ES8104200A1 - Un procedimiento para preparar mercaptoacildipeptidos - Google Patents

Un procedimiento para preparar mercaptoacildipeptidos

Info

Publication number
ES8104200A1
ES8104200A1 ES490166A ES490166A ES8104200A1 ES 8104200 A1 ES8104200 A1 ES 8104200A1 ES 490166 A ES490166 A ES 490166A ES 490166 A ES490166 A ES 490166A ES 8104200 A1 ES8104200 A1 ES 8104200A1
Authority
ES
Spain
Prior art keywords
formula
alcohyl
alcanoyl
ester
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES490166A
Other languages
English (en)
Other versions
ES490166A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of ES490166A0 publication Critical patent/ES490166A0/es
Publication of ES8104200A1 publication Critical patent/ES8104200A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE MERCAPTOACILDIPEPTIDOS DE FORMULA (I) O UN ESTER ALCOHILO O UNA SAL DEL MISMO. EN LA FORMULA (I), N ES 0 O 1; A1 Y A2 SON, CADA UNO, UN RESTO DE UN ALFA-AMINOACIDO; R2 ES HIDROGENO, ALCOHILO O FENILALCOHILO; Y R1 ES HIDROGENO, ALCANOILO O UN GRUPO DE FORMULA (II) EN LA QUE LOS SIMBOLOS TIENEN LOS SIGNIFICADOS YA DADOS. EL PROCEDIMIENTO SE BASA EN LA ACILACION DE UN DIPEPTIDO DE LOS GRUPOS A1 Y A2 O UNO DE SUS DERIVADOS DE ESTER ALCOHILICO, CON UN TIOACIDO DE FORMULA (III) EN LA QUE R1 ES ALCANOILO O BENZOILO. LOS PRODUCTOS OBTENIDOS SON SOMETIDOS A HIDROLISIS Y POSTERIORMENTE OXIDADOS. *FORMULA*
ES490166A 1979-04-02 1980-04-01 Un procedimiento para preparar mercaptoacildipeptidos Expired ES8104200A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2570179A 1979-04-02 1979-04-02

Publications (2)

Publication Number Publication Date
ES490166A0 ES490166A0 (es) 1981-04-01
ES8104200A1 true ES8104200A1 (es) 1981-04-01

Family

ID=21827594

Family Applications (1)

Application Number Title Priority Date Filing Date
ES490166A Expired ES8104200A1 (es) 1979-04-02 1980-04-01 Un procedimiento para preparar mercaptoacildipeptidos

Country Status (22)

Country Link
JP (1) JPS55133345A (es)
AT (1) AT373577B (es)
AU (1) AU537592B2 (es)
BE (1) BE882601A (es)
CH (1) CH645092A5 (es)
DE (1) DE3012140A1 (es)
DK (1) DK140480A (es)
ES (1) ES8104200A1 (es)
FR (1) FR2453135A1 (es)
GB (1) GB2045771B (es)
GR (1) GR67752B (es)
HU (1) HU181087B (es)
IE (1) IE49653B1 (es)
IT (1) IT1147332B (es)
LU (1) LU82316A1 (es)
NL (1) NL8001675A (es)
NO (1) NO150360C (es)
NZ (1) NZ193142A (es)
PH (1) PH22024A (es)
PT (1) PT71044A (es)
SE (1) SE8002512L (es)
ZA (1) ZA801527B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5692848A (en) * 1979-12-27 1981-07-27 Dainippon Pharmaceut Co Ltd Preparation of 1- 3-lower alaknoylthio-2-methylpropanoyl prolylphenylalanine
JPS56139455A (en) 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid
US4336950A (en) * 1980-09-08 1982-06-29 John Zepkowski Sled
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
JPS57142967A (en) * 1981-02-27 1982-09-03 Dainippon Pharmaceut Co Ltd N-(acylthioalkanoyloxy)succinimide and its use
US4512979A (en) * 1981-03-23 1985-04-23 Merck & Co., Inc. Dipeptides containing thialysine and related amino acids as antihypertensives
US4382081A (en) * 1981-06-12 1983-05-03 E. R. Squibb & Sons, Inc. Inhibitors of mammalian collagenase
IT1195287B (it) * 1981-11-05 1988-10-12 Ausonia Farma Srl Derivato tiazolico,procedimento per la sua preparazione e relative composizioni farmaceutiche
US4434151A (en) * 1982-11-08 1984-02-28 Medi-Physics, Inc. Bifunctional chelating agents
DE3243369A1 (de) * 1982-11-24 1984-05-24 Basf Ag, 6700 Ludwigshafen Bis-(benzoylthio)-carbonsaeuren, ihre herstellung und verwendung zur herstellung von wirkstoffen
US4642355A (en) * 1984-02-24 1987-02-10 Otsuka Pharmaceutical Factory, Inc. Proline derivatives
US4560506A (en) * 1984-05-25 1985-12-24 E. R. Squibb & Sons, Inc. Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides
DE3432307A1 (de) * 1984-09-03 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeurederivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
DE3436569A1 (de) * 1984-10-05 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeurederivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
US4894437A (en) * 1985-11-15 1990-01-16 The Upjohn Company Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
EP0245361A1 (en) * 1985-11-15 1987-11-19 The Upjohn Company Novel renin inhibiting polypeptide analogs containing s-aryl-d- or l- or dl-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
JPH0662671B2 (ja) * 1986-01-17 1994-08-17 株式会社大塚製薬工場 プロリン誘導体
EP0500989B1 (en) * 1991-02-27 1998-12-09 Lacer, S.A. N-(alpha-substituted-pyridinyl) carbonyl dipeptide antihypertensive agents
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
GB9310075D0 (en) * 1993-05-17 1993-06-30 Fujisawa Pharmaceutical Co New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
US7390789B2 (en) * 2005-09-13 2008-06-24 William H Simmons Thio-containing inhibitors of aminopeptidase P, and compositions thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS559058A (en) * 1978-07-06 1980-01-22 Dainippon Pharmaceut Co Ltd 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative

Also Published As

Publication number Publication date
IT8021110A0 (it) 1980-04-01
NO150360B (no) 1984-06-25
DE3012140A1 (de) 1980-10-23
GR67752B (es) 1981-09-18
FR2453135A1 (fr) 1980-10-31
HU181087B (en) 1983-05-30
AU537592B2 (en) 1984-07-05
GB2045771A (en) 1980-11-05
NO800931L (no) 1980-10-03
CH645092A5 (de) 1984-09-14
PH22024A (en) 1988-05-13
JPS55133345A (en) 1980-10-17
GB2045771B (en) 1983-01-26
ATA179480A (de) 1983-06-15
BE882601A (fr) 1980-10-02
NZ193142A (en) 1984-08-24
FR2453135B1 (es) 1983-06-17
PT71044A (en) 1980-05-01
DK140480A (da) 1980-10-03
AU5638080A (en) 1980-10-09
IE49653B1 (en) 1985-11-13
ZA801527B (en) 1981-03-25
ES490166A0 (es) 1981-04-01
IE800638L (en) 1980-10-02
SE8002512L (sv) 1980-10-03
IT1147332B (it) 1986-11-19
NO150360C (no) 1984-10-03
NL8001675A (nl) 1980-10-06
LU82316A1 (fr) 1980-12-16
AT373577B (de) 1984-02-10

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000201