ZA849343B - New indole derivatives,pharmaceutical compositions containing these compounds and processes for preparing them - Google Patents

New indole derivatives,pharmaceutical compositions containing these compounds and processes for preparing them

Info

Publication number
ZA849343B
ZA849343B ZA849343A ZA849343A ZA849343B ZA 849343 B ZA849343 B ZA 849343B ZA 849343 A ZA849343 A ZA 849343A ZA 849343 A ZA849343 A ZA 849343A ZA 849343 B ZA849343 B ZA 849343B
Authority
ZA
South Africa
Prior art keywords
group
alkyl
hydrogen
chlorine
alkoxy
Prior art date
Application number
ZA849343A
Other languages
English (en)
Inventor
Manfred Dr Reiffen
Joachim Dr Heider
Volkhard Dr Austel
Norbert Dr Hauel
Walter Prof Dr Kobinger
Christian Dr Lillie
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of ZA849343B publication Critical patent/ZA849343B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA849343A 1983-12-03 1984-11-30 New indole derivatives,pharmaceutical compositions containing these compounds and processes for preparing them ZA849343B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833343801 DE3343801A1 (de) 1983-12-03 1983-12-03 Neue indolderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
ZA849343B true ZA849343B (en) 1986-08-27

Family

ID=6215987

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA849343A ZA849343B (en) 1983-12-03 1984-11-30 New indole derivatives,pharmaceutical compositions containing these compounds and processes for preparing them

Country Status (20)

Country Link
US (1) US4616011A (xx)
EP (1) EP0146787B1 (xx)
JP (1) JPS60132981A (xx)
KR (1) KR910010134B1 (xx)
AT (1) ATE36530T1 (xx)
AU (1) AU577811B2 (xx)
CA (1) CA1225089A (xx)
DD (1) DD229699A5 (xx)
DE (2) DE3343801A1 (xx)
DK (1) DK571284A (xx)
ES (2) ES538120A0 (xx)
FI (1) FI82462C (xx)
GR (1) GR81106B (xx)
HU (1) HU193305B (xx)
IL (1) IL73696A (xx)
NO (1) NO159596C (xx)
NZ (1) NZ210403A (xx)
PH (1) PH23221A (xx)
PT (1) PT79600B (xx)
ZA (1) ZA849343B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0204349A3 (de) * 1985-06-01 1990-01-03 Dr. Karl Thomae GmbH Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5175157A (en) * 1985-11-27 1992-12-29 Boehringer Ingelheim Gmbh Cyclic amine derivatives, pharmaceutical compositions containing these compounds and methods for preparing them
DE3631013A1 (de) * 1986-09-12 1988-03-24 Thomae Gmbh Dr K Neue naphthylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
FR2932800B1 (fr) * 2008-06-20 2015-02-20 Servier Lab Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR3003859B1 (fr) * 2013-03-26 2015-03-13 Servier Lab "procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"
US11352326B2 (en) 2016-11-16 2022-06-07 The General Hospital Corporation Myeloperoxidase imaging agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4059583A (en) * 1975-11-13 1977-11-22 Mcneil Laboratories, Incorporated Substituted indoles
DE2639718C2 (de) * 1976-09-03 1987-03-05 Dr. Karl Thomae Gmbh, 7950 Biberach 1-[6,7-Dimethoxy-3,4-dihydro-2H-isochinolin-1-on-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-äthyl)-amino]-propan, dessen physiologisch verträgliche Säureadditionssalze und diese Verbindungen enthaltende Arzneimittel
EP0000151B1 (en) * 1977-06-28 1981-05-20 Sandoz Ag 1-substituted aminoindolines, process for their production and pharmaceutical compositions containing them
US4462933A (en) * 1979-11-05 1984-07-31 Hoechst-Roussel Pharmaceuticals, Incorporated Process for preparing 4-phenyl-1,3-benzodiazepines
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4490369A (en) * 1981-05-19 1984-12-25 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Benzazepine derivatives, their pharmaceutical compositions and method of use

Also Published As

Publication number Publication date
AU3606884A (en) 1985-06-06
JPS60132981A (ja) 1985-07-16
ES8603471A1 (es) 1985-12-16
EP0146787A2 (de) 1985-07-03
NO159596C (no) 1989-01-18
EP0146787A3 (en) 1985-11-21
EP0146787B1 (de) 1988-08-17
HU193305B (en) 1987-09-28
IL73696A0 (en) 1985-02-28
DD229699A5 (de) 1985-11-13
DK571284A (da) 1985-06-04
ATE36530T1 (de) 1988-09-15
PT79600B (de) 1986-12-12
PH23221A (en) 1989-06-06
DE3473451D1 (en) 1988-09-22
FI82462B (fi) 1990-11-30
GR81106B (en) 1985-04-01
KR910010134B1 (ko) 1991-12-17
FI82462C (fi) 1991-03-11
ES8601974A1 (es) 1985-11-01
ES538120A0 (es) 1985-11-01
JPH0437831B2 (xx) 1992-06-22
IL73696A (en) 1987-10-30
PT79600A (de) 1985-01-01
CA1225089A (en) 1987-08-04
ES542723A0 (es) 1985-12-16
NO159596B (no) 1988-10-10
DK571284D0 (da) 1984-11-30
NZ210403A (en) 1988-02-12
KR850004753A (ko) 1985-07-27
AU577811B2 (en) 1988-10-06
HUT37143A (en) 1985-11-28
FI844709A0 (fi) 1984-11-30
FI844709L (fi) 1985-06-04
NO844780L (no) 1985-06-04
DE3343801A1 (de) 1985-06-13
US4616011A (en) 1986-10-07

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