ES541437A0 - Un procedimiento de marcar acidos nucleicos al menos par- cialmente de doble cadena - Google Patents

Un procedimiento de marcar acidos nucleicos al menos par- cialmente de doble cadena

Info

Publication number
ES541437A0
ES541437A0 ES541437A ES541437A ES541437A0 ES 541437 A0 ES541437 A0 ES 541437A0 ES 541437 A ES541437 A ES 541437A ES 541437 A ES541437 A ES 541437A ES 541437 A0 ES541437 A0 ES 541437A0
Authority
ES
Spain
Prior art keywords
labeling
nucleic acids
double stranded
stranded nucleic
partially double
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES541437A
Other languages
English (en)
Other versions
ES8606386A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of ES8606386A1 publication Critical patent/ES8606386A1/es
Publication of ES541437A0 publication Critical patent/ES541437A0/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
ES541437A 1984-03-21 1985-03-21 Un procedimiento de marcar acidos nucleicos al menos par- cialmente de doble cadena Expired ES8606386A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59181184A 1984-03-21 1984-03-21
US06/683,263 US4582789A (en) 1984-03-21 1984-12-18 Process for labeling nucleic acids using psoralen derivatives

Publications (2)

Publication Number Publication Date
ES8606386A1 ES8606386A1 (es) 1986-04-16
ES541437A0 true ES541437A0 (es) 1986-04-16

Family

ID=27081258

Family Applications (1)

Application Number Title Priority Date Filing Date
ES541437A Expired ES8606386A1 (es) 1984-03-21 1985-03-21 Un procedimiento de marcar acidos nucleicos al menos par- cialmente de doble cadena

Country Status (7)

Country Link
US (1) US4582789A (es)
EP (2) EP0156287A3 (es)
AU (1) AU589893B2 (es)
DE (1) DE156287T1 (es)
DK (1) DK121685A (es)
ES (1) ES8606386A1 (es)
IL (1) IL74658A (es)

