ES8104790A1 - Procedimiento para la preparacion de derivados de la glici- namida - Google Patents
Procedimiento para la preparacion de derivados de la glici- namidaInfo
- Publication number
- ES8104790A1 ES8104790A1 ES490536A ES490536A ES8104790A1 ES 8104790 A1 ES8104790 A1 ES 8104790A1 ES 490536 A ES490536 A ES 490536A ES 490536 A ES490536 A ES 490536A ES 8104790 A1 ES8104790 A1 ES 8104790A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- linear
- ramified
- represents hydrogen
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical class NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- UXTFKIJKRJJXNV-UHFFFAOYSA-N 1-$l^{1}-oxidanylethanone Chemical compound CC([O])=O UXTFKIJKRJJXNV-UHFFFAOYSA-N 0.000 abstract 1
- MBVFRSJFKMJRHA-UHFFFAOYSA-N 4-fluoro-1-benzofuran-7-carbaldehyde Chemical group FC1=CC=C(C=O)C2=C1C=CO2 MBVFRSJFKMJRHA-UHFFFAOYSA-N 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical compound O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical group C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU81069A LU81069A1 (fr) | 1979-03-22 | 1979-03-22 | Derive de glycinamide, preparation de ce derive, son utilisation ainsi que composition contenant ce derive |
| LU81068A LU81068A1 (fr) | 1979-03-22 | 1979-03-22 | Derives de la glycinamide, leur preparation et utilisation, ainsi que compositions contenant ces derives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES490536A0 ES490536A0 (es) | 1981-04-16 |
| ES8104790A1 true ES8104790A1 (es) | 1981-04-16 |
Family
ID=26640253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES490536A Expired ES8104790A1 (es) | 1979-03-22 | 1980-03-21 | Procedimiento para la preparacion de derivados de la glici- namida |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4639468A (Direct) |
| AT (1) | AT381302B (Direct) |
| AU (1) | AU536499B2 (Direct) |
| CA (1) | CA1184567A (Direct) |
| CH (1) | CH645091A5 (Direct) |
| DE (2) | DE3010599A1 (Direct) |
| DK (1) | DK162714C (Direct) |
| ES (1) | ES8104790A1 (Direct) |
| FI (1) | FI82033C (Direct) |
| FR (1) | FR2451913A1 (Direct) |
| GB (1) | GB2048852B (Direct) |
| GR (1) | GR68005B (Direct) |
| IE (1) | IE49751B1 (Direct) |
| IL (1) | IL59679A (Direct) |
| NL (1) | NL191508C (Direct) |
| NO (1) | NO157817C (Direct) |
| PT (1) | PT70992A (Direct) |
| SE (1) | SE453917B (Direct) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2937698A1 (de) * | 1979-09-18 | 1981-04-02 | A. Nattermann & Cie GmbH, 5000 Köln | N-propionylsarcosinanilide, deren herstellungsverfahren und arzneimittel auf deren basis |
| FI832935A7 (fi) * | 1982-08-20 | 1984-02-21 | Midit | Derivat av w-aminosyror, deras framstaellning samt dessa derivat innehaollande blandningar |
| US4798687A (en) * | 1987-02-06 | 1989-01-17 | Pennwalt Corporation | 2-Amino-N-[1,2-Diphenyl-1-(thifluoromethyl)ethyl]acetamide derivatives |
| US4904681A (en) * | 1987-12-01 | 1990-02-27 | G. D. Searle & Co. | D-cycloserine and its prodrugs as cognitive enhancers |
| US4891058A (en) * | 1988-07-18 | 1990-01-02 | Ici Americas Inc. | 1-alkyl-3-aryl imidazolidine-2,4-diones and herbicidal use |
| US5278191A (en) * | 1988-08-31 | 1994-01-11 | G. D. Searle & Co. | Diphenylmethylaminoacetamide derivatives as anti-convulsants |
