken-(2)-one-(5),verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| JPS588016A (ja) * | 1981-07-06 | 1983-01-18 | Mitsubishi Chem Ind Ltd | 強心剤 |
-
1985
- 1985-05-07 CA CA000480903A patent/CA1248099A/en not_active Expired
- 1985-05-07 IL IL75122A patent/IL75122A/xx unknown
- 1985-05-07 ZA ZA853440A patent/ZA853440B/xx unknown
- 1985-05-08 PT PT80414A patent/PT80414B/pt not_active IP Right Cessation
- 1985-05-08 GR GR851121A patent/GR851121B/el unknown
- 1985-05-09 AR AR85300328A patent/AR241531A1/es active
- 1985-05-09 NZ NZ212023A patent/NZ212023A/en unknown
- 1985-05-09 PH PH32245A patent/PH21862A/en unknown
- 1985-05-10 DE DE8585303310T patent/DE3578822D1/de not_active Expired - Lifetime
- 1985-05-10 EP EP85303310A patent/EP0161918B1/en not_active Expired - Lifetime
- 1985-05-10 AT AT85303310T patent/ATE54915T1/de not_active IP Right Cessation
- 1985-05-10 DK DK207785A patent/DK207785A/da not_active Application Discontinuation
- 1985-05-12 EG EG296/85D patent/EG17342A/xx active
- 1985-05-13 HU HU851801A patent/HU194873B/hu not_active IP Right Cessation
- 1985-05-13 ES ES543078A patent/ES8609308A1/es not_active Expired
- 1985-05-13 SU SU853911552A patent/SU1486060A3/ru active
- 1985-05-13 JP JP60102499A patent/JPH0643417B2/ja not_active Expired - Lifetime
- 1985-05-13 AU AU42405/85A patent/AU577372B2/en not_active Ceased
- 1985-05-14 KR KR1019850003271A patent/KR870000274B1/ko not_active Expired
-
1987
- 1987-09-22 MY MYPI87001859A patent/MY101520A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL75122A0 (en) | 1985-09-29 |
| NZ212023A (en) | 1988-04-29 |
| DE3578822D1 (de) | 1990-08-30 |
| EP0161918A3 (en) | 1986-11-20 |
| KR870000274B1 (ko) | 1987-02-23 |
| JPH0643417B2 (ja) | 1994-06-08 |
| EP0161918A2 (en) | 1985-11-21 |
| SU1486060A3 (ru) | 1989-06-07 |
| JPS6122080A (ja) | 1986-01-30 |
| GR851121B (h) | 1985-11-25 |
| PT80414A (en) | 1985-06-01 |
| KR850008166A (ko) | 1985-12-13 |
| CA1248099A (en) | 1989-01-03 |
| HUT37783A (en) | 1986-02-28 |
| PH21862A (en) | 1988-03-25 |
| DK207785D0 (da) | 1985-05-10 |
| ZA853440B (en) | 1986-12-30 |
| AU4240585A (en) | 1985-11-21 |
| ATE54915T1 (de) | 1990-08-15 |
| MY101520A (en) | 1991-11-30 |
| PT80414B (en) | 1987-04-16 |
| HU194873B (en) | 1988-03-28 |
| AU577372B2 (en) | 1988-09-22 |
| AR241531A1 (es) | 1992-08-31 |
| DK207785A (da) | 1985-11-15 |
| EP0161918B1 (en) | 1990-07-25 |
| EG17342A (en) | 1991-03-30 |
| IL75122A (en) | 1989-02-28 |
| ES543078A0 (es) | 1986-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970519 |