JPS56145220A - Antihypertensive agent containing prolylamino acid derivative and diuretic agent as main constituent - Google Patents

Antihypertensive agent containing prolylamino acid derivative and diuretic agent as main constituent

Info

Publication number
JPS56145220A
JPS56145220A JP4760980A JP4760980A JPS56145220A JP S56145220 A JPS56145220 A JP S56145220A JP 4760980 A JP4760980 A JP 4760980A JP 4760980 A JP4760980 A JP 4760980A JP S56145220 A JPS56145220 A JP S56145220A
Authority
JP
Japan
Prior art keywords
lower alkyl
agent
prolylamino
acid derivative
antihypertensive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4760980A
Other languages
Japanese (ja)
Inventor
Tadahiro Sawayama
Atsuki Nishimura
Kunihiko Takeyama
Kazu Hosoki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Priority to JP4760980A priority Critical patent/JPS56145220A/en
Publication of JPS56145220A publication Critical patent/JPS56145220A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain an antihypertensive agent having an enhanced effect of action, by using a prolylamino acid derivative and a diuretic agent as main constituents.
CONSTITUTION: An antihypertensive agent prepared by using a prolylamino acid derivative of the formula (R is H, lower alkyl, etc.; R1 is H, R4CO-, R5S- or R6R7N- CX-; R2 is H or lower alkyl; R3 is H, lower alkyl, etc.; R4 is H, lower alkyl, phenyl, etc.; R5 is lower alkyl, phenyl, etc.; R6 is H or lower alkyl; R7 is lower alkyl, etc.; X is =O or =S), e.g. 1-(D-3-acetylthio-2-methylpropanoyl)-L-prolyl-L- phenylalanine, and a diuretic agent selected from hydrochlorothiazide, hydroflumethiazide, etc. as main constituents. The compound of the formula is known to have an antihypertensive action mainly caused by the inhibitory action on the angiotensin I converting enzyme, and the action is enhanced by the use of the diuretic agent together. The agent is usually administered orally.
COPYRIGHT: (C)1981,JPO&Japio
JP4760980A 1980-04-10 1980-04-10 Antihypertensive agent containing prolylamino acid derivative and diuretic agent as main constituent Pending JPS56145220A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4760980A JPS56145220A (en) 1980-04-10 1980-04-10 Antihypertensive agent containing prolylamino acid derivative and diuretic agent as main constituent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4760980A JPS56145220A (en) 1980-04-10 1980-04-10 Antihypertensive agent containing prolylamino acid derivative and diuretic agent as main constituent

Publications (1)

Publication Number Publication Date
JPS56145220A true JPS56145220A (en) 1981-11-11

Family

ID=12779969

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4760980A Pending JPS56145220A (en) 1980-04-10 1980-04-10 Antihypertensive agent containing prolylamino acid derivative and diuretic agent as main constituent

Country Status (1)

Country Link
JP (1) JPS56145220A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0215357A2 (en) * 1985-09-09 1987-03-25 Hoechst Aktiengesellschaft Pharmaceutical preparation for the treatment of hypertension
FR2616070A1 (en) * 1987-06-08 1988-12-09 Squibb & Sons Inc NEUTRAL ENDOPEPTIDASE INHIBITORS

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0215357A2 (en) * 1985-09-09 1987-03-25 Hoechst Aktiengesellschaft Pharmaceutical preparation for the treatment of hypertension
DE3532036A1 (en) * 1985-09-09 1987-03-26 Hoechst Ag PHARMACEUTICAL PREPARATION FOR TREATING HIGH PRESSURE
FR2616070A1 (en) * 1987-06-08 1988-12-09 Squibb & Sons Inc NEUTRAL ENDOPEPTIDASE INHIBITORS

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