ES8609236A1 - Un metodo para preparar derivados de 1-sulfo-2-oxoazetidina - Google Patents
Un metodo para preparar derivados de 1-sulfo-2-oxoazetidinaInfo
- Publication number
- ES8609236A1 ES8609236A1 ES543809A ES543809A ES8609236A1 ES 8609236 A1 ES8609236 A1 ES 8609236A1 ES 543809 A ES543809 A ES 543809A ES 543809 A ES543809 A ES 543809A ES 8609236 A1 ES8609236 A1 ES 8609236A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- protected
- optionally
- compound
- sulfo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- CDFGMYLBUSYTKQ-UHFFFAOYSA-N 2-oxoazetidine-1-sulfonic acid Chemical class OS(=O)(=O)N1CCC1=O CDFGMYLBUSYTKQ-UHFFFAOYSA-N 0.000 title abstract 2
- -1 carbamoylamino, N-sulfocarbamoylamino, carbamoyl Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 241000282414 Homo sapiens Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Cephalosporin Compounds (AREA)
Abstract
METODO PARA PREPARAR NUEVOS DERIVADOS DE 1-SULFO-2-OXOAZETIDINA, EMPLEO DE LOS MISMOS Y COMPUESTOS INTERMEDIOS. EL NUEVO DERIVADO TIENE FORMULA (I) EN LA QUE R ES UN RESTO ORGANICO UNIDO AL ANILLO DE AZETIDINA, R1 ES UN GRUPO AMINO OPCIONALMENTE ACILADO O PROTEGIDO, X ES UN HIDROGENO O METOXI O UNA SAL O ESTER FARMACEUTICAMENTE ACEPTABLE DEL NUEVO DERIVADO. EL DRIVADO (I) PUEDE OBTENERSE POR SULFONACION DE UN COMPUESTO DE FORMULA (II) O POR ACILACION DE UN COMPUESTO DE LA FORMULA (III). LOS DERIVADOS DE LA 1-SULFO-2-OXOAZETIDINA, SUS SALES, E ISOMEROS OPTICOS TIENEN EXCELENTE ACTIVIDAD COMO ANTIMICROBIANOS E INHIBIDORES DE LAS B-LACTAMASAS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57073728A JPS58189176A (ja) | 1982-04-30 | 1982-04-30 | １−スルホ−２−アゼチジノン誘導体およびその製造法 |
| JP57093463A JPS58210061A (ja) | 1982-05-31 | 1982-05-31 | １−スルホ−２−オキソアゼチジン誘導体、その製造法および用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8609236A1 true ES8609236A1 (es) | 1986-09-01 |
| ES543809A0 ES543809A0 (es) | 1986-09-01 |
Family
ID=26414878
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES521954A Granted ES521954A0 (es) | 1982-04-30 | 1983-04-29 | Un metodo de producir un derivado de 1-sulfo-2-oxoazetidina. |
| ES528562A Expired ES8607924A1 (es) | 1982-04-30 | 1983-12-30 | Un metodo de producir un derivado de 1-sulfo-2-oxoazetidina |
| ES543809A Expired ES8609236A1 (es) | 1982-04-30 | 1985-06-01 | Un metodo para preparar derivados de 1-sulfo-2-oxoazetidina |
| ES551942A Expired ES8800186A1 (es) | 1982-04-30 | 1986-02-13 | Un metodo para preparar derivados de tiazol |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES521954A Granted ES521954A0 (es) | 1982-04-30 | 1983-04-29 | Un metodo de producir un derivado de 1-sulfo-2-oxoazetidina. |
| ES528562A Expired ES8607924A1 (es) | 1982-04-30 | 1983-12-30 | Un metodo de producir un derivado de 1-sulfo-2-oxoazetidina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES551942A Expired ES8800186A1 (es) | 1982-04-30 | 1986-02-13 | Un metodo para preparar derivados de tiazol |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0093376B2 (es) |
