ES8501961A1 - Procedimiento para la obtencion de sorbita con propiedades de tabletizacion - Google Patents

Procedimiento para la obtencion de sorbita con propiedades de tabletizacion

Info

Publication number
ES8501961A1
ES8501961A1 ES527845A ES527845A ES8501961A1 ES 8501961 A1 ES8501961 A1 ES 8501961A1 ES 527845 A ES527845 A ES 527845A ES 527845 A ES527845 A ES 527845A ES 8501961 A1 ES8501961 A1 ES 8501961A1
Authority
ES
Spain
Prior art keywords
sorbitol
compressive force
less
solution
sorbit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527845A
Other languages
English (en)
Other versions
ES527845A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6179970&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8501961(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of ES8501961A1 publication Critical patent/ES8501961A1/es
Publication of ES527845A0 publication Critical patent/ES527845A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/18—Polyhydroxylic acyclic alcohols
    • C07C31/26—Hexahydroxylic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • C07C29/78—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by condensation or crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/18—Polyhydroxylic acyclic alcohols
    • C07C31/24—Tetrahydroxylic alcohols, e.g. pentaerythritol

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Seasonings (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Glass Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Prostheses (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE SORBITA CON PROPIEDADES DE TABLETIZACION MEJORADAS.CONSISTE EN: A) HIDROGENAR A UNA TEMPERATURA INFERIOR A 170JC, UNA SOLUCION DE GLUCOSA CRISTALIZADA, PARA OBTENER UNA SOLUCION DE SORBITA; Y B) SECAR POR PULVERIZACION A UNA TEMPERATURA ENTRE 140 Y 170JC, LA SOLUCION DE SORBITA, PARA OBTENER UN PRODUCTO CON UN CONTENIDO EN AGUA INFERIOR A UN 1, UN PUNTO DE FUSION DE 96JC, UN PESO A GRANEL (SEGUN DIN 53912) DE 0,3 A 0,6 G/CC, UN CONTENIDO EN SORBITA BGB DE UN 90; UNA PUREZA DE UN 98; UNA SUPERFICIE ESPECIFICA (SEGUN BET) DE 0,7 A 1,5 M/G; UNA RESISTENCIA A LA FLEXION SUPERIOR A 7 N/MM CON UNA FUERZA DE PRESION SUPERIOR A 10.000 N Y UNA FRIABILIDAD INFERIOR A UN 1 CON UNA FUERZA DE PRESION DE 10.000 N.
ES527845A 1982-12-07 1983-12-06 Procedimiento para la obtencion de sorbita con propiedades de tabletizacion Granted ES527845A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823245170 DE3245170A1 (de) 1982-12-07 1982-12-07 Verbesserter sorbit, verfahren zur herstellung und verwendung

Publications (2)

Publication Number Publication Date
ES8501961A1 true ES8501961A1 (es) 1984-12-16
ES527845A0 ES527845A0 (es) 1984-12-16

Family

ID=6179970

Family Applications (1)

Application Number Title Priority Date Filing Date
ES527845A Granted ES527845A0 (es) 1982-12-07 1983-12-06 Procedimiento para la obtencion de sorbita con propiedades de tabletizacion

Country Status (10)

