ES8301237A1 - Un procedimiento para la preparacion de un derivado 2-tiope-nem - Google Patents

Un procedimiento para la preparacion de un derivado 2-tiope-nem

Info

Publication number
ES8301237A1
ES8301237A1 ES504764A ES504764A ES8301237A1 ES 8301237 A1 ES8301237 A1 ES 8301237A1 ES 504764 A ES504764 A ES 504764A ES 504764 A ES504764 A ES 504764A ES 8301237 A1 ES8301237 A1 ES 8301237A1
Authority
ES
Spain
Prior art keywords
formula
group
preparation
organic radical
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES504764A
Other languages
English (en)
Other versions
ES504764A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP81301683A external-priority patent/EP0041768B1/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8301237A1 publication Critical patent/ES8301237A1/es
Publication of ES504764A0 publication Critical patent/ES504764A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 2-TIOPENEMA Y DE SUS SALES O ESTERES HIDROLIZABLES <004>IN VIVO<005> FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R ES UN RADICAL ORGANICO; Y R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN TIOL DE FORMULA R SH O UN DERIVADO REACTIVO DEL MISMO CON UN SULFOXIDO DE FORMULA (II), EN LA QUE R ES UN RADICAL ORGANICO; R<018> ES HIDROGENO O UN GRUPO PROTECTOR DEL CARBOXILO; Y R , R Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE, A UNA TEMPERATURA ENTRE -20<025>C Y -70<025>C. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE INFECCIONES ANTIBACTERIANAS.
ES504764A 1980-08-16 1981-08-14 Un procedimiento para la preparacion de un derivado 2-tiope-nem Granted ES504764A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8026733 1980-08-16
EP81301683A EP0041768B1 (en) 1980-04-24 1981-04-15 Beta-lactam compounds, their preparation and use

Publications (2)

Publication Number Publication Date
ES8301237A1 true ES8301237A1 (es) 1982-12-01
ES504764A0 ES504764A0 (es) 1982-12-01

Family

ID=26082013

Family Applications (1)

Application Number Title Priority Date Filing Date
ES504764A Granted ES504764A0 (es) 1980-08-16 1981-08-14 Un procedimiento para la preparacion de un derivado 2-tiope-nem

Country Status (9)

Country Link
US (1) US4517124A (es)
EP (1) EP0046363B1 (es)
AU (1) AU7420281A (es)
DE (1) DE3167198D1 (es)
ES (1) ES504764A0 (es)
GB (1) GB2083462B (es)
GR (1) GR74622B (es)
NZ (1) NZ198048A (es)
PT (1) PT73514B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58198486A (ja) * 1982-05-14 1983-11-18 Sankyo Co Ltd ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法
US4650794A (en) * 1982-04-29 1987-03-17 Merck & Co., Inc. 6-(1-hydroxyethyl)-2-carbamimidoyl-pen-2-em-3-carboxylic acids
US4748162A (en) * 1982-03-01 1988-05-31 Merck & Co., Inc. 6-substituted-2-carbaminidoyl-pen-2-em-3-carboxylic acids
DE3377132D1 (en) * 1982-07-08 1988-07-28 Hoechst Uk Ltd Antibacterial penem derivatives
ATE112778T1 (de) * 1982-11-29 1994-10-15 Schering Corp Verfahren zur herstellung von penem-verbindungen.
US4675317A (en) * 1983-01-25 1987-06-23 Merck & Co., Inc. 2-unsaturated alkylthio-pen-2-em-3-carboxylic acids
FI82471C (fi) * 1984-01-26 1991-03-11 Beecham Group Plc Foerfarande foer framstaellning av farmakologiskt aktiva 6-metylenpenemderivater.
US4806637A (en) * 1986-03-17 1989-02-21 Schering Corporation 6-(Hydroxyethyl)-2-(heterocyclylthio)-penem-3-carboxylates
US4876365A (en) * 1988-12-05 1989-10-24 Schering Corporation Intermediate compounds for preparing penems and carbapenems
US5541317A (en) * 1991-05-31 1996-07-30 Sankyo Company, Limited Azetidinone compounds useful in the preparation of carbapenem antibiotics and process for preparing carbapenem and penem compounds
CA2105746A1 (en) * 1992-09-09 1994-03-10 Akira Yoshida Process for preparing carbapenem and penem compounds and new compounds involved in that process

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
EP0042026B1 (de) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
DE2965394D1 (en) * 1978-11-01 1983-06-16 Sanraku Ocean Co Process for producing antibiotic beta-lactam compounds
IL59081A0 (en) * 1979-01-10 1980-05-30 Schering Corp 2-penem compounds and a method for preparing them
US4372965A (en) * 1979-10-15 1983-02-08 Merck & Co., Inc. 6-, 1- And 2-substituted-thio-1-carbadethiapen-2-em-3-carboxylic acid S-oxides
EP0176064A1 (en) * 1980-11-06 1986-04-02 Hoechst Uk Limited Intermediates for the production of 7-oxo-4-thia-1-aza[3,2,0]heptane and 7-oxo-4-thia-1-aza[3,2,0]hept-2-ene derivatives
US4347183A (en) * 1981-02-02 1982-08-31 Schering Corporation Process for the synthesis of penems and carbapenems

Also Published As

Publication number Publication date
GR74622B (es) 1984-06-29
DE3167198D1 (en) 1984-12-20
PT73514B (en) 1982-10-28
EP0046363B1 (en) 1984-11-14
EP0046363A1 (en) 1982-02-24
ES504764A0 (es) 1982-12-01
GB2083462B (en) 1984-05-02
GB2083462A (en) 1982-03-24
NZ198048A (en) 1985-04-30
AU7420281A (en) 1982-02-25
PT73514A (en) 1981-09-01
US4517124A (en) 1985-05-14

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