| KR (1) | KR840004403A (es) |
| AT (1) | ATE51223T1 (es) |
| AU (1) | AU564150B2 (es) |
| CS (1) | CS305383A2 (es) |
| DD (1) | DD212510B3 (es) |
| DE (1) | DE3381353D1 (es) |
| DK (1) | DK161832C (es) |
| ES (4) | ES521954A0 (es) |
| FI (2) | FI831457L (es) |
| GB (2) | GB2124207B (es) |
| GR (1) | GR78189B (es) |
| HU (2) | HU194876B (es) |
| IL (1) | IL68451A0 (es) |
| MC (1) | MC1513A1 (es) |
| MX (1) | MX155085A (es) |
| NO (2) | NO160581C (es) |
| NZ (2) | NZ204039A (es) |
| PH (1) | PH22251A (es) |
| PT (1) | PT76621B (es) |
| SU (1) | SU1480763A3 (es) |
| ZW (1) | ZW9283A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2558467B2 (fr) * | 1981-10-23 | 1987-03-20 | Roussel Uclaf | Nouveau produit derive de l'acide 3-amino 2-oxo azetidine 1-sulfamique, son procede de preparation, son application comme medicament et un produit intermediaire necessaire a sa preparation |
| FR2515182B1 (fr) * | 1981-10-23 | 1986-05-09 | Roussel Uclaf | Nouveaux produits derives de l'acide 3-amino 2-oxo azetidine 1-sulfamique, leur procede de preparation, leur application comme medicaments et les produits intermediaires necessaires a leur preparation |
| US4501697A (en) * | 1983-06-17 | 1985-02-26 | E. R. Squibb & Sons, Inc. | 4-[[(Amidomethyl)oxy]methyl]-2-oxo-1-azetidinesulfonic acid salts |
| EP0151411A1 (de) * | 1984-02-03 | 1985-08-14 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Antibakterielle Komposition |
| EP0187500B1 (en) * | 1984-12-20 | 1993-04-28 | The Upjohn Company | Monobactams |
| US4883869A (en) * | 1984-12-20 | 1989-11-28 | The Upjohn Company | Novel beta-lactams containing amino acid substituents |
| US4684722A (en) * | 1986-01-06 | 1987-08-04 | E. R. Squibb & Sons, Inc. | Monosulfactams |
| GB8614710D0 (en) * | 1986-06-17 | 1986-07-23 | Ici Plc | Process |
| US5194604A (en) * | 1990-06-29 | 1993-03-16 | E. R. Squibb & Sons, Inc. | Process and intermediates for beta-lactams having aminothiazole(iminooxyacetic acid)acetic acid sidechains |
| IT1244699B (it) * | 1991-02-01 | 1994-08-08 | Luso Farmaco Inst | Processo per la preparazione di acidi 3 acilammino-4- carbamoilossimetil-2-azetidinone-l-solfonici ed intermedi per la loro preparazione |
| CA2266639A1 (en) * | 1996-09-23 | 1998-03-26 | Rajeshwar Singh | 3,4-disubstituted azetidin-2-one derivatives useful as cysteine proteinase regulators |
| AT406773B (de) * | 1998-04-02 | 2000-08-25 | Biochemie Gmbh | Neues salz von 7-(2-(aminothiazol-4yl)-2- |
| LT3122745T (lt) * | 2014-03-24 | 2019-04-10 | Novartis Ag | Monobaktamo organiniai junginiai, skirti bakterinių infekcijų gydymui |
| WO2017050218A1 (en) | 2015-09-23 | 2017-03-30 | Novartis Ag | Salts and solid forms of monobactam antibiotic |
| US11414411B2 (en) | 2017-08-02 | 2022-08-16 | Novartis Ag | Chemical process for manufacturing monobactam antibiotic and intermediates thereof |
