ES8502708A1 - Un procedimiento para la preparacion de derivados de azetidina. - Google Patents
Un procedimiento para la preparacion de derivados de azetidina.Info
- Publication number
- ES8502708A1 ES8502708A1 ES525138A ES525138A ES8502708A1 ES 8502708 A1 ES8502708 A1 ES 8502708A1 ES 525138 A ES525138 A ES 525138A ES 525138 A ES525138 A ES 525138A ES 8502708 A1 ES8502708 A1 ES 8502708A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- optionally substituted
- intermediates
- aryl
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 150000001728 carbonyl compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000004986 diarylamino group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- -1 o-phenylenedioxy Chemical group 0.000 abstract 1
- 125000005017 substituted alkenyl group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000004426 substituted alkynyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
- C07D477/04—Preparation by forming the ring or condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE AZETIDINA, DE FORMULA GENERAL (I).CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III).DE APLICACION COMO COMPUESTOS INTERMEDIARIOS EN LA PREPARACION DE CIERTOS DERIVADOS DE CARBAPENEM, MUCHOS DE LOS CUALES TIENEN PROPIEDADES ANTIBIOTICAS VALIOSAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP57145574A JPS5946265A (ja) | 1982-08-24 | 1982-08-24 | アゼチジノン誘導体の製造法 |
JP57158604A JPS5951286A (ja) | 1982-09-10 | 1982-09-10 | カルバペネム誘導体の製造法 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8502708A1 true ES8502708A1 (es) | 1985-01-16 |
ES525138A0 ES525138A0 (es) | 1985-01-16 |
Family
ID=26476650
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES525138A Granted ES525138A0 (es) | 1982-08-24 | 1983-08-24 | Un procedimiento para la preparacion de derivados de azetidina. |
ES531561A Granted ES531561A0 (es) | 1982-08-24 | 1984-04-12 | Un procedimiento para la preparacion de derivados de azetidina |
ES531562A Granted ES531562A0 (es) | 1982-08-24 | 1984-04-12 | Un procedimiento para la preparacion de derivados de azetidina |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES531561A Granted ES531561A0 (es) | 1982-08-24 | 1984-04-12 | Un procedimiento para la preparacion de derivados de azetidina |
ES531562A Granted ES531562A0 (es) | 1982-08-24 | 1984-04-12 | Un procedimiento para la preparacion de derivados de azetidina |
Country Status (7)
Country | Link |
---|---|
US (1) | US5856556A (es) |
EP (1) | EP0102239B1 (es) |
KR (1) | KR900006449B1 (es) |
CA (1) | CA1232903A (es) |
DE (1) | DE3374063D1 (es) |
ES (3) | ES525138A0 (es) |
FI (1) | FI80887C (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4696923A (en) * | 1984-04-23 | 1987-09-29 | Merck & Co., Inc. | 6-[1-hydroxyethyl]-2-SR8 -1-methyl-1-carbadethiapen-2-em-3-carboxylic acids |
DK270685A (da) * | 1984-06-29 | 1985-12-30 | Hoffmann La Roche | Carbapenemderivater |
US4895939A (en) * | 1986-02-24 | 1990-01-23 | Bristol-Myers Company | High percentage β-yield synthesis of carbapenem intermediates |
KR880006244A (ko) * | 1986-11-24 | 1988-07-22 | 후지사와 도모 기찌 로 | 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법 |
EP0272455B1 (en) * | 1986-11-24 | 1993-02-10 | Fujisawa Pharmaceutical Co., Ltd. | 3-Pyrrolidinylthio-1-azabicyclo [3.2.0] hept-2-ene-2-carboxylic acid compounds |
US4820815A (en) * | 1987-09-01 | 1989-04-11 | University Of Notre Dame Du Lac | Azetidinone N-phosphonomethyl esters |
US4925838A (en) * | 1988-03-18 | 1990-05-15 | Fujisawa Pharmaceutical Company, Ltd. | 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid compounds |
