ZA801527B - Mercaptoacyldipeptides - Google Patents

Mercaptoacyldipeptides

Info

Publication number
ZA801527B
ZA801527B ZA00801527A ZA801527A ZA801527B ZA 801527 B ZA801527 B ZA 801527B ZA 00801527 A ZA00801527 A ZA 00801527A ZA 801527 A ZA801527 A ZA 801527A ZA 801527 B ZA801527 B ZA 801527B
Authority
ZA
South Africa
Prior art keywords
mercaptoacyldipeptides
Prior art date
Application number
ZA00801527A
Inventor
M Ondetti
J Pluscec
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of ZA801527B publication Critical patent/ZA801527B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052Val-amino acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
ZA00801527A 1979-04-02 1980-03-14 Mercaptoacyldipeptides ZA801527B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2570179A 1979-04-02 1979-04-02

Publications (1)

Publication Number Publication Date
ZA801527B true ZA801527B (en) 1981-03-25

Family

ID=21827594

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00801527A ZA801527B (en) 1979-04-02 1980-03-14 Mercaptoacyldipeptides

Country Status (22)

Country Link
JP (1) JPS55133345A (en)
AT (1) AT373577B (en)
AU (1) AU537592B2 (en)
BE (1) BE882601A (en)
CH (1) CH645092A5 (en)
DE (1) DE3012140A1 (en)
DK (1) DK140480A (en)
ES (1) ES490166A0 (en)
FR (1) FR2453135A1 (en)
GB (1) GB2045771B (en)
GR (1) GR67752B (en)
HU (1) HU181087B (en)
IE (1) IE49653B1 (en)
IT (1) IT1147332B (en)
LU (1) LU82316A1 (en)
NL (1) NL8001675A (en)
NO (1) NO150360C (en)
NZ (1) NZ193142A (en)
PH (1) PH22024A (en)
PT (1) PT71044A (en)
SE (1) SE8002512L (en)
ZA (1) ZA801527B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5692848A (en) * 1979-12-27 1981-07-27 Dainippon Pharmaceut Co Ltd Preparation of 1- 3-lower alaknoylthio-2-methylpropanoyl prolylphenylalanine
JPS56139455A (en) 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid
US4336950A (en) * 1980-09-08 1982-06-29 John Zepkowski Sled
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
JPS57142967A (en) * 1981-02-27 1982-09-03 Dainippon Pharmaceut Co Ltd N-(acylthioalkanoyloxy)succinimide and its use
US4512979A (en) * 1981-03-23 1985-04-23 Merck & Co., Inc. Dipeptides containing thialysine and related amino acids as antihypertensives
US4382081A (en) * 1981-06-12 1983-05-03 E. R. Squibb & Sons, Inc. Inhibitors of mammalian collagenase
IT1195287B (en) * 1981-11-05 1988-10-12 Ausonia Farma Srl THIAZOLIC DERIVATIVE, PROCEDURE FOR ITS PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS
US4434151A (en) * 1982-11-08 1984-02-28 Medi-Physics, Inc. Bifunctional chelating agents
DE3243369A1 (en) * 1982-11-24 1984-05-24 Basf Ag, 6700 Ludwigshafen BIS- (BENZOYLTHIO) CARBONIC ACIDS, THEIR PRODUCTION AND USE FOR THE PRODUCTION OF ACTIVE SUBSTANCES
US4642355A (en) * 1984-02-24 1987-02-10 Otsuka Pharmaceutical Factory, Inc. Proline derivatives
US4560506A (en) * 1984-05-25 1985-12-24 E. R. Squibb & Sons, Inc. Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides
DE3432307A1 (en) * 1984-09-03 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim AMINO ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS
DE3436569A1 (en) * 1984-10-05 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim AMINO ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS
US4894437A (en) * 1985-11-15 1990-01-16 The Upjohn Company Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
JPS63501364A (en) * 1985-11-15 1988-05-26 ジ・アップジョン・カンパニ− Novel renin-inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl groups
JPH0662671B2 (en) * 1986-01-17 1994-08-17 株式会社大塚製薬工場 Proline derivative
DE69130605T2 (en) * 1991-02-27 1999-05-20 Lacer Sa Antihypertensive N- (alpha-substituted pyridyl) carbonyl dipeptides
FR2679564A1 (en) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med NOVEL ACYLMERCAPTOALCANOLDIPEPTIDES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM.
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
GB9310075D0 (en) * 1993-05-17 1993-06-30 Fujisawa Pharmaceutical Co New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
US7390789B2 (en) * 2005-09-13 2008-06-24 William H Simmons Thio-containing inhibitors of aminopeptidase P, and compositions thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS559058A (en) * 1978-07-06 1980-01-22 Dainippon Pharmaceut Co Ltd 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative

Also Published As

Publication number Publication date
NL8001675A (en) 1980-10-06
SE8002512L (en) 1980-10-03
CH645092A5 (en) 1984-09-14
DE3012140A1 (en) 1980-10-23
LU82316A1 (en) 1980-12-16
FR2453135A1 (en) 1980-10-31
HU181087B (en) 1983-05-30
NO150360C (en) 1984-10-03
IE800638L (en) 1980-10-02
GB2045771A (en) 1980-11-05
JPS55133345A (en) 1980-10-17
DK140480A (en) 1980-10-03
NO800931L (en) 1980-10-03
IE49653B1 (en) 1985-11-13
GB2045771B (en) 1983-01-26
NO150360B (en) 1984-06-25
FR2453135B1 (en) 1983-06-17
PT71044A (en) 1980-05-01
PH22024A (en) 1988-05-13
AU537592B2 (en) 1984-07-05
IT1147332B (en) 1986-11-19
GR67752B (en) 1981-09-18
AU5638080A (en) 1980-10-09
ES8104200A1 (en) 1981-04-01
AT373577B (en) 1984-02-10
BE882601A (en) 1980-10-02
NZ193142A (en) 1984-08-24
ATA179480A (en) 1983-06-15
IT8021110A0 (en) 1980-04-01
ES490166A0 (en) 1981-04-01

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