Families Citing this family (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4713326A (en) * 1983-07-05 1987-12-15 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
US4737454A (en) * 1983-07-14 1988-04-12 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
US4959309A (en) * 1983-07-14 1990-09-25 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
US4724202A (en) * 1983-12-12 1988-02-09 Molecular Diagnostics, Inc. Use of non-hybridizable nucleic acids for the detection of nucleic acid hybridization
US4751313A (en) * 1984-03-21 1988-06-14 Cetus Corporation Precursor to nucleic acid probe
US4803297A (en) * 1984-03-21 1989-02-07 Cetus Corporation Carbamic acid ester useful for preparing a nucleic acid probe
US4705886A (en) * 1984-03-21 1987-11-10 Cetus Corporation Precursor to nucleic acid probe
US4754065A (en) * 1984-12-18 1988-06-28 Cetus Corporation Precursor to nucleic acid probe
US4824775A (en) * 1985-01-03 1989-04-25 Molecular Diagnostics, Inc. Cells labeled with multiple Fluorophores bound to a nucleic acid carrier
EP0187332B1 (en) * 1985-01-10 1989-02-01 Molecular Diagnostics, Inc. Photochemical method of labelling nucleic acids for detection in hybridization assays
US5026840A (en) * 1985-01-10 1991-06-25 Molecular Diagnostics, Inc. Photochemical nucleic acid-labeling reagent having a polyalklamine spacer
US5176995A (en) * 1985-03-28 1993-01-05 Hoffmann-La Roche Inc. Detection of viruses by amplification and hybridization
US5656493A (en) * 1985-03-28 1997-08-12 The Perkin-Elmer Corporation System for automated performance of the polymerase chain reaction
US5333675C1 (en) * 1986-02-25 2001-05-01 Perkin Elmer Corp Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US5273882A (en) * 1985-06-13 1993-12-28 Amgen Method and kit for performing nucleic acid hybridization assays
ES8707343A1 (es) * 1985-06-13 1987-07-16 Amgen Un metodo para aislar una secuencia de acido nucleico objetivo seleccionada
JPS622164A (ja) * 1985-06-25 1987-01-08 シスカ・ダイアグノステイツクス・インコ−ポレ−テツド N4−(置換アミノ)シチジンを含む核酸プロ−ブ
US4833251A (en) * 1985-06-25 1989-05-23 Siska Diagnostics, Inc. Compounds for tagging nucleic acid probes
CA1295559C (en) * 1985-08-13 1992-02-11 Jannis Stavrianopoulos Method for labeling polynucleotide sequences
US4822731A (en) * 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
US5756696A (en) * 1986-01-16 1998-05-26 Regents Of The University Of California Compositions for chromosome-specific staining
US5276140A (en) * 1986-03-17 1994-01-04 Cetus Oncology Corporation Cross-linking agents
US4797491A (en) * 1986-03-17 1989-01-10 Cetus Corporation Compound 1-(3-(2-pyridyldithio)propionamido)-12-(5-hydrazidoglutaramido)-4,9-dioxadodecane
US5242797A (en) * 1986-03-21 1993-09-07 Myron J. Block Nucleic acid assay method
CA1338457C (en) 1986-08-22 1996-07-16 Henry A. Erlich Purified thermostable enzyme
GB8621337D0 (en) * 1986-09-04 1986-10-15 Agricultural Genetics Co Non-radioactive nucleic acid hybridization probes
US5912339A (en) * 1986-10-28 1999-06-15 The Johns Hopkins University Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids
US4880750A (en) * 1987-07-09 1989-11-14 Miragen, Inc. Individual-specific antibody identification methods
US5639604A (en) * 1987-09-21 1997-06-17 Gen-Probe Incorporated Homogeneous protection assay
US5283174A (en) * 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US6004745A (en) * 1987-09-21 1999-12-21 Gen-Probe Incorporated Hybridization protection assay
US5196351A (en) * 1987-09-30 1993-03-23 Beckman Instruments, Inc. Bidentate conjugate and method of use thereof
EP0310361A3 (en) * 1987-09-30 1989-05-24 Beckman Instruments, Inc. Tridentate conjugate and method of use thereof