GB8811237D0 (en) * | 1988-05-12 | 1988-06-15 | Fujisawa Pharmaceutical Co | 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives |
US4963544A (en) * | 1988-05-23 | 1990-10-16 | Fujisawa Pharmaceutical Company, Ltd. | 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid compounds |
GB8923844D0 (en) * | 1989-10-23 | 1989-12-13 | Fujisawa Pharmaceutical Co | Carbapenem compounds |
IL99513A0 (en) * | 1990-09-20 | 1992-08-18 | Hoechst Ag | Process for the preparation of carbapenem compounds |
GB9103034D0 (en) * | 1991-02-13 | 1991-03-27 | Fujisawa Pharmaceutical Co | Processes for preparing carbapenem derivatives |
GB9305813D0 (en) * | 1993-03-20 | 1993-05-05 | Glaxo Spa | Chemical process |
US6395894B2 (en) | 1998-04-16 | 2002-05-28 | Philip J. Pye | Process for the synthesis of carbapenem intermidiates, and compounds produced |
EP1104424B1 (en) | 1998-06-17 | 2004-04-07 | Merck & Co., Inc. | Process for the synthesis of carbapenem intermediates |
US6194568B1 (en) | 1998-07-13 | 2001-02-27 | Merck & Co., Inc. | Process for synthesizing carbapenem intermediates |
US7241308B2 (en) * | 2003-06-09 | 2007-07-10 | Xtent, Inc. | Stent deployment systems and methods |
GB0400382D0 (en) * | 2004-01-09 | 2004-02-11 | Glaxo Group Ltd | Novel processes |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4348320A (en) * | 1976-11-19 | 1982-09-07 | Merck & Co., Inc. | Substituted azetidiones |
GB1593524A (en) * | 1976-11-19 | 1981-07-15 | Merck & Co Inc | 1-carba-2-penem-3-carboxylic acids |
US4446146A (en) * | 1978-07-26 | 1984-05-01 | Beecham Group Limited | β-Lactam containing compounds, their preparation and use |
JPS579784A (en) * | 1980-06-23 | 1982-01-19 | Sankyo Co Ltd | Production of penem-3-carboxylic derivative |
DK329381A (da) * | 1980-07-24 | 1982-01-25 | Takeda Chemical Industries Ltd | Fremgangsmaade til frmstilling af 1,1-disubstitueret carba-z -penem samt salte og estere deraf |
US4347183A (en) * | 1981-02-02 | 1982-08-31 | Schering Corporation | Process for the synthesis of penems and carbapenems |
EP0057565A1 (en) * | 1981-02-04 | 1982-08-11 | Beecham Group Plc | Beta-lactam antibiotics, their preparation and use |
EP0060077A1 (en) * | 1981-03-04 | 1982-09-15 | Beecham Group Plc | Beta-lactam antibiotics, their preparation and use |
-
1983
- 1983-08-23 KR KR1019830003938A patent/KR900006449B1/ko not_active IP Right Cessation
- 1983-08-24 FI FI833034A patent/FI80887C/fi not_active IP Right Cessation
- 1983-08-24 DE DE8383304904T patent/DE3374063D1/de not_active Expired
- 1983-08-24 EP EP83304904A patent/EP0102239B1/en not_active Expired
- 1983-08-24 CA CA000435304A patent/CA1232903A/en not_active Expired
- 1983-08-24 ES ES525138A patent/ES525138A0/es active Granted
-
1984
- 1984-04-12 ES ES531561A patent/ES531561A0/es active Granted
- 1984-04-12 ES ES531562A patent/ES531562A0/es active Granted
-
1993
- 1993-03-23 US US08/035,915 patent/US5856556A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA1232903A (en) | 1988-02-16 |
KR840006008A (ko) | 1984-11-21 |
FI833034A0 (fi) | 1983-08-24 |
ES8602796A1 (es) | 1985-12-01 |
ES531561A0 (es) | 1985-12-01 |
FI80887B (fi) | 1990-04-30 |
FI833034A (fi) | 1984-02-25 |
FI80887C (fi) | 1990-08-10 |
ES8507491A1 (es) | 1985-09-01 |
DE3374063D1 (en) | 1987-11-19 |
ES531562A0 (es) | 1985-09-01 |
EP0102239B1 (en) | 1987-10-14 |
EP0102239A1 (en) | 1984-03-07 |
KR900006449B1 (ko) | 1990-08-31 |
ES525138A0 (es) | 1985-01-16 |
US5856556A (en) | 1999-01-05 |
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