| US5288905A (en) * | 1988-10-07 | 1994-02-22 | G. D. Searle & Co. | Glycyl urea derivatives as anti-convulsants |
| US4944796A (en) * | 1988-11-14 | 1990-07-31 | Ici Americas Inc. | Certain 2-(disubstituted amino) acetanilide herbicides |
| DE3915755A1 (de) * | 1989-05-13 | 1990-11-29 | Bayer Ag | Fungizide mittel sowie substituierte aminosaeureamid-derivate und deren herstellung |
| IL94466A (en) * | 1989-05-25 | 1995-01-24 | Erba Carlo Spa | Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation |
| US5075337A (en) * | 1989-07-26 | 1991-12-24 | G. D. Searle & Co. | Alpha-deuterated 2-alkylaminoacetamide derivatives having reduced toxicity for treatment of CNS disorders |
| US5153226A (en) * | 1989-08-31 | 1992-10-06 | Warner-Lambert Company | Acat inhibitors for treating hypocholesterolemia |
| DE4102042A1 (de) * | 1991-01-24 | 1992-07-30 | Bayer Ag | Substituierte aminosaeureamid-derivate deren herstellung und verwendung als fungizide |
| US5141960A (en) * | 1991-06-25 | 1992-08-25 | G. D. Searle & Co. | Tricyclic glycinamide derivatives as anti-convulsants |
| GB9306886D0 (en) * | 1993-04-01 | 1993-05-26 | Erba Carlo Spa | Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation |
| GB9306899D0 (en) * | 1993-04-01 | 1993-05-26 | Erba Carlo Spa | Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation |
| US5585358A (en) * | 1993-07-06 | 1996-12-17 | Yissum Research Development Corporation Of The Hebrew University Of Jerusalem | Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents |
| US6191165B1 (en) * | 1996-05-31 | 2001-02-20 | Allelix Neuroscience Inc. | Pharmaceutical for treatment of neurological and neuropsychiatric disorders |
| PT1014966E (pt) * | 1996-05-31 | 2006-12-29 | Allelix Neuroscience Inc | Composição farmacêutica para o tratamento de disturbios neurológicos e neuropsiquiátricos. |
| IT1283489B1 (it) * | 1996-07-23 | 1998-04-21 | Chiesi Farma Spa | Ammidi di alfa-amminoacidi,loro preparazione e loro impiego terapeutico |
| GB9727523D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| WO1999048858A2 (en) * | 1998-03-26 | 1999-09-30 | University Of Saskatchewan Technologies Inc. | Aliphatic amino carboxylic and amino phosphonic acids, amino nitriles and amino tetrazoles as cellular rescue agents |
| US6984754B1 (en) | 1998-03-26 | 2006-01-10 | University Of Saskatchewan Technologies Inc. | Aliphatic amino carboxylic and amino phosphonic acids amino nitriles and amino tetrazoles as cellular rescue agents |
| EP1153010A1 (en) * | 1999-02-08 | 2001-11-14 | Checkpoint Genetics, Inc. | $i(N)-SUBSTITUTED AMINO ACIDS, ANTIOXIDANT PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND METHODS USING SAME |
| CZ2004266A3 (cs) * | 2000-07-21 | 2005-02-16 | Teva Pharmaceutical Industries, Ltd. | Použití derivátů amidů kyseliny valproové a kyseliny 2-valproenové pro léčbu mánie při bipolární poruše |
| ES2245377T3 (es) * | 2000-08-17 | 2006-01-01 | Teva Pharmaceutical Industries Ltd. | Uso de derivados de amidas de acido valproico y amidas de acido 2-valproenico para el tratamiento o prevencion del dolor y/o trastornos de dolor de cabeza. |