Country Link
US (2) US4507511A (es)
EP (1) EP0111209B1 (es)
JP (1) JPS59118058A (es)
AT (1) ATE47830T1 (es)
AU (1) AU565326B2 (es)
CA (1) CA1202331A (es)
DD (1) DD215079A5 (es)
DE (2) DE3245170A1 (es)
ES (1) ES527845A0 (es)
FI (1) FI79093C (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2571046B1 (fr) * 1984-10-03 1987-10-16 Roquette Freres Procede de preparation de mannitol granulaire directement compressible
FR2571045B1 (fr) * 1984-10-03 1987-12-11 Roquette Freres Mannitol granulaire directement compressible et son procede de fabrication
DE3541302A1 (de) * 1985-11-22 1987-05-27 Merck Patent Gmbh Suessmittel
DD252003B1 (de) * 1986-08-01 1990-06-20 Hydrierwerk Rodleben Veb Verfahren zur herstellung eines trockensorbitols mit verbesserten anwendungstechnischen eigenschaften
US4959226A (en) * 1987-03-16 1990-09-25 Wm. Wrigley Jr. Company Method of optimizing texture and processability of chewing gums and compositions made therefrom
US4803083A (en) * 1987-03-16 1989-02-07 Wm. Wrigley Jr. Company Method of optimizing texture and processability of chewing gums and compositions made therefrom
FR2613619B1 (fr) * 1987-04-07 1993-10-15 Recherche Informatique Pharmacie Medicaments, produits dietetiques ou produits d'hygiene sous forme de compositions pulverulentes obtenues par adsorption de principes actifs sur un sucre a dissolution rapide
US5023092A (en) * 1988-06-16 1991-06-11 Ici Americas Inc. Mannitol having gamma sorbitol polymorph
ATE128959T1 (de) * 1989-01-24 1995-10-15 Spi Polyols Inc Kryoschützende kristalline sorbitolkügelchen.
CA2029069A1 (en) * 1989-11-07 1991-05-08 Mansukh M. Patel Chewing gum with improved sweetness profile incorporating finely ground bulk sweetener without starch
JP2577698B2 (ja) * 1993-08-05 1997-02-05 信道 中野 流動性の高いソルビトール粉末の製造方法
DE4439858A1 (de) * 1994-11-08 1996-05-09 Merck Patent Gmbh Durch Co-Sprühtrocknung erhältliche Polyol-Zusammensetzung
EP0820237A4 (en) * 1995-01-25 1999-01-20 Wrigley W M Jun Co IMPROVED DUST MIXTURE AND METHOD FOR PRODUCING CHEWING GUM WITH YOUR HELP
US6235947B1 (en) 1997-04-14 2001-05-22 Takeda Chemical Industries, Ltd. D-mannitol and its preparation
PT902777E (pt) 1996-04-16 2001-11-30 Bayer Ag D-manitol e sua preparacao
DE19615418A1 (de) * 1996-04-22 1997-10-23 Merck Patent Gmbh Polyol-Zusammensetzung
DE19629640C1 (de) * 1996-07-23 1997-08-28 Metallgesellschaft Ag Verfahren zur Herstellung von kristallinem D-Sorbit
US5939091A (en) * 1997-05-20 1999-08-17 Warner Lambert Company Method for making fast-melt tablets
DE19848200A1 (de) * 1998-10-20 2000-04-27 Basf Ag Verfahren zur Trocknung von Phenoxymethylbenzoesäuren
FR2787110B1 (fr) * 1998-12-11 2001-02-16 Roquette Freres Sorbitol pulverulent et son procede de preparation
US7118765B2 (en) 2001-12-17 2006-10-10 Spi Pharma, Inc. Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms
DE10249336B9 (de) * 2002-10-22 2006-12-14 Dhw Deutsche Hydrierwerke Gmbh Rodleben Verfahren zur Herstellung von sprühgetrocknetem Sorbitol und Trocknung der Sorbitolpartikel auf einem nachgeschalteten Fließbett und sprühgetrockneter Sorbitol
US20040109889A1 (en) * 2002-12-04 2004-06-10 Bunick Frank J. Surface treatment composition for soft substrates
