ES8601859A1 - Un procedimiento para preparar compuestos de amida de acido carboxilico - Google Patents

Un procedimiento para preparar compuestos de amida de acido carboxilico

Info

Publication number
ES8601859A1
ES8601859A1 ES528409A ES528409A ES8601859A1 ES 8601859 A1 ES8601859 A1 ES 8601859A1 ES 528409 A ES528409 A ES 528409A ES 528409 A ES528409 A ES 528409A ES 8601859 A1 ES8601859 A1 ES 8601859A1
Authority
ES
Spain
Prior art keywords
carboxylic acid
derivatives
compounds
diseases
acid amides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528409A
Other languages
English (en)
Other versions
ES528409A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of ES8601859A1 publication Critical patent/ES8601859A1/es
Publication of ES528409A0 publication Critical patent/ES528409A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/59—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS EN LAS FUNCIONES AMIDA Y ACIDO CARBOXILICO, REPRESENTADOS POR LA FORMULA GENERAL (I), EN LA QUE A CONSTITUYE JUNTO CON LOS DOS ATOMOS DE CARBONO REPRESENTADOS RESPECTIVAMENTE POR A Y B, UN GRUPO ESPECIAL DE FORMULA (II). CONSISTE EN HACER REACCIONAR UN COMPUESTO DE 3,5-BISTRIFLUOROMETIL-ANILINA, CON ANHIDRIDO CARBOXILICO, REPRESENTADO POR LA FORMULA GENERAL (III), EN LA QUE A TIENE LOS SIGNIFICADOS YA MENCIONADOS. DE APLICACION COMO AGENTES PARA EL TRATAMIENTO, PREVENCION Y MEJORA DE LAS ENFERMEDADES QUE VIENEN ACOMPAÑADAS DE DISFUNCION CEREBRAL, TAL COMO LA EPILEPSIA, SECUELAS DE ENFERMEDADES CEREBRO-VASCULARES, SECUELAS DE HERIDAS EN LA CABEZA Y SIMILARES.
ES528409A 1982-12-27 1983-12-26 Un procedimiento para preparar compuestos de amida de acido carboxilico Granted ES528409A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57226685A JPS59118750A (ja) 1982-12-27 1982-12-27 カルボン酸アミド化合物およびその誘導体

Publications (2)

Publication Number Publication Date
ES8601859A1 true ES8601859A1 (es) 1985-11-01
ES528409A0 ES528409A0 (es) 1985-11-01

Family

ID=16849045

Family Applications (2)

Application Number Title Priority Date Filing Date
ES528409A Granted ES528409A0 (es) 1982-12-27 1983-12-26 Un procedimiento para preparar compuestos de amida de acido carboxilico
ES543810A Expired ES8608486A1 (es) 1982-12-27 1985-06-01 Un procedimiento para preparar un compuesto de carboximida

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES543810A Expired ES8608486A1 (es) 1982-12-27 1985-06-01 Un procedimiento para preparar un compuesto de carboximida

Country Status (18)

Country Link
US (1) US4661630A (es)
JP (1) JPS59118750A (es)
KR (1) KR840007714A (es)
AU (1) AU2253183A (es)
BE (1) BE898570A (es)
CA (1) CA1202312A (es)
CH (1) CH656875A5 (es)
DE (1) DE3346814A1 (es)
DK (1) DK596083A (es)
ES (2) ES528409A0 (es)
FR (1) FR2538386B1 (es)
GB (1) GB2133006B (es)
HU (1) HU189799B (es)
IT (1) IT1170275B (es)
NL (1) NL8304406A (es)
PH (1) PH19459A (es)
SE (1) SE8307119L (es)
ZA (1) ZA839546B (es)

