DE3164243D1 - (3sr, 4rs)-3-((rs)-1-hydroxyethyl)- and -((rs)-1-acyloxyethyl)-2-oxo-4-azetidineacetic acid compounds and a process for preparing the same - Google Patents

(3sr, 4rs)-3-((rs)-1-hydroxyethyl)- and -((rs)-1-acyloxyethyl)-2-oxo-4-azetidineacetic acid compounds and a process for preparing the same

Info

Publication number
DE3164243D1
DE3164243D1 DE8181100185T DE3164243T DE3164243D1 DE 3164243 D1 DE3164243 D1 DE 3164243D1 DE 8181100185 T DE8181100185 T DE 8181100185T DE 3164243 T DE3164243 T DE 3164243T DE 3164243 D1 DE3164243 D1 DE 3164243D1
Authority
DE
Germany
Prior art keywords
acyloxyethyl
oxo
hydroxyethyl
preparing
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181100185T
Other languages
English (en)
Inventor
Thomas M H Liu
David G Melillo
Kenneth M Ryan
Ichiro Shinkai
Meyer Sletzinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3164243D1 publication Critical patent/DE3164243D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8181100185T 1980-01-14 1981-01-13 (3sr, 4rs)-3-((rs)-1-hydroxyethyl)- and -((rs)-1-acyloxyethyl)-2-oxo-4-azetidineacetic acid compounds and a process for preparing the same Expired DE3164243D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/112,035 US4287123A (en) 1980-01-14 1980-01-14 Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate

Publications (1)

Publication Number Publication Date
DE3164243D1 true DE3164243D1 (en) 1984-07-26

Family

ID=22341785

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181100185T Expired DE3164243D1 (en) 1980-01-14 1981-01-13 (3sr, 4rs)-3-((rs)-1-hydroxyethyl)- and -((rs)-1-acyloxyethyl)-2-oxo-4-azetidineacetic acid compounds and a process for preparing the same

Country Status (10)

