ES8306086A1 - Un procedimiento para la preparacion de nuevos 3-(2-hidroxifenil-4-sustituido)-4 (o 5)-sustituido cicloalcanonas y ciclo-alcanoles. - Google Patents

Un procedimiento para la preparacion de nuevos 3-(2-hidroxifenil-4-sustituido)-4 (o 5)-sustituido cicloalcanonas y ciclo-alcanoles.

Info

Publication number
ES8306086A1
ES8306086A1 ES514604A ES514604A ES8306086A1 ES 8306086 A1 ES8306086 A1 ES 8306086A1 ES 514604 A ES514604 A ES 514604A ES 514604 A ES514604 A ES 514604A ES 8306086 A1 ES8306086 A1 ES 8306086A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
substituted
pharmaceutical compositions
nr6r7
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514604A
Other languages
English (en)
Other versions
ES514604A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES514604A0 publication Critical patent/ES514604A0/es
Publication of ES8306086A1 publication Critical patent/ES8306086A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/42—Halogenated derivatives containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/02—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains containing only carbon and hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/44—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/60—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/26—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C47/27—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/46—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/47—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757—Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 3- 2-HIDROXIFENIL-4-SUSTITUIDOS -4(O 5)-SUSTITUIDOS CICLOALCANONAS Y CICLOALCANOLES, DE FORMULA (I), EN LA QUE R ES HIDROGENO O BENCILO; S ES 1 O 2; W ES HIDROGENO O PIRIDILO; Y ES -CH(R )CH(R>O )- O -CH(R>O )CH -, SIENDO R HIDROGENO O METILO Y R>O Y R>O SON OXIALQUILO; Y Z ES ALQUILENO DE 3 A 8 ATOMOS DE CARBONO. CONSISTE EN SOMETER A UNA REACCION DE OXIDACION UN COMPUESTO DE FORMULA (II), EN LA QUE S, R , Z Y W TIENEN LOS SIGNIFICADOS YA INDICADOS; E Y ES -CH(R )CH(R>O )- O -CH(R>O )CH -, DONDE R TIENE EL SIGNIFICADO YA INDICADO; Y R>O Y R>O SON ALQUENILO. DE APLICACION COMO AGENTES ACTIVOS SOBRE EL SISTEMA NERVIOSO CENTRAL, COMO ANTIDIARREICOS Y COMO ANTIEMETICOS.
ES514604A 1980-09-19 1982-07-30 Un procedimiento para la preparacion de nuevos 3-(2-hidroxifenil-4-sustituido)-4 (o 5)-sustituido cicloalcanonas y ciclo-alcanoles. Expired ES8306086A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18879580A 1980-09-19 1980-09-19

Publications (2)

Publication Number Publication Date
ES514604A0 ES514604A0 (es) 1983-05-01
ES8306086A1 true ES8306086A1 (es) 1983-05-01

Family

ID=22694556

Family Applications (3)

Application Number Title Priority Date Filing Date
ES505624A Granted ES505624A0 (es) 1980-09-19 1981-09-18 Un procedimiento para la preparacion de nuevos-3-(2-hidroxifenil-4-sustituido)-4 (o 5)-sustituido cicloalcanonas y cicloalcanoles.
ES514604A Expired ES8306086A1 (es) 1980-09-19 1982-07-30 Un procedimiento para la preparacion de nuevos 3-(2-hidroxifenil-4-sustituido)-4 (o 5)-sustituido cicloalcanonas y ciclo-alcanoles.
ES514603A Granted ES514603A0 (es) 1980-09-19 1982-07-30 Un procedimiento para la preparacion de nuevos 3-(2-hidroxifenil-4-sustituido)-4 (o 5)-sustituido cicloalcanonas y ciclo-alcanoles.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES505624A Granted ES505624A0 (es) 1980-09-19 1981-09-18 Un procedimiento para la preparacion de nuevos-3-(2-hidroxifenil-4-sustituido)-4 (o 5)-sustituido cicloalcanonas y cicloalcanoles.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES514603A Granted ES514603A0 (es) 1980-09-19 1982-07-30 Un procedimiento para la preparacion de nuevos 3-(2-hidroxifenil-4-sustituido)-4 (o 5)-sustituido cicloalcanonas y ciclo-alcanoles.

