ES8601935A1 - Procedimiento para la obtencion de isoxazoles - Google Patents

Procedimiento para la obtencion de isoxazoles

Info

Publication number
ES8601935A1
ES8601935A1 ES530121A ES530121A ES8601935A1 ES 8601935 A1 ES8601935 A1 ES 8601935A1 ES 530121 A ES530121 A ES 530121A ES 530121 A ES530121 A ES 530121A ES 8601935 A1 ES8601935 A1 ES 8601935A1
Authority
ES
Spain
Prior art keywords
group
preparation
formula
image
stand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530121A
Other languages
English (en)
Other versions
ES530121A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Biogal Gyogyszergyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT, Biogal Gyogyszergyar Rt filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES530121A0 publication Critical patent/ES530121A0/es
Publication of ES8601935A1 publication Critical patent/ES8601935A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ISOXAZOLES. COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UNA BASE FUERTE, COMO HIDROXIDOS ALCALINOS, ALCOHOLATOS DE METAL ALCALINO, DIAZABICICLO 5,4,0 UNDEC-5-ENO, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO X E Y, INDEPENDIENTEMENTE, NITRILO, UN GRUPO CARBOXILO EN CASO DADO ACTIVADO, O COOZ O CONRR; Z, UN GRUPO ALQUILO DE C 1 A 6; R Y R; H, GRUPO FENILO, BENCILO Y OTROS; Y X E Y, JUNTOS UN GRUPO ANHIDRIDO DE FORMULA O C-O-C O; Y B) AISLAR EL PRODUCTO OBTENIDO QUE CONTIENE COMO SUSTITUYENTES Y UN GRUPO CARBOXILO Y COMO SUSTITUYENTE X UN GRUPO NITRILO. SE UTILIZAN COMO INTERMEDIOS DEL ANTIBIOTICO THIENAMICINA, DE GRAN ESPECTRO DE ACTIVIDAD.
ES530121A 1983-02-28 1984-02-28 Procedimiento para la obtencion de isoxazoles Expired ES8601935A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU83661A HU189236B (en) 1983-02-28 1983-02-28 Process for producing new type isoxazoles

Publications (2)

Publication Number Publication Date
ES530121A0 ES530121A0 (es) 1985-11-16
ES8601935A1 true ES8601935A1 (es) 1985-11-16

Family

ID=10950718

Family Applications (3)

Application Number Title Priority Date Filing Date
ES530121A Expired ES8601935A1 (es) 1983-02-28 1984-02-28 Procedimiento para la obtencion de isoxazoles
ES544192A Expired ES8604175A1 (es) 1983-02-28 1985-06-14 Procedimiento para la obtencion de isoxazoles
ES544191A Expired ES8604174A1 (es) 1983-02-28 1985-06-14 Procedimiento para la obtencion de isoxazoles

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES544192A Expired ES8604175A1 (es) 1983-02-28 1985-06-14 Procedimiento para la obtencion de isoxazoles
ES544191A Expired ES8604174A1 (es) 1983-02-28 1985-06-14 Procedimiento para la obtencion de isoxazoles

Country Status (12)

Country Link
JP (1) JPS59164784A (es)
BE (1) BE899007A (es)
CH (1) CH658655A5 (es)
DE (1) DE3405422A1 (es)
ES (3) ES8601935A1 (es)
FR (1) FR2541678A1 (es)
GB (1) GB2135996B (es)
HU (1) HU189236B (es)
IT (1) IT1174498B (es)
NL (1) NL8400575A (es)
PT (1) PT78157B (es)
SE (1) SE8401064L (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366987A (en) * 1991-08-22 1994-11-22 Warner-Lambert Company Isoxazolyl-substituted alkyl amide ACAT inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163057A (en) * 1977-12-27 1979-07-31 Sandoz, Inc. Isoxazole-4-carboxamides as tranquilizers, sleep-inducers and muscle relaxants

Also Published As

Publication number Publication date
ES544191A0 (es) 1986-01-16
SE8401064L (sv) 1984-08-29
FR2541678A1 (fr) 1984-08-31
IT1174498B (it) 1987-07-01
GB8405001D0 (en) 1984-04-04
ES8604175A1 (es) 1986-01-16
GB2135996A (en) 1984-09-12
ES530121A0 (es) 1985-11-16
PT78157A (de) 1984-03-01
IT8419806A0 (it) 1984-02-27
CH658655A5 (de) 1986-11-28
HU189236B (en) 1986-06-30
ES8604174A1 (es) 1986-01-16
ES544192A0 (es) 1986-01-16
JPS59164784A (ja) 1984-09-17
NL8400575A (nl) 1984-09-17
GB2135996B (en) 1986-09-10
BE899007A (fr) 1984-08-27
DE3405422A1 (de) 1984-08-30
SE8401064D0 (sv) 1984-02-27
PT78157B (de) 1986-05-19

Similar Documents

Publication Publication Date Title
EG20440A (en) Process for preparing of substituted pyrazoles
ES8607287A1 (es) Un procedimiento para preparar derivados de 1,8-naftiridina
JPS559058A (en) 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative
TW341565B (en) Indole derivatives processes and intermediates for their preparation and pharmaceutical compositions containing them
TW256832B (es)
ES8503686A1 (es) Procedimiento de preparar derivados de penicilina.
ES8403466A1 (es) Procedimiento para la obtencion de derivados de hidroxialquinil-azolilo.
HUP0203787A2 (hu) Hidroxi-acetil-piperazinnal szubsztituált oxazolidinon-benzoesav-észterek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
GB9215844D0 (en) Novel compounds
ES8706371A1 (es) Procedimiento para preparar derivados de tetrazol con actividad insecticida
ES8706144A1 (es) Un procedimiento para preparar derivados de 1,8-naftiridina
ES8700669A1 (es) Procedimiento de preparar derivados penam y sus sales
TW427990B (en) Process for preparing substituted oxazinoindole carboxamides and the intermediates therefor
ES8604175A1 (es) Procedimiento para la obtencion de isoxazoles
ES8101589A1 (es) Un procedimiento para la preparacion de nuevos compuestos iminicos heterociclicos.
IE830469L (en) Fungicidal cyanopropenoates
ES8305359A1 (es) Un procedimiento para la preparacion de benzamitas sustituidas.
ES8101646A1 (es) Un procedimiento para producir un compuesto opticamente ac- tivo
ES8200649A1 (es) Procedimiento de preparacion de derivados del acido ciclo- propano-carboxilico
HU886767D0 (en) Process for the preparation of new 20,21-dinor-eburnamenine derivatives, new intermediates thereof, as well as pharmaceutical compositions containing said compounds as active ingredients
AU543519B2 (en) New peptide amides and process for their manufacture
ES8503655A1 (es) Un procedimiento para preparar nuevas dihidropiridinas.
ES8200142A1 (es) Un procedimiento para la produccion de analogos de cefalosporina.
ES8105306A1 (es) Un procedimiento para la preparacion de nuevos derivados de oxazolina y tiazolina
ES479959A1 (es) Un procedimiento para la produccion industrial de 1,2-diaci-lamino-1,2-di(4-piridil)etanos.