ES8105781A1 - Un procedimiento para la preparacion de sales y esteres, de monacolina k utiles como agentes antitlipercolesteremicos. - Google Patents
Un procedimiento para la preparacion de sales y esteres, de monacolina k utiles como agentes antitlipercolesteremicos.Info
- Publication number
- ES8105781A1 ES8105781A1 ES493726A ES493726A ES8105781A1 ES 8105781 A1 ES8105781 A1 ES 8105781A1 ES 493726 A ES493726 A ES 493726A ES 493726 A ES493726 A ES 493726A ES 8105781 A1 ES8105781 A1 ES 8105781A1
- Authority
- ES
- Spain
- Prior art keywords
- monacolin
- salts
- esters
- prepared
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical class C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 title abstract 4
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 241000233866 Fungi Species 0.000 abstract 1
- 241000228347 Monascus <ascomycete fungus> Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000008687 biosynthesis inhibition Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 150000002596 lactones Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/46—Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9581479A JPS5621594A (en) | 1979-07-27 | 1979-07-27 | Mb-530b carboxylic acid metal salt and its preparation |
| JP12346179A JPS5646841A (en) | 1979-09-26 | 1979-09-26 | Mb-530b carboxylic acid ester and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES493726A0 ES493726A0 (es) | 1981-06-16 |
| ES8105781A1 true ES8105781A1 (es) | 1981-06-16 |
Family
ID=26436995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES493726A Expired ES8105781A1 (es) | 1979-07-27 | 1980-07-24 | Un procedimiento para la preparacion de sales y esteres, de monacolina k utiles como agentes antitlipercolesteremicos. |
Country Status (16)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1327360C (en) * | 1983-11-14 | 1994-03-01 | William F. Hoffman | Oxo-analogs of mevinolin-like antihypercholesterolemic agents |
| CA1282425C (en) * | 1984-06-04 | 1991-04-02 | Meyer Sletzinger | Process for preparing hmg-coa reductase inhibitors with a 3,5-dihydroxypentanoate subunit |
| EP0204287A3 (en) * | 1985-06-04 | 1987-07-01 | Merck & Co. Inc. | Process for the preparation of hmg-coa reductase inhibitors with a 3,5-dihydroxypentanoate subunit |
| USRE33033E (en) * | 1985-07-05 | 1989-08-22 | Merck & Co., Inc. | Process for the preparation of HMG-CoA reductase inhibitors intermediates |
| US4611081A (en) * | 1985-07-05 | 1986-09-09 | Merck & Co., Inc. | Process for the preparation of HMG-CoA reductase inhibitors intermediates |
| US7238348B2 (en) | 1996-09-30 | 2007-07-03 | Beijing Peking University Wbl Corporation Ltd. | Method of treatment of osteoporosis with compositions of red rice fermentation products |
| US6046022A (en) | 1996-09-30 | 2000-04-04 | Peking University | Methods and compositions employing red rice fermentation products |
| AU754767B2 (en) * | 1998-06-24 | 2002-11-21 | Merck & Co., Inc. | Compositions and methods for treating elevated blood cholesterol |
| SI20070A (sl) | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Nove soli inhibitorjev HMG-CoA reduktaze |
| US6806290B2 (en) | 2000-06-09 | 2004-10-19 | Lek Pharmaceuticals D.D. | Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same |
| PL362764A1 (en) * | 2000-06-09 | 2004-11-02 | Lek Pharmaceuticals D.D. | Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same |
| EP1324972A4 (en) * | 2000-09-06 | 2004-06-30 | Merck & Co Inc | OPEN-CHAIN DIHYDROXY ACID SALT BY SIMVASTATIN |
| PL367885A1 (en) | 2001-06-13 | 2005-03-07 | Ranbaxy Laboratories Limited | Methyl analogs of simvastatin as novel hmg-coa reductase inhibitors |
| KR100379075B1 (en) | 2002-03-07 | 2003-04-08 | Jinis Biopharmaceuticals Co | Method for producing low cholesterol animal food product and food product therefrom |
| US8158362B2 (en) | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4137322A (en) * | 1976-11-02 | 1979-01-30 | Sankyo Company Limited | ML-236B carboxylic acid derivatives and their use as antihyperlipemic agents |
| JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
-
1980
- 1980-07-24 ES ES493726A patent/ES8105781A1/es not_active Expired
- 1980-07-25 CH CH5736/80A patent/CH647749A5/de not_active IP Right Cessation
- 1980-07-25 NO NO802244A patent/NO156210C/no unknown
- 1980-07-25 FR FR8016452A patent/FR2462417A1/fr active Granted
- 1980-07-25 DK DK322380A patent/DK322380A/da not_active Application Discontinuation
- 1980-07-25 SE SE8005386A patent/SE445828B/sv not_active IP Right Cessation
- 1980-07-25 FI FI802357A patent/FI71300C/fi not_active IP Right Cessation
- 1980-07-25 DE DE19803028284 patent/DE3028284A1/de active Granted
- 1980-07-25 NZ NZ194445A patent/NZ194445A/en unknown
- 1980-07-26 PL PL22590180A patent/PL225901A1/xx unknown
- 1980-07-27 NL NL8004303A patent/NL8004303A/nl not_active Application Discontinuation
- 1980-07-28 IT IT68211/80A patent/IT1147763B/it active
- 1980-07-28 GB GB8024665A patent/GB2055100A/en not_active Withdrawn
- 1980-07-28 DD DD80222916A patent/DD153827A5/de unknown
- 1980-07-28 AT AT0392380A patent/AT375334B/de not_active IP Right Cessation
- 1980-07-28 AU AU60839/80A patent/AU6083980A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| FI71300B (fi) | 1986-09-09 |
| NO802244L (no) | 1981-01-28 |
| PL225901A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1982-07-19 |
| FI71300C (fi) | 1986-12-19 |
| DK322380A (da) | 1981-01-28 |
| DE3028284C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-08-09 |
| SE8005386L (sv) | 1981-01-28 |
| ATA392380A (de) | 1983-12-15 |
| FI802357A7 (fi) | 1981-01-28 |
| AU6083980A (en) | 1981-01-29 |
| AT375334B (de) | 1984-07-25 |
| CH647749A5 (de) | 1985-02-15 |
| FR2462417A1 (fr) | 1981-02-13 |
| ES493726A0 (es) | 1981-06-16 |
| DE3028284A1 (de) | 1981-02-19 |
| GB2055100A (en) | 1981-02-25 |
| FR2462417B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1984-01-20 |
| NZ194445A (en) | 1984-07-06 |
| IT8068211A0 (it) | 1980-07-28 |
| IT1147763B (it) | 1986-11-26 |
| DD153827A5 (de) | 1982-02-03 |
| NL8004303A (nl) | 1981-01-29 |
| NO156210B (no) | 1987-05-04 |
| NO156210C (no) | 1987-08-12 |
| SE445828B (sv) | 1986-07-21 |
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