IE800954L - Derivatives of mercaptoacyl amino acids. - Google Patents

Derivatives of mercaptoacyl amino acids.

Info

Publication number
IE800954L
IE800954L IE800954A IE95480A IE800954L IE 800954 L IE800954 L IE 800954L IE 800954 A IE800954 A IE 800954A IE 95480 A IE95480 A IE 95480A IE 800954 L IE800954 L IE 800954L
Authority
IE
Ireland
Prior art keywords
derivatives
amino acids
mercaptoacyl amino
alpha
hydrogen
Prior art date
Application number
IE800954A
Other versions
IE49790B1 (en
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of IE800954L publication Critical patent/IE800954L/en
Publication of IE49790B1 publication Critical patent/IE49790B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

<IMAGE> and alkyl esters and salts thereof, wherein R1 is hydrogen, alkanoyl or benzoyl, R2 is hydrogen, alkyl or trifluoromethyl, n is 0 or 1 and A1 and A2 each is an alpha -amino or alpha -imino acid residue, have hypotensive activity and can be incorporated into pharmaceutical compositions. [GB2050359A]
IE954/80A 1979-05-18 1980-05-08 Derivatives of mercaptoacyl amino acids IE49790B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4033579A 1979-05-18 1979-05-18

Publications (2)

Publication Number Publication Date
IE800954L true IE800954L (en) 1980-11-18
IE49790B1 IE49790B1 (en) 1985-12-11

Family

ID=21910442

Family Applications (1)

Application Number Title Priority Date Filing Date
IE954/80A IE49790B1 (en) 1979-05-18 1980-05-08 Derivatives of mercaptoacyl amino acids

Country Status (7)

Country Link
JP (1) JPS5612365A (en)
DE (1) DE3018467A1 (en)
FR (2) FR2468589A1 (en)
GB (1) GB2050359B (en)
IE (1) IE49790B1 (en)
IT (1) IT1140954B (en)
ZA (1) ZA802420B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0038117A1 (en) * 1980-03-10 1981-10-21 University Of Miami Methods for preparing anti-hypertensive agents
US4482725A (en) * 1980-04-03 1984-11-13 E. R. Squibb & Sons, Inc. S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics
AT386603B (en) * 1981-06-19 1988-09-26 Chugai Pharmaceutical Co Ltd METHOD FOR PRODUCING NEW PROLIN DERIVATIVES
JPS57209270A (en) * 1981-06-19 1982-12-22 Chugai Pharmaceut Co Ltd Proline derivative
JPS5839661A (en) * 1981-09-03 1983-03-08 Chugai Pharmaceut Co Ltd Preparation of proline derivative
AT377496B (en) * 1981-06-19 1985-03-25 Voith Gmbh J M DEVICE FOR WINDING A TRACK OF GOODS ON A NEWLY INSERTED WRAPPING SLEEVE IN A DOUBLE-CARRIER ROLLING MACHINE
JPS58131968A (en) * 1981-09-09 1983-08-06 Chugai Pharmaceut Co Ltd Thiol ester compound
JPS6345252A (en) * 1987-03-18 1988-02-26 Chugai Pharmaceut Co Ltd Proline derivative

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1591598A (en) * 1967-07-31 1970-05-04
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4113715A (en) * 1977-01-17 1978-09-12 E. R. Squibb & Sons, Inc. Amino acid derivatives
FR2412537A1 (en) * 1977-12-22 1979-07-20 Science Union & Cie NEW SUBSTITUTE THIOBUTYRAMIDES, THEIR METHODS OF OBTAINING AND THEIR PHARMACEUTICAL APPLICATION
PH15381A (en) * 1978-02-21 1982-12-17 Squibb & Sons Inc Halogen substituted mercaptoacylamino acids
GR73585B (en) * 1978-09-11 1984-03-26 Univ Miami
ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents

Also Published As

Publication number Publication date
JPH0135824B2 (en) 1989-07-27
ZA802420B (en) 1981-04-29
IE49790B1 (en) 1985-12-11
GB2050359A (en) 1981-01-07
DE3018467A1 (en) 1981-01-22
FR2467198A1 (en) 1981-04-17
FR2467198B1 (en) 1983-06-17
JPS5612365A (en) 1981-02-06
FR2468589A1 (en) 1981-05-08
IT8022148A0 (en) 1980-05-16
GB2050359B (en) 1983-05-18
IT1140954B (en) 1986-10-10
FR2468589B1 (en) 1983-07-18

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Legal Events

Date Code Title Description
MM4A Patent lapsed