AU2005254167B2 (en) * 2004-06-17 2011-10-06 Cargill Inc. Steam agglomeration of polyols
JP4736509B2 (ja) * 2005-03-31 2011-07-27 小林製薬株式会社 錠菓
JP4955974B2 (ja) * 2005-09-30 2012-06-20 小林製薬株式会社 錠菓
EP1970053A1 (en) * 2007-03-14 2008-09-17 Boehringer Ingelheim Pharma GmbH & Co. KG Pharmaceutical composition
KR101817361B1 (ko) 2009-03-09 2018-01-11 에스피아이 파르마, 인크. 고도 압착성 및 내구성 직접 압축성 부형제 및 부형제 시스템
EP2451447B1 (de) * 2009-07-10 2017-10-11 Merck Patent GmbH Wasserarmes tablettierhilfsmittel und verfahren zu seiner herstellung
BE1022099B1 (nl) * 2014-01-17 2016-02-16 Syral Belgium Nv Werkwijze voor het bereiden van een sorbitolrijke stroop met hoge zuiverheid
FR3023128B1 (fr) * 2014-07-01 2017-11-10 Roquette Freres Nouvelle composition edulcorante
KR102065863B1 (ko) * 2015-09-11 2020-01-13 아처 다니엘 미드랜드 캄파니 이소이다이드의 제조 방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD35860A (es) *
US2280975A (en) * 1938-08-17 1942-04-28 Atlas Powder Co Hydrogenation of invertible saccharides
FR1040994A (fr) * 1950-08-17 1953-10-20 Basf Ag Procédé pour l'hydrogénation catalytique des sucres
NL302696A (es) * 1962-12-31
US3308171A (en) * 1964-07-17 1967-03-07 Yokohama Seito Kabushiki Kaish Method for producing granular or powdery sorbitol from sorbitol solution
US3484492A (en) * 1967-02-27 1969-12-16 Atlas Chem Ind Crystallization of mannitol from sorbitol
DK133603B (da) * 1968-02-05 1976-06-14 Kroyer K K K Fremgangsmåde og apparat til udvinding af et tørt fritstrømmende produkt af en opløsning eller opslemning af vanskeligt krystalliserbare kulhydrater eller tilsvarende alkoholer.
DE1941956A1 (de) * 1968-09-17 1970-03-26 Hydrierwerk Rodleben Veb Verfahren zur Gewinnung von Trockensorbit aus konzentrierten waessrigen Sorbitloesungen oder Sorbitschmelze
BE759609A (fr) * 1969-12-16 1971-04-30 Towa Kasei Kogyo Cy Ltd Procede de preparation de sorbitol cristallin sous forme granulaire et nouveau produit ainsi obtenu
JPS51108005A (en) * 1975-03-19 1976-09-25 Setsu Hiraiwa Sorubitooruno zoryuhoho
US4292451A (en) * 1978-03-30 1981-09-29 Ici Americas Inc. High mannitol process (alkaline hydrogenation in presence of alkali metal carbonate)
FR2451357A1 (fr) * 1979-03-16 1980-10-10 Roquette Freres Procede pour la mise sous forme comprimee du sorbitol et produit resultant
US4293570A (en) * 1979-04-02 1981-10-06 Chimicasa Gmbh Process for the preparation of sweetener containing product
US4252794A (en) * 1979-12-20 1981-02-24 Ici Americas Inc. Gamma-sorbitol polymorph
US4380680A (en) * 1982-05-21 1983-04-19 Uop Inc. Method for hydrogenating aqueous solutions of carbohydrates

Also Published As

Publication number Publication date
JPS59118058A (ja) 1984-07-07
US4605794A (en) 1986-08-12
FI79093B (fi) 1989-07-31
DD215079A5 (de) 1984-10-31
AU565326B2 (en) 1987-09-10
AU2029983A (en) 1984-06-14
FI834450A (fi) 1984-06-08
DE3245170A1 (de) 1984-06-07
EP0111209A3 (en) 1986-03-26
JPH051247B2 (es) 1993-01-07
EP0111209A2 (de) 1984-06-20
ES527845A0 (es) 1984-12-16
CA1202331A (en) 1986-03-25
DE3380812D1 (en) 1989-12-14
FI834450A0 (fi) 1983-12-05
EP0111209B1 (de) 1989-11-08
ATE47830T1 (de) 1989-11-15
US4507511A (en) 1985-03-26
FI79093C (fi) 1990-05-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303