ES8205767A1 - Un procedimiento para la preparacion de derivados del acido azetidinacetico. - Google Patents

Un procedimiento para la preparacion de derivados del acido azetidinacetico.

Info

Publication number
ES8205767A1
ES8205767A1 ES498502A ES498502A ES8205767A1 ES 8205767 A1 ES8205767 A1 ES 8205767A1 ES 498502 A ES498502 A ES 498502A ES 498502 A ES498502 A ES 498502A ES 8205767 A1 ES8205767 A1 ES 8205767A1
Authority
ES
Spain
Prior art keywords
acyloxyethyl
oxo
hydroxyethyl
preparing
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498502A
Other languages
English (en)
Other versions
ES498502A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES498502A0 publication Critical patent/ES498502A0/es
Publication of ES8205767A1 publication Critical patent/ES8205767A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDO AZETIDINACETICO DE FORMULA (I), EN LA QUE R ES HIDROGENO O UN GRUPO PROTECTOR FACILMENTE ESCINDIBLE. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA R1COOH, EN PRESENCIA DE UNA TRIORGANOFOSFINA Y DE UNA AGENTE ACTIVANTE DE LA MISMA, SEGUIDA DE LA REACCION DE HIDROLISIS DEL PRODUCTO OBTENIDO PARA SEPARAR EL GRUPO (I) Y R1 ES TAL QUE EL GRUPO -COR1 ES UN RADICAL ACILO FACILMENTE SEPARABLE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIBIOTICOS.
ES498502A 1980-01-14 1981-01-14 Un procedimiento para la preparacion de derivados del acido azetidinacetico. Expired ES8205767A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/112,035 US4287123A (en) 1980-01-14 1980-01-14 Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate

Publications (2)

Publication Number Publication Date
ES498502A0 ES498502A0 (es) 1982-07-01
ES8205767A1 true ES8205767A1 (es) 1982-07-01

Family

ID=22341785

Family Applications (1)

Application Number Title Priority Date Filing Date
ES498502A Expired ES8205767A1 (es) 1980-01-14 1981-01-14 Un procedimiento para la preparacion de derivados del acido azetidinacetico.

Country Status (10)

