ES479959A1 - Un procedimiento para la produccion industrial de 1,2-diaci-lamino-1,2-di(4-piridil)etanos. - Google Patents

Un procedimiento para la produccion industrial de 1,2-diaci-lamino-1,2-di(4-piridil)etanos.

Info

Publication number
ES479959A1
ES479959A1 ES479959A ES479959A ES479959A1 ES 479959 A1 ES479959 A1 ES 479959A1 ES 479959 A ES479959 A ES 479959A ES 479959 A ES479959 A ES 479959A ES 479959 A1 ES479959 A1 ES 479959A1
Authority
ES
Spain
Prior art keywords
diacylamino
ethanes
pyridyl
producing
saturated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES479959A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Made SA
Original Assignee
Laboratorios Made SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Made SA filed Critical Laboratorios Made SA
Priority to ES479959A priority Critical patent/ES479959A1/es
Publication of ES479959A1 publication Critical patent/ES479959A1/es
Priority to DE19803008492 priority patent/DE3008492A1/de
Priority to US06/128,427 priority patent/US4288597A/en
Priority to GB8008054A priority patent/GB2048248B/en
Priority to CH194180A priority patent/CH642630A5/de
Priority to FR8006123A priority patent/FR2455041A1/fr
Priority to PT71000A priority patent/PT71000A/pt
Priority to JP5411180A priority patent/JPS55145666A/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procedimiento para la producción industrial de 1,2-diacilamino-1,2-di-(a-piridil)etanos de fórmula general **(Fórmula-01)** en la que R es un grupo alquilo saturado o insaturado, un anillo aromático homocíclico o heterocíclico con o sin sustituyentes o un cicloalquilo saturado o insaturado, caracterizado por hacer reaccionar una N-(4-picolil)-amida o preferiblemente su N-óxido de fórmula **(Fórmula-02)** en la que R tiene el significado antes indicado, con haluros o anhídridos de ácido a temperaturas superiores a 110ºC, con o sin disolventes, entre una y venticuatro horas, precipitando el producto en el seno de la reacción, y a continuación filtrar y purificar por cristalización en el seno de un disolvente apropiado de la forma habitual.
ES479959A 1979-04-26 1979-04-26 Un procedimiento para la produccion industrial de 1,2-diaci-lamino-1,2-di(4-piridil)etanos. Expired ES479959A1 (es)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ES479959A ES479959A1 (es) 1979-04-26 1979-04-26 Un procedimiento para la produccion industrial de 1,2-diaci-lamino-1,2-di(4-piridil)etanos.
DE19803008492 DE3008492A1 (de) 1979-04-26 1980-03-05 1,2-diacylamino-1,2-di-(4-pyridyl)aethane, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate
US06/128,427 US4288597A (en) 1979-04-26 1980-03-10 1,2-Diacylamino-1,2-di(4-pyridyl)ethanes and process for producing thereof
GB8008054A GB2048248B (en) 1979-04-26 1980-03-10 1,2-diacylamino-1,2-di(4-pyridyl) ethanes
CH194180A CH642630A5 (de) 1979-04-26 1980-03-12 1,2-diacylamino-1,2-di-(4-pyridyl)-aethane, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate.
FR8006123A FR2455041A1 (fr) 1979-04-26 1980-03-19 Nouveaux 1,2-diacylamino-1,2-di(4-pyridyl)-ethanes, leur procede de production et medicament les contenant
PT71000A PT71000A (en) 1979-04-26 1980-03-24 Process for the production of 1,2-diacylamino-1,2-di(4-pirydil)-ethanes
JP5411180A JPS55145666A (en) 1979-04-26 1980-04-23 Manufacture of 1*22diacylaminoo1*22 di*44pyridyl*ethane

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES479959A ES479959A1 (es) 1979-04-26 1979-04-26 Un procedimiento para la produccion industrial de 1,2-diaci-lamino-1,2-di(4-piridil)etanos.

Publications (1)

Publication Number Publication Date
ES479959A1 true ES479959A1 (es) 1979-12-01

Family

ID=8478144

Family Applications (1)

Application Number Title Priority Date Filing Date
ES479959A Expired ES479959A1 (es) 1979-04-26 1979-04-26 Un procedimiento para la produccion industrial de 1,2-diaci-lamino-1,2-di(4-piridil)etanos.

Country Status (8)

Country Link
US (1) US4288597A (es)
JP (1) JPS55145666A (es)
CH (1) CH642630A5 (es)
DE (1) DE3008492A1 (es)
ES (1) ES479959A1 (es)
FR (1) FR2455041A1 (es)
GB (1) GB2048248B (es)
PT (1) PT71000A (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA20552A1 (fr) * 1985-10-11 1986-07-01 Pan Medica Sa Alkylacarboxamides de pyridylalkylamines,leurs preparations et leurs utilisations
US5227492A (en) * 1988-01-20 1993-07-13 Yamanouchi Pharmaceutical Co., Ltd. Diurea derivatives useful as medicaments and processes for the preparation thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2493068A (en) * 1946-12-14 1950-01-03 Du Pont N,n'-diacyl-tetrahydro-1,3,5-oxadiazines
ES420074A1 (es) * 1973-10-30 1976-07-01 Made Labor Sa Un metodo para la produccion industrial de dipropilacetami-das n-sustituidas.
FR2269933A1 (en) * 1974-03-29 1975-12-05 Made Labor Sa 3,5-Dimethylbenzamide derivs - with anti-inflammatory and anticonvulsant activity

Also Published As

Publication number Publication date
DE3008492A1 (de) 1980-11-06
PT71000A (en) 1980-04-01
GB2048248B (en) 1983-01-26
JPS55145666A (en) 1980-11-13
GB2048248A (en) 1980-12-10
US4288597A (en) 1981-09-08
FR2455041B1 (es) 1983-09-02
CH642630A5 (de) 1984-04-30
FR2455041A1 (fr) 1980-11-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010301