| CN111303144B (zh) * | 2019-12-13 | 2020-11-27 | 苏州信诺维医药科技有限公司 | 一种治疗细菌感染的化合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ205240A (en) * | 1980-02-07 | 1984-07-31 | Squibb & Sons Inc | Sulphonamide derivatives,being starting materials for producing beta-lactams |
| NL8100539A (nl) * | 1980-02-12 | 1981-09-01 | Rhone Poulenc Ind | Nieuwe thiolesters, de bereiding daarvan en hun gebruik bij syntheses. |
| WO1982001873A1 (en) * | 1980-12-05 | 1982-06-10 | Takeda Chemical Industries Ltd | 1-sulfo-2-oxoazetidine derivatives and process for their preparation |
| MX7096E (es) * | 1980-12-05 | 1987-06-19 | Takeda Chemical Industries Ltd | Metodo para preparacion de derivados de 2-oxoazetidina |
| CA1262128A (en) * | 1981-08-27 | 1989-10-03 | Christian N. Hubschwerlen | .beta.-lactams |
| DE3377061D1 (en) * | 1982-06-03 | 1988-07-21 | Hoffmann La Roche | Process for the preparation of 1-sulfo-2-oxoazetidine derivatives |
-
1983
- 1983-04-12 AU AU13445/83A patent/AU564150B2/en not_active Ceased
- 1983-04-19 GB GB08310520A patent/GB2124207B/en not_active Expired
- 1983-04-21 IL IL68451A patent/IL68451A0/xx unknown
- 1983-04-22 ZW ZW92/83A patent/ZW9283A1/xx unknown
- 1983-04-26 EP EP83104061A patent/EP0093376B2/en not_active Expired - Lifetime
- 1983-04-26 DE DE8383104061T patent/DE3381353D1/de not_active Expired - Fee Related
- 1983-04-26 AT AT83104061T patent/ATE51223T1/de not_active IP Right Cessation
- 1983-04-28 NZ NZ204039A patent/NZ204039A/en unknown
- 1983-04-28 SU SU833590552A patent/SU1480763A3/ru active
- 1983-04-28 DK DK188983A patent/DK161832C/da not_active IP Right Cessation
- 1983-04-28 FI FI831457A patent/FI831457L/fi not_active Application Discontinuation
- 1983-04-28 GR GR71251A patent/GR78189B/el unknown
- 1983-04-28 NZ NZ215805A patent/NZ215805A/en unknown
- 1983-04-29 HU HU831486A patent/HU194876B/hu not_active IP Right Cessation
- 1983-04-29 NO NO831514A patent/NO160581C/no unknown
- 1983-04-29 DD DD83250410A patent/DD212510B3/xx not_active IP Right Cessation
- 1983-04-29 MC MC831631A patent/MC1513A1/xx unknown
- 1983-04-29 PT PT76621A patent/PT76621B/pt unknown
- 1983-04-29 CS CS833053A patent/CS305383A2/cs unknown
- 1983-04-29 HU HU882264A patent/HU199115B/hu not_active IP Right Cessation
- 1983-04-29 MX MX8483A patent/MX155085A/es unknown
- 1983-04-29 KR KR1019830001836A patent/KR840004403A/ko not_active Application Discontinuation
- 1983-04-29 ES ES521954A patent/ES521954A0/es active Granted
- 1983-12-30 ES ES528562A patent/ES8607924A1/es not_active Expired
-
1984
- 1984-08-03 PH PH31065A patent/PH22251A/en unknown
-
1985
- 1985-04-09 GB GB08509070A patent/GB2156350B/en not_active Expired
- 1985-06-01 ES ES543809A patent/ES8609236A1/es not_active Expired
-
1986
- 1986-02-13 ES ES551942A patent/ES8800186A1/es not_active Expired
-
1987
- 1987-03-10 NO NO870981A patent/NO870981D0/no unknown
-
1988
- 1988-04-05 FI FI881563A patent/FI881563A0/fi not_active Application Discontinuation
Also Published As
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