US4914210A (en) * 1987-10-02 1990-04-03 Cetus Corporation Oligonucleotide functionalizing reagents
US5002883A (en) * 1987-10-30 1991-03-26 Abbott Laboratories Covalent attachment of antibodies and antigens to solid phases using extended length heterobifunctional coupling agents
US4994385A (en) * 1987-10-30 1991-02-19 Abbott Laboratories Heterobifunctional coupling agents
DK641487A (da) 1987-12-07 1989-06-08 Gluetech Aps Fremgangsmaade til modificering af polymeroverflader
US5449602A (en) * 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
WO1989006702A1 (en) * 1988-01-21 1989-07-27 Chemex Pharmaceuticals, Inc. Selective inhibition of gene expression by photoactivatable oligonucleotides
DE3804243A1 (de) * 1988-02-11 1989-08-24 Max Planck Gesellschaft Teils einzel- und teils doppelstraengige nukleinsaeuresonde und verfahren zu ihrer herstellung
EP0333465B1 (en) * 1988-03-18 1994-07-13 Baylor College Of Medicine Mutation detection by competitive oligonucleotide priming
WO1989009221A1 (en) * 1988-03-25 1989-10-05 University Of Virginia Alumni Patents Foundation Oligonucleotide n-alkylphosphoramidates
US6326136B1 (en) * 1988-04-01 2001-12-04 Digene Corporation Macromolecular conjugate made using unsaturated aldehydes
US4868311A (en) * 1988-04-02 1989-09-19 The Trustees Of Columbia University In The City Of New York Biotinylated psoralens
US5824796A (en) * 1988-09-28 1998-10-20 Epoch Pharmaceuticals, Inc. Cross-linking oligonucleotides
US5849482A (en) * 1988-09-28 1998-12-15 Epoch Pharmaceuticals, Inc. Crosslinking oligonucleotides
WO1990003370A1 (en) * 1988-09-28 1990-04-05 Microprobe Corporation DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE
USRE38416E1 (en) 1988-09-28 2004-02-03 Epoch Biosciences, Inc. Cross-linking oligonucleotides
US5998135A (en) 1989-02-24 1999-12-07 Enzo Diagnostics, Inc. Energy transfer hybridization assay using intercalators and lanthanide metals
US5049489A (en) * 1989-04-17 1991-09-17 The Standard Oil Company 16S rRNA oligonucleotide probes for the identification of sulfate-reducing bacteria
US5547839A (en) * 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5151369A (en) * 1989-07-13 1992-09-29 Miles Inc. Lithium salts as red blood cell lysing and hemoglobin denaturing reagents
JP2646814B2 (ja) * 1990-08-07 1997-08-27 アイシン精機株式会社 核酸等の検定方法
JPH04222600A (ja) * 1990-12-21 1992-08-12 Aisin Seiki Co Ltd ナフトール誘導体ホスフェートによる核酸等の検定方法
JPH06509704A (ja) * 1991-04-18 1994-11-02 ザ ソールク インスチチュート フォア バイオロジカル スタディズ 特定dna配列に選択的に結合する蛋白質に対する偽構築体として有用なオリゴデオキシヌクレオチドおよびオリゴヌクレオチド
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
DE69213112T2 (de) * 1991-06-20 1997-04-03 Hoffmann La Roche Verbesserte Methoden zur Nukleinsäure-Amplifizierung
DE4123540A1 (de) * 1991-07-16 1993-01-21 Boehringer Mannheim Gmbh Immobilisierung von nukleinsaeuren
US6136601A (en) * 1991-08-21 2000-10-24 Epoch Pharmaceuticals, Inc. Targeted mutagenesis in living cells using modified oligonucleotides
US5426025A (en) * 1992-05-28 1995-06-20 Florida State University Species-specific DNA probes for vibrio vulnificus methods and kits
FR2695036B1 (fr) * 1992-09-03 1994-10-28 Goupil Jean Jacques Huile contenant du 5-méthoxypsoralène à une concentration de 60 à 100 PPM et son utilisation pour le traitement du psoriasis.
JPH08509857A (ja) * 1993-01-07 1996-10-22 シーケノム・インコーポレーテッド マススペクトロメトリーによるdna配列決定法
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US6194144B1 (en) 1993-01-07 2001-02-27 Sequenom, Inc. DNA sequencing by mass spectrometry
DE4302241A1 (de) * 1993-01-27 1994-07-28 Boehringer Mannheim Gmbh Neues Biotinylierungsreagenz
US6495676B1 (en) 1993-04-13 2002-12-17 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US6277570B1 (en) 1993-04-13 2001-08-21 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US5767259A (en) 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