Country Link
US (1) US4287123A (de)
EP (1) EP0032400B1 (de)
JP (2) JPS56150058A (de)
AT (1) ATE8044T1 (de)
DE (1) DE3164243D1 (de)
DK (1) DK12281A (de)
ES (1) ES8205767A1 (de)
GR (1) GR73108B (de)
IE (1) IE50681B1 (de)
PT (1) PT72333B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4414155A (en) * 1980-01-14 1983-11-08 Merck & Co., Inc. Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
US4383946A (en) * 1980-03-27 1983-05-17 Merck & Co., Inc. Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals
AU548727B2 (en) * 1981-03-12 1986-01-02 Gruppo Lepetit S.P.A. Beta-lactam acetic acid derivatives
US4360684A (en) * 1981-04-08 1982-11-23 Merck & Co., Inc. Process for the preparation of (2S)-tetrahydro-2α-methyl-6-oxo-4βα-carboxylic acid
US4473502A (en) * 1981-04-08 1984-09-25 Merck & Co., Inc. Synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid
US4454332A (en) * 1981-04-17 1984-06-12 Merck & Co., Inc. Hydroxy amino dicarboxylic acids and esters
ATE27159T1 (de) * 1981-08-27 1987-05-15 Fujisawa Pharmaceutical Co Carbapenamverbindung und verfahren zu ihrer herstellung.
CA1190236A (en) * 1981-10-23 1985-07-09 Edward J.J. Grabowski Antibiotic synthesis
HU185081B (en) * 1981-12-30 1984-11-28 Richter Gedeon Vegyeszet Process for preparing azetidinone-acetic acid derivatives
JPS58174376A (ja) * 1982-04-08 1983-10-13 Toyama Chem Co Ltd Ｄ―ヘキソピラノース誘導体
US4710568A (en) * 1982-04-09 1987-12-01 Bristol-Myers Company Carbapenem antibiotics
US4642341A (en) * 1982-04-09 1987-02-10 Bristol-Myers Company Carbapenem antibiotics
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics
US4640799A (en) * 1982-06-18 1987-02-03 Bristol-Myers Company Carbapenem antibiotics
US4665170A (en) * 1982-06-18 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
HU190404B (en) * 1982-07-30 1986-09-29 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing amino-lactone-carboxylic acid
JPS5946265A (ja) * 1982-08-24 1984-03-15 Sankyo Co Ltd アゼチジノン誘導体の製造法
US4746736A (en) * 1982-09-28 1988-05-24 Bristol-Myers Company Carbapenem antibiotics
US4732977A (en) * 1982-09-28 1988-03-22 Bristol Myers Company Carbapenem antibiotics
HU188913B (en) * 1983-06-23 1986-05-28 Richter Gedeon Vegyeszeti Gyar,Rt,Hu Process for producing new azetidinyl-acetic acid esters
HU194203B (en) * 1984-08-15 1988-01-28 Richter Gedeon Rt Process for producing amino-lactone
GB8531638D0 (en) * 1985-12-23 1986-02-05 Ici Plc Chemical compounds
GB8605413D0 (en) * 1986-03-05 1986-04-09 Ici Plc Chemical compounds
EP0279781A3 (de) * 1987-02-17 1989-07-26 Ciba-Geigy Ag Verfahren zur Herstellung von 4-Acetoxy-3-hydroxyethyl-azetidinon
US5312914A (en) * 1987-02-17 1994-05-17 Ciba-Geigy Corp Process for the manufacture of 4-acetoxy-3-hydroxyethyl-azetidinone
US4894450A (en) * 1987-05-11 1990-01-16 Merck & Co., Inc. Process for 2-(aminoalkylthio) carbapenems
JP2503247B2 (ja) * 1988-04-01 1996-06-05 三共株式会社 アゼチジノン誘導体
US5241064A (en) * 1989-10-02 1993-08-31 Fujisawa Pharmaceutical Co., Ltd. Enzymatic process for preparing optically active 3-substituted azetidinones
JPH03123770A (ja) * 1989-10-06 1991-05-27 Mercian Corp アゼチジノン誘導体及びその製法
ES2194866T3 (es) * 1993-02-12 2003-12-01 Daiichi Suntory Pharma Co Ltd Procedimiento para sintetizar derivados de azetidinona sustituidos en posicion 4.
US5493018A (en) * 1994-01-25 1996-02-20 Merck & Co., Inc. Process for synthesizing carbapenem intermediates using a rhodium catalyst and lewis acid
KR100874589B1 (ko) 2007-04-18 2008-12-16 성균관대학교산학협력단 페넴 중간체의 제조방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3994888A (en) * 1973-06-18 1976-11-30 Eli Lilly And Company Cephalosporin cleavage process
US4008229A (en) * 1974-07-11 1977-02-15 Eli Lilly And Company Halo substituted β-lactam antibiotics
US4008230A (en) * 1975-10-29 1977-02-15 Eli Lilly And Company Process for preparing 3-hydroxy cephalosporins
US4089956A (en) * 1976-09-08 1978-05-16 Smithkline Corporation 7-Acylamino-8-oxo-3-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid derivatives and bactericidal compositions and use thereof
CA1145347A (en) * 1977-09-30 1983-04-26 Akira Sato 2-azetidinone derivatives

Also Published As

Publication number Publication date
IE810052L (en) 1981-07-14
DK12281A (da) 1981-07-15
ES498502A0 (es) 1982-07-01
IE50681B1 (en) 1986-06-11
JPH046704B2 (de) 1992-02-06
EP0032400B1 (de) 1984-06-20
PT72333B (en) 1982-07-23
EP0032400A1 (de) 1981-07-22
US4287123A (en) 1981-09-01
JPS56150058A (en) 1981-11-20
ATE8044T1 (de) 1984-07-15
JPH0144700B2 (de) 1989-09-29
ES8205767A1 (es) 1982-07-01
JPH02170A (ja) 1990-01-05
PT72333A (en) 1981-02-01
GR73108B (de) 1984-02-02

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee