ES533557A0 - Procedimiento para la preparacion de derivados de leucina - Google Patents
Procedimiento para la preparacion de derivados de leucinaInfo
- Publication number
- ES533557A0 ES533557A0 ES533557A ES533557A ES533557A0 ES 533557 A0 ES533557 A0 ES 533557A0 ES 533557 A ES533557 A ES 533557A ES 533557 A ES533557 A ES 533557A ES 533557 A0 ES533557 A0 ES 533557A0
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- preparation
- image
- leucine derivatives
- leucine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002613 leucine derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 102000004882 Lipase Human genes 0.000 abstract 1
- 108090001060 Lipase Proteins 0.000 abstract 1
- 239000004367 Lipase Substances 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 241000946767 Streptomyces toxytricini Species 0.000 abstract 1
- 235000019421 lipase Nutrition 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 210000000496 pancreas Anatomy 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
- C07D305/12—Beta-lactones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Epoxy Compounds (AREA)
- Steroid Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH341583 | 1983-06-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8600650A1 ES8600650A1 (es) | 1985-10-16 |
| ES533557A0 true ES533557A0 (es) | 1985-10-16 |
Family
ID=4255488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES533557A Granted ES533557A0 (es) | 1983-06-22 | 1984-06-20 | Procedimiento para la preparacion de derivados de leucina |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4598089A (OSRAM) |
| EP (1) | EP0129748B1 (OSRAM) |
| JP (1) | JPS6013777A (OSRAM) |
| KR (1) | KR920002314B1 (OSRAM) |
| AT (1) | ATE30025T1 (OSRAM) |
| AU (1) | AU572851B2 (OSRAM) |
| BG (1) | BG60766B2 (OSRAM) |
| CA (1) | CA1247547A (OSRAM) |
| DE (2) | DE3466538D1 (OSRAM) |
| DK (1) | DK160496C (OSRAM) |
| ES (1) | ES533557A0 (OSRAM) |
| FI (1) | FI78694C (OSRAM) |
| GR (1) | GR82120B (OSRAM) |
| HU (1) | HU193579B (OSRAM) |
| IE (1) | IE57761B1 (OSRAM) |
| IL (1) | IL72122A (OSRAM) |
| LU (1) | LU90302I2 (OSRAM) |
| LV (1) | LV5747B4 (OSRAM) |
| MC (1) | MC1602A1 (OSRAM) |
| MX (1) | MX9203633A (OSRAM) |
| NL (1) | NL980029I2 (OSRAM) |
| NO (2) | NO159941C (OSRAM) |
| NZ (1) | NZ208521A (OSRAM) |
| PH (1) | PH19704A (OSRAM) |
| PT (1) | PT78777B (OSRAM) |
| ZA (1) | ZA844558B (OSRAM) |
Families Citing this family (234)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1328881C (en) * | 1984-12-21 | 1994-04-26 | Pierre Barbier | Process for the manufacture of oxetanones |
| ZA859574B (en) * | 1984-12-21 | 1986-08-27 | Hoffmann La Roche | Process for the manufacture of oxetanones |
| CA1270837A (en) * | 1984-12-21 | 1990-06-26 | Hoffmann-La Roche Limited | Oxetanones |
| JPH0618793Y2 (ja) * | 1986-06-13 | 1994-05-18 | パイオニア株式会社 | 作業台 |
| US4816477A (en) * | 1987-05-26 | 1989-03-28 | Merck & Co., Inc. | Antihypercholesterolemic β-lactones |
| US4806564A (en) * | 1987-05-26 | 1989-02-21 | Merck & Co., Inc. | Antihypercholesterolemic beta-lactones |
| US5063210A (en) * | 1989-04-20 | 1991-11-05 | Lange Iii Louis G | Use of sulfated polysaccharides to decrease cholesterol and fatty acid absorption |
| US5017565A (en) * | 1989-04-20 | 1991-05-21 | Lange Iii Louis G | Use of sulfated polysaccharides to inhibit pancreatic cholesterol esterase |
| US5484777A (en) * | 1989-04-20 | 1996-01-16 | Lange, Iii; Louis G. | Pancreatic cholesterol esterase inhibitor |
| JP2960947B2 (ja) * | 1989-12-25 | 1999-10-12 | 日清製粉株式会社 | 脂質分解酵素阻害剤 |
| US5376640A (en) * | 1989-12-25 | 1994-12-27 | Nisshin Flour Milling Co., Ltd. | Lipolytic enzyme inhibitors |
| CA2098167C (en) * | 1992-06-24 | 2006-12-19 | Dorothea Isler | Foodstuffs and feedstuffs containing a lipase inhibitor |
| TW381025B (en) * | 1993-08-05 | 2000-02-01 | Hoffmann La Roche | Pharmaceutical composition containing a glucosidase inhibitor and a lipase inhibitor |
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| MY116591A (en) * | 1996-04-26 | 2004-02-28 | Hoffmann La Roche | Process for the production of lipstatin and tetrahydrolipstatin |
