ES8603471A1 - Procedimiento para preparar nuevos derivados de indol - Google Patents

Procedimiento para preparar nuevos derivados de indol

Info

Publication number
ES8603471A1
ES8603471A1 ES542723A ES542723A ES8603471A1 ES 8603471 A1 ES8603471 A1 ES 8603471A1 ES 542723 A ES542723 A ES 542723A ES 542723 A ES542723 A ES 542723A ES 8603471 A1 ES8603471 A1 ES 8603471A1
Authority
ES
Spain
Prior art keywords
alkyl
alkoxy
compounds
preparation
indole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES542723A
Other languages
English (en)
Other versions
ES542723A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES8603471A1 publication Critical patent/ES8603471A1/es
Publication of ES542723A0 publication Critical patent/ES542723A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS DE INDOL. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN DERIVADO DE ACIDO CARBONICO DE FORMULA W-CO-W, PARA OBTENER DERIVADOS DE INDOL DE FORMULA (I) Y SUS SALES DE ADICION DE ACIDOS DE FORMULA (I), DONDE A ES UN GRUPO -N5H-CO- Y B SIGNIFICA UN GRUPO METILENO, CARBONILO O TIOCARBONILO; E SIGNIFICA UN GRUPO ALQUILENO CON C 2 A 4; G SIGNIFICA UN GRUPO ALQUILENO CON C 1 A 5; R1 SIGNIFICA UN ATOMO DE H, CLORO O BROMO Y OTROS; R2 SIGNIFICA UN ATOMO DE H, O UN GRUPO HIDROXI, ALCOXI Y OTROS; R3 SIGNIFICA UN ATOMO DE H, UN GRUPO ALQUILO CON C 1 A 4 O CLORO O BROMO; R4 SIGNIFICA UN ATOMO DE H, UN GRUPO ALQUILO O FENILALQUILO; R5 SIGNIFICA UN ATOMO DE H, FLUOR O CLORO, O UN GRUPO ALQUILO, HIDROXI Y OTROS; R6 ES UN ATOMO DE H O UN GRUPO ALCOXI CON C 1 A 3; Y R7 ES UN ATOMO DE H UN GRUPO ALQUENILO CON C 3 A 5 Y OTROS. TIENEN PROPIEDADES FARMACEUTICAS PARA ENFERMEDADES CARDIACAS.
ES542723A 1983-12-03 1985-04-30 Procedimiento para preparar nuevos derivados de indol Granted ES542723A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833343801 DE3343801A1 (de) 1983-12-03 1983-12-03 Neue indolderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES8603471A1 true ES8603471A1 (es) 1985-12-16
ES542723A0 ES542723A0 (es) 1985-12-16

Family

ID=6215987

Family Applications (2)

Application Number Title Priority Date Filing Date
ES538120A Granted ES538120A0 (es) 1983-12-03 1984-11-30 Procedimiento para preparar derivados de indol
ES542723A Granted ES542723A0 (es) 1983-12-03 1985-04-30 Procedimiento para preparar nuevos derivados de indol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES538120A Granted ES538120A0 (es) 1983-12-03 1984-11-30 Procedimiento para preparar derivados de indol

Country Status (20)

Country Link
US (1) US4616011A (es)
EP (1) EP0146787B1 (es)
JP (1) JPS60132981A (es)
KR (1) KR910010134B1 (es)
AT (1) ATE36530T1 (es)
AU (1) AU577811B2 (es)
CA (1) CA1225089A (es)
DD (1) DD229699A5 (es)
DE (2) DE3343801A1 (es)
DK (1) DK571284A (es)
ES (2) ES538120A0 (es)
FI (1) FI82462C (es)
GR (1) GR81106B (es)
HU (1) HU193305B (es)
IL (1) IL73696A (es)
NO (1) NO159596C (es)
NZ (1) NZ210403A (es)
PH (1) PH23221A (es)
PT (1) PT79600B (es)
ZA (1) ZA849343B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0204349A3 (de) * 1985-06-01 1990-01-03 Dr. Karl Thomae GmbH Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5175157A (en) * 1985-11-27 1992-12-29 Boehringer Ingelheim Gmbh Cyclic amine derivatives, pharmaceutical compositions containing these compounds and methods for preparing them
DE3631013A1 (de) * 1986-09-12 1988-03-24 Thomae Gmbh Dr K Neue naphthylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
FR2932800B1 (fr) * 2008-06-20 2015-02-20 Servier Lab Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR3003859B1 (fr) * 2013-03-26 2015-03-13 Servier Lab "procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"
US11352326B2 (en) 2016-11-16 2022-06-07 The General Hospital Corporation Myeloperoxidase imaging agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4059583A (en) * 1975-11-13 1977-11-22 Mcneil Laboratories, Incorporated Substituted indoles
DE2639718C2 (de) * 1976-09-03 1987-03-05 Dr. Karl Thomae Gmbh, 7950 Biberach 1-[6,7-Dimethoxy-3,4-dihydro-2H-isochinolin-1-on-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-äthyl)-amino]-propan, dessen physiologisch verträgliche Säureadditionssalze und diese Verbindungen enthaltende Arzneimittel
EP0000151B1 (en) * 1977-06-28 1981-05-20 Sandoz Ag 1-substituted aminoindolines, process for their production and pharmaceutical compositions containing them
US4462933A (en) * 1979-11-05 1984-07-31 Hoechst-Roussel Pharmaceuticals, Incorporated Process for preparing 4-phenyl-1,3-benzodiazepines
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4490369A (en) * 1981-05-19 1984-12-25 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Benzazepine derivatives, their pharmaceutical compositions and method of use

Also Published As

Publication number Publication date
AU3606884A (en) 1985-06-06
JPS60132981A (ja) 1985-07-16
EP0146787A2 (de) 1985-07-03
NO159596C (no) 1989-01-18
EP0146787A3 (en) 1985-11-21
EP0146787B1 (de) 1988-08-17
HU193305B (en) 1987-09-28
IL73696A0 (en) 1985-02-28
DD229699A5 (de) 1985-11-13
DK571284A (da) 1985-06-04
ATE36530T1 (de) 1988-09-15
PT79600B (de) 1986-12-12
ZA849343B (en) 1986-08-27
PH23221A (en) 1989-06-06
DE3473451D1 (en) 1988-09-22
FI82462B (fi) 1990-11-30
GR81106B (en) 1985-04-01
KR910010134B1 (ko) 1991-12-17
FI82462C (fi) 1991-03-11
ES8601974A1 (es) 1985-11-01
ES538120A0 (es) 1985-11-01
JPH0437831B2 (es) 1992-06-22
IL73696A (en) 1987-10-30
PT79600A (de) 1985-01-01
CA1225089A (en) 1987-08-04
ES542723A0 (es) 1985-12-16
NO159596B (no) 1988-10-10
DK571284D0 (da) 1984-11-30
NZ210403A (en) 1988-02-12
KR850004753A (ko) 1985-07-27
AU577811B2 (en) 1988-10-06
HUT37143A (en) 1985-11-28
FI844709A0 (fi) 1984-11-30
FI844709L (fi) 1985-06-04
NO844780L (no) 1985-06-04
DE3343801A1 (de) 1985-06-13
US4616011A (en) 1986-10-07

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603