ES8301952A1 - Un procedimiento para la preparacion de un derivado de piperazina. - Google Patents

Un procedimiento para la preparacion de un derivado de piperazina.

Info

Publication number
ES8301952A1
ES8301952A1 ES499504A ES499504A ES8301952A1 ES 8301952 A1 ES8301952 A1 ES 8301952A1 ES 499504 A ES499504 A ES 499504A ES 499504 A ES499504 A ES 499504A ES 8301952 A1 ES8301952 A1 ES 8301952A1
Authority
ES
Spain
Prior art keywords
alkyl
piperazine derivative
alkoxy
hydrogen
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499504A
Other languages
English (en)
Other versions
ES499504A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of ES499504A0 publication Critical patent/ES499504A0/es
Publication of ES8301952A1 publication Critical patent/ES8301952A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN DERIVADO DE PIPERAZINA, DE FORMULA GENERAL (I), EN DONDE R ES HIDROGENO, ALQUILO, ALCOXI, ALQUENILO O ALQUIL-SUFONILO; EL ANILLO A ES FENILO, ALQUIL-FENILO O HALOGENOFENILO Y N ES UN NUMERO ENTERO DE 2 A 6; O UNA SAL DE ADICION DE UN ACIDO FARMACEUTICAMENTE ACEPTABLE. CONSISTE EN HACER REACCIONAR UN COMPUESTO, DE FORMULA (II), CON UN COMPUESTO DE FORMULA (III) Y CON UN COMPUESTO DE FORMULA: R <065><024>X , DONDE W ES <024>(CH )<009><024>Y O UN ATOMO DE HIDROGENO; W'' ES UN ATOMO DE HIDROGENO O <024>(CH )<009><024>Z; Y Y Z SON GRUPOS O ATOMOS REACTIVOS; R <065> ES ALQUILO; R <065> ES ALQUENILO O ALCOXI-CARBONIL-ALQUILO; X ES HALOGENO; EL ANILLO A Y N TIENEN LOS SIGNIFICADOS YA INDICADOS. DE APLICACION EN EL TRATAMIENTO DE ENFERMEDADES CEREBRALES Y TAMBIEN COMO TRANQUILIZANTE Y ANALGESICO.
ES499504A 1980-02-18 1981-02-17 Un procedimiento para la preparacion de un derivado de piperazina. Expired ES8301952A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1885580A JPS56115769A (en) 1980-02-18 1980-02-18 Piperazine derivative and its preparation

Publications (2)

Publication Number Publication Date
ES499504A0 ES499504A0 (es) 1983-01-01
ES8301952A1 true ES8301952A1 (es) 1983-01-01

Family

ID=11983145

Family Applications (1)

Application Number Title Priority Date Filing Date
ES499504A Expired ES8301952A1 (es) 1980-02-18 1981-02-17 Un procedimiento para la preparacion de un derivado de piperazina.

Country Status (8)

Country Link
US (1) US4413006A (es)
EP (1) EP0034284B1 (es)
JP (1) JPS56115769A (es)
CA (1) CA1202973A (es)
DE (1) DE3161059D1 (es)
ES (1) ES8301952A1 (es)
IT (1) IT1136563B (es)
SE (1) SE452615B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58164583A (ja) * 1982-03-18 1983-09-29 Nippon Shinyaku Co Ltd フエノキシプロパノ−ルアミン誘導体
JPS6022136U (ja) * 1983-07-23 1985-02-15 株式会社　山見藤見鉄工所 豆刈り機
SE8500573D0 (sv) * 1985-02-08 1985-02-08 Ferrosan Ab Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain
US5106973A (en) * 1987-11-23 1992-04-21 Janssen Pharmaceutica N.V. Pyridzainamine derivatives
AU712082B2 (en) * 1996-02-28 1999-10-28 Merck & Co., Inc. Fibrinogen receptor antagonists
FR2761064B1 (fr) * 1997-03-20 1999-06-04 Pf Medicament Piperazines derivees d'amines cycliques, leur preparation et leur application comme medicaments
KR100342947B1 (ko) * 1997-04-30 2002-08-22 주식회사 엘지씨아이 제초활성 아릴피페라진아미드 유도체
US7709516B2 (en) * 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
TWI329102B (en) * 2006-08-15 2010-08-21 Nat Health Research Institutes Thiourea compounds and method for inhibiting hepatitis c virus infection
US7985763B2 (en) * 2007-04-10 2011-07-26 National Health Research Institutes Hepatitis C virus inhibitors
WO2008154091A1 (en) * 2007-06-08 2008-12-18 National Health Research Institutes Thiourea derivatives
US8198284B2 (en) * 2008-04-30 2012-06-12 National Health Research Institutes Treatment of neurodegenerative disorders with thiourea compounds
DE102013009248A1 (de) 2013-06-03 2014-12-04 MEYTON Elektronik GmbH Messrahmen zur berührungslosen optischen ermittlung einer durchschussposition und zugehöriges messverfahren
DE202013005777U1 (de) 2013-06-27 2013-07-10 MEYTON Elektronik GmbH Vorrichtung zum Wechseln eines Zielbildes und Messrahmen zur berührungslosen optischen Ermittlung einer Durchschussposition
DE202017101091U1 (de) 2017-02-27 2017-04-19 MEYTON Elektronik GmbH Messrahmen mit optischem Filter zur berührungslosen optischen Ermittlung einer Durchschussposition

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB997166A (en) * 1961-07-14 1965-07-07 May & Baker Ltd N-phenylpiperazine derivatives
FR1535403A (fr) * 1962-12-26 1968-08-09 Abbott Lab Procédé de préparation d'éthers et de thio-éthers aromatiques de pipérazines n-substituées
GB1053301A (es) * 1963-01-14
US3764602A (en) * 1969-12-04 1973-10-09 Hoffmann La Roche 3-(4-phenyl-1 2, 6 di keto piperazinyl)-2-hydroxy-propoxy)-aniline
BE792187A (fr) * 1971-12-03 1973-03-30 Sumitomo Chemical Co Nouveaux derives d'alkylamines
US4100282A (en) * 1972-12-23 1978-07-11 Boehringer Ingelheim Gmbh N-Aryl-N'-(phenyl- or phenoxy-alkyl)-piperazines and salts thereof
JPS5840551B2 (ja) * 1976-08-06 1983-09-06 田辺製薬株式会社 プロパノ−ル誘導体及びその製法

Also Published As

Publication number Publication date
IT1136563B (it) 1986-09-03
SE452615B (sv) 1987-12-07
DE3161059D1 (en) 1983-11-10
EP0034284B1 (en) 1983-10-05
IT8119814A0 (it) 1981-02-17
EP0034284A2 (en) 1981-08-26
ES499504A0 (es) 1983-01-01
JPS56115769A (en) 1981-09-11
CA1202973A (en) 1986-04-08
EP0034284A3 (en) 1981-12-09
JPH0132222B2 (es) 1989-06-29
SE8100852L (sv) 1981-08-19
US4413006A (en) 1983-11-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303