US5399719A (en) * 1993-06-28 1995-03-21 Steritech, Inc. Compounds for the photodecontamination of pathogens in blood
US5747352A (en) * 1994-05-23 1998-05-05 Beckman Instruments, Inc. Reagents and methods for the rapid and quantitative assay of pharmacological agents
US6428955B1 (en) 1995-03-17 2002-08-06 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
JPH10509984A (ja) * 1995-08-03 1998-09-29 デイド、ケミストリー、システムズ、インコーポレイテッド キニジン抱合体およびイムノアッセイにおけるそれらの使用
US6277592B1 (en) 1996-07-31 2001-08-21 Purina Mills, Inc. Porcine leptin protein, nucleic acid sequences coding therefor and uses thereof
US6297027B1 (en) 1996-07-31 2001-10-02 Purina Mills, Inc. Bovine leptin protein, nucleic acid sequences coding therefor and uses thereof
US6133436A (en) * 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
EP1457496B1 (en) 1996-11-06 2014-01-15 Sequenom, Inc. High density immobilization of nucleic acids
US20030129589A1 (en) * 1996-11-06 2003-07-10 Hubert Koster Dna diagnostics based on mass spectrometry
AU5794498A (en) 1996-12-10 1998-07-03 Genetrace Systems, Inc. Releasable nonvolatile mass-label molecules
US6268131B1 (en) 1997-12-15 2001-07-31 Sequenom, Inc. Mass spectrometric methods for sequencing nucleic acids
US6723564B2 (en) 1998-05-07 2004-04-20 Sequenom, Inc. IR MALDI mass spectrometry of nucleic acids using liquid matrices
EP2360271A1 (en) 1998-06-24 2011-08-24 Illumina, Inc. Decoding of array sensors with microspheres
US7071324B2 (en) * 1998-10-13 2006-07-04 Brown University Research Foundation Systems and methods for sequencing by hybridization
US6187566B1 (en) 1999-03-09 2001-02-13 Applied Gene Technologies, Inc. Method of labeling a nucleic acid amplicon with simultaneous contamination prevention
US20060275782A1 (en) * 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20030207295A1 (en) * 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
AU5882000A (en) 1999-06-22 2001-01-09 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
US6830902B1 (en) 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
US6242188B1 (en) 1999-07-30 2001-06-05 Applied Gene Technologies, Inc. Sample processing to release nucleic acids for direct detection
US7955794B2 (en) * 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) * 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
DK1259643T3 (da) * 2000-02-07 2009-02-23 Illumina Inc Fremgangsmåde til detektion af nukleinsyre ved anvendelse af universel priming
US7611869B2 (en) * 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
AU2001268468A1 (en) 2000-06-13 2001-12-24 The Trustees Of Boston University Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing
US20070037144A1 (en) * 2000-10-20 2007-02-15 Jay Wohlgemuth Leukocyte expression profiling
US6794141B2 (en) 2000-12-22 2004-09-21 Arcturus Bioscience, Inc. Nucleic acid amplification
ATE455857T1 (de) 2001-05-09 2010-02-15 Monsanto Technology Llc Metabolitentransporter
EP1950305A1 (en) 2001-05-09 2008-07-30 Monsanto Technology, LLC Tyr a genes and uses thereof
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7235358B2 (en) * 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US20030165859A1 (en) * 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
EP1530634A4 (en) * 2002-06-26 2005-11-02 Human Genome Sciences Inc SHINE-DALGARNO SEQUENCES AND METHODS OF USE
US20040259105A1 (en) * 2002-10-03 2004-12-23 Jian-Bing Fan Multiplex nucleic acid analysis using archived or fixed samples
US20040067492A1 (en) * 2002-10-04 2004-04-08 Allan Peng Reverse transcription on microarrays
