ES8604175A1 - Procedimiento para la obtencion de isoxazoles - Google Patents

Procedimiento para la obtencion de isoxazoles

Info

Publication number
ES8604175A1
ES8604175A1 ES544192A ES544192A ES8604175A1 ES 8604175 A1 ES8604175 A1 ES 8604175A1 ES 544192 A ES544192 A ES 544192A ES 544192 A ES544192 A ES 544192A ES 8604175 A1 ES8604175 A1 ES 8604175A1
Authority
ES
Spain
Prior art keywords
group
preparation
formula
image
stand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544192A
Other languages
English (en)
Other versions
ES544192A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Biogal Gyogyszergyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT, Biogal Gyogyszergyar Rt filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES8604175A1 publication Critical patent/ES8604175A1/es
Publication of ES544192A0 publication Critical patent/ES544192A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ISOZAXOLES. COMPRENDE: A) ACTIVAR AL ACIDO ISOXAZOLCARBOXILICO CON HALOGENURO DE ALQUILO, PARA OBTENER UN COMPUESTO DE FORMULA (II); B) TRATAR A (II) CON MAGNESIO O TERC-BUTILATO POTASICO, PARA REALIZAR UN COMPUESTO DE FORMULA (III); C) HACER REACCIONAR A (III) CON HIDROCLORURO DE HIDROXILAMINA, PARA CONSEGUIR UN COMPUESTO DE FORMULA (IV); D) TRATAR A (IV) CON ACIDO ACETICO, EN PRESENCIA DE SO4H2, PARA DAR UN COMPUESTO DE FORMULA (V); Y E) HACER REACCIONAR A (V) CON UNA BASE FUERTE, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: X E Y, NITRILO, UN GRUPO CARBOXILO O -COOZ; Z ALQUILO DE C 1 A 6; Y Q, HAL O ALCOXI CARBONILO DE C 1 A 5. SE UTILIZAN COMO INTERMEDIOS DEL ANTIBIOTICO THIENAMICINA.
ES544192A 1983-02-28 1985-06-14 Procedimiento para la obtencion de isoxazoles Expired ES8604175A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU83661A HU189236B (en) 1983-02-28 1983-02-28 Process for producing new type isoxazoles

Publications (2)

Publication Number Publication Date
ES8604175A1 true ES8604175A1 (es) 1986-01-16
ES544192A0 ES544192A0 (es) 1986-01-16

Family

ID=10950718

Family Applications (3)

Application Number Title Priority Date Filing Date
ES530121A Expired ES8601935A1 (es) 1983-02-28 1984-02-28 Procedimiento para la obtencion de isoxazoles
ES544192A Expired ES8604175A1 (es) 1983-02-28 1985-06-14 Procedimiento para la obtencion de isoxazoles
ES544191A Expired ES8604174A1 (es) 1983-02-28 1985-06-14 Procedimiento para la obtencion de isoxazoles

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES530121A Expired ES8601935A1 (es) 1983-02-28 1984-02-28 Procedimiento para la obtencion de isoxazoles

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES544191A Expired ES8604174A1 (es) 1983-02-28 1985-06-14 Procedimiento para la obtencion de isoxazoles

Country Status (12)

Country Link
JP (1) JPS59164784A (es)
BE (1) BE899007A (es)
CH (1) CH658655A5 (es)
DE (1) DE3405422A1 (es)
ES (3) ES8601935A1 (es)
FR (1) FR2541678A1 (es)
GB (1) GB2135996B (es)
HU (1) HU189236B (es)
IT (1) IT1174498B (es)
NL (1) NL8400575A (es)
PT (1) PT78157B (es)
SE (1) SE8401064L (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366987A (en) * 1991-08-22 1994-11-22 Warner-Lambert Company Isoxazolyl-substituted alkyl amide ACAT inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163057A (en) * 1977-12-27 1979-07-31 Sandoz, Inc. Isoxazole-4-carboxamides as tranquilizers, sleep-inducers and muscle relaxants

Also Published As

Publication number Publication date
ES544191A0 (es) 1986-01-16
SE8401064L (sv) 1984-08-29
FR2541678A1 (fr) 1984-08-31
IT1174498B (it) 1987-07-01
GB8405001D0 (en) 1984-04-04
GB2135996A (en) 1984-09-12
ES530121A0 (es) 1985-11-16
PT78157A (de) 1984-03-01
ES8601935A1 (es) 1985-11-16
IT8419806A0 (it) 1984-02-27
CH658655A5 (de) 1986-11-28
HU189236B (en) 1986-06-30
ES8604174A1 (es) 1986-01-16
ES544192A0 (es) 1986-01-16
JPS59164784A (ja) 1984-09-17
NL8400575A (nl) 1984-09-17
GB2135996B (en) 1986-09-10
BE899007A (fr) 1984-08-27
DE3405422A1 (de) 1984-08-30
SE8401064D0 (sv) 1984-02-27
PT78157B (de) 1986-05-19

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