ES2194866T3 - Procedimiento para sintetizar derivados de azetidinona sustituidos en posicion 4. - Google Patents

Procedimiento para sintetizar derivados de azetidinona sustituidos en posicion 4.

Info

Publication number
ES2194866T3
ES2194866T3 ES94906364T ES94906364T ES2194866T3 ES 2194866 T3 ES2194866 T3 ES 2194866T3 ES 94906364 T ES94906364 T ES 94906364T ES 94906364 T ES94906364 T ES 94906364T ES 2194866 T3 ES2194866 T3 ES 2194866T3
Authority
ES
Spain
Prior art keywords
general formula
synthesizing
co2r3
alkenyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94906364T
Other languages
English (en)
Inventor
Masaji Ishiguro
Takashi Nakatsuka
Rie Tanaka
Tetsuo Shimamoto
Takuro Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asubio Pharma Co Ltd
Original Assignee
Daiichi Suntory Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Suntory Pharma Co Ltd filed Critical Daiichi Suntory Pharma Co Ltd
Application granted granted Critical
Publication of ES2194866T3 publication Critical patent/ES2194866T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Abstract

EL INVENTO SE REFIERE A UN PROCESO PARA SINTETIZAR UN DERIVADO DE ACETIDINONA 4 GENERAL (3) (EN DONDE OR1 REPRESENTA UN GRUPO HIDROXILO PROTEGIDO; CO2R3 REPRESENTA UN GRUPO CARBOXILO ESTERIFICADO; Y X E Y REPRESENTAN CADA UNO INDEPENDIENTEMENTE ALQUILO, ALQUENILO, ARALQUILO, ARILO, ALQUILTIO, ALCOXI, UN HETEROCICLO, ACIL, AMINO, HIDROGENO O HALOGENO, O ALTERNATIVAMENTE X E Y SE COMBINAN JUNTOS PARA REPRESENTAR UN CICLOALCANO MEDIO DE LA REACCION DE UN DERIVADO DE UNA ACETIDINONA REPRESENTADA POR LA FORMULA GENERAL (1) (EN DONDE OR1 ES COMO SE DEFINE ARRIBA, Y R2 REPRESENTA ALQUIL, ALQUENIL O ARIL) CON UN COMPUESTO ESTER REPRESENTADO POR LA FORMULA GENERAL (2): (EN DONDE CO2R3, X E Y SON CADA UNO COMO SE DEFINE ARRIBA) EN PRESENCIA DE COMPUESTOS DE CINC Y COBRE. EL INVENTO TAMBIEN SE REFIERE A UN COMPUESTO REPRESENTADO POR LA FORMULA GENERAL (3) Y ADEMAS A UN COMPUESTO PREPARADO POR LA DESCARBOXILACION DEL COMPUESTO (3), SIENDO UTILES AMBOS COMO INTERMEDIARIOS PARA SINTETIZAR COMPUESTOS CARBAPENEM ANTIBACTERIANOS.
ES94906364T 1993-02-12 1994-02-10 Procedimiento para sintetizar derivados de azetidinona sustituidos en posicion 4. Expired - Lifetime ES2194866T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4755293 1993-02-12

Publications (1)

Publication Number Publication Date
ES2194866T3 true ES2194866T3 (es) 2003-12-01

Family

ID=12778334

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94906364T Expired - Lifetime ES2194866T3 (es) 1993-02-12 1994-02-10 Procedimiento para sintetizar derivados de azetidinona sustituidos en posicion 4.

Country Status (5)

Country Link
EP (1) EP0638552B1 (es)
AT (1) ATE242211T1 (es)
DE (1) DE69432777T2 (es)
ES (1) ES2194866T3 (es)
WO (1) WO1994018163A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5309680B2 (ja) * 2008-05-09 2013-10-09 大正製薬株式会社 フッ素化エステル化合物の製造方法及びその中間体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287123A (en) * 1980-01-14 1981-09-01 Merck & Co., Inc. Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
US4309346A (en) * 1980-03-27 1982-01-05 Merck & Co., Inc. Process for the preparation of 1-carbapenems and intermediates via trithioorthoacetates
DK329381A (da) * 1980-07-24 1982-01-25 Takeda Chemical Industries Ltd Fremgangsmaade til frmstilling af 1,1-disubstitueret carba-z -penem samt salte og estere deraf
JPS5946265A (ja) * 1982-08-24 1984-03-15 Sankyo Co Ltd アゼチジノン誘導体の製造法
JPH0623187B2 (ja) * 1985-01-18 1994-03-30 住友製薬株式会社 β−ラクタム化合物の新規製造法
GB8607921D0 (en) * 1986-04-01 1986-05-08 Fujisawa Pharmaceutical Co 3,4-disubstituted-2-azetidinone derivatives
EP0546742B1 (en) * 1991-12-09 2001-06-20 Takasago International Corporation 4-(1,1-Dialkoxycarbonyl-alkyl)azetidin-2-one derivatives and synthesis of 4-(1-carboxy-alkyl)azetidin-2-one derivatives therefrom
JP2958834B2 (ja) * 1991-12-09 1999-10-06 高砂香料工業株式会社 アゼチジン−２−オン誘導体

Also Published As

Publication number Publication date
EP0638552B1 (en) 2003-06-04
WO1994018163A1 (en) 1994-08-18
DE69432777D1 (de) 2003-07-10
EP0638552A1 (en) 1995-02-15
DE69432777T2 (de) 2004-03-18
ATE242211T1 (de) 2003-06-15
EP0638552A4 (en) 1995-03-29

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