FR2538386B1 - Nouveaux amides et imides carboxyliques procedes pour leur preparation et composition pharmaceutique les contenant - Google Patents

Nouveaux amides et imides carboxyliques procedes pour leur preparation et composition pharmaceutique les contenant

Info

Publication number
FR2538386B1
FR2538386B1 FR8320864A FR8320864A FR2538386B1 FR 2538386 B1 FR2538386 B1 FR 2538386B1 FR 8320864 A FR8320864 A FR 8320864A FR 8320864 A FR8320864 A FR 8320864A FR 2538386 B1 FR2538386 B1 FR 2538386B1
Authority
FR
France
Prior art keywords
imides
processes
preparation
pharmaceutical composition
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8320864A
Other languages
English (en)
Other versions
FR2538386A1 (fr
Inventor
Yasuji Harigaya
Hiroo Ogura
Mitsuo Mihara
Motosuke Yamanaka
Kiyomi Yamatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of FR2538386A1 publication Critical patent/FR2538386A1/fr
Application granted granted Critical
Publication of FR2538386B1 publication Critical patent/FR2538386B1/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/59—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR8320864A 1982-12-27 1983-12-27 Nouveaux amides et imides carboxyliques procedes pour leur preparation et composition pharmaceutique les contenant Expired FR2538386B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57226685A JPS59118750A (ja) 1982-12-27 1982-12-27 カルボン酸アミド化合物およびその誘導体

Publications (2)

Publication Number Publication Date
FR2538386A1 FR2538386A1 (fr) 1984-06-29
FR2538386B1 true FR2538386B1 (fr) 1986-04-18

Family

ID=16849045

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8320864A Expired FR2538386B1 (fr) 1982-12-27 1983-12-27 Nouveaux amides et imides carboxyliques procedes pour leur preparation et composition pharmaceutique les contenant

Country Status (18)

Country Link
US (1) US4661630A (fr)
JP (1) JPS59118750A (fr)
KR (1) KR840007714A (fr)
AU (1) AU2253183A (fr)
BE (1) BE898570A (fr)
CA (1) CA1202312A (fr)
CH (1) CH656875A5 (fr)
DE (1) DE3346814A1 (fr)
DK (1) DK596083A (fr)
ES (2) ES528409A0 (fr)
FR (1) FR2538386B1 (fr)
GB (1) GB2133006B (fr)
HU (1) HU189799B (fr)
IT (1) IT1170275B (fr)
NL (1) NL8304406A (fr)
PH (1) PH19459A (fr)
SE (1) SE8307119L (fr)
ZA (1) ZA839546B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59231057A (ja) * 1983-06-14 1984-12-25 Eisai Co Ltd カルボン酸アミド化合物およびその誘導体
DE3334822A1 (de) * 1983-09-26 1985-04-04 Bayer Ag, 5090 Leverkusen Neue flammschutzmittel, ihre herstellung und ihre verwendung zur flammfestausruestung von polycarbonaten
EP1854798A3 (fr) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Composés de succinimide hétérocyclique fondu et leurs analogies, modulateurs de la fonction de récepteur d'hormone nucléaire
JP4224566B2 (ja) * 2000-12-18 2009-02-18 株式会社医薬分子設計研究所 炎症性サイトカイン産生遊離抑制剤
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
MXPA04000224A (es) 2001-07-10 2005-07-25 4Sc Ag Novedosos compuestos como agentes antiinflamatorios, inmunomoduladores y antiproliferativos.
DE10222895A1 (de) * 2002-05-23 2003-12-11 Bosch Gmbh Robert Hochdruckspeicher für Kraftstoffeinspritzsysteme mit integriertem Druckregelventil
JPWO2003103647A1 (ja) * 2002-06-05 2005-10-06 株式会社医薬分子設計研究所 Ａｐ−１及びｎｆａｔ活性化阻害剤
WO2003103648A1 (fr) * 2002-06-05 2003-12-18 株式会社医薬分子設計研究所 Medicaments therapeutiques destines au diabete
TW200407112A (en) * 2002-06-05 2004-05-16 Inst Med Molecular Design Inc Immunity-related protein kinase inhibitors
CN1658872B (zh) * 2002-06-06 2010-09-22 株式会社医药分子设计研究所 抗过敏药
KR101118807B1 (ko) * 2002-06-06 2012-04-12 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 Ｏ-치환 히드록시아릴 유도체
AU2003242098B2 (en) * 2002-06-10 2008-11-20 Institute Of Medicinal Molecular Design, Inc Inhibitors against activation of NFkappaB
CN100506221C (zh) * 2002-06-10 2009-07-01 株式会社医药分子设计研究所 癌症治疗药
JP4635130B2 (ja) * 2002-06-11 2011-02-16 株式会社医薬分子設計研究所 神経変性疾患治療剤
US7959161B2 (en) * 2002-11-12 2011-06-14 Nok Corporation Rubber-like elastic part
US7071355B2 (en) 2002-12-23 2006-07-04 4 Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
US7365094B2 (en) 2002-12-23 2008-04-29 4Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
EP1541198A1 (fr) * 2003-12-05 2005-06-15 4Sc Ag Composés cycloalkyles utilisés comme agents anti-inflammatoires, immunomodulateurs et anti-proliferatifs
EP1581478A1 (fr) * 2002-12-23 2005-10-05 4Sc Ag Inhibiteurs de l'enzyme dhodh et leur procede d'identification
US7247736B2 (en) * 2002-12-23 2007-07-24 4Sc Ag Method of identifying inhibitors of DHODH
AU2011270872A1 (en) * 2010-06-24 2013-01-31 Allergan, Inc. Derivatives of cycloalkyl- and cycloalkenyl-1,2-dicarboxylic acid compounds having formyl peptide receptor like-1 (FPRL-1) agonist or antagonist activity
UA108760C2 (uk) 2010-07-01 2015-06-10 Кальцієві солі сполуки як протизапальні, імуномодулюючі та антипроліферативні засоби
IL307422A (en) 2018-03-16 2023-12-01 Immunic Ag Polymorphs of the calcium salts that suppress dihydrouroatate dehydrogenase, and methods for their production
EP4056285A1 (fr) 2021-03-12 2022-09-14 Atotech Deutschland GmbH & Co. KG Composé de silane de triazine et son utilisation en tant que promoteur d'adhésion
EP4057782A1 (fr) 2021-03-12 2022-09-14 Atotech Deutschland GmbH & Co. KG Méthode pour augmenter la force d'adhésion entre le cuivre et un matériau organique et réduire la formation de halo et de vide cunéiforme en modifiant la surface de cuivre et/ou en utilisant des composés de silane hétéroaromatiques