| DK1017408T3 (da) * | 1997-02-05 | 2005-08-01 | Hoffmann La Roche | Anvendelse af tetrahydrolipstatin i behandling af diabetes type II |
| US6004996A (en) * | 1997-02-05 | 1999-12-21 | Hoffman-La Roche Inc. | Tetrahydrolipstatin containing compositions |
| US7344713B1 (en) * | 1997-07-07 | 2008-03-18 | Pimentel Julio L | Decreased fat absorption with an anti-lipase antibody |
| RU2234917C2 (ru) * | 1997-12-24 | 2004-08-27 | Кнолль Акциенгезелльшафт | Терапевтические средства |
| GB9727131D0 (en) * | 1997-12-24 | 1998-02-25 | Knoll Ag | Therapeutic agents |
| US6299868B1 (en) | 1999-07-14 | 2001-10-09 | Geltex Pharmaceuticals, Inc. | Fat-binding polymers |
| US7048917B1 (en) | 1998-01-09 | 2006-05-23 | Genzyme Corporation | Fat-binding polymers |
| US6264937B1 (en) | 1998-01-09 | 2001-07-24 | Geltex Pharmaceuticals, Inc. | Fat-binding polymers |
| PT1105123E (pt) * | 1998-08-14 | 2004-08-31 | Hoffmann La Roche | Composicoes farmaceuticas contendo inibidores da lipase e quitosano |
| ATE293970T1 (de) | 1998-08-14 | 2005-05-15 | Hoffmann La Roche | Lipasehemmer enthaltende pharmazeutische zusammensetzungen |
| NZ512536A (en) | 1998-12-23 | 2003-11-28 | G | Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications |
| AU776664B2 (en) | 1998-12-23 | 2004-09-16 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications |
| DE69907960T2 (de) | 1998-12-23 | 2004-02-26 | G.D. Searle Llc, Chicago | Kombinationen von ileumgallensäuretransports inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen |
| EP1340510A1 (en) | 1998-12-23 | 2003-09-03 | G.D. Searle LLC. | Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications |
| EP1340508A1 (en) | 1998-12-23 | 2003-09-03 | G.D. Searle LLC. | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications |
| WO2000038722A1 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS |
| PT1140190E (pt) | 1998-12-23 | 2003-02-28 | Searle Llc | Combinacoes de inibidores do transporte ileal dos acidos biliares e agentes sequestrantes dos acidos biliares usadas para problemas cardiovasculares |
| ES2185523T3 (es) * | 1999-01-29 | 2003-05-01 | Hoffmann La Roche | Purificacion de lipstatina. |
| MXPA02000492A (es) * | 1999-07-14 | 2002-07-02 | Geltex Pharma Inc | Polimeros enlazantes de grasas, opcionalmente combinados con inhibidores de lipasas. |
| AR025609A1 (es) * | 1999-09-13 | 2002-12-04 | Hoffmann La Roche | Formulaciones lipidas solidas |
| AR025587A1 (es) * | 1999-09-13 | 2002-12-04 | Hoffmann La Roche | Formulaciones en dispersion que contienen inhibidores de lipasa |
| EP1132389A1 (en) | 2000-03-06 | 2001-09-12 | Vernalis Research Limited | New aza-indolyl derivatives for the treatment of obesity |
| US6794544B2 (en) | 2000-03-10 | 2004-09-21 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
| EP1142572A1 (de) * | 2000-04-04 | 2001-10-10 | Volker Dr. Helmstädter | Oxetanon-enthaltende Präparate zur Behandlung von Darmerkrankungen |
| DE10021618A1 (de) * | 2000-05-04 | 2001-11-15 | Volker Helmstaedter | Präparat für Darmerkrankungen und dessen Verwendung |
| MXPA02012583A (es) | 2000-06-27 | 2003-04-10 | Hoffmann La Roche | Metodo para preparacion de una composicion. |
| DK1307263T3 (da) * | 2000-07-28 | 2005-08-22 | Hoffmann La Roche | Hidtil ukendt anvendelse af lipaseinhibitorer |
| AU2001289699B2 (en) | 2000-07-28 | 2006-06-01 | Cheplapharm Arzneimittel Gmbh | New pharmaceutical composition |
| WO2002011719A2 (en) * | 2000-08-09 | 2002-02-14 | F. Hoffmann-La Roche Ag | Lipase inhibitors for the treatment of dyspepsia |
| US6900226B2 (en) | 2000-09-06 | 2005-05-31 | Hoffman-La Roche Inc. | Neuropeptide Y antagonists |
| DE60135239D1 (de) | 2000-10-16 | 2008-09-18 | Vernalis Res Ltd | Indolinderivate und deren verwendung als 5-ht2 rezeptor liganden |
| GB0030710D0 (en) * | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
| ATE369368T1 (de) | 2000-12-27 | 2007-08-15 | Hoffmann La Roche | Indolderivate und deren verwendung als 5-ht2b- und 5-ht2c-rezeptorliganden |
| GB0106177D0 (en) * | 2001-03-13 | 2001-05-02 | Hoffmann La Roche | Piperazine derivatives |
| US20030072804A1 (en) * | 2001-03-19 | 2003-04-17 | The Procter & Gamble Company | Use of non-digestible polymeric foams to sequester ingested materials thereby inhibiting their absorption by the body |
