ES2001940A6 - Procedimiento para producir un preparado farmaceutico a base de un inhibidor de la enzima convertidora de angiotensina y un diuretico de asa - Google Patents

Procedimiento para producir un preparado farmaceutico a base de un inhibidor de la enzima convertidora de angiotensina y un diuretico de asa

Info

Publication number
ES2001940A6
ES2001940A6 ES8601665A ES8601665A ES2001940A6 ES 2001940 A6 ES2001940 A6 ES 2001940A6 ES 8601665 A ES8601665 A ES 8601665A ES 8601665 A ES8601665 A ES 8601665A ES 2001940 A6 ES2001940 A6 ES 2001940A6
Authority
ES
Spain
Prior art keywords
hypertension
treatment
pharmaceutical preparation
converting enzyme
enzyme inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601665A
Other languages
English (en)
Inventor
Reinhard Becker
Rolf Geiger
Rainer Henning
Volker Teetz
Hansjorg Urbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6280420&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2001940(A6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES2001940A6 publication Critical patent/ES2001940A6/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Toys (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA PRODUCIR UN PREPARADO FARMACEUTICO A BASE DE UN INHIBIDOR DE LA ENZIMA CONVERTIDORA DE ANGIOTENSINA Y UN DIURETICO DE ASA, EN EL QUE SE HACEN REACCIONAR FRAGMENTOS DE DICHO INHIBIDOR DE FORMULA: DONDE N ES 1 O 2, R5-R8 SON HIDROGENO O UN RADICAL ORGANICO, Y R9 Y R10 FORMAN CON LOS ATOMOS PORTADORES UN SISTEMA DE ANILLO HETEROCICLICO, SE REDUCEN EVENTUALMENTE LOS COMPUESTOS INTERMEDIOS RESULTANTES, SE SEPARAN LOS GRUPOS PROTECTORES, Y LOS COMPUESTOS OBTENIDOS, COMO TALES O TRANSFORMADOS EVENTUALMENTE EN SALES, SE MEZCLAN CON UN DIURETICO DE ASA O UNA SAL DEL MISMO, JUNTO CON UN VEHICULO Y EVENTUALMENTE OTRAS SUSTANCIAS AUXILIARES O ADITIVAS, PARA OBTENER UNA FORMA DE ADMINISTRACION FARMACEUTICA APROPIADA. LOS PREPARADOS ASI PRODUCIDOS SON UTILES PARA EL TRATAMIENTO DE LA HIPERTENSION SANGUINEA.
ES8601665A 1985-09-09 1986-09-05 Procedimiento para producir un preparado farmaceutico a base de un inhibidor de la enzima convertidora de angiotensina y un diuretico de asa Expired ES2001940A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853532036 DE3532036A1 (de) 1985-09-09 1985-09-09 Pharmazeutische zubereitung zur behandlung des bluthochdrucks

Publications (1)

Publication Number Publication Date
ES2001940A6 true ES2001940A6 (es) 1988-07-01

Family

ID=6280420

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601665A Expired ES2001940A6 (es) 1985-09-09 1986-09-05 Procedimiento para producir un preparado farmaceutico a base de un inhibidor de la enzima convertidora de angiotensina y un diuretico de asa

Country Status (19)

Country Link
EP (1) EP0215357B1 (es)
JP (1) JPH089549B2 (es)
KR (1) KR940010032B1 (es)
AT (1) ATE75610T1 (es)
AU (1) AU597270B2 (es)
CA (1) CA1340722C (es)
DE (2) DE3532036A1 (es)
DK (1) DK166755B1 (es)
ES (1) ES2001940A6 (es)
FI (1) FI863594A (es)
GR (1) GR862285B (es)
HU (1) HU200685B (es)
IE (1) IE59308B1 (es)
IL (1) IL79965A (es)
NO (1) NO863583L (es)
NZ (1) NZ217489A (es)
PH (1) PH23716A (es)
PT (1) PT83322B (es)
ZA (1) ZA866810B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337400C (en) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibitors of neutral endopeptidase
DK9200258U4 (da) * 1992-03-11 1993-07-23 Merck & Co Inc Farmaceutisk præparat indeholdende enalapril til brug mod hypertension
AU2001255730A1 (en) * 2000-04-26 2001-11-07 First Horizon Pharmaceutical Corporation Methods and compositions for the treatment of cardiac indications
US20080234353A1 (en) 2004-03-24 2008-09-25 Reynir Eyjolfsson Formulations of Ramipril
PL3173075T3 (pl) 2015-11-27 2019-04-30 Accupharma Spolka Z Ograniczona Odpowiedzialnoscia Farmaceutyczny preparat złożony inhibitora ACE i diuretyku pętlowego

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4283407A (en) * 1977-09-28 1981-08-11 Science Union Et Cie Thiopropionamides, and the pharmaceutical compositions
CA1120400A (en) * 1977-12-27 1982-03-23 Zola P. Horovitz Method of treating hypertension and medicaments therefor
US4217347A (en) * 1977-12-27 1980-08-12 E. R. Squibb & Sons, Inc. Method of treating hypertension and medicaments therefor
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
FR2419728A1 (fr) * 1979-01-05 1979-10-12 Science Union & Cie Nouvelles compositions pharmaceutiques a action hypotensive et procede pour les preparer
US4482725A (en) * 1980-04-03 1984-11-13 E. R. Squibb & Sons, Inc. S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics
JPS56145220A (en) * 1980-04-10 1981-11-11 Dainippon Pharmaceut Co Ltd Antihypertensive agent containing prolylamino acid derivative and diuretic agent as main constituent

Also Published As

Publication number Publication date
DK166755B1 (da) 1993-07-12
CA1340722C (en) 1999-09-07
FI863594A (fi) 1987-03-10
NZ217489A (en) 1990-07-26
DE3685177T (es) 1992-06-11
EP0215357B1 (de) 1992-05-06
IE862392L (en) 1987-03-09
GR862285B (en) 1987-01-12
PT83322A (pt) 1986-10-01
AU597270B2 (en) 1990-05-31
DE3685177D1 (de) 1992-06-11
IL79965A (en) 1990-08-31
HU200685B (en) 1990-08-28
DK427886D0 (da) 1986-09-08
AU6243186A (en) 1987-03-12
EP0215357A2 (de) 1987-03-25
KR940010032B1 (ko) 1994-10-21
ATE75610T1 (de) 1992-05-15
IE59308B1 (en) 1994-02-09
DK427886A (da) 1987-03-10
NO863583L (no) 1987-03-10
KR870002844A (ko) 1987-04-13
ZA866810B (en) 1987-04-29
HUT41640A (en) 1987-05-28
DE3532036A1 (de) 1987-03-26
PH23716A (en) 1989-09-27
JPS6261928A (ja) 1987-03-18
JPH089549B2 (ja) 1996-01-31
PT83322B (pt) 1989-05-12
IL79965A0 (en) 1986-12-31
FI863594A0 (fi) 1986-09-05
EP0215357A3 (en) 1989-07-26
NO863583D0 (no) 1986-09-08

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-09-05

FD1A Patent lapsed

Effective date: 20060906