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2794811A (en) * 1954-06-03 1957-06-04 Allied Chem & Dye Corp Production of cis-cyclohexane-1, 2-dicarboxylic anhydride
US2959599A (en) * 1956-11-19 1960-11-08 Allied Chem Isomerization of cyclohexene-1, 2-dicarboxylic anhydrides
US3085096A (en) * 1961-05-31 1963-04-09 Petro Tex Chem Corp Preparation of cis-4-cyclohexene-1, 2-di-carboxylic acid anhydride
US3507904A (en) * 1966-04-01 1970-04-21 Herbert Schwartz Novel tetrahydrophthalamic acids and derivatives thereof
CH489993A (de) * 1967-12-19 1970-05-15 Ciba Geigy Das Pflanzenwachstum regulierendes und phytocides Mittel
US3922158A (en) * 1967-12-19 1975-11-25 Ciba Geigy Ag Method for inhibiting the growth of dicotyledonous plants
US3549655A (en) * 1967-12-21 1970-12-22 Dow Chemical Co N-(substituted phenyl) cyclobutanedicarboximides
US3745170A (en) * 1969-03-19 1973-07-10 Sumitomo Chemical Co Novel n-(3,5-dihalophenyl)-imide compounds
FR2059977A1 (fr) * 1969-08-14 1971-06-11 Socibre
US3825594A (en) * 1970-01-20 1974-07-23 Sandoz Ag Bis(trifluoromethyl)benzamides
US3654302A (en) * 1970-01-30 1972-04-04 Herbert Schwartz Tetrahydrophthalanils
US3987056A (en) * 1973-05-07 1976-10-19 Phillips Petroleum Company Disproportionation of n-aryl-1,2,3,6-tetrahydrophthalimides
US4002460A (en) * 1974-03-13 1977-01-11 Stauffer Chemical Company Triazine-antidote compositions and methods of use for cotton
US4025505A (en) * 1975-02-04 1977-05-24 Ciba-Geigy Corporation Aromatic dicarboxamides
CH615912A5 (fr) * 1975-06-18 1980-02-29 Ciba Geigy Ag
FR2369252B1 (fr) * 1976-10-29 1979-02-23 Inst Nat Rech Chimique Composes a,a-difluoroalkylbenzenes substitues et leur fabricationÿ
NL7714092A (nl) * 1976-12-22 1978-06-26 Monsanto Co Werkwijze voor het bereiden van nieuwe ftalamine- en nicotinezuren.
JPS5524127A (en) * 1978-08-08 1980-02-21 Morishita Seiyaku Kk 3,6-endomethylene-delta4-1,2,3,6-tetrahydrophtalimide derivative
AR223708A1 (es) * 1979-04-20 1981-09-15 Ciba Geigy Nuevos derivados de(3,5-diclorofenil)-imida de acido ciclobutan-1,2-dicarboxilico,composiciones que los contienen y procedimiento para su preparacion
JPS56169669A (en) * 1980-05-30 1981-12-26 Takeda Chem Ind Ltd Hexahydroisoindole derivative, its preparation and herbicide
JPS59231057A (ja) * 1983-06-14 1984-12-25 Eisai Co Ltd カルボン酸アミド化合物およびその誘導体