| US20030091610A1 (en) * | 2001-03-19 | 2003-05-15 | The Procter & Gamble Company | Use of non-digestible polymeric foams to sequester ingested materials thereby inhibiting their absorption by the body |
| CN100376557C (zh) | 2001-05-21 | 2008-03-26 | 霍夫曼-拉罗奇有限公司 | 作为神经肽y受体的配体的喹啉衍生物 |
| US20030027786A1 (en) | 2001-06-06 | 2003-02-06 | Karsten Maeder | Lipase inhibiting composition |
| US6730319B2 (en) | 2001-06-06 | 2004-05-04 | Hoffmann-La Roche Inc. | Pharmaceutical compositions having depressed melting points |
| US7049345B2 (en) | 2001-06-29 | 2006-05-23 | Genzyme Corporation | Fat-binding polymers |
| US7041280B2 (en) * | 2001-06-29 | 2006-05-09 | Genzyme Corporation | Aryl boronate functionalized polymers for treating obesity |
| WO2003020282A1 (en) | 2001-08-30 | 2003-03-13 | Alizyme Therapeutics Limited | Thieno-(1,3)-oxazin-4-ones with lipase inhibiting activity |
| US6787558B2 (en) * | 2001-09-28 | 2004-09-07 | Hoffmann-La Roche Inc. | Quinoline derivatives |
| US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US20070281003A1 (en) | 2001-10-12 | 2007-12-06 | Fuisz Richard C | Polymer-Based Films and Drug Delivery Systems Made Therefrom |
| US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
| US8603514B2 (en) | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
| US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
| US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
| US20190328679A1 (en) | 2001-10-12 | 2019-10-31 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
| US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
| US20110033542A1 (en) | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
| GB0125659D0 (en) * | 2001-10-25 | 2001-12-19 | Ssl Int Plc | Spermicides |
| BR0213501A (pt) | 2001-11-02 | 2004-08-24 | Searle Llc | Compostos de benzotiepina mono- e di-fluorada como inibidores de transporte de ácido biliar co-dependente de sódio apical (asbt) e captação de taurocolato |
| EP1470116A4 (en) | 2001-12-04 | 2005-04-06 | Biogal Gyogyszergyar | PREPARATION OF THE ORLISTAT AND CRYSTALLINE FORMS OF THE ORLISTAT |
| WO2003048335A2 (en) | 2001-12-04 | 2003-06-12 | Biogal Gyogyszergyar Rt | A fermentation process for lipstatin and method of extracting lipstatin from a fermentation broth |
| EP1467978A4 (en) | 2001-12-20 | 2005-11-02 | Osi Pharm Inc | "COMPOUNDS THAT CONTAIN VACCINATES DRUG LIPASE, THEIR SYNTHESIS AND USE" |
| CA2471639A1 (en) | 2002-01-17 | 2003-07-31 | Pharmacia Corporation | Novel alkyl/aryl hydroxy or keto thiepines. |
| GB0202015D0 (en) * | 2002-01-29 | 2002-03-13 | Hoffmann La Roche | Piperazine Derivatives |
| RU2298002C2 (ru) * | 2002-02-04 | 2007-04-27 | Ф. Хоффманн-Ля Рош Аг | Производные хинолина в качестве антагонистов npy |
| MXPA04008379A (es) * | 2002-02-28 | 2004-11-26 | Hoffmann La Roche | Derivados de tiazol como antagonistas del receptor de neuropeptido y (npy). |
| AU2003226370A1 (en) * | 2002-04-17 | 2003-11-03 | The Burnham Institute | Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation |
| US7728153B2 (en) | 2002-04-17 | 2010-06-01 | The Burnham Institute For Medical Research | Method for the asymmetric synthesis of beta-lactone compounds |
| CA2483002C (en) * | 2002-04-26 | 2011-02-01 | F. Hoffmann-La Roche Ag | New pharmaceutical composition |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| JP2005535648A (ja) * | 2002-07-05 | 2005-11-24 | エフ.ホフマン−ラ ロシュ アーゲー | キナゾリン誘導体 |
| JP2006502131A (ja) * | 2002-08-07 | 2006-01-19 | エフ.ホフマン−ラ ロシュ アーゲー | チアゾール誘導体 |
| BR0314261A (pt) * | 2002-09-12 | 2005-07-26 | Hoffmann La Roche | Compostos, processo de preparação de um composto, composição farmacêutica que compreende o mesmo, utilização de um composto, método para tratamento e/ou profilaxia de enfermidades e utilização e/ou método de tratamento |
| DE60323130D1 (de) * | 2002-11-25 | 2008-10-02 | Hoffmann La Roche | Indolderivaten |
| US8372430B2 (en) | 2002-12-17 | 2013-02-12 | The Procter & Gamble Company | Compositions, methods, and kits useful for the alleviation of gastrointestinal effects |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US20040178058A1 (en) * | 2003-03-10 | 2004-09-16 | Hsueh-Chung Chen | Electro-chemical deposition apparatus and method of preventing cavities in an ECD copper film |
