FR2378762A2 - Amides aromatiques de composes heterocycliques et leur application en tant que medicament - Google Patents

Amides aromatiques de composes heterocycliques et leur application en tant que medicament

Info

Publication number
FR2378762A2
FR2378762A2 FR7733111A FR7733111A FR2378762A2 FR 2378762 A2 FR2378762 A2 FR 2378762A2 FR 7733111 A FR7733111 A FR 7733111A FR 7733111 A FR7733111 A FR 7733111A FR 2378762 A2 FR2378762 A2 FR 2378762A2
Authority
FR
France
Prior art keywords
methoxy
chlorobenzamide
ylõ
piperid
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7733111A
Other languages
English (en)
Other versions
FR2378762B2 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anphar SA
Original Assignee
Anphar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anphar SA filed Critical Anphar SA
Publication of FR2378762A2 publication Critical patent/FR2378762A2/fr
Application granted granted Critical
Publication of FR2378762B2 publication Critical patent/FR2378762B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente addition concerne les produits suivants : le N-Ø1-(m-trifluorométhylbenzyl)pipérid-4-ylõ -2-méthoxy-4-amino-5-chlorobenzamide, le N-Ø1-(1-phényléthyl)pipérid-4-ylõ - 2-éthoxy-4-amino-5-chlorobenzamide, le N- Ø1-(2-méthoxy-5-chlorobenzyl)pipérid-4-ylõ -2-méthoxy-4-amino-5-chlorobenzamide, le N Ø1- beta -naphtylméthyl) pipérid-4-ylõ-2-méthoxy-4-amino-5-chlorobenzamide, le N-Ø1-(p-méthyl-benzyl)pipérid-4-ylõ-2-méthoxy-4-amino-5-chlorobenzamide, le N-Ø1-p-bromobenzyl)-pipérid-4-ylõ -2-méthoxy-4-amino-5-chlorobenzamide, le N-Ø1-(p-fluorobenzyl)pipérid-4-ylõ-2-méthoxy-4-amino-5-chlorobenzamide, le N-Ø1-(p-méthylbenzyl)pipérid-4-ylõ -2- méthoxy-4-amino-5-chlorobenzamide, le N-(1-benzylpérid-4-yl)-2-méthoxy-4,5-diaminobenzamide, le N-Ø1-(p-nitrobenzyl)-pipérid-4-ylõ-2-méthoxy-4-amino-5-chlorobenzamide, le N-Ø1-(1-phénylethyl)pipérid-4-ylõ-2-méthoxy-4-amino-5-bromobenzamide, le N-Ø1-(m-méthylbenzyl)pipérid-4-ylõ-2-méthoxy-4-amino-5-chlorobenzamide, le N-(1-benzylpipérid-4-yl)-2-méthoxy-4-amino-5-chlorobenzamide, le N-Ø1-1-phényléthyl)-pipérid-4-ylõ-2-méthoxy-4,5-diamino-benzamide, le N-(1-benzypipérid-4-yl)-2-méthoxy -4-diméthylamino -5-chlorobenzamide, le N-Ø1-(1-phényléthyl)pipérid-4-ylõ -2-méthoxy-4-acétamido-5-aminobenzamide, le N-(1-benzylpipérid)2-méthoxy-4-méthylamino-5-chlorobenzamide, le N-(1-benzylpyérid-4-yl)-2-allyloxy-4-amino-5-chlorobenzamide, le N-(1-p-methylbenzylpipérid-4-yl)-2-méthoxy-4-acétamido-5-aminobenzamide, le N-(1-benzylpipérid-4-yl) -2-méthoxy -4-acétamido-5-aminobenzamide, le N-Ø1-(2-méthoxy-5-chloro-benzyl) -pipérid-4-ylõ -2-méthoxy-4-acétamido-5-aminobenzamide et le N-(1-benzylpipérid-4-yl)-2-éthoxy-4-méthylamino-5-chlorobenzamide ainsi que les sels pharmaceutiquement acceptables de ces composés. Ces composés présentent une activité intéressante vis-à-vis de l'anorexie, de la vasodilatation, de l'inhibition de sécrétion d'acide gastrique et de la formation d'ulcères.
FR7733111A 1976-10-27 1977-10-26 Amides aromatiques de composes heterocycliques et leur application en tant que medicament Granted FR2378762A2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4464976A GB1593851A (en) 1976-10-27 1976-10-27 N-(4-piperidyl)-benzamides and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
FR2378762A2 true FR2378762A2 (fr) 1978-08-25
FR2378762B2 FR2378762B2 (fr) 1980-09-12

Family

ID=10434204

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7733111A Granted FR2378762A2 (fr) 1976-10-27 1977-10-26 Amides aromatiques de composes heterocycliques et leur application en tant que medicament

Country Status (8)

Country Link
JP (1) JPS5392783A (fr)
BE (1) BE860139R (fr)
CA (1) CA1085855A (fr)
CH (1) CH625219A5 (fr)
ES (1) ES463557A2 (fr)
FR (1) FR2378762A2 (fr)
GB (1) GB1593851A (fr)
NL (1) NL7711690A (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1057101A (en) * 1999-11-17 2001-05-30 Kissei Pharmaceutical Co. Ltd. Hydroxyethoxybenzamide derivatives and drugs containing the same
TW200800953A (en) 2002-10-30 2008-01-01 Theravance Inc Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
US7368463B2 (en) 2003-07-11 2008-05-06 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5916M (fr) * 1966-01-21 1968-05-06
FR2105223A1 (fr) * 1970-09-03 1972-04-28 Wyeth John & Brother Ltd

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5916M (fr) * 1966-01-21 1968-05-06
FR2105223A1 (fr) * 1970-09-03 1972-04-28 Wyeth John & Brother Ltd

Also Published As

Publication number Publication date
CH625219A5 (en) 1981-09-15
JPS5392783A (en) 1978-08-15
CA1085855A (fr) 1980-09-16
ES463557A2 (es) 1978-11-16
NL7711690A (nl) 1978-05-02
GB1593851A (en) 1981-07-22
FR2378762B2 (fr) 1980-09-12
BE860139R (fr) 1978-02-15

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