ES8504119A1 - Procedimiento para la preparacion de nuevos derivados acidos 4-oxo-2-azetidina-carboxilicos. - Google Patents

Procedimiento para la preparacion de nuevos derivados acidos 4-oxo-2-azetidina-carboxilicos.

Info

Publication number
ES8504119A1
ES8504119A1 ES518719A ES518719A ES8504119A1 ES 8504119 A1 ES8504119 A1 ES 8504119A1 ES 518719 A ES518719 A ES 518719A ES 518719 A ES518719 A ES 518719A ES 8504119 A1 ES8504119 A1 ES 8504119A1
Authority
ES
Spain
Prior art keywords
general formula
image
defined above
compound
thienamycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518719A
Other languages
English (en)
Other versions
ES518719A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES518719A0 publication Critical patent/ES518719A0/es
Publication of ES8504119A1 publication Critical patent/ES8504119A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS ACIDOS 4-OXO-2-AZETIDINA-CARBOXILICOS.CONSISTE EN HIDROLIZAR LA MEZCLA DE ISOMEROS CIS Y TRANS DE FORMULA (II) O BIEN SOLAMENTE EL ISOMERO TRANS DE LA FORMULA (III), TRAS LO CUAL EL COMPUESTO ASI FORMADO DE FORMULA (I) SE SEPARA DE LA MEZCLA DE REACCION, DONDE Y E Y SON UN GRUPO PROTECTOR CARBONILO SEPARABLE, TAL COMO UN GRUPO CETAL O UN TIOANALOGO DEL MISMO; R ES UN GRUPO PROTECTOR AMIDO SEPARABLE, TAL COMO UN GRUPO BENCILO; Y Z ES UN GRUPO ALQUILO C 1 A 5. LA HIDROLISIS SE REALIZA EN PRESENCIA DE UN EQUIVALENTE MOLAR DE UN ALCALI, CALCULADO PARA EL COMPUESTO DE FORMULA (II) O (III).TIENEN APLICACION COMO PRODUCTOS INTERMEDIOS EN LA SINTESIS DE LA TIENOMICINA Y DE LOS COMPUESTOS CON ELLA RELACIONADOS.
ES518719A 1981-12-30 1982-12-30 Procedimiento para la preparacion de nuevos derivados acidos 4-oxo-2-azetidina-carboxilicos. Expired ES8504119A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU814011A HU184494B (en) 1981-12-30 1981-12-30 Process for producing new azetidinone-caraoxylic acids

Publications (2)

Publication Number Publication Date
ES518719A0 ES518719A0 (es) 1985-04-16
ES8504119A1 true ES8504119A1 (es) 1985-04-16

Family

ID=10966500

Family Applications (1)

Application Number Title Priority Date Filing Date
ES518719A Expired ES8504119A1 (es) 1981-12-30 1982-12-30 Procedimiento para la preparacion de nuevos derivados acidos 4-oxo-2-azetidina-carboxilicos.

Country Status (19)

Country Link
JP (1) JPS58118565A (es)
AT (1) AT378769B (es)
AU (1) AU556905B2 (es)
BE (1) BE895493A (es)
CA (1) CA1189864A (es)
CH (1) CH655927A5 (es)
DE (1) DE3248671A1 (es)
ES (1) ES8504119A1 (es)
FI (1) FI824515L (es)
FR (1) FR2518997B1 (es)
GB (1) GB2112392B (es)
GR (1) GR78430B (es)
HU (1) HU184494B (es)
IT (1) IT1210967B (es)
LU (1) LU84566A1 (es)
NL (1) NL8205069A (es)
PL (1) PL137738B1 (es)
SE (1) SE453082B (es)
ZA (1) ZA829592B (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55111463A (en) * 1979-02-21 1980-08-28 Sankyo Co Ltd Beta-lactam compound and its preparation
DE3071008D1 (en) * 1979-04-27 1985-09-26 Merck & Co Inc Process for the preparation of 3-(1-hydroxyethyl)-azetidinones
JPS56142259A (en) * 1980-03-11 1981-11-06 Sankyo Co Ltd Beta-lactam compound and its preparation

Also Published As

Publication number Publication date
FR2518997A1 (fr) 1983-07-01
SE8207474L (sv) 1983-07-01
FI824515L (fi) 1983-07-01
DE3248671A1 (de) 1983-07-07
IT1210967B (it) 1989-09-29
CH655927A5 (de) 1986-05-30
GR78430B (es) 1984-09-27
GB2112392B (en) 1985-08-14
GB2112392A (en) 1983-07-20
BE895493A (fr) 1983-06-28
FI824515A0 (fi) 1982-12-30
IT8225059A0 (it) 1982-12-30
JPS58118565A (ja) 1983-07-14
ES518719A0 (es) 1985-04-16
LU84566A1 (fr) 1984-10-22
ATA450682A (de) 1985-02-15
PL239884A1 (en) 1984-01-02
SE453082B (sv) 1988-01-11
PL137738B1 (en) 1986-07-31
AU9196782A (en) 1983-07-07
NL8205069A (nl) 1983-07-18
HU184494B (en) 1984-08-28
CA1189864A (en) 1985-07-02
AU556905B2 (en) 1986-11-27
SE8207474D0 (sv) 1982-12-29
ZA829592B (en) 1983-10-26
AT378769B (de) 1985-09-25
FR2518997B1 (fr) 1985-09-06

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