ES8107201A1 - Un procedimiento para la preparacion de derivados de morfo- lina - Google Patents
Un procedimiento para la preparacion de derivados de morfo- linaInfo
- Publication number
- ES8107201A1 ES8107201A1 ES496074A ES496074A ES8107201A1 ES 8107201 A1 ES8107201 A1 ES 8107201A1 ES 496074 A ES496074 A ES 496074A ES 496074 A ES496074 A ES 496074A ES 8107201 A1 ES8107201 A1 ES 8107201A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- lower alkyl
- alkyl
- formula
- obtaining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Lubricants (AREA)
- Signal Processing For Digital Recording And Reproducing (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7936502 | 1979-10-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES496074A0 ES496074A0 (es) | 1981-10-01 |
| ES8107201A1 true ES8107201A1 (es) | 1981-10-01 |
Family
ID=10508675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES496074A Expired ES8107201A1 (es) | 1979-10-20 | 1980-10-18 | Un procedimiento para la preparacion de derivados de morfo- lina |
Country Status (17)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2125793B (en) * | 1982-08-19 | 1985-10-02 | Wyeth John & Brother Ltd | Morpholine derivatives |
| GB8305638D0 (en) * | 1983-03-01 | 1983-03-30 | Wyeth John & Brother Ltd | Morpholine derivatives |
| FR2553412B1 (fr) * | 1983-10-17 | 1986-03-21 | Lafon Labor | Derives de 4-alkyl-2-methyl-2-phenyl-morpholine, procede de preparation et utilisation en therapeutique |
| GB8418657D0 (en) * | 1984-07-21 | 1984-08-22 | Beecham Group Plc | Compounds |
| FR2581383A1 (fr) * | 1985-05-03 | 1986-11-07 | Cerm Cent Europ Rech Mauvernay | 2-alkyl-2-aryl morpholines substituees, leur preparation et les compositions pharmaceutiques les contenant |
| DE3621775A1 (de) * | 1986-03-13 | 1988-01-07 | Thomae Gmbh Dr K | Neue substituierte thiazole und oxazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| GB9108629D0 (en) * | 1991-04-23 | 1991-06-12 | Wellcome Found | Heterocyclic pharmaceutical compounds,preparation and use |
| US6048859A (en) | 1992-06-29 | 2000-04-11 | Merck & Co., Inc. | Morpholine and thiomorpholine tachykinin receptor antagonists |
| US5719147A (en) * | 1992-06-29 | 1998-02-17 | Merck & Co., Inc. | Morpholine and thiomorpholine tachykinin receptor antagonists |
| US5637699A (en) * | 1992-06-29 | 1997-06-10 | Merck & Co., Inc. | Process for preparing morpholine tachykinin receptor antagonists |
| IL112778A0 (en) * | 1994-03-04 | 1995-05-26 | Merck & Co Inc | Substituted heterocycles, their preparation and pharmaceutical compositions containing them |
| WO1996033172A1 (en) * | 1995-04-20 | 1996-10-24 | Pfizer Inc. | Arylsulfonyl hydroxamic acid derivatives as mmp and tnf inhibitors |
| AU2003300967B2 (en) * | 2002-12-19 | 2009-05-28 | Merck Sharp & Dohme Corp. | Substituted amides |
| EA016485B1 (ru) | 2003-06-17 | 2012-05-30 | Арена Фармасьютикалз, Инк. | Способы получения 3-бензазепинов |
| EP2471779A1 (en) | 2006-04-03 | 2012-07-04 | Arena Pharmaceuticals, Inc. | Process for the resolution of a mixture of (R)- and (S)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine |
| JP5404414B2 (ja) | 2006-12-05 | 2014-01-29 | アリーナ ファーマシューティカルズ， インコーポレイテッド | （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンおよびその中間体を調製するための方法 |
| JP5491421B2 (ja) | 2008-03-04 | 2014-05-14 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス |
| EP2443080A2 (en) | 2009-06-18 | 2012-04-25 | Arena Pharmaceuticals, Inc. | Process for the preparation of 5-ht2c receptor agonists |
| WO2011146821A2 (en) | 2010-05-21 | 2011-11-24 | Research Triangle Institute | 1 - phenylmorpholine derivatives as hydroxybupropion analogues for treating drug dependence |
| ES2687095T3 (es) | 2010-05-21 | 2018-10-23 | Research Triangle Institute | Fenilimorfolinas y análogos de las mismas |
| KR20130112848A (ko) | 2010-06-02 | 2013-10-14 | 아레나 파마슈티칼스, 인크. | 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법 |
| MX2013002418A (es) | 2010-09-01 | 2013-08-01 | Arena Pharm Inc | Administracion de lorcaserina a individuos con daño renal. |