US6943768B2 (en) 2003-02-21 2005-09-13 Xtellus Inc. Thermal control system for liquid crystal cell
US20040265870A1 (en) * 2003-04-09 2004-12-30 Invitrogen Corporation Methods of synthesizing and labeling nucleic acid molecules
US7892745B2 (en) * 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
EP1689888A2 (en) 2003-10-23 2006-08-16 Illumigen Biosciences Inc. Detection of mutations in a gene associated with resistance to viral infection, oas1
US7645575B2 (en) * 2004-09-08 2010-01-12 Xdx, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
ES2322175T3 (es) * 2004-09-17 2009-06-17 EISAI R&D MANAGEMENT CO., LTD. Composicion medicinal con estabilidad mejorada y gelificacion reducida.
US20060275792A1 (en) * 2004-11-15 2006-12-07 Lee Jun E Enhancement of nucleic acid amplification using double-stranded DNA binding proteins
US20060105348A1 (en) * 2004-11-15 2006-05-18 Lee Jun E Compositions and methods for the detection and discrimination of nucleic acids
US7550583B2 (en) * 2005-02-04 2009-06-23 Geno Sensor Corp. Method of isolating, labeling and profiling small RNAs
EP1885889A4 (en) * 2005-05-11 2010-01-20 Expression Diagnostics Inc METHOD FOR MONITORING THE OPERATING STATUS OF TRANSPLANTS OVER GENLISTS
JP4989476B2 (ja) 2005-08-02 2012-08-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質の効果を検定する方法
JP2007043937A (ja) * 2005-08-09 2007-02-22 Matsushita Electric Ind Co Ltd 遺伝子検出方法
WO2007026864A1 (ja) * 2005-09-01 2007-03-08 Eisai R & D Management Co., Ltd. 崩壊性の改善された医薬組成物の製造方法
US20090053236A1 (en) 2005-11-07 2009-02-26 Eisai R & D Management Co., Ltd. USE OF COMBINATION OF ANTI-ANGIOGENIC SUBSTANCE AND c-kit KINASE INHIBITOR
AU2007212278A1 (en) 2006-02-09 2007-08-16 University Of South Florida Detection of cancer by elevated levels of Bcl-2
CA2648580A1 (en) * 2006-04-07 2008-05-02 Xdx, Inc. Steroid responsive nucleic acid expression and prediction of disease activity
WO2007136103A1 (ja) * 2006-05-18 2007-11-29 Eisai R & D Management Co., Ltd. 甲状腺癌に対する抗腫瘍剤
CA2653248C (en) 2006-05-25 2017-09-26 Monsanto Technology Llc A method to identify disease resistant quantitative trait loci in soybean and compositions thereof
WO2008021431A2 (en) * 2006-08-14 2008-02-21 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
WO2008026748A1 (fr) * 2006-08-28 2008-03-06 Eisai R & D Management Co., Ltd. Agent antitumoral pour cancer gastrique non différencié
EP2102367A2 (en) * 2006-11-09 2009-09-23 XDX, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
US20100190662A1 (en) * 2007-01-26 2010-07-29 Rebecca Sutphen Methods and materials for detection, diagnosis and management of ovarian cancer
KR101445892B1 (ko) * 2007-01-29 2014-09-29 에자이 알앤드디 매니지먼트 가부시키가이샤 미분화형 위암 치료용 조성물
CN101680035B (zh) 2007-03-28 2017-05-31 孟山都技术有限公司 与主要大豆植物成熟期和生长习性基因组区域相关的snp标记的效用
NZ581742A (en) 2007-06-08 2012-09-28 Biogen Idec Inc Biomarkers for predicting anti-tnf responsiveness or non-responsiveness
US8709445B2 (en) * 2007-07-31 2014-04-29 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Vaccination with killed but metabolically active (KBMA) protozoans with toll-like receptor agonists
AR071243A1 (es) 2007-08-29 2010-06-09 Monsanto Technology Llc Metodos y composiciones para usar plantas haploides en el mapeo genetico de caracteristicas, como resistencia a enfermedades
US8952035B2 (en) * 2007-11-09 2015-02-10 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
CN104388568B (zh) 2008-04-24 2017-04-12 孟山都技术有限公司 鉴定大豆中亚洲大豆锈病抗性数量性状基因座的方法和其组合物
US9207242B2 (en) 2008-10-09 2015-12-08 The University Of Hong Kong Cadherin-17 as diagnostic marker and therapeutic target for liver cancer
US20100299773A1 (en) * 2009-05-20 2010-11-25 Monsanto Technology Llc Methods and compositions for selecting an improved plant
