ES487721A1 - Procedimiento de preparacion de nuevos derivados del nor- tropano - Google Patents

Procedimiento de preparacion de nuevos derivados del nor- tropano

Info

Publication number
ES487721A1
ES487721A1 ES487721A ES487721A ES487721A1 ES 487721 A1 ES487721 A1 ES 487721A1 ES 487721 A ES487721 A ES 487721A ES 487721 A ES487721 A ES 487721A ES 487721 A1 ES487721 A1 ES 487721A1
Authority
ES
Spain
Prior art keywords
substituted
tropane derivatives
benzyl
methyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES487721A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7900971A external-priority patent/FR2446823A1/fr
Application filed by Delalande SA filed Critical Delalande SA
Publication of ES487721A1 publication Critical patent/ES487721A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)

Abstract

Procedimientos de preparación de nuevos derivados del nor-tropano, que responden a la fórmula general: **(Fórmula)** Debe notarse que en la fórmula (I), el encadenamiento A-CO-NH está en posición ecuatorial y los nor-tropanos que llevan un substituyente de este tipo en posición ecuatorial serán denominados beta a continuación. La presente invención se refiere también a las sales de adición con ácidos minerales u orgánicos, farmacéuticamente aceptables, de los compuestos precitados.
ES487721A 1979-01-16 1980-01-15 Procedimiento de preparacion de nuevos derivados del nor- tropano Expired ES487721A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7900971A FR2446823A1 (fr) 1979-01-16 1979-01-16 Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
FR7931656A FR2476088A2 (fr) 1979-01-16 1979-12-26 Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ES487721A1 true ES487721A1 (es) 1980-06-16

Family

ID=26220957

Family Applications (1)

Application Number Title Priority Date Filing Date
ES487721A Expired ES487721A1 (es) 1979-01-16 1980-01-15 Procedimiento de preparacion de nuevos derivados del nor- tropano

Country Status (14)

Country Link
US (2) US4471120A (es)
AU (1) AU542537B2 (es)
BE (1) BE881134A (es)
CA (1) CA1130286A (es)
CH (2) CH647520A5 (es)
DE (2) DE3001328A1 (es)
ES (1) ES487721A1 (es)
FR (1) FR2476088A2 (es)
GB (1) GB2042522B (es)
GR (1) GR66499B (es)
IT (2) IT1148801B (es)
LU (1) LU82083A1 (es)
NL (1) NL8000277A (es)
SE (2) SE444941B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL61642A0 (en) * 1979-12-20 1981-01-30 Beecham Group Ltd Aniline derivatives,their preparation and pharmalceutical compositions containing them
FR2493848B2 (fr) * 1980-11-07 1986-05-16 Delalande Sa Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique
NZ199080A (en) * 1980-12-12 1984-07-31 Beecham Group Ltd 2-alkoxy-4-amino-5-alkylsulphonyl-n-(3beta-(8-hydrocarbyl-8-azabicyclo (3,2,1)octyl))benzamides
EP0069481A1 (en) * 1981-06-17 1983-01-12 Beecham Group Plc Azabicycloalkyl benzamides, process for their preparation and pharmaceutical compositions containing them
EP0067615B1