JPS5692848A - Preparation of 1- 3-lower alaknoylthio-2-methylpropanoyl prolylphenylalanine - Google Patents

Preparation of 1- 3-lower alaknoylthio-2-methylpropanoyl prolylphenylalanine

Info

Publication number
JPS5692848A
JPS5692848A JP17243579A JP17243579A JPS5692848A JP S5692848 A JPS5692848 A JP S5692848A JP 17243579 A JP17243579 A JP 17243579A JP 17243579 A JP17243579 A JP 17243579A JP S5692848 A JPS5692848 A JP S5692848A
Authority
JP
Japan
Prior art keywords
compound
formula
methylpropanoyl
alaknoylthio
prolylphenylalanine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP17243579A
Other languages
Japanese (ja)
Other versions
JPS6318599B2 (en
Inventor
Tadahiro Sawayama
Hiroaki Kinugasa
Atsuki Nishimura
Kunihiko Takeyama
Kazu Hosoki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Priority to JP17243579A priority Critical patent/JPS5692848A/en
Publication of JPS5692848A publication Critical patent/JPS5692848A/en
Publication of JPS6318599B2 publication Critical patent/JPS6318599B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:The titled compound of formula I (R1 is lower alkyl). EXAMPLE:1-(D-3-Acethylthio-2-methylpropanoyl)-L-prolyl-L-phenylalanine. USE:A hypotensive agent having a mild action with a long duration based on the inhibitory action on an angiotensin I converting enzyme. PROCESS:A compound of formula II or a reactive derivative at the carboxyl group thereof is reacted with a compound of formula III (R2 is H or t-butyl). The group R2, if t-butyl, is then removed, and the reaction product is separated into individual isomers if desired to give the compound of formula I.
JP17243579A 1979-12-27 1979-12-27 Preparation of 1- 3-lower alaknoylthio-2-methylpropanoyl prolylphenylalanine Granted JPS5692848A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17243579A JPS5692848A (en) 1979-12-27 1979-12-27 Preparation of 1- 3-lower alaknoylthio-2-methylpropanoyl prolylphenylalanine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17243579A JPS5692848A (en) 1979-12-27 1979-12-27 Preparation of 1- 3-lower alaknoylthio-2-methylpropanoyl prolylphenylalanine

Publications (2)

Publication Number Publication Date
JPS5692848A true JPS5692848A (en) 1981-07-27
JPS6318599B2 JPS6318599B2 (en) 1988-04-19

Family

ID=15941920

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17243579A Granted JPS5692848A (en) 1979-12-27 1979-12-27 Preparation of 1- 3-lower alaknoylthio-2-methylpropanoyl prolylphenylalanine

Country Status (1)

Country Link
JP (1) JPS5692848A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55133345A (en) * 1979-04-02 1980-10-17 Squibb & Sons Inc Mercaptoacyldipeptides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55133345A (en) * 1979-04-02 1980-10-17 Squibb & Sons Inc Mercaptoacyldipeptides

Also Published As

Publication number Publication date
JPS6318599B2 (en) 1988-04-19

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