| CA2808912C (en) | 2010-09-01 | 2019-09-17 | Zezhi Jesse Shao | Modified-release dosage forms of 5-ht2c agonists useful for weight management |
| SG10201506865WA (en) | 2010-09-01 | 2015-10-29 | Arena Pharm Inc | Non-hygroscopic salts of 5-ht2c agonists |
| WO2012030938A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Salts of lorcaserin with optically active acids |
| AR088670A1 (es) | 2012-10-09 | 2014-06-25 | Arena Pharm Inc | Metodo de control del peso |
| WO2024238765A2 (en) * | 2023-05-16 | 2024-11-21 | Springworks Therapeutics, Inc. | Benzopiperazine and related analogs for inhibiting yap/taz-tead |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2835669A (en) * | 1958-05-20 | Process for the production of substi- | ||
| US2997469A (en) * | 1961-08-22 | Preparation of substituted | ||
| GB773780A (en) | 1953-07-01 | 1957-05-01 | Albert Boehringer | Improvements in or relating to the preparation of substituted morpholines |
| GB791416A (en) | 1956-04-09 | 1958-03-05 | Albert Boehringer | Improvements in or relating to the production of substituted tetrahydrooxazines |
| US3112311A (en) * | 1957-04-05 | 1963-11-26 | Geigy Chem Corp | 2-phenyl-5, 6-dimethyl-morpholines and 2-phenyl-5, 6-tetramethylene-morpholines |
| ES247829A1 (es) | 1958-03-13 | 1960-03-16 | Boehringer Sohn Ingelheim | Procedimeinto para la obtencion de tetrahidro-oxazinas sustituidas |
| US3296076A (en) * | 1962-06-11 | 1967-01-03 | Boehringer Sohn Ingelheim | Pilomotor shaving compositions and method of using same |
| GB1336732A (en) * | 1970-10-28 | 1973-11-07 | Istituto Gentili Spa Pisa | Diethanolamine derivatives |
| GB1452701A (en) * | 1974-05-07 | 1976-10-13 | Ici Ltd | Morpholine derivatives |
-
1980
- 1980-09-24 IE IE1995/80A patent/IE50355B1/en unknown
- 1980-09-29 ZA ZA00806017A patent/ZA806017B/xx unknown
- 1980-10-01 CA CA361,904A patent/CA1126731A/en not_active Expired
- 1980-10-02 EP EP80303473A patent/EP0027695B1/en not_active Expired
- 1980-10-02 AU AU62922/80A patent/AU531586B2/en not_active Ceased
- 1980-10-02 DE DE8080303473T patent/DE3065304D1/de not_active Expired
- 1980-10-02 GB GB8031816A patent/GB2061272B/en not_active Expired
- 1980-10-02 AT AT80303473T patent/ATE4980T1/de not_active IP Right Cessation
- 1980-10-02 GR GR63034A patent/GR70235B/el unknown
- 1980-10-03 US US06/193,779 patent/US4360519A/en not_active Expired - Lifetime
- 1980-10-17 FI FI803277A patent/FI803277A7/fi not_active Application Discontinuation
- 1980-10-17 DK DK441080A patent/DK151800C/da not_active IP Right Cessation
- 1980-10-17 JP JP14556480A patent/JPS5665880A/ja active Pending
- 1980-10-18 ES ES496074A patent/ES8107201A1/es not_active Expired
- 1980-10-18 KR KR1019800003997A patent/KR840002427B1/ko not_active Expired
- 1980-10-20 PT PT71940A patent/PT71940B/pt unknown
-
1984
- 1984-10-06 KR KR1019840006196A patent/KR840002428B1/ko not_active Expired
-
1985
- 1985-12-30 MY MY468/85A patent/MY8500468A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK151800C (da) | 1988-06-06 |
| DK151800B (da) | 1988-01-04 |
| ES496074A0 (es) | 1981-10-01 |
| AU6292280A (en) | 1981-04-30 |
| KR830004277A (ko) | 1983-07-09 |
| ATE4980T1 (de) | 1983-10-15 |
| CA1126731A (en) | 1982-06-29 |
| GB2061272A (en) | 1981-05-13 |
| KR840002427B1 (ko) | 1984-12-27 |
| EP0027695B1 (en) | 1983-10-12 |
| FI803277L (fi) | 1981-04-21 |
| MY8500468A (en) | 1985-12-31 |
| AU531586B2 (en) | 1983-09-01 |
| IE801995L (en) | 1981-04-20 |
| FI803277A7 (fi) | 1981-04-21 |
| ZA806017B (en) | 1982-04-28 |
| GB2061272B (en) | 1983-08-10 |
| DK441080A (da) | 1981-04-21 |
| PT71940A (en) | 1980-11-01 |
| US4360519A (en) | 1982-11-23 |
| IE50355B1 (en) | 1986-04-02 |
| GR70235B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1982-09-01 |
| PT71940B (pt) | 1981-08-31 |
| JPS5665880A (en) | 1981-06-03 |
| DE3065304D1 (en) | 1983-11-17 |
| KR840002428B1 (ko) | 1984-12-27 |
| EP0027695A1 (en) | 1981-04-29 |
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