| WO2002042256A2 (en) * | 2000-11-21 | 2002-05-30 | Ucb, S.A. | N-alkylated gaba compounds, processes for their preparation and their use as medicaments |
| BR0207307A (pt) | 2001-02-16 | 2004-08-17 | Allelix Neuroscience Inc | Inibidores de glyt-1 |
| US20030035784A1 (en) * | 2001-03-05 | 2003-02-20 | Kao Corporation | Hair cosmetic, aminocarboxylic acid amide and method for producing the same |
| IL160523A0 (en) | 2001-09-03 | 2004-07-25 | Newron Pharm Spa | PHARMACEUTICAL COMPOSITION COMPRISING GABAPENTIN OR AN ANALOGUE THEREOF AND AN alpha-AMINOAMIDE AND ITS ANALGESIC USE |
| EP1438956A1 (en) * | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
| PL1809271T3 (pl) * | 2004-09-10 | 2010-10-29 | Newron Pharm Spa | Zastosowania (R)-(halobenzyloksy)benzyloamino-propanamidów jako modulator kanałów sodowych i/lub wapniowych |
| BRPI0515260A (pt) * | 2004-09-13 | 2008-07-15 | Ciba Sc Holding Ag | aditivos lubrificantes de alquilaminoacetamida |
| FR2896991A1 (fr) * | 2006-02-03 | 2007-08-10 | Inst Nat Sante Rech Med | Procede pour preparer un compose organique a l'etat solide et compositions pharmaceutiques comprenant ledit compose organique |
| CN102351733B (zh) * | 2011-07-21 | 2014-03-19 | 凯莱英医药化学（阜新）技术有限公司 | 一种制备2-氨基-n,n-二甲基乙酰胺盐酸盐的方法 |
| US9738593B2 (en) | 2014-06-25 | 2017-08-22 | Acuitas Therapeutics Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| JP6053724B2 (ja) * | 2014-06-26 | 2016-12-27 | 国立大学法人九州大学 | イオン交換樹脂及び金属の吸着分離方法 |
| US10221127B2 (en) | 2015-06-29 | 2019-03-05 | Acuitas Therapeutics, Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| CN113636947A (zh) | 2015-10-28 | 2021-11-12 | 爱康泰生治疗公司 | 用于递送核酸的新型脂质和脂质纳米颗粒制剂 |
| CN106187829B (zh) * | 2016-07-29 | 2017-12-15 | 万华化学集团股份有限公司 | 一种制备乙二胺基乙磺酸盐的方法 |
| US12491261B2 (en) | 2016-10-26 | 2025-12-09 | Acuitas Therapeutics, Inc. | Lipid nanoparticle formulations |
| WO2018191657A1 (en) | 2017-04-13 | 2018-10-18 | Acuitas Therapeutics, Inc. | Lipids for delivery of active agents |
| ES2981244T3 (es) | 2017-04-28 | 2024-10-07 | Acuitas Therapeutics Inc | Novedosas formulaciones de nanopartículas de lípidos de carbonilo y lípidos para la administración de ácidos nucleicos |
| CA3073020A1 (en) | 2017-08-16 | 2019-02-21 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| US11524932B2 (en) | 2017-08-17 | 2022-12-13 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| EP3668834B1 (en) | 2017-08-17 | 2024-10-02 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| US11542225B2 (en) | 2017-08-17 | 2023-01-03 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| IL322436A (en) | 2018-09-21 | 2025-09-01 | Acuitas Therapeutics Inc | Systems and methods for producing lipid nanoparticles and liposomes |
| KR101953366B1 (ko) | 2018-12-26 | 2019-02-28 | 정종문 | 침향을 포함하는 기억력 및 인지능력을 향상시키는 기능성 건강식품 및 이의 제조방법 |
| HUE068416T2 (hu) | 2019-01-11 | 2024-12-28 | Acuitas Therapeutics Inc | Lipidek hatóanyagok lipid nanorészecskék formájában való adagolására |
| USD926577S1 (en) | 2019-09-23 | 2021-08-03 | Verdant Ventures | Tamper-resistant lid assembly |
| US11326923B2 (en) | 2019-10-08 | 2022-05-10 | Verdant Ventures | Tamper-resistant lid assembly for dispensing a premeasured amount of liquid |
| CA3189338A1 (en) | 2020-07-16 | 2022-01-20 | Acuitas Therapeutics, Inc. | Cationic lipids for use in lipid nanoparticles |
