ES8302728A1 - Procedimiento para preparar derivados de prolina . - Google Patents

Procedimiento para preparar derivados de prolina .

Info

Publication number
ES8302728A1
ES8302728A1 ES507672A ES507672A ES8302728A1 ES 8302728 A1 ES8302728 A1 ES 8302728A1 ES 507672 A ES507672 A ES 507672A ES 507672 A ES507672 A ES 507672A ES 8302728 A1 ES8302728 A1 ES 8302728A1
Authority
ES
Spain
Prior art keywords
phosphinylalkanoyl
substituted prolines
prolines
phosphinylalkanoyl substituted
hypertension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES507672A
Other languages
English (en)
Other versions
ES507672A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22792901&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8302728(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of ES507672A0 publication Critical patent/ES507672A0/es
Publication of ES8302728A1 publication Critical patent/ES8302728A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65615—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing a spiro condensed ring system of the formula where at least one of the atoms X or Y is a hetero atom, e.g. S

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PROLINA Y DE SUS SALES, DE FORMULA (I), EN LA QUE R ES HIDROGENO O ALCOHILO; R , R , R Y R PUEDEN SER VARIOS TIPOS DE RADICALES; Y N VALE 0 O 1. CONSISTE EN LA REACCION DE UN COMPUESTO, DE FORMULA H<024>R <024>COOR , CON UN ACIDO FOSFINILACETICO O -PROPIONICO DE FORMULA (II), EN LAS QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN AGENTE DE ACOPLAMIENTO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD HIPOTENSORA.
ES507672A 1980-12-04 1981-12-03 Procedimiento para preparar derivados de prolina . Expired ES8302728A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/212,911 US4337201A (en) 1980-12-04 1980-12-04 Phosphinylalkanoyl substituted prolines

Publications (2)

Publication Number Publication Date
ES507672A0 ES507672A0 (es) 1983-01-16
ES8302728A1 true ES8302728A1 (es) 1983-01-16

Family

ID=22792901

Family Applications (1)

Application Number Title Priority Date Filing Date
ES507672A Expired ES8302728A1 (es) 1980-12-04 1981-12-03 Procedimiento para preparar derivados de prolina .

Country Status (19)

Country Link
US (1) US4337201A (es)
EP (1) EP0053902B1 (es)
JP (1) JPS57126495A (es)
AT (1) ATE12502T1 (es)
AU (1) AU549302B2 (es)
CA (1) CA1169073A (es)
DE (2) DE19875040I2 (es)
DK (1) DK169679B1 (es)
ES (1) ES8302728A1 (es)
GR (1) GR76330B (es)
HU (1) HU187381B (es)
IE (1) IE51876B1 (es)
IL (1) IL64415A (es)
LU (2) LU88295I2 (es)
NL (1) NL930144I2 (es)
NZ (1) NZ199003A (es)
PH (1) PH16988A (es)
PT (1) PT74079B (es)
ZA (1) ZA818340B (es)

Families Citing this family (181)

* Cited by examiner, † Cited by third party
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CA1169073A (en) 1984-06-12
DK169679B1 (da) 1995-01-09
IL64415A (en) 1985-11-29
JPS57126495A (en) 1982-08-06
ES507672A0 (es) 1983-01-16
AU549302B2 (en) 1986-01-23
IL64415A0 (en) 1982-03-31
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HU187381B (en) 1985-12-28
PT74079A (en) 1982-01-01
PT74079B (en) 1983-05-11
US4337201A (en) 1982-06-29
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AU7786081A (en) 1982-06-10
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NL930144I1 (nl) 1994-02-01
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ATE12502T1 (de) 1985-04-15
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