JPS56145220A - Antihypertensive agent containing prolylamino acid derivative and diuretic agent as main constituent - Google Patents
Antihypertensive agent containing prolylamino acid derivative and diuretic agent as main constituentInfo
- Publication number
- JPS56145220A JPS56145220A JP4760980A JP4760980A JPS56145220A JP S56145220 A JPS56145220 A JP S56145220A JP 4760980 A JP4760980 A JP 4760980A JP 4760980 A JP4760980 A JP 4760980A JP S56145220 A JPS56145220 A JP S56145220A
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- agent
- prolylamino
- acid derivative
- antihypertensive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain an antihypertensive agent having an enhanced effect of action, by using a prolylamino acid derivative and a diuretic agent as main constituents.
CONSTITUTION: An antihypertensive agent prepared by using a prolylamino acid derivative of the formula (R is H, lower alkyl, etc.; R1 is H, R4CO-, R5S- or R6R7N- CX-; R2 is H or lower alkyl; R3 is H, lower alkyl, etc.; R4 is H, lower alkyl, phenyl, etc.; R5 is lower alkyl, phenyl, etc.; R6 is H or lower alkyl; R7 is lower alkyl, etc.; X is =O or =S), e.g. 1-(D-3-acetylthio-2-methylpropanoyl)-L-prolyl-L- phenylalanine, and a diuretic agent selected from hydrochlorothiazide, hydroflumethiazide, etc. as main constituents. The compound of the formula is known to have an antihypertensive action mainly caused by the inhibitory action on the angiotensin I converting enzyme, and the action is enhanced by the use of the diuretic agent together. The agent is usually administered orally.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4760980A JPS56145220A (en) | 1980-04-10 | 1980-04-10 | Antihypertensive agent containing prolylamino acid derivative and diuretic agent as main constituent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4760980A JPS56145220A (en) | 1980-04-10 | 1980-04-10 | Antihypertensive agent containing prolylamino acid derivative and diuretic agent as main constituent |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56145220A true JPS56145220A (en) | 1981-11-11 |
Family
ID=12779969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4760980A Pending JPS56145220A (en) | 1980-04-10 | 1980-04-10 | Antihypertensive agent containing prolylamino acid derivative and diuretic agent as main constituent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56145220A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0215357A2 (en) * | 1985-09-09 | 1987-03-25 | Hoechst Aktiengesellschaft | Pharmaceutical preparation for the treatment of hypertension |
FR2616070A1 (en) * | 1987-06-08 | 1988-12-09 | Squibb & Sons Inc | NEUTRAL ENDOPEPTIDASE INHIBITORS |
-
1980
- 1980-04-10 JP JP4760980A patent/JPS56145220A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0215357A2 (en) * | 1985-09-09 | 1987-03-25 | Hoechst Aktiengesellschaft | Pharmaceutical preparation for the treatment of hypertension |
DE3532036A1 (en) * | 1985-09-09 | 1987-03-26 | Hoechst Ag | PHARMACEUTICAL PREPARATION FOR TREATING HIGH PRESSURE |
FR2616070A1 (en) * | 1987-06-08 | 1988-12-09 | Squibb & Sons Inc | NEUTRAL ENDOPEPTIDASE INHIBITORS |
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