| US12129223B2 (en) | 2021-12-16 | 2024-10-29 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2368208A (en) * | 1940-12-16 | 1945-01-30 | Emulsol Corp | Chemical compounds and method of preparing same |
| US2781385A (en) * | 1953-09-21 | 1957-02-12 | Gefgy Chemical Corp | Diamidocarboxylic acids and certain salts thereof |
| FI41563B (Direct) * | 1962-05-09 | 1969-09-01 | Ferrosan Ab | |
| JPS5319654B2 (Direct) * | 1974-03-14 | 1978-06-22 | ||
| DE2832009A1 (de) * | 1978-07-20 | 1980-01-31 | Deutsches Krebsforsch | Verwendung von sarkosin und sarkosinderivaten ls tumorhemmende wirksubstanzen |
-
1980
- 1980-03-20 DE DE19803010599 patent/DE3010599A1/de active Granted
- 1980-03-20 DE DE3050800A patent/DE3050800C2/de not_active Expired
- 1980-03-21 DK DK123580A patent/DK162714C/da not_active IP Right Cessation
- 1980-03-21 PT PT70992A patent/PT70992A/pt active IP Right Revival
- 1980-03-21 ES ES490536A patent/ES8104790A1/es not_active Expired
- 1980-03-21 AT AT0154680A patent/AT381302B/de not_active IP Right Cessation
- 1980-03-21 IL IL59679A patent/IL59679A/xx unknown
- 1980-03-21 SE SE8002204A patent/SE453917B/sv not_active IP Right Cessation
- 1980-03-21 FI FI800900A patent/FI82033C/fi not_active IP Right Cessation
- 1980-03-21 FR FR8006390A patent/FR2451913A1/fr active Granted
- 1980-03-21 CH CH225380A patent/CH645091A5/fr not_active IP Right Cessation
- 1980-03-21 NO NO800830A patent/NO157817C/no unknown
- 1980-03-22 GR GR61512A patent/GR68005B/el unknown
- 1980-03-24 CA CA000348319A patent/CA1184567A/en not_active Expired
- 1980-03-24 IE IE599/80A patent/IE49751B1/en not_active IP Right Cessation
- 1980-03-24 GB GB8009801A patent/GB2048852B/en not_active Expired
- 1980-03-24 NL NL8001721A patent/NL191508C/xx not_active IP Right Cessation
- 1980-03-24 AU AU56784/80A patent/AU536499B2/en not_active Expired
-
1985
- 1985-08-23 US US06/768,185 patent/US4639468A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2451913B1 (Direct) | 1984-07-13 |
| DE3050800C2 (Direct) | 1989-06-22 |
| FI800900A7 (fi) | 1980-09-23 |
| AT381302B (de) | 1986-09-25 |
| SE8002204L (sv) | 1980-09-23 |
| DE3010599A1 (de) | 1980-10-09 |
| CH645091A5 (fr) | 1984-09-14 |
| AU5678480A (en) | 1980-09-25 |
| FI82033B (fi) | 1990-09-28 |
| IL59679A0 (en) | 1980-06-30 |
| SE453917B (sv) | 1988-03-14 |
| PT70992A (fr) | 1980-04-01 |
| ES490536A0 (es) | 1981-04-16 |
| GB2048852B (en) | 1983-03-30 |
| FI82033C (fi) | 1991-01-10 |
| NO157817C (no) | 1988-05-25 |
| ATA154680A (de) | 1986-02-15 |
| US4639468A (en) | 1987-01-27 |
| IE49751B1 (en) | 1985-12-11 |
| AU536499B2 (en) | 1984-05-10 |
| IL59679A (en) | 1984-11-30 |
| GR68005B (Direct) | 1981-10-26 |
| NO157817B (no) | 1988-02-15 |
| NL191508C (nl) | 1995-08-21 |
| CA1184567A (en) | 1985-03-26 |
| DK162714C (da) | 1992-04-21 |
| NL191508B (nl) | 1995-04-18 |
| NO800830L (no) | 1980-09-23 |
| FR2451913A1 (fr) | 1980-10-17 |
| DK162714B (da) | 1991-12-02 |
| GB2048852A (en) | 1980-12-17 |
| DE3010599C2 (Direct) | 1989-03-02 |
| NL8001721A (nl) | 1980-09-24 |
| DK123580A (da) | 1980-09-23 |
| IE800599L (en) | 1980-09-22 |
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