FR2453135A1 - MERCAPTO-ACYLDIPEPTIDES WITH ANTI-HYPERTENSIVE ACTION - Google Patents

MERCAPTO-ACYLDIPEPTIDES WITH ANTI-HYPERTENSIVE ACTION

Info

Publication number
FR2453135A1
FR2453135A1 FR8006711A FR8006711A FR2453135A1 FR 2453135 A1 FR2453135 A1 FR 2453135A1 FR 8006711 A FR8006711 A FR 8006711A FR 8006711 A FR8006711 A FR 8006711A FR 2453135 A1 FR2453135 A1 FR 2453135A1
Authority
FR
France
Prior art keywords
acyldipeptides
mercapto
hypertensive action
hypertensive
action
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8006711A
Other languages
French (fr)
Other versions
FR2453135B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2453135A1 publication Critical patent/FR2453135A1/en
Application granted granted Critical
Publication of FR2453135B1 publication Critical patent/FR2453135B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Composés de formule :Formula compounds:

FR8006711A 1979-04-02 1980-03-26 MERCAPTO-ACYLDIPEPTIDES WITH ANTI-HYPERTENSIVE ACTION Granted FR2453135A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2570179A 1979-04-02 1979-04-02

Publications (2)

Publication Number Publication Date
FR2453135A1 true FR2453135A1 (en) 1980-10-31
FR2453135B1 FR2453135B1 (en) 1983-06-17

Family

ID=21827594

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8006711A Granted FR2453135A1 (en) 1979-04-02 1980-03-26 MERCAPTO-ACYLDIPEPTIDES WITH ANTI-HYPERTENSIVE ACTION

Country Status (22)

Country Link
JP (1) JPS55133345A (en)
AT (1) AT373577B (en)
AU (1) AU537592B2 (en)
BE (1) BE882601A (en)
CH (1) CH645092A5 (en)
DE (1) DE3012140A1 (en)
DK (1) DK140480A (en)
ES (1) ES8104200A1 (en)
FR (1) FR2453135A1 (en)
GB (1) GB2045771B (en)
GR (1) GR67752B (en)
HU (1) HU181087B (en)
IE (1) IE49653B1 (en)
IT (1) IT1147332B (en)
LU (1) LU82316A1 (en)
NL (1) NL8001675A (en)
NO (1) NO150360C (en)
NZ (1) NZ193142A (en)
PH (1) PH22024A (en)
PT (1) PT71044A (en)
SE (1) SE8002512L (en)
ZA (1) ZA801527B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5692848A (en) * 1979-12-27 1981-07-27 Dainippon Pharmaceut Co Ltd Preparation of 1- 3-lower alaknoylthio-2-methylpropanoyl prolylphenylalanine
JPS56139455A (en) 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid
US4336950A (en) * 1980-09-08 1982-06-29 John Zepkowski Sled
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
JPS57142967A (en) * 1981-02-27 1982-09-03 Dainippon Pharmaceut Co Ltd N-(acylthioalkanoyloxy)succinimide and its use
US4512979A (en) * 1981-03-23 1985-04-23 Merck & Co., Inc. Dipeptides containing thialysine and related amino acids as antihypertensives
US4382081A (en) * 1981-06-12 1983-05-03 E. R. Squibb & Sons, Inc. Inhibitors of mammalian collagenase
IT1195287B (en) * 1981-11-05 1988-10-12 Ausonia Farma Srl THIAZOLIC DERIVATIVE, PROCEDURE FOR ITS PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS
US4434151A (en) * 1982-11-08 1984-02-28 Medi-Physics, Inc. Bifunctional chelating agents
DE3243369A1 (en) * 1982-11-24 1984-05-24 Basf Ag, 6700 Ludwigshafen BIS- (BENZOYLTHIO) CARBONIC ACIDS, THEIR PRODUCTION AND USE FOR THE PRODUCTION OF ACTIVE SUBSTANCES
US4642355A (en) * 1984-02-24 1987-02-10 Otsuka Pharmaceutical Factory, Inc. Proline derivatives
US4560506A (en) * 1984-05-25 1985-12-24 E. R. Squibb & Sons, Inc. Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides
DE3432307A1 (en) * 1984-09-03 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim AMINO ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS
DE3436569A1 (en) * 1984-10-05 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim AMINO ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS
WO1987002986A1 (en) * 1985-11-15 1987-05-21 The Upjohn Company Novel renin inhibiting polypeptide analogs containing s-aryl-d- or l- or dl-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
US4894437A (en) * 1985-11-15 1990-01-16 The Upjohn Company Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
JPH0662671B2 (en) * 1986-01-17 1994-08-17 株式会社大塚製薬工場 Proline derivative
DE69130605T2 (en) * 1991-02-27 1999-05-20 Lacer Sa Antihypertensive N- (alpha-substituted pyridyl) carbonyl dipeptides
FR2679564A1 (en) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med NOVEL ACYLMERCAPTOALCANOLDIPEPTIDES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM.
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
GB9310075D0 (en) * 1993-05-17 1993-06-30 Fujisawa Pharmaceutical Co New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
US7390789B2 (en) * 2005-09-13 2008-06-24 William H Simmons Thio-containing inhibitors of aminopeptidase P, and compositions thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007477A1 (en) * 1978-07-06 1980-02-06 Dainippon Pharmaceutical Co., Ltd. 1-(3-Mercapto-2-methylpropanoyl)prolyl amino acid derivatives and salts thereof, processes for their preparation, and pharmaceutical compositions containing such compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007477A1 (en) * 1978-07-06 1980-02-06 Dainippon Pharmaceutical Co., Ltd. 1-(3-Mercapto-2-methylpropanoyl)prolyl amino acid derivatives and salts thereof, processes for their preparation, and pharmaceutical compositions containing such compounds

Also Published As

Publication number Publication date
HU181087B (en) 1983-05-30
AU5638080A (en) 1980-10-09
PT71044A (en) 1980-05-01
AU537592B2 (en) 1984-07-05
NO800931L (en) 1980-10-03
IT8021110A0 (en) 1980-04-01
ATA179480A (en) 1983-06-15
FR2453135B1 (en) 1983-06-17
SE8002512L (en) 1980-10-03
GR67752B (en) 1981-09-18
JPS55133345A (en) 1980-10-17
IE800638L (en) 1980-10-02
AT373577B (en) 1984-02-10
ES490166A0 (en) 1981-04-01
LU82316A1 (en) 1980-12-16
NL8001675A (en) 1980-10-06
NO150360B (en) 1984-06-25
ZA801527B (en) 1981-03-25
ES8104200A1 (en) 1981-04-01
DE3012140A1 (en) 1980-10-23
PH22024A (en) 1988-05-13
IE49653B1 (en) 1985-11-13
CH645092A5 (en) 1984-09-14
IT1147332B (en) 1986-11-19
GB2045771A (en) 1980-11-05
GB2045771B (en) 1983-01-26
BE882601A (en) 1980-10-02
NO150360C (en) 1984-10-03
NZ193142A (en) 1984-08-24
DK140480A (en) 1980-10-03

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Legal Events

Date Code Title Description
ST Notification of lapse