| EP1457206A1 (en) * | 2003-03-13 | 2004-09-15 | Fournier Laboratories Ireland Limited | Combined use of a fibrate and orlistat for the treatment of obesity |
| BRPI0410840A (pt) * | 2003-05-30 | 2006-07-04 | Ranbaxy Lab Ltd | derivados substituìdos de pirrol, composição farmacêutica contendo os mesmos e processo para sua preparação |
| WO2004113314A1 (en) * | 2003-06-23 | 2004-12-29 | Biocon Limited | Novel boronate esters |
| GB0314967D0 (en) * | 2003-06-26 | 2003-07-30 | Hoffmann La Roche | Piperazine derivatives |
| US20060025337A1 (en) * | 2003-07-01 | 2006-02-02 | President And Fellows Of Harvard College | Sirtuin related therapeutics and diagnostics for neurodegenerative diseases |
| AU2003253254A1 (en) * | 2003-07-17 | 2005-02-04 | Biocon Limited | Preparation of tetrahydrolipstatin by hydrogenation of lipstatin, solvent extraction and purification |
| MXPA06001570A (es) * | 2003-08-12 | 2006-05-15 | Hoffmann La Roche | Antagonistas del receptor de neuropeptido y (npy) 2-amino-5-benzoiltiazol. |
| AU2004263312A1 (en) * | 2003-08-12 | 2005-02-17 | F. Hoffmann-La Roche Ag | Thiazole derivatives as NPY antagonists |
| US20050239859A2 (en) * | 2003-09-03 | 2005-10-27 | Solvay Pharmaceuticals Gmbh | Novel medical uses of 4,5-dihydro-1h-pyrazole derivatives having cb1- antagonistic activity |
| ATE547404T1 (de) | 2003-09-22 | 2012-03-15 | Msd Kk | Piperidinderivate |
| US20050124660A1 (en) * | 2003-10-27 | 2005-06-09 | Jochen Antel | Novel medical uses of compounds showing CB1-antagonistic activity and combination treatment involving said compounds |
| US20050143441A1 (en) * | 2003-10-27 | 2005-06-30 | Jochen Antel | Novel medical combination treatment of obesity involving 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity |
| WO2005051298A2 (en) | 2003-11-19 | 2005-06-09 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
| US20050171027A1 (en) * | 2003-12-29 | 2005-08-04 | President And Fellows Of Harvard College | Compositions for treating or preventing obesity and insulin resistance disorders |
| US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| PL209905B1 (pl) | 2004-01-15 | 2011-11-30 | Bringwell Internat Ab | Preparat do leczenia otyłości i związanego z nią syndromu metabolicznego |
| CA2551119C (en) | 2004-01-16 | 2013-02-12 | Fuji Oil Company Limited | Lipase inhibitor |
| US7074822B2 (en) | 2004-02-23 | 2006-07-11 | Solvay Pharmaceuticals Gmbh | Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| EP1744772B1 (en) | 2004-05-10 | 2017-08-16 | University of Copenhagen | Flaxseeds for body weight management |
| WO2006007851A2 (en) * | 2004-07-19 | 2006-01-26 | Novo Nordisk A/S | Capsaicin inhibitors for treating obesity and-related disorders |
| WO2006045799A2 (en) | 2004-10-25 | 2006-05-04 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising cb1 cannabinoid receptor antagonists and potassium channel openers for the treatment of diabetes mellitus type i, obesity and related conditions |
| DE602005016009D1 (de) * | 2004-11-23 | 2009-09-24 | Warner Lambert Co | 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptansäure-derivate als hmg-co-a-reductase-inhibitoren zur behandlung von lipidemia |
| US20060246141A1 (en) * | 2005-04-12 | 2006-11-02 | Elan Pharma International, Limited | Nanoparticulate lipase inhibitor formulations |
| EP1888585B1 (en) * | 2005-05-03 | 2011-06-29 | F. Hoffmann-La Roche AG | Tetracyclic azapyrazinoindolines as 5-ht2 ligands |
| BRPI0610580B8 (pt) | 2005-05-30 | 2021-05-25 | Banyu Pharma Co Ltd | composto derivado de piperidina |
| WO2006138418A2 (en) * | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Improvement of cognitive performance with sirtuin activators |
| US20070149466A1 (en) * | 2005-07-07 | 2007-06-28 | Michael Milburn | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| US20100216758A1 (en) | 2005-08-10 | 2010-08-26 | Makoto Ando | Pyridone Compounds |
| KR100962827B1 (ko) * | 2005-08-18 | 2010-06-10 | 에프. 호프만-라 로슈 아게 | H3 수용체 조절제로서 유용한 티아졸릴 피페리딘 유도체 |
| CA2619770A1 (en) | 2005-08-24 | 2007-03-01 | Banyu Pharmaceutical Co., Ltd. | Phenylpyridone derivative |
