ES8105781A1 - Monacolin K derivatives - Google Patents
Monacolin K derivativesInfo
- Publication number
- ES8105781A1 ES8105781A1 ES493726A ES493726A ES8105781A1 ES 8105781 A1 ES8105781 A1 ES 8105781A1 ES 493726 A ES493726 A ES 493726A ES 493726 A ES493726 A ES 493726A ES 8105781 A1 ES8105781 A1 ES 8105781A1
- Authority
- ES
- Spain
- Prior art keywords
- monacolin
- salts
- esters
- prepared
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/46—Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Salts and esters of the parent acid corresponding to the lactone Monacolin K may be prepared by salification or esterification of Monacolin K or of a reactive derivative thereof and the salts may be prepared by cultivation of various fungi of the genus Monascus under appropriate conditions. These salts and esters have an activity greater than or comparable with that of Monacolin K itself in the inhibition of biosynthesis of cholesterol. They are, accordingly, valuable antihypercholesteraemic agents.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9581479A JPS5621594A (en) | 1979-07-27 | 1979-07-27 | Mb-530b carboxylic acid metal salt and its preparation |
JP12346179A JPS5646841A (en) | 1979-09-26 | 1979-09-26 | Mb-530b carboxylic acid ester and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8105781A1 true ES8105781A1 (en) | 1981-06-16 |
ES493726A0 ES493726A0 (en) | 1981-06-16 |
Family
ID=26436995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES493726A Granted ES493726A0 (en) | 1979-07-27 | 1980-07-24 | A PROCEDURE FOR THE PREPARATION OF SALTS AND ESTERS OF MONACOLINE K USEFUL AS ANTITLIPERCOLESTEREMIC AGENTS. |
Country Status (16)
Country | Link |
---|---|
AT (1) | AT375334B (en) |
AU (1) | AU6083980A (en) |
CH (1) | CH647749A5 (en) |
DD (1) | DD153827A5 (en) |
DE (1) | DE3028284A1 (en) |
DK (1) | DK322380A (en) |
ES (1) | ES493726A0 (en) |
FI (1) | FI71300C (en) |
FR (1) | FR2462417A1 (en) |
GB (1) | GB2055100A (en) |
IT (1) | IT1147763B (en) |
NL (1) | NL8004303A (en) |
NO (1) | NO156210C (en) |
NZ (1) | NZ194445A (en) |
PL (1) | PL225901A1 (en) |
SE (1) | SE445828B (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1327360C (en) * | 1983-11-14 | 1994-03-01 | William F. Hoffman | Oxo-analogs of mevinolin-like antihypercholesterolemic agents |
DE3580863D1 (en) * | 1984-06-04 | 1991-01-24 | Merck & Co Inc | PRODUCTION METHOD OF INHIBITORS OF HMG-COA REDUCTASE WITH A 3,5-DIHYDROXYPENTANOATE PART STRUCTURE. |
EP0204287A3 (en) * | 1985-06-04 | 1987-07-01 | Merck & Co. Inc. | Process for the preparation of hmg-coa reductase inhibitors with a 3,5-dihydroxypentanoate subunit |
US4611081A (en) * | 1985-07-05 | 1986-09-09 | Merck & Co., Inc. | Process for the preparation of HMG-CoA reductase inhibitors intermediates |
USRE33033E (en) * | 1985-07-05 | 1989-08-22 | Merck & Co., Inc. | Process for the preparation of HMG-CoA reductase inhibitors intermediates |
US7238348B2 (en) | 1996-09-30 | 2007-07-03 | Beijing Peking University Wbl Corporation Ltd. | Method of treatment of osteoporosis with compositions of red rice fermentation products |
US6046022A (en) | 1996-09-30 | 2000-04-04 | Peking University | Methods and compositions employing red rice fermentation products |
JP2002518448A (en) * | 1998-06-24 | 2002-06-25 | メルク エンド カムパニー インコーポレーテッド | Compositions and methods for treating high blood cholesterol |
SI20070A (en) | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | NOVEL SALTS OF INHIBITORS OF HMG-CoA REDUCTASE |
RU2246943C2 (en) * | 2000-06-09 | 2005-02-27 | Лек Фармасьютикал Энд Кемикал Компани Д.Д. | Stabilized pharmaceutically effective composition and pharmaceutical preparation comprising thereof |
US6806290B2 (en) | 2000-06-09 | 2004-10-19 | Lek Pharmaceuticals D.D. | Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same |
AU2001288724A1 (en) * | 2000-09-06 | 2002-03-22 | Merck & Co., Inc. | Dihydroxy open-acid salt of simvastatin |
PL367885A1 (en) | 2001-06-13 | 2005-03-07 | Ranbaxy Laboratories Limited | Methyl analogs of simvastatin as novel hmg-coa reductase inhibitors |
KR100379075B1 (en) | 2002-03-07 | 2003-04-08 | Jinis Biopharmaceuticals Co | Method for producing low cholesterol animal food product and food product therefrom |
US8158362B2 (en) | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