Also Published As

Publication number Publication date
ZA839546B (en) 1984-08-29
ES8601859A1 (es) 1985-11-01
GB2133006B (en) 1986-10-22
PH19459A (en) 1986-04-18
CA1202312A (fr) 1986-03-25
KR840007714A (ko) 1984-12-10
US4661630A (en) 1987-04-28
BE898570A (fr) 1984-06-27
ES8608486A1 (es) 1986-06-16
IT8324351A0 (it) 1983-12-23
AU2253183A (en) 1984-07-05
GB8333713D0 (en) 1984-01-25
JPS59118750A (ja) 1984-07-09
FR2538386A1 (fr) 1984-06-29
DK596083A (da) 1984-06-28
SE8307119D0 (sv) 1983-12-22
SE8307119L (sv) 1984-06-28
ES543810A0 (es) 1986-06-16
NL8304406A (nl) 1984-07-16
IT1170275B (it) 1987-06-03
ES528409A0 (es) 1985-11-01
HU189799B (en) 1986-07-28
DE3346814A1 (de) 1984-06-28
JPH0136819B2 (fr) 1989-08-02
DK596083D0 (da) 1983-12-23
CH656875A5 (de) 1986-07-31
GB2133006A (en) 1984-07-18

Similar Documents

Publication Publication Date Title
FR2538386B1 (fr) Nouveaux amides et imides carboxyliques procedes pour leur preparation et composition pharmaceutique les contenant
BE896986A (fr) Derives d'indole, procedes pour leur preparation et composition pharmaceutiques les contenant
FR2518095B1 (fr) Nouveaux l-oxa-, thia- et aza-spirocyclo-benzene-acetamides et benzamides, leur procede de preparation et composition pharmaceutique les contenant
FR2569402B1 (fr) Derives d'acide 3,5-pyridine-dicarboxylique, procede pour leur preparation et composition pharmaceutique les contenant
FR2505835B1 (fr) Nouvelles 1,2-diaminocyclobutene-3,4-diones, leur procede de preparation et composition pharmaceutique les contenant
PT72631A (fr) Procede pour la preparations de nouveaux composes hetherocycliques et de compositions pharmaceutiques qui les contiennent
FR2411839B1 (fr) Derives de l'acide cephalosporanique, procedes pour leur preparation et composition pharmaceutique les contenant
PT83896A (fr) Procede pour la preparation de nouveaux conjuges de la vinblas-tine et de ses derives et de compositions pharmaceutiques les contenant
PT73210A (fr) Procede pour la preparation de benzamides substituees et compositions pharmaceutiques qui les contiennent
PT78275B (fr) Procede de preparation de nouveaux acides flavone-carboxyliques-4' et de compositions pharmaceutiques les contenant
PT73763B (fr) Procede pour la preparation de nouveaux epoxides d'alkaloides benzofenantridiniques et de compositions pharmaceutiques qui les contiennent
FR2546517B1 (fr) Nouveaux dipeptides du -l-5-hydroxy-tryptophane, procedes pour leur preparation et medicaments les contenant
FR2579460B1 (fr) Nouvelles poudres de poudrage contenant une substance bioactive et procede pour leur preparation
FR2528425B1 (fr) 1,4-dihydropyridines et composition pharmaceutique les contenant
BE884101A (fr) Derives d'isoquinoleine contenant du soufre, procedes pour leur preparation et composition pharmaceutiques les contenant
PT77428B (fr) Procede pour preparer de nouvelles amino-2-substitue-5-oxazoli-nes-2 et des compositions les contenant
PT77429A (fr) Procede pour preparer de nouvelles n-(amino-methyl-5 oxazolin-2 yl-2)n'-phenylurees et de compositions les contenant
FR2528422B1 (fr) Nouveaux derives du 1,2,3,4-tetrahydronaphtalene, procede pour leur preparation et composition pharmaceutique contenant ces derives
FR2315910A1 (fr) Compositions pharmaceutiques contenant de la " debrycine " heterocolloidale et procede pour leur preparation
FR2513994B1 (fr) Tripeptides anorexigenes, procede pour leur preparation et compositions pharmaceutiques les contenant
BE884530A (fr) Nouveaux hexahydro-trans-pyrido-indoles et composition pharmaceutique les contenant
PT82853A (fr) Procede de preparation de nouveaux benzamides et des compositions pharmaceutiques les contenant
FR2517672B1 (fr) Thioalcanoyl-carnitines, procede pour leur preparation et composition pharmaceutique les contenant
BE883859A (fr) Nouveaux pyridylaminotriazoles et composition pharmaceutique les contenant
FR2528829B1 (fr) Composes polyprenyliques, procedes pour leur preparation et composition therapeutique les contenant

Legal Events

Date Code Title Description
ST Notification of lapse