| CA2621470A1 (en) | 2005-09-07 | 2007-03-15 | Banyu Pharmaceutical Co., Ltd. | Bicyclic aromatic substituted pyridone derivative |
| US7355055B2 (en) * | 2005-09-08 | 2008-04-08 | Reliance Life Sciences Pvt. Ltd. | Compounds for treatment of lipase-mediated diseases |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| KR20080059233A (ko) | 2005-10-21 | 2008-06-26 | 노파르티스 아게 | 레닌 억제제, 및 항이상지질혈증제 및/또는 항비만제의조합물 |
| WO2007049798A1 (ja) | 2005-10-27 | 2007-05-03 | Banyu Pharmaceutical Co., Ltd. | 新規ベンゾオキサチイン誘導体 |
| EP1948599A1 (en) * | 2005-11-08 | 2008-07-30 | Ranbaxy Laboratories Limited | Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
| KR101318127B1 (ko) | 2005-11-10 | 2013-10-16 | 엠에스디 가부시키가이샤 | 아자 치환된 스피로 유도체 |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| BRPI0619233A2 (pt) * | 2005-11-30 | 2011-09-20 | Hoffmann La Roche | compostos, processo para a sua manufatura, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, uso dos compostos e método para o tratamento ou prevenção de obesidade e de diabetes do tipo ii em um ser humano ou animal |
| CN101316840B (zh) * | 2005-11-30 | 2012-08-08 | 霍夫曼-拉罗奇有限公司 | 1,5-取代的吲哚-2-基酰胺衍生物 |
| JP4879996B2 (ja) * | 2005-11-30 | 2012-02-22 | エフ.ホフマン−ラ ロシュ アーゲー | H3調節剤として使用するための1,1−ジオキソ−チオモルホリニルインドリルメタノン誘導体 |
| WO2007065820A1 (en) * | 2005-12-09 | 2007-06-14 | F. Hoffmann-La Roche Ag | Tricyclic amide derivatives useful for treating obesity |
| CA2631694A1 (en) * | 2005-12-15 | 2007-06-21 | F. Hoffmann-La Roche Ag | Pyrrolo[2,3-c]pyridine derivatives |
| JP2009519293A (ja) * | 2005-12-16 | 2009-05-14 | エフ.ホフマン−ラ ロシュ アーゲー | H3レセプター調節剤としてのピロロ[2,3−b]ピリジン誘導体 |
| SK22006A3 (sk) * | 2006-01-03 | 2007-08-02 | Biotika, A. S. | Kmeň Streptomyces toxytricini produkujúci lipstatín a príprava lipstatínu s uvedeným kmeňom |
| US20080021092A1 (en) * | 2006-01-06 | 2008-01-24 | Deepak Murpani | Stable pharmaceutical compositions of orlistat |
| RU2008132966A (ru) * | 2006-01-13 | 2010-02-20 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные циклогексилпиперазинилметанона и их применение в качестве модуляторов гистамин н3 рецептора |
| WO2007082840A1 (en) * | 2006-01-23 | 2007-07-26 | F. Hoffmann-La Roche Ag | Cyclohexyl sulfonamide derivatives having h3 receptor activity |
| CL2007000667A1 (es) * | 2006-03-14 | 2008-03-14 | Ranbaxi Lab Ltd | Composicion farmaceutica que comprende al acido 7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroximetilfenilamino)carbonil]pirrol-1-il]-3,5-dihidroxi-heptanoico o una sal y al menos un agente estabilizante; procedimiento de preparacion, util en e |
| KR101252635B1 (ko) | 2006-04-20 | 2013-04-10 | (주)아모레퍼시픽 | 리파아제 저해제 및 친유성 오일흡수제를 포함하는 약학조성물 및 이로부터 제조된 경구 투여용 제제 |
| US7432255B2 (en) * | 2006-05-16 | 2008-10-07 | Hoffmann-La Roche Inc. | 1H-indol-5-yl-piperazin-1-yl-methanone derivatives |
| CN101448820A (zh) * | 2006-05-30 | 2009-06-03 | 霍夫曼-拉罗奇有限公司 | 哌啶基嘧啶衍生物 |
| MX2009000439A (es) * | 2006-07-14 | 2009-02-04 | Ranbaxy Lab Ltd | Formas polimorficas de un inhibidor de hmg-coa reductasa y usos de las mismas. |
| US7514433B2 (en) | 2006-08-03 | 2009-04-07 | Hoffmann-La Roche Inc. | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives |
| WO2008038692A1 (en) | 2006-09-28 | 2008-04-03 | Banyu Pharmaceutical Co., Ltd. | Diaryl ketimine derivative |
| WO2008045564A2 (en) * | 2006-10-12 | 2008-04-17 | Epix Delaware, Inc. | Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor |
| WO2008070496A2 (en) | 2006-12-01 | 2008-06-12 | Bristol-Myers Squibb Company | N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
| US20080146559A1 (en) | 2006-12-08 | 2008-06-19 | Li Chen | 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives |
| US20080200422A1 (en) * | 2007-01-09 | 2008-08-21 | Cavener Douglas R | Methods for reduction of adipose tissue mass |
| JP5319518B2 (ja) | 2007-04-02 | 2013-10-16 | Msd株式会社 | インドールジオン誘導体 |
| AU2008236616A1 (en) * | 2007-04-09 | 2008-10-16 | Scidose, Llc | Combinations of statins and anti-obesity agent |
| WO2008124122A1 (en) * | 2007-04-09 | 2008-10-16 | Scidose, Llc | Combinations of statins and anti-obesity agent and glitazones |