Country Status (26)

Country Link
EP (1) EP0048572B1 (es)
JP (1) JPS5782331A (es)
KR (1) KR860000299B1 (es)
AR (1) AR229873A1 (es)
AT (1) ATE28323T1 (es)
AU (1) AU526412B2 (es)
CA (1) CA1170656A (es)
CS (1) CS242871B2 (es)
DD (2) DD202367A5 (es)
DE (1) DE3176311D1 (es)
DK (1) DK415381A (es)
ES (3) ES505624A0 (es)
FI (1) FI75144C (es)
GR (1) GR75351B (es)
HU (2) HU195944B (es)
IE (1) IE52713B1 (es)
IL (1) IL63870A (es)
IN (1) IN162851B (es)
NO (1) NO813185L (es)
NZ (1) NZ198387A (es)
PH (1) PH18140A (es)
PL (3) PL137360B1 (es)
PT (1) PT73701B (es)
SU (2) SU1378780A3 (es)
YU (1) YU226081A (es)
ZA (1) ZA816492B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8330099D0 (en) * 1983-11-11 1983-12-21 Ici Plc Cycloalkane derivatives
GB8405112D0 (en) * 1984-02-28 1984-04-04 Akzo Nv Anti-arrhythmic amino-alcohols
IL75480A0 (en) * 1985-06-11 1985-10-31 Yissum Res Dev Co Alkoxyphenol derivatives and pharmaceutical compositions containing them
DE10004926A1 (de) * 2000-02-04 2001-08-09 Gruenenthal Gmbh Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1137M (fr) * 1966-02-08 1962-02-19 Laboratoires Valda Applications thérapeutiques de cyclohexyl-phénols.
US3576882A (en) * 1966-12-27 1971-04-27 Monsanto Co Production of thioethers and ethers from fluorine aryl compounds
GB1464695A (en) * 1974-06-24 1977-02-16 Smithkline Corp Dibenzo-b,c-pyrans and pharmaceutical compositions thereof
US4283569A (en) * 1977-09-13 1981-08-11 Pfizer Inc. Hydroxyalkyl and oxoalkyl substituted phenols as analgesics and sedatives
SE431085B (sv) * 1977-09-13 1984-01-16 Pfizer 3-(2-hydroxi-4-(substituerade)fenyl)cykloalkanoner och -cykloalkanoder och vissa derivat derav till anvendning for farmakologiska och medicinska endamal

Also Published As

Publication number Publication date
IL63870A (en) 1985-03-31
IE812161L (en) 1982-03-19
PT73701A (en) 1981-10-01
PT73701B (en) 1983-10-19
ES8306695A1 (es) 1983-06-01
IE52713B1 (en) 1988-02-03
AU7547581A (en) 1982-05-20
IL63870A0 (en) 1981-12-31
DK415381A (da) 1982-04-22
CS242871B2 (en) 1986-05-15
JPS6230968B2 (es) 1987-07-06
ES505624A0 (es) 1983-06-01
AU526412B2 (en) 1983-01-06
SU1378780A3 (ru) 1988-02-28
PH18140A (en) 1985-04-03
DE3176311D1 (en) 1987-08-20
YU226081A (en) 1984-06-30
EP0048572A3 (en) 1982-12-08
ES8305673A1 (es) 1983-04-16
EP0048572A2 (en) 1982-03-31
ES514603A0 (es) 1983-04-16
PL138850B1 (en) 1986-11-29
ES514604A0 (es) 1983-05-01
AR229873A1 (es) 1983-12-30
KR830007591A (ko) 1983-11-04
CA1170656A (en) 1984-07-10
HU195944B (en) 1988-08-29
NO813185L (no) 1982-03-22
EP0048572B1 (en) 1987-07-15
FI812928L (fi) 1982-03-20
DD202367A5 (de) 1983-09-14
IN162851B (es) 1988-07-16
ZA816492B (en) 1982-09-29
KR860000299B1 (ko) 1986-03-31
NZ198387A (en) 1985-03-20
FI75144B (fi) 1988-01-29
DD210253A5 (de) 1984-06-06
FI75144C (fi) 1988-05-09
HU196353B (en) 1988-11-28
PL137360B1 (en) 1986-05-31
SU1181535A3 (ru) 1985-09-23
PL238378A1 (en) 1983-04-11
ATE28323T1 (de) 1987-08-15
PL233021A1 (en) 1983-01-31
CS676481A2 (en) 1985-08-15
GR75351B (es) 1984-07-13
PL238377A1 (en) 1983-04-11
JPS5782331A (en) 1982-05-22