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JPS59231057A (ja) * 1983-06-14 1984-12-25 Eisai Co Ltd カルボン酸アミド化合物およびその誘導体
DE3334822A1 (de) * 1983-09-26 1985-04-04 Bayer Ag, 5090 Leverkusen Neue flammschutzmittel, ihre herstellung und ihre verwendung zur flammfestausruestung von polycarbonaten
EP1854798A3 (en) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
ATE548031T1 (de) * 2000-12-18 2012-03-15 Inst Med Molecular Design Inc Inhibitoren gegen die produktion und freisetzung entzündungfördernder zytokine
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
WO2003006424A1 (en) 2001-07-10 2003-01-23 4Sc Ag Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
DE10222895A1 (de) * 2002-05-23 2003-12-11 Bosch Gmbh Robert Hochdruckspeicher für Kraftstoffeinspritzsysteme mit integriertem Druckregelventil
EP1510207A4 (en) * 2002-06-05 2008-12-31 Inst Med Molecular Design Inc THERAPEUTIC MEDICAMENT AGAINST DIABETES
AU2003242131A1 (en) * 2002-06-05 2003-12-22 Institute Of Medicinal Molecular Design, Inc. Immunity-related protein kinase inhibitors
EP1512396A4 (en) * 2002-06-05 2008-12-31 Inst Med Molecular Design Inc INHIBITORS OF AP-1 AND NFAT ACTIVATION
KR20110028554A (ko) * 2002-06-06 2011-03-18 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 Ｏ-치환 히드록시아릴 유도체
CN1658872B (zh) * 2002-06-06 2010-09-22 株式会社医药分子设计研究所 抗过敏药
EA010835B1 (ru) * 2002-06-10 2008-12-30 Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. Лекарственное средство для лечения рака
WO2003103654A1 (ja) * 2002-06-10 2003-12-18 株式会社医薬分子設計研究所 ＮＦ−κＢ活性化阻害剤
JP4635130B2 (ja) * 2002-06-11 2011-02-16 株式会社医薬分子設計研究所 神経変性疾患治療剤
EP1561978B1 (en) * 2002-11-12 2008-04-09 Nok Corporation Rubber-like elastic part
US7247736B2 (en) * 2002-12-23 2007-07-24 4Sc Ag Method of identifying inhibitors of DHODH
EP1581478A1 (en) * 2002-12-23 2005-10-05 4Sc Ag Dhodh-inhibitors and method for their identification
WO2004056746A1 (en) * 2002-12-23 2004-07-08 4Sc Ag Cycloalkene dicarboxylic acid compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
US7365094B2 (en) 2002-12-23 2008-04-29 4Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
EP1541198A1 (en) * 2003-12-05 2005-06-15 4Sc Ag Cycloalkyl compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
CA2803920A1 (en) * 2010-06-24 2011-12-29 Richard Beard Derivatives of cycloalkyl- and cycloalkenyl-1,2-dicarboxylic acid compounds having formyl peptide receptor like-1 (fprl-1) agonist or antagonist activity
UA108760C2 (uk) 2010-07-01 2015-06-10 Кальцієві солі сполуки як протизапальні, імуномодулюючі та антипроліферативні засоби
RS65563B1 (sr) 2018-03-16 2024-06-28 Immunic Ag Novi polimorfi kalcijumove soli kao anti-inflamatorni, imunomodulatorni i anti-proliferativni agensi
EP4056285A1 (en) 2021-03-12 2022-09-14 Atotech Deutschland GmbH & Co. KG Triazine silane compound and its usage as adhesion promotor
EP4057782A1 (en) 2021-03-12 2022-09-14 Atotech Deutschland GmbH & Co. KG Method for increasing adhesion strength between copper and an organic material and reducing halo and wedge void formation by modifying the copper surface and/or by using heteroaromatic silane compounds

Family Cites Families (21)

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US2794811A (en) * 1954-06-03 1957-06-04 Allied Chem & Dye Corp Production of cis-cyclohexane-1, 2-dicarboxylic anhydride
US2959599A (en) * 1956-11-19 1960-11-08 Allied Chem Isomerization of cyclohexene-1, 2-dicarboxylic anhydrides
US3085096A (en) * 1961-05-31 1963-04-09 Petro Tex Chem Corp Preparation of cis-4-cyclohexene-1, 2-di-carboxylic acid anhydride
US3507904A (en) * 1966-04-01 1970-04-21 Herbert Schwartz Novel tetrahydrophthalamic acids and derivatives thereof
US3922158A (en) * 1967-12-19 1975-11-25 Ciba Geigy Ag Method for inhibiting the growth of dicotyledonous plants
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US3825594A (en) * 1970-01-20 1974-07-23 Sandoz Ag Bis(trifluoromethyl)benzamides
US3654302A (en) * 1970-01-30 1972-04-04 Herbert Schwartz Tetrahydrophthalanils
US3987056A (en) * 1973-05-07 1976-10-19 Phillips Petroleum Company Disproportionation of n-aryl-1,2,3,6-tetrahydrophthalimides
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JPS59231057A (ja) * 1983-06-14 1984-12-25 Eisai Co Ltd カルボン酸アミド化合物およびその誘導体

Also Published As

Publication number Publication date
ES8608486A1 (es) 1986-06-16
CA1202312A (en) 1986-03-25
AU2253183A (en) 1984-07-05
GB2133006B (en) 1986-10-22
GB8333713D0 (en) 1984-01-25
US4661630A (en) 1987-04-28
GB2133006A (en) 1984-07-18
CH656875A5 (de) 1986-07-31
NL8304406A (nl) 1984-07-16
FR2538386A1 (fr) 1984-06-29
BE898570A (fr) 1984-06-27
ES543810A0 (es) 1986-06-16
PH19459A (en) 1986-04-18
DK596083D0 (da) 1983-12-23
DK596083A (da) 1984-06-28
IT8324351A0 (it) 1983-12-23
ZA839546B (en) 1984-08-29
JPS59118750A (ja) 1984-07-09
HU189799B (en) 1986-07-28
JPH0136819B2 (es) 1989-08-02
DE3346814A1 (de) 1984-06-28
SE8307119D0 (sv) 1983-12-22
KR840007714A (ko) 1984-12-10
ES528409A0 (es) 1985-11-01
IT1170275B (it) 1987-06-03
FR2538386B1 (fr) 1986-04-18
SE8307119L (sv) 1984-06-28

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