| EP2572712A3 (en) * | 2007-06-01 | 2013-11-20 | The Trustees Of Princeton University | Treatment of viral infections by modulation of host cell metabolic pathways |
| ES2393885T7 (es) | 2007-06-04 | 2014-01-30 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| US8680298B2 (en) * | 2007-06-06 | 2014-03-25 | Ranbaxy Laboratories Limited | Process for the preparation of orlistat |
| EP2190303A1 (en) * | 2007-09-12 | 2010-06-02 | Københavns Universitet | Compositions and methods for increasing the suppression of hunger and reducing the digestibility of non-fat energy satiety |
| US20100196464A1 (en) * | 2007-09-17 | 2010-08-05 | Dr. Reddy's Laboratories Limited | Orlistat pharmaceutical formulations |
| WO2009044380A2 (en) | 2007-10-05 | 2009-04-09 | Ranbaxy Laboratories Limited | Formulations containing orlistat particles having controlled particle size |
| US20100317642A1 (en) * | 2007-10-15 | 2010-12-16 | Inventis Dds Pvt Limited | Pharmaceutical composition of orlistat |
| US8298583B2 (en) * | 2007-10-19 | 2012-10-30 | Monosol Rx, Llc | Film delivery system for tetrahydrolipstatin |
| JP2011506466A (ja) | 2007-12-11 | 2011-03-03 | 株式会社サイトパスファインダー | カルボキサミド化合物ならびにケモカイン受容体アゴニストとしてのそれらの使用 |
| US20090214682A1 (en) * | 2008-02-22 | 2009-08-27 | Heuer Marvin A | Composition and methods for weight loss in a subject |
| AU2009220605A1 (en) | 2008-03-06 | 2009-09-11 | Msd K.K. | Alkylaminopyridine derivative |
| JP2011515100A (ja) * | 2008-03-26 | 2011-05-19 | バイオコン リミテッド | 消費脂肪酸に対して高い収率係数のリパーゼ阻害剤を得る改善された発酵プロセス |
| AU2009229860A1 (en) | 2008-03-28 | 2009-10-01 | Msd K.K. | Diarylmethylamide derivative having antagonistic activity on melanin-concentrating hormone receptor |
| WO2009149279A2 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| AU2009261248A1 (en) | 2008-06-19 | 2009-12-23 | Banyu Pharmaceutical Co., Ltd. | Spirodiamine-diarylketoxime derivative |
| EP2141236A1 (en) * | 2008-07-03 | 2010-01-06 | KRKA, D.D., Novo Mesto | Process for production of lipstatin and microorganisms therefore |
| AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| EP2319841A1 (en) | 2008-07-30 | 2011-05-11 | Msd K.K. | (5-membered)-(5-membered) or (5-membered)-(6-membered) fused ring cycloalkylamine derivative |
| CN102170798B (zh) | 2008-10-03 | 2013-06-12 | 西格马食品可变资本有限公司 | 用于促进对总胆固醇和ldl胆固醇的控制和/或体重减轻和/或生热作用的组合物 |
| WO2010042499A1 (en) * | 2008-10-06 | 2010-04-15 | Banner Pharmacaps, Inc. | Stable solutions of orlistat for pharmaceutical dosage forms |
| WO2010043592A1 (en) * | 2008-10-15 | 2010-04-22 | Revotar Biopharmaceuticals Ag | Lipase inhibitors for use for the treatment of obesity |
| CA2741125A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| CN102271509A (zh) | 2008-10-31 | 2011-12-07 | 默沙东公司 | 用于抗糖尿病药的新型环苯并咪唑衍生物 |
| WO2010093601A1 (en) | 2009-02-10 | 2010-08-19 | Metabasis Therapeutics, Inc. | Novel sulfonic acid-containing thyromimetics, and methods for their use |
| US20120053172A1 (en) | 2009-02-12 | 2012-03-01 | Cooperatieve Mirzorg U.A. | Use of a combination of diazoxide and metformin for treating obesity or obesity related disorders |
| US20100215635A1 (en) * | 2009-02-23 | 2010-08-26 | Zoltan Kiss | Small molecules to induce weight loss or to reduce weight gain |
| WO2010112569A1 (en) | 2009-03-31 | 2010-10-07 | Robert Zimmermann | Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor |
| WO2010115825A2 (en) | 2009-03-31 | 2010-10-14 | Robert Zimmermann | Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor |
| BRPI0901602B8 (pt) | 2009-04-03 | 2021-05-25 | Ems S/A | formulação farmacêuticas |
| RU2412713C2 (ru) * | 2009-05-14 | 2011-02-27 | Открытое Акционерное Общество Завод Экологической Техники И Экопитания "Диод" | Фармацевтическая композиция, биологически активная добавка и способ уменьшения поглощения жира из пищи |
| US9334266B2 (en) | 2009-09-04 | 2016-05-10 | The University Of Toledo | Catalysts and related processes for producing optically pure beta-lactones from aldehydes and compositions produced thereby |
| WO2011051864A1 (en) | 2009-11-02 | 2011-05-05 | Pfizer Inc. | Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives |
