JPS56125391A - Novel penicillin derivative, its intermediate and preparation - Google Patents

Novel penicillin derivative, its intermediate and preparation

Info

Publication number
JPS56125391A
JPS56125391A JP2798180A JP2798180A JPS56125391A JP S56125391 A JPS56125391 A JP S56125391A JP 2798180 A JP2798180 A JP 2798180A JP 2798180 A JP2798180 A JP 2798180A JP S56125391 A JPS56125391 A JP S56125391A
Authority
JP
Japan
Prior art keywords
formula
benzyl
compound
penicillin derivative
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2798180A
Other languages
Japanese (ja)
Inventor
Hamao Umezawa
Masaji Ono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP2798180A priority Critical patent/JPS56125391A/en
Publication of JPS56125391A publication Critical patent/JPS56125391A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A penicillin derivative and its intermediate of formula I (R is H or benzyl).
EXAMPLE: Benzyl 6β-[ (benzyloxycarbonylhexamethyleneiminomethylene)amino ]- 2',2-dimethylpenam-3α-carboxylate.
USE: Useful as a remedy for diseases of a man and an animal having improved antimicrobial activity against Gram-positive and Gram-negative bacteria.
PROCESS: A 1- ( benzyloxycarbonyl-ethylthiomethylene )hexamethyleneimmoniumtetrafluoroborate of formul II is reacted with benzyl ester of 6-aminopenicillanic acid of formula III usually in a solvent, e.g. acetone, under cooling or at room temperature to give a compound of formula IV in which R is benzyl group. The resultant compound is hydrogenated if desired to give the compound of formula I in which R is H.
COPYRIGHT: (C)1981,JPO&Japio
JP2798180A 1980-03-07 1980-03-07 Novel penicillin derivative, its intermediate and preparation Pending JPS56125391A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2798180A JPS56125391A (en) 1980-03-07 1980-03-07 Novel penicillin derivative, its intermediate and preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2798180A JPS56125391A (en) 1980-03-07 1980-03-07 Novel penicillin derivative, its intermediate and preparation

Publications (1)

Publication Number Publication Date
JPS56125391A true JPS56125391A (en) 1981-10-01

Family

ID=12236028

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2798180A Pending JPS56125391A (en) 1980-03-07 1980-03-07 Novel penicillin derivative, its intermediate and preparation

Country Status (1)

Country Link
JP (1) JPS56125391A (en)

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