IE800638L - Mercaptoacyldipeptides - Google Patents

Mercaptoacyldipeptides

Info

Publication number
IE800638L
IE800638L IE800638A IE63880A IE800638L IE 800638 L IE800638 L IE 800638L IE 800638 A IE800638 A IE 800638A IE 63880 A IE63880 A IE 63880A IE 800638 L IE800638 L IE 800638L
Authority
IE
Ireland
Prior art keywords
hydrogen
image
alkyl
mercaptoacyldipeptides
gb2045771a
Prior art date
Application number
IE800638A
Other versions
IE49653B1 (en
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of IE800638L publication Critical patent/IE800638L/en
Publication of IE49653B1 publication Critical patent/IE49653B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Compounds having the formula <IMAGE> and alkyl esters and salts thereof. R1 is hydrogen, alkanoyl, benzoyl or <IMAGE> R2 is hydrogen, alkyl, or phenylalkyl; n is 0 or 1; and A1 and A2 each is an ???-amino or ???-imino acid residue joined through a peptide bond, have hypotensive activity. [GB2045771A]
IE638/80A 1979-04-02 1980-03-28 Mercaptoacyldipeptides IE49653B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2570179A 1979-04-02 1979-04-02

Publications (2)

Publication Number Publication Date
IE800638L true IE800638L (en) 1980-10-02
IE49653B1 IE49653B1 (en) 1985-11-13

Family

ID=21827594

Family Applications (1)

Application Number Title Priority Date Filing Date
IE638/80A IE49653B1 (en) 1979-04-02 1980-03-28 Mercaptoacyldipeptides

Country Status (22)

Country Link
JP (1) JPS55133345A (en)
AT (1) AT373577B (en)
AU (1) AU537592B2 (en)
BE (1) BE882601A (en)
CH (1) CH645092A5 (en)
DE (1) DE3012140A1 (en)
DK (1) DK140480A (en)
ES (1) ES8104200A1 (en)
FR (1) FR2453135A1 (en)
GB (1) GB2045771B (en)
GR (1) GR67752B (en)
HU (1) HU181087B (en)
IE (1) IE49653B1 (en)
IT (1) IT1147332B (en)
LU (1) LU82316A1 (en)
NL (1) NL8001675A (en)
NO (1) NO150360C (en)
NZ (1) NZ193142A (en)
PH (1) PH22024A (en)
PT (1) PT71044A (en)
SE (1) SE8002512L (en)
ZA (1) ZA801527B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5692848A (en) * 1979-12-27 1981-07-27 Dainippon Pharmaceut Co Ltd Preparation of 1- 3-lower alaknoylthio-2-methylpropanoyl prolylphenylalanine
JPS56139455A (en) 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid
US4336950A (en) * 1980-09-08 1982-06-29 John Zepkowski Sled
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
JPS57142967A (en) * 1981-02-27 1982-09-03 Dainippon Pharmaceut Co Ltd N-(acylthioalkanoyloxy)succinimide and its use
US4512979A (en) * 1981-03-23 1985-04-23 Merck & Co., Inc. Dipeptides containing thialysine and related amino acids as antihypertensives
US4382081A (en) * 1981-06-12 1983-05-03 E. R. Squibb & Sons, Inc. Inhibitors of mammalian collagenase
IT1195287B (en) * 1981-11-05 1988-10-12 Ausonia Farma Srl THIAZOLIC DERIVATIVE, PROCEDURE FOR ITS PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS
US4434151A (en) * 1982-11-08 1984-02-28 Medi-Physics, Inc. Bifunctional chelating agents
DE3243369A1 (en) * 1982-11-24 1984-05-24 Basf Ag, 6700 Ludwigshafen BIS- (BENZOYLTHIO) CARBONIC ACIDS, THEIR PRODUCTION AND USE FOR THE PRODUCTION OF ACTIVE SUBSTANCES
US4642355A (en) * 1984-02-24 1987-02-10 Otsuka Pharmaceutical Factory, Inc. Proline derivatives
US4560506A (en) * 1984-05-25 1985-12-24 E. R. Squibb & Sons, Inc. Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides
DE3432307A1 (en) * 1984-09-03 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim AMINO ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS
DE3436569A1 (en) * 1984-10-05 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim AMINO ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS
US4894437A (en) * 1985-11-15 1990-01-16 The Upjohn Company Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
EP0245361A1 (en) * 1985-11-15 1987-11-19 The Upjohn Company Novel renin inhibiting polypeptide analogs containing s-aryl-d- or l- or dl-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
JPH0662671B2 (en) * 1986-01-17 1994-08-17 株式会社大塚製薬工場 Proline derivative
EP0500989B1 (en) * 1991-02-27 1998-12-09 Lacer, S.A. N-(alpha-substituted-pyridinyl) carbonyl dipeptide antihypertensive agents
FR2679564A1 (en) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med NOVEL ACYLMERCAPTOALCANOLDIPEPTIDES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM.
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
GB9310075D0 (en) * 1993-05-17 1993-06-30 Fujisawa Pharmaceutical Co New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
US7390789B2 (en) * 2005-09-13 2008-06-24 William H Simmons Thio-containing inhibitors of aminopeptidase P, and compositions thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS559058A (en) * 1978-07-06 1980-01-22 Dainippon Pharmaceut Co Ltd 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative

Also Published As

Publication number Publication date
IT8021110A0 (en) 1980-04-01
NO150360B (en) 1984-06-25
DE3012140A1 (en) 1980-10-23
GR67752B (en) 1981-09-18
FR2453135A1 (en) 1980-10-31
HU181087B (en) 1983-05-30
AU537592B2 (en) 1984-07-05
GB2045771A (en) 1980-11-05
NO800931L (en) 1980-10-03
CH645092A5 (en) 1984-09-14
PH22024A (en) 1988-05-13
JPS55133345A (en) 1980-10-17
GB2045771B (en) 1983-01-26
ATA179480A (en) 1983-06-15
BE882601A (en) 1980-10-02
NZ193142A (en) 1984-08-24
FR2453135B1 (en) 1983-06-17
PT71044A (en) 1980-05-01
DK140480A (en) 1980-10-03
AU5638080A (en) 1980-10-09
IE49653B1 (en) 1985-11-13
ZA801527B (en) 1981-03-25
ES490166A0 (en) 1981-04-01
ES8104200A1 (en) 1981-04-01
SE8002512L (en) 1980-10-03
IT1147332B (en) 1986-11-19
NO150360C (en) 1984-10-03
NL8001675A (en) 1980-10-06
LU82316A1 (en) 1980-12-16
AT373577B (en) 1984-02-10

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Legal Events

Date Code Title Description
MM4A Patent lapsed