| UA107369C2 (en) | 2010-02-01 | 2014-12-25 | Lab Bago S A | Pharmaceutical composition with anti-obesity activity comprising a premixture of pure orlistat and preparation process |
| US8524909B2 (en) | 2010-02-02 | 2013-09-03 | Hoffmann-La Roche Inc. | Tetrahydro-pyran derivatives |
| RU2441654C2 (ru) * | 2010-02-17 | 2012-02-10 | Лабораториос Баго С.А. | Фармацевтическая композиция с активностью против ожирения, включающая премикс чистого орлистата, и способ ее изготовления |
| AU2011218830B2 (en) | 2010-02-25 | 2014-07-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| EP2566853B1 (en) | 2010-05-05 | 2017-01-25 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
| US8450350B2 (en) | 2010-05-05 | 2013-05-28 | Infinity Pharmaceuticals, Inc. | Triazoles as inhibitors of fatty acid synthase |
| CA2799708A1 (en) | 2010-05-21 | 2011-11-24 | Pfizer Inc. | 2-phenyl benzoylamides |
| ES2662710T3 (es) | 2010-05-24 | 2018-04-09 | Swedish Oat Fiber Ab | Dispersión acuosa que comprende galactolípidos y método de producción de la misma |
| EP2392327A1 (en) | 2010-06-04 | 2011-12-07 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Use of orlistat for the anti-parasitic treatment of a parasitic disease |
| SG186275A1 (en) | 2010-07-06 | 2013-01-30 | Astrazeneca Ab | Therapeutic agents 976 |
| CN101885713B (zh) * | 2010-07-19 | 2011-11-30 | 大邦(湖南)生物制药有限公司 | 一种毒三素链霉菌发酵液中分离提取利普司他汀的工艺 |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| CN101948450B (zh) * | 2010-10-13 | 2013-04-24 | 鲁南制药集团股份有限公司 | 一种生产制备奥利司他的方法 |
| US9149959B2 (en) | 2010-10-22 | 2015-10-06 | Monosol Rx, Llc | Manufacturing of small film strips |
| JP5889321B2 (ja) | 2010-11-04 | 2016-03-22 | アルビレオ アクチエボラグ | 肝疾患の処置用のibat阻害剤 |
| WO2012064267A1 (en) | 2010-11-08 | 2012-05-18 | Albireo Ab | A pharmaceutical combination comprising an ibat inhibitor and a bile acid binder |
| KR101668514B1 (ko) | 2011-02-25 | 2016-10-21 | 머크 샤프 앤드 돔 코포레이션 | 항당뇨병제로서 유용한 신규 시클릭 아자벤즈이미다졸 유도체 |
| WO2012120414A2 (en) | 2011-03-04 | 2012-09-13 | Pfizer Inc. | Edn3-like peptides and uses thereof |
| UY34194A (es) | 2011-07-15 | 2013-02-28 | Astrazeneca Ab | ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad? |
| CN102304105B (zh) * | 2011-07-15 | 2013-07-10 | 鲁南新时代生物技术有限公司 | 一种制备高纯度奥利司他的方法 |
| CN103030613B (zh) * | 2011-09-29 | 2014-11-12 | 北大方正集团有限公司 | 一种利普司他汀的提纯方法 |
| JP2013249293A (ja) * | 2012-06-04 | 2013-12-12 | Kao Corp | リパーゼ活性阻害剤、抗真菌剤、及びフケ抑制剤 |
| EP2880028B1 (en) | 2012-08-02 | 2020-09-30 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| WO2014060445A1 (en) | 2012-10-19 | 2014-04-24 | Akzo Nobel Chemicals International B.V. | Method for preparing high purity orlistat |
| CN102936234B (zh) * | 2012-11-15 | 2015-04-01 | 江苏阿尔法药业有限公司 | 一种制备脂肪酶抑制剂奥利司他的方法 |
| CN102993134B (zh) * | 2012-12-31 | 2015-08-05 | 鲁南新时代生物技术有限公司 | 一种利普司他汀的提纯方法 |
| CN104994848A (zh) | 2013-02-22 | 2015-10-21 | 默沙东公司 | 抗糖尿病二环化合物 |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| JP2016516804A (ja) | 2013-04-17 | 2016-06-09 | ファイザー・インク | 心血管疾患を治療するためのn−ピペリジン−3−イルベンズアミド誘導体 |
| EP3004138B1 (en) | 2013-06-05 | 2024-03-13 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| MX389591B (es) | 2014-08-29 | 2025-03-20 | Tes Pharma S R L | INHIBIDORES DE ACIDO A-AMINO-ß-CARBOXIMUCONICO SEMIALDEHIDO DESCARBOXILASA |
| US10743813B2 (en) | 2014-09-11 | 2020-08-18 | Rattan Nath | Diabetes control using postprandial feedback |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| US12427121B2 (en) | 2016-05-05 | 2025-09-30 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
| US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
| US12433850B2 (en) | 2016-05-05 | 2025-10-07 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine and prodrug compositions |
| KR20190005199A (ko) | 2016-05-05 | 2019-01-15 | 어퀘스티브 테라퓨틱스, 아이엔씨. | 강화된 전달 에프네프린 조성물 |
| US20180134667A1 (en) | 2016-10-14 | 2018-05-17 | TES Pharma S.r.I. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| EP3558298A4 (en) | 2016-12-20 | 2020-08-05 | Merck Sharp & Dohme Corp. | ANTIDIABETIC SPIROCHROMAN COMPOUNDS |
| AR117122A1 (es) | 2018-11-20 | 2021-07-14 | Tes Pharma S R L | INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA |
| BR112021013807A2 (pt) | 2019-01-18 | 2021-11-30 | Astrazeneca Ab | Inibidores de pcsk9 e seus métodos de uso |
