ES8305764A1 - Un procedimiento para la preparacion de derivados carbapenen-2-tio-sustituidos. - Google Patents

Un procedimiento para la preparacion de derivados carbapenen-2-tio-sustituidos.

Info

Publication number
ES8305764A1
ES8305764A1 ES509437A ES509437A ES8305764A1 ES 8305764 A1 ES8305764 A1 ES 8305764A1 ES 509437 A ES509437 A ES 509437A ES 509437 A ES509437 A ES 509437A ES 8305764 A1 ES8305764 A1 ES 8305764A1
Authority
ES
Spain
Prior art keywords
preparation
formula
organic group
azabicyclo
hept
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509437A
Other languages
English (en)
Other versions
ES509437A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8305764A1 publication Critical patent/ES8305764A1/es
Publication of ES509437A0 publication Critical patent/ES509437A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE CARBAPENEM-2-TIO-SUSTITUIDOS, DE FORMULA GENERAL (I), DONDE R Y R REPRESENTAN INDEPENDIENTEMENTE HIDROGENO O UN GRUPO ORGANICO; Y R REPRESENTA UN GRUPO ORGANICO UNIDO A TRAVES DE UN ATOMO DE CARBONO AL ATOMO DE AZUFRE, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), DONDE R>A ES UN GRUPO BLOQUEANTE DE CARBOXI O HIDROGENO; R REPRESENTA UN GRUPO ORGANICO DISTINTO DEL GRUPO R ; Y R Y R TIENEN EL SIGNIFICADO YA INDICADO, CON UN COMPUESTO DE FORMULA (III) O UN DERIVADO REACTIVO DEL MISMO, DONDE R TIENE EL SIGNIFICADO YA INDICADO. DE APLICACION COMO AGENTES ANTIBACTERIANOS PARA EL TRATAMIENTO DE INFECCIONES.
ES509437A 1981-02-04 1982-02-04 Un procedimiento para la preparacion de derivados carbapenen-2-tio-sustituidos. Granted ES509437A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8103350 1981-02-04

Publications (2)

Publication Number Publication Date
ES8305764A1 true ES8305764A1 (es) 1983-04-16
ES509437A0 ES509437A0 (es) 1983-04-16

Family

ID=10519434

Family Applications (1)

Application Number Title Priority Date Filing Date
ES509437A Granted ES509437A0 (es) 1981-02-04 1982-02-04 Un procedimiento para la preparacion de derivados carbapenen-2-tio-sustituidos.

Country Status (9)

Country Link
US (1) US4477662A (es)
EP (1) EP0060612A1 (es)
JP (1) JPS57146778A (es)
AU (1) AU8011582A (es)
ES (1) ES509437A0 (es)
GR (1) GR74742B (es)
IE (1) IE820240L (es)
PT (1) PT74367B (es)
ZA (1) ZA82551B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5865291A (ja) * 1981-10-14 1983-04-18 Sankyo Co Ltd カルバペネム−３−カルボン酸誘導体およびその製法
US4640915A (en) * 1982-03-29 1987-02-03 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives
FI832619A (fi) * 1982-07-26 1984-01-27 Sandoz Ag Fluoralkylerade karbapenemderivat
JPS5946288A (ja) * 1982-09-10 1984-03-15 Sanraku Inc β−ラクタム誘導体の製造方法
DK140584A (da) * 1983-03-08 1984-09-09 Bristol Myers Co Fremgangsmaade til fremstilling af carbapenemderivater
US4717728A (en) * 1983-11-21 1988-01-05 Merck & Co., Inc. Cyclic amidinyl and cyclic guanidinyl thio carbapenems
NZ215957A (en) * 1985-04-27 1988-04-29 Sankyo Co Carbapenem derivatives and pharmaceutical compositions
US5541317A (en) * 1991-05-31 1996-07-30 Sankyo Company, Limited Azetidinone compounds useful in the preparation of carbapenem antibiotics and process for preparing carbapenem and penem compounds
FI104822B (fi) * 1992-09-09 2000-04-14 Sankyo Co Menetelmä karbapeneemi- ja peneemiyhdisteiden valmistamiseksi
US5602118A (en) * 1993-03-16 1997-02-11 American Cyanamid Company 2-thiosubstituted carbapenems
US5496816A (en) * 1994-03-14 1996-03-05 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
JPH1059970A (ja) * 1996-08-16 1998-03-03 Suntory Ltd カルバペネム誘導体およびこれを含有する抗菌剤
JPH1077285A (ja) 1996-09-04 1998-03-24 Sumitomo Pharmaceut Co Ltd 新規なβ−ラクタム化合物およびその製造法
KR100621782B1 (ko) * 2004-06-14 2006-09-19 한국과학기술연구원 1-베타메틸카바페넴 유도체 및 이의 제조방법
US7687490B2 (en) * 2005-04-12 2010-03-30 Meiji Seika Kaisha, Ltd. 2-thioethenyl substituted carbapenem derivatives
WO2014158943A1 (en) * 2013-03-13 2014-10-02 Avon Products, Inc Tyrosinase inhibitors
US9364405B2 (en) 2013-03-13 2016-06-14 Avon Products, Inc. Tyrosinase inhibitors
WO2014164200A1 (en) 2013-03-13 2014-10-09 Avon Products, Inc Tyrosinase inhibitors
EP4021453A4 (en) * 2019-08-29 2022-11-16 The Regents of The University of California COMPOUNDS FOR IDENTIFYING BETA-LACTAMASES AND METHODS OF USE THEREOF

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210661A (en) * 1977-01-27 1980-07-01 Beecham Group Limited Synthetic β-lactam compounds, a process for their preparation and compositions containing them
EP0011173B1 (en) * 1978-11-01 1983-05-11 Sanraku-Ocean Co., Ltd. Process for producing antibiotic beta-lactam compounds

Also Published As

Publication number Publication date
AU8011582A (en) 1982-08-12
ZA82551B (en) 1982-12-29
JPS57146778A (en) 1982-09-10
PT74367A (en) 1982-03-01
PT74367B (en) 1983-08-16
ES509437A0 (es) 1983-04-16
US4477662A (en) 1984-10-16
EP0060612A1 (en) 1982-09-22
GR74742B (es) 1984-07-11
IE820240L (en) 1982-08-04

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