Similar Documents

Publication Publication Date Title
AU538494B2 (en) Substituted piperidines and pyrrolidines
ES466856A1 (es) Procedimiento para la preparacion de compuestos derivados dela pirrolidin-2-ona.
ES470789A1 (es) Un procedimiento para la preparacion de una composicion limpiadora cosmetica
ZA82567B (en) Process for the preparation of 2-penem compounds,novel 2-penem compounds produced thereby,and pharmaceutical compositions containing them
ES8306086A1 (es) Un procedimiento para la preparacion de nuevos 3-(2-hidroxifenil-4-sustituido)-4 (o 5)-sustituido cicloalcanonas y ciclo-alcanoles.
ES485153A1 (es) Procedimiento para la obtencion de 6-arilpiridazin-3-onas
ES8106289A1 (es) Procedimiento de preparacion de nuevos derivados del a-fe- nil-2-pirrolidin-metanol
ES8105976A1 (es) Procedimiento para la preparacion de acilureas
ES264044A1 (es) Un metodo de reducir la corrosiën de metal en contacto con un hidrocarburo y un corroyente acido
WO1993025568A3 (en) Antihypercholesterolemic compounds and related pharmaceutical compositions and methods of use
ES476385A1 (es) Un procedimiento para preparar derivados de transpirindina
DE3069986D1 (en) Antibacterial compositions comprising a beta-lactam-type compound and a 3-substituted propenoate
ES341635A1 (es) Un procedimiento para la preparacion de esteres de 3-pirro-lidinometanoles 1-sustituidos-alfa alfa-disustituidos.
JPS5559127A (en) Novel intermediate compound for producing prostanoids and its manufacture
GB984119A (en) Substituted piperidines and methods for their preparation
FR2496638B1 (es)
GB1058542A (en) Nortropane derivatives and the preparation thereof
CA2163080A1 (en) Cephem compound, process for producing the compound, and antimicrobial composition containing the same
CS302790A3 (en) Functional derivatives of 4-(2,4-difluorobiphenylyl)-2-methyl -4- oxobutanoic acid
ES8105300A1 (es) Procedimiento para preparar derivados de benoimidazol
ES303275A1 (es) Procedimiento de preparaciën de esteres
ES481057A1 (es) Procedimiento para preparar una composicion protectora de - plantas que comprende como antidoto un derivado de 1,4-oxa- za-spirohidrocarburo.
ES8102110A1 (es) Procedimiento para la preparacion de acido 1,2,3-tiadiazol- 5-il-tioglicolico
ES8504772A1 (es) Un procedimiento para preparar un compuesto de 7-(4-piridil)-1,8-naftiridina.
ES8106500A1 (es) Procedimiento de preparacion de nuevos derivados de 1-(1-(3,4-dimetoxi-fenil)-3-amino-propil)-6,7-dimetoxi-iso- quinoleina

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991108