| NL2022615B1 (en) | 2019-02-21 | 2020-08-31 | Patrick Alexander Unger | Pharmaceutical composition comprising tetrahydrocannabivarin for the prevention and treatment of overweight |
| EP4101467A4 (en) | 2020-02-05 | 2024-03-06 | NOF Corporation | AGENT FOR TREATING OR PREVENTING PANCREATIC FISTULA |
| US12465564B2 (en) | 2021-10-25 | 2025-11-11 | Aquestive Therapeutics, Inc. | Oral and nasal compositions and methods of treatment |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS608117B2 (ja) * | 1977-02-08 | 1985-02-28 | 財団法人微生物化学研究会 | 新生理活性物質エステラスチンおよびその製造法 |
| GB2023604B (en) * | 1978-05-25 | 1982-07-28 | Microbial Chem Res Found | Physiologically active derivatives of esterastin and production thereof |
| JPS56128774A (en) * | 1980-03-14 | 1981-10-08 | Microbial Chem Res Found | New physiologically active substance ebelactone and its preparation |
| CA1328881C (en) * | 1984-12-21 | 1994-04-26 | Pierre Barbier | Process for the manufacture of oxetanones |
-
1984
- 1984-05-25 CA CA000455089A patent/CA1247547A/en not_active Expired
- 1984-06-05 EP EP84106420A patent/EP0129748B1/de not_active Expired
- 1984-06-05 AT AT84106420T patent/ATE30025T1/de active
- 1984-06-05 DE DE8484106420T patent/DE3466538D1/de not_active Expired
- 1984-06-05 DE DE1998175045 patent/DE19875045I2/de active Active
- 1984-06-14 FI FI842422A patent/FI78694C/fi not_active IP Right Cessation
- 1984-06-15 IL IL72122A patent/IL72122A/xx not_active IP Right Cessation
- 1984-06-15 NZ NZ208521A patent/NZ208521A/en unknown
- 1984-06-15 ZA ZA844558A patent/ZA844558B/xx unknown
- 1984-06-18 US US06/621,827 patent/US4598089A/en not_active Expired - Lifetime
- 1984-06-18 AU AU29478/84A patent/AU572851B2/en not_active Expired
- 1984-06-20 GR GR75059A patent/GR82120B/el unknown
- 1984-06-20 MC MC841710A patent/MC1602A1/fr unknown
- 1984-06-20 HU HU842372A patent/HU193579B/hu unknown
- 1984-06-20 PT PT78777A patent/PT78777B/pt unknown
- 1984-06-20 ES ES533557A patent/ES533557A0/es active Granted
- 1984-06-21 KR KR1019840003509A patent/KR920002314B1/ko not_active Expired
- 1984-06-21 NO NO842512A patent/NO159941C/no not_active IP Right Cessation
- 1984-06-21 IE IE1566/84A patent/IE57761B1/en not_active IP Right Cessation
- 1984-06-21 PH PH30863A patent/PH19704A/en unknown
- 1984-06-22 JP JP59127698A patent/JPS6013777A/ja active Granted
- 1984-06-22 DK DK308584A patent/DK160496C/da not_active IP Right Cessation
-
1992
- 1992-06-26 MX MX9203633A patent/MX9203633A/es unknown
-
1994
- 1994-02-21 BG BG098503A patent/BG60766B2/bg unknown
-
1996
- 1996-05-24 LV LV960154A patent/LV5747B4/xx unknown
-
1998
- 1998-10-21 LU LU90302C patent/LU90302I2/fr unknown
- 1998-10-26 NL NL980029C patent/NL980029I2/nl unknown
-
2000
- 2000-05-31 NO NO2000003C patent/NO2000003I1/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES533557A0 (es) | Procedimiento para la preparacion de derivados de leucina | |
| FI905575A0 (fi) | Ny polypeptidfoerening och foerfarande foer dess framstaellning. | |
| DK237885A (da) | Fremgangsmaade til fremstilling af diol og furan og mikroorganisme, som er i stand til dette | |
| AU578065B2 (en) | Stabilized enzyme conjugate compositions | |
| DK578083A (da) | Antibiotika benaevnt a51568 faktor a og b og fremgangsmaade til fremstilling heraf | |
| FI912914A0 (fi) | Ws622a mono- eller di-sulfat, foerfarande foer dess framstaellning och dess anvaendning. | |
| ES539343A0 (es) | Procedimiento para preparar tritiofosfonatos insecticidas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SPCF | Request for supplementary protection certificate filed |
Free format text: ORLISTAT (XENICAL) Spc suppl protection certif: C9800034 Filing date: 19980910 |
|
| SPCG | Supplementary protection certificate granted |
Free format text: ORLISTAT (XENICAL) Spc suppl protection certif: C9800034 Filing date: 19980910 Expiry date: 20100423 Effective date: 20020122 |
|
| SPCG | Supplementary protection certificate granted |
Free format text: ORLISTAT (XENICAL) Spc suppl protection certif: C9800034 Filing date: 19980910 Expiry date: 20100423 Effective date: 20020122 |
|
| FD1A | Patent lapsed |
Effective date: 20050425 |