BR112012032462A2 (pt) 2010-06-25 2016-11-08 Eisai R&D Man Co Ltd agente antitumoral empregando compostos que, em combinação, têm efeito inibidor de quinase.
EP2418286A1 (en) 2010-08-10 2012-02-15 QIAGEN GmbH Improved method for isothermal amplification of nucleic acids
US8962650B2 (en) 2011-04-18 2015-02-24 Eisai R&D Management Co., Ltd. Therapeutic agent for tumor
WO2012159089A1 (en) 2011-05-19 2012-11-22 Sequenom, Inc. Products and processes for multiplex nucleic acid identification
EP3444363B1 (en) 2011-06-03 2020-11-25 Eisai R&D Management Co., Ltd. Biomarkers for prediciting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
US9682970B2 (en) 2012-06-29 2017-06-20 Biotium, Inc. Fluorescent compounds and uses thereof
MX2015004979A (es) 2012-12-21 2015-07-17 Eisai R&D Man Co Ltd Forma amorfa de derivado de quinolina y metodo para su produccion.
ES2687968T3 (es) 2013-05-14 2018-10-30 Eisai R&D Management Co., Ltd. Biomarcadores para pronosticar y evaluar la reactividad de sujetos con cáncer de endometrio a compuestos con lenvatinib
ES2927871T3 (es) 2014-02-21 2022-11-11 Syngenta Participations Ag Loci genéticos asociados con una mayor fertilidad en el maíz
BR112017002827B1 (pt) 2014-08-28 2023-04-18 Eisai R&D Management Co., Ltd Derivado de quinolina altamente puro e método para produção do mesmo
MX2017010474A (es) 2015-02-25 2017-11-28 Eisai R&D Man Co Ltd Metodo para suprimir el amargor de un derivado de quinoleina.
KR20240064733A (ko) 2015-03-04 2024-05-13 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
EP3286328B1 (en) 2015-04-24 2020-10-21 Agena Bioscience, Inc. Multiplex methods for detection and quantification of minor variants
US10233489B2 (en) 2015-04-24 2019-03-19 Agena Bioscience, Inc. Multiplexed method for the identification and quantitation of minor alleles and polymorphisms
EP3298151B1 (en) 2015-05-19 2021-03-10 The University of Chicago Methods and composition for determining ph
SG11201710198YA (en) 2015-06-16 2018-01-30 Eisai R&D Man Co Ltd Anticancer agent
WO2018191561A1 (en) * 2017-04-12 2018-10-18 The University Of Chicago Methods and compositions for spacial and temporal measurement of catalytic activity
KR20200112906A (ko) 2018-01-25 2020-10-05 바이오젠 엠에이 인코포레이티드 척추 근위축증의 치료 방법
EP3924739A1 (en) 2019-02-12 2021-12-22 Biogen MA Inc. Biomarkers of progressive multifocal leukoencephalopathy
CN112698025B (zh) * 2020-12-14 2022-10-18 四川沃文特生物技术有限公司 抗原或抗体包被磁微粒的方法、应用及试剂盒
CN112920174B (zh) * 2021-02-02 2022-11-04 上海交通大学 一种光敏感型化合物及其制备方法和应用
CN116262760A (zh) * 2023-01-18 2023-06-16 杭州纽龙生物科技有限公司 一种生物素化异硫氰酸荧光素的制备方法及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4124598A (en) * 1976-10-20 1978-11-07 Hoffmann-La Roche Inc. Psoralens
FR2422956A1 (fr) * 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US4358535A (en) * 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
CA1219824A (en) * 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
CA1180647A (en) * 1981-07-17 1985-01-08 Cavit Akin Light-emitting polynucleotide hybridization diagnostic method
US4652533A (en) * 1983-04-28 1987-03-24 Pandex Laboratories, Inc. Method of solid phase immunoassay incorporating a luminescent label
US4542102A (en) * 1983-07-05 1985-09-17 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods

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AU4018885A (en) 1985-09-26
DE156287T1 (de) 1986-05-22
ES8606386A1 (es) 1986-04-16
IL74658A0 (en) 1985-06-30
US4582789A (en) 1986-04-15
IL74658A (en) 1989-06-30
EP0156287A2 (en) 1985-10-02
EP0309006A1 (en) 1989-03-29
AU589893B2 (en) 1989-10-26
DK121685D0 (da) 1985-03-18
DK121685A (da) 1985-09-22
EP0156287A3 (en) 1987-06-03

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