CN101659923B (en) * | 2008-08-26 | 2011-10-26 | 北京北大维信生物科技有限公司 | Method for preparing open-loop lovastatin |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2748825C2 (en) * | 1976-11-02 | 1986-11-27 | Sankyo Co., Ltd., Tokio/Tokyo | Substituted 3,5-dihydroxyheptanoic acid derivatives and medicaments for hyperlipemia containing them |
JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
-
1980
- 1980-07-24 ES ES493726A patent/ES493726A0/en active Granted
- 1980-07-25 NZ NZ194445A patent/NZ194445A/en unknown
- 1980-07-25 CH CH5736/80A patent/CH647749A5/en not_active IP Right Cessation
- 1980-07-25 DK DK322380A patent/DK322380A/en not_active Application Discontinuation
- 1980-07-25 FR FR8016452A patent/FR2462417A1/en active Granted
- 1980-07-25 FI FI802357A patent/FI71300C/en not_active IP Right Cessation
- 1980-07-25 NO NO802244A patent/NO156210C/en unknown
- 1980-07-25 DE DE19803028284 patent/DE3028284A1/en active Granted
- 1980-07-25 SE SE8005386A patent/SE445828B/en not_active IP Right Cessation
- 1980-07-26 PL PL22590180A patent/PL225901A1/xx unknown
- 1980-07-27 NL NL8004303A patent/NL8004303A/en not_active Application Discontinuation
- 1980-07-28 AT AT0392380A patent/AT375334B/en not_active IP Right Cessation
- 1980-07-28 IT IT68211/80A patent/IT1147763B/en active
- 1980-07-28 DD DD80222916A patent/DD153827A5/en unknown
- 1980-07-28 GB GB8024665A patent/GB2055100A/en not_active Withdrawn
- 1980-07-28 AU AU60839/80A patent/AU6083980A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
SE8005386L (en) | 1981-01-28 |
SE445828B (en) | 1986-07-21 |
FR2462417B1 (en) | 1984-01-20 |
NZ194445A (en) | 1984-07-06 |
FI71300C (en) | 1986-12-19 |
GB2055100A (en) | 1981-02-25 |
FI71300B (en) | 1986-09-09 |
CH647749A5 (en) | 1985-02-15 |
NO156210B (en) | 1987-05-04 |
DK322380A (en) | 1981-01-28 |
IT8068211A0 (en) | 1980-07-28 |
DE3028284C2 (en) | 1990-08-09 |
PL225901A1 (en) | 1982-07-19 |
AT375334B (en) | 1984-07-25 |
AU6083980A (en) | 1981-01-29 |
FI802357A (en) | 1981-01-28 |
NO156210C (en) | 1987-08-12 |
DE3028284A1 (en) | 1981-02-19 |
NL8004303A (en) | 1981-01-29 |
DD153827A5 (en) | 1982-02-03 |
FR2462417A1 (en) | 1981-02-13 |
ES493726A0 (en) | 1981-06-16 |
IT1147763B (en) | 1986-11-26 |
ATA392380A (en) | 1983-12-15 |
NO802244L (en) | 1981-01-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8105781A1 (en) | Monacolin K derivatives | |
IE801232L (en) | Polyhydro-3, 7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2h-¹pyran-2-yl)-ethyl)-1-naphthalenyl-2-methylbutanoates. | |
ES8404400A1 (en) | Manufacture of non-saponifiable compounds from natural substances and the resulting products | |
ES8107306A1 (en) | A method for the production of antibiotic C-15003 P-3. | |
AU662430B2 (en) | Derivatives of quinic acid and a process for their production | |
JPS57122076A (en) | Hypocholesterolemic fermentation product and manufacture | |
FR2467199B1 (en) | ||
IE39397B1 (en) | Emulsifiers derived from hydroxycarboxylic acids | |
AU547968B2 (en) | Ml-236b derivatives i.e. alactone and the corresponding free hydroxy-carboxylic acid | |
IE790299L (en) | Testosterone esters | |
IE39924B1 (en) | Benzimidazole -1-carboximido acid esters | |
AU5482080A (en) | Phthyalidyl esters of acetone adduct of epicillin | |
AU518081B2 (en) | 2-oxo-3-benzothiazolinyl)-alkyl esters as plant growth regulants | |
IE792294L (en) | Process for the preparation of 2-ketogulonic acid. | |
ES8200639A1 (en) | Cyclopropane-carboxylic acid esters, process for their preparation and their use. | |
IE781105L (en) | Esters of alkyl-dioxo-pyrazolidine derivatives. | |
GB1513158A (en) | Dry extracts of plants of the senecio genus | |
JPS52128319A (en) | Production of n-substituted amino-acid or its acid salt | |
IE46106L (en) | Reduction of 2,5-diketogluconic acid | |
GB1527825A (en) | Preparation of stable clear substrate solutions for the analysis of ester hydrolases | |
GB1080679A (en) | A hydrolysis product derived from meso-inositol hexa-nicotinate | |
AU517641B2 (en) | 3-aryl-4-isotliazole carboxylic acids and 3-aryl-4 isoxazole carboxylic acids as plant growth regulants | |
JPS53142595A (en) | Preparation of alpha-alanine by fermentation process | |
JPS5661377A (en) | Optically active cephaloasporin analog |