Country Link
US (1) US4287123A (es)
EP (1) EP0032400B1 (es)
JP (2) JPS56150058A (es)
AT (1) ATE8044T1 (es)
DE (1) DE3164243D1 (es)
DK (1) DK12281A (es)
ES (1) ES8205767A1 (es)
GR (1) GR73108B (es)
IE (1) IE50681B1 (es)
PT (1) PT72333B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4414155A (en) * 1980-01-14 1983-11-08 Merck & Co., Inc. Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
US4383946A (en) * 1980-03-27 1983-05-17 Merck & Co., Inc. Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals
AU548727B2 (en) * 1981-03-12 1986-01-02 Gruppo Lepetit S.P.A. Beta-lactam acetic acid derivatives
US4360684A (en) * 1981-04-08 1982-11-23 Merck & Co., Inc. Process for the preparation of (2S)-tetrahydro-2α-methyl-6-oxo-4βα-carboxylic acid
US4473502A (en) * 1981-04-08 1984-09-25 Merck & Co., Inc. Synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid
US4454332A (en) * 1981-04-17 1984-06-12 Merck & Co., Inc. Hydroxy amino dicarboxylic acids and esters
DE3276316D1 (en) * 1981-08-27 1987-06-19 Fujisawa Pharmaceutical Co Carbapenam compound and processes for the preparation thereof
CA1190236A (en) * 1981-10-23 1985-07-09 Edward J.J. Grabowski Antibiotic synthesis
HU185081B (en) * 1981-12-30 1984-11-28 Richter Gedeon Vegyeszet Process for preparing azetidinone-acetic acid derivatives
JPS58174376A (ja) * 1982-04-08 1983-10-13 Toyama Chem Co Ltd Ｄ―ヘキソピラノース誘導体
US4710568A (en) * 1982-04-09 1987-12-01 Bristol-Myers Company Carbapenem antibiotics
US4642341A (en) * 1982-04-09 1987-02-10 Bristol-Myers Company Carbapenem antibiotics
US4665170A (en) * 1982-06-18 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics
US4640799A (en) * 1982-06-18 1987-02-03 Bristol-Myers Company Carbapenem antibiotics
HU190404B (en) * 1982-07-30 1986-09-29 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing amino-lactone-carboxylic acid
JPS5946265A (ja) * 1982-08-24 1984-03-15 Sankyo Co Ltd アゼチジノン誘導体の製造法
US4732977A (en) * 1982-09-28 1988-03-22 Bristol Myers Company Carbapenem antibiotics
US4746736A (en) * 1982-09-28 1988-05-24 Bristol-Myers Company Carbapenem antibiotics
HU188913B (en) * 1983-06-23 1986-05-28 Richter Gedeon Vegyeszeti Gyar,Rt,Hu Process for producing new azetidinyl-acetic acid esters
HU194203B (en) * 1984-08-15 1988-01-28 Richter Gedeon Rt Process for producing amino-lactone
GB8531638D0 (en) * 1985-12-23 1986-02-05 Ici Plc Chemical compounds
GB8605413D0 (en) * 1986-03-05 1986-04-09 Ici Plc Chemical compounds
US5312914A (en) * 1987-02-17 1994-05-17 Ciba-Geigy Corp Process for the manufacture of 4-acetoxy-3-hydroxyethyl-azetidinone
SG45180A1 (en) * 1987-02-17 1998-01-16 Ciba Geigy Ag A process for the manufacture of 4-acetoxy-3- hydroxy-ethyl-azetidinone
US4894450A (en) * 1987-05-11 1990-01-16 Merck & Co., Inc. Process for 2-(aminoalkylthio) carbapenems
JP2503247B2 (ja) * 1988-04-01 1996-06-05 三共株式会社 アゼチジノン誘導体
US5241064A (en) * 1989-10-02 1993-08-31 Fujisawa Pharmaceutical Co., Ltd. Enzymatic process for preparing optically active 3-substituted azetidinones
JPH03123770A (ja) * 1989-10-06 1991-05-27 Mercian Corp アゼチジノン誘導体及びその製法
ES2194866T3 (es) * 1993-02-12 2003-12-01 Daiichi Suntory Pharma Co Ltd Procedimiento para sintetizar derivados de azetidinona sustituidos en posicion 4.
US5493018A (en) * 1994-01-25 1996-02-20 Merck & Co., Inc. Process for synthesizing carbapenem intermediates using a rhodium catalyst and lewis acid
KR100874589B1 (ko) 2007-04-18 2008-12-16 성균관대학교산학협력단 페넴 중간체의 제조방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3994888A (en) * 1973-06-18 1976-11-30 Eli Lilly And Company Cephalosporin cleavage process
US4008229A (en) * 1974-07-11 1977-02-15 Eli Lilly And Company Halo substituted β-lactam antibiotics
US4008230A (en) * 1975-10-29 1977-02-15 Eli Lilly And Company Process for preparing 3-hydroxy cephalosporins
US4089956A (en) * 1976-09-08 1978-05-16 Smithkline Corporation 7-Acylamino-8-oxo-3-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid derivatives and bactericidal compositions and use thereof
FR2404632A1 (fr) * 1977-09-30 1979-04-27 Kyowa Hakko Kogyo Kk Nouveaux derives de l'azetidinone et leurs procedures de fabrication

Also Published As

Publication number Publication date
JPS56150058A (en) 1981-11-20
PT72333A (en) 1981-02-01
DK12281A (da) 1981-07-15
JPH0144700B2 (es) 1989-09-29
US4287123A (en) 1981-09-01
JPH02170A (ja) 1990-01-05
PT72333B (en) 1982-07-23
GR73108B (es) 1984-02-02
ES498502A0 (es) 1982-07-01
EP0032400A1 (en) 1981-07-22
IE810052L (en) 1981-07-14
ATE8044T1 (de) 1984-07-15
IE50681B1 (en) 1986-06-11
DE3164243D1 (en) 1984-07-26
EP0032400B1 (en) 1984-06-20
JPH046704B2 (es) 1992-02-06

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203