ES8202787A1 - Un procedimiento para la preparacion de un hexapeptido ci- clico - Google Patents

Un procedimiento para la preparacion de un hexapeptido ci- clico

Info

Publication number
ES8202787A1
ES8202787A1 ES496424A ES496424A ES8202787A1 ES 8202787 A1 ES8202787 A1 ES 8202787A1 ES 496424 A ES496424 A ES 496424A ES 496424 A ES496424 A ES 496424A ES 8202787 A1 ES8202787 A1 ES 8202787A1
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
preparation
compositions containing
somatostatin analogs
somatostatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES496424A
Other languages
English (en)
Other versions
ES496424A0 (es
Inventor
Daniel F Veber
Roger M Freidinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/089,827 external-priority patent/US4235886A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8202787A1 publication Critical patent/ES8202787A1/es
Publication of ES496424A0 publication Critical patent/ES496424A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN HEXAPEPTIDO CICLICO, DE FORMULA (I) O (II), EN LAS QUE X E Y SON AZUFRE O (H2)N, DONDE N VALE 0-2; Y R1, R2, R3, R4 Y R5 PUEDEN SER VARIOS TIPOS DE RADICALES. SE BASA EN LA TECNICA DE SINTESIS SECUENCIAL EN FASE SOLIDA, PREPARANDO EL CORRESPONDIENTE PEPTIDO LINEAL BLOQUEADO UNIDO A UNA RESINA EN FASE SOLIDA, SEGUIDO DEL DESBLOQUEO SELECTIVO DEL GRUPO AMINO N-TERMINAL, LA SEPARACION DEL PEPTIDO, OBTENCION DEL HEXAPEPTIDO CICLICO MEDIANTE LA FORMACION DE UN ENLACE AMIDICO POR TRATAMIENTO CON UN AGENTE CICLANTE, QUE FORMA LA UNION AMIDICA, Y POSTERIOR SEPARACION DE LOS GRUPOS PROTECTORES DE LA CADENA LATERAL.
ES496424A 1979-10-31 1980-10-30 Un procedimiento para la preparacion de un hexapeptido ci- clico Granted ES496424A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8982879A 1979-10-31 1979-10-31
US06/089,827 US4235886A (en) 1979-10-31 1979-10-31 Cyclic hexapeptide somatostatin analogs

Publications (2)

Publication Number Publication Date
ES8202787A1 true ES8202787A1 (es) 1982-02-16
ES496424A0 ES496424A0 (es) 1982-02-16

Family

ID=26780979

Family Applications (1)

Application Number Title Priority Date Filing Date
ES496424A Granted ES496424A0 (es) 1979-10-31 1980-10-30 Un procedimiento para la preparacion de un hexapeptido ci- clico

Country Status (17)

Country Link
EP (1) EP0029310B1 (es)
KR (1) KR860001961B1 (es)
AU (1) AU540140B2 (es)
CA (1) CA1216844A (es)
DD (1) DD153684A5 (es)
DE (1) DE3064499D1 (es)
DK (1) DK152505C (es)
ES (1) ES496424A0 (es)
FI (1) FI74711C (es)
GR (1) GR70725B (es)
IE (1) IE50364B1 (es)
NO (1) NO150958C (es)
NZ (1) NZ195303A (es)
PL (1) PL128347B1 (es)
PT (1) PT71966B (es)
RO (1) RO81523A (es)
YU (1) YU278780A (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4360516A (en) * 1981-04-13 1982-11-23 Merck & Co., Inc. Modified D-retro cyclic hexapeptide somatostatin analogs
US4374060A (en) * 1981-07-15 1983-02-15 Merck & Co., Inc. Process for the preparation of cyclic hexapeptide
US4427661A (en) * 1982-07-30 1984-01-24 Merck & Co., Inc. Fluorinated cyclic hexapeptide somatostatin analogs
DE3379657D1 (en) * 1982-12-06 1989-05-24 Merck & Co Inc Dicyclic hexapeptides, processes for their preparation and pharmaceutical compositions containing them
DE3303345A1 (de) * 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Cyclische peptide mit somatostatin-wirkung
US4505897A (en) * 1983-04-18 1985-03-19 The Administrators Of The Tulane Educational Fund Cyclic pentapeptides displaying somatostatin antagonism and method of treatment of mammals therewith
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
ES2158897T3 (es) * 1993-06-23 2001-09-16 Diatide Inc Peptidos radiomarcados derivados de somatostatina y utilizados en procedimientos de formacion de imagenes y terapeuticos.
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
MY147327A (en) * 1995-06-29 2012-11-30 Novartis Ag Somatostatin peptides
GB0018891D0 (en) 2000-08-01 2000-09-20 Novartis Ag Organic compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1101843A (en) * 1976-08-02 1981-05-26 Daniel F. Veber Cyclic hexapeptides useful for increasing feed efficiency
IE47421B1 (en) * 1977-06-08 1984-03-07 Merck & Co Inc Somatostatin analogs,process for their preparation and pharmaceutical compositions containing them
LU78191A1 (de) * 1977-09-28 1979-05-25 Ciba Geigy Ag Verfahren zur herstellung von neuen cyclopeptiden

Also Published As

Publication number Publication date
CA1216844A (en) 1987-01-20
DK152505B (da) 1988-03-07
NO150958B (no) 1984-10-08
GR70725B (es) 1983-01-18
PL227577A1 (es) 1981-10-02
PT71966A (en) 1980-11-01
NO803245L (no) 1981-05-04
FI803306L (fi) 1981-05-01
AU6358180A (en) 1981-05-07
IE802224L (en) 1981-04-30
RO81523A (ro) 1983-08-03
AU540140B2 (en) 1984-11-01
DK460580A (da) 1981-05-01
EP0029310B1 (en) 1983-08-03
RO81523B (ro) 1983-07-30
IE50364B1 (en) 1986-04-02
NZ195303A (en) 1984-10-19
ES496424A0 (es) 1982-02-16
FI74711B (fi) 1987-11-30
PT71966B (en) 1982-03-31
PL128347B1 (en) 1984-01-31
DK152505C (da) 1988-07-25
KR860001961B1 (ko) 1986-11-05
DD153684A5 (de) 1982-01-27
KR830004223A (ko) 1983-07-09
YU278780A (en) 1983-01-21
FI74711C (fi) 1988-03-10
EP0029310A1 (en) 1981-05-27
DE3064499D1 (en) 1983-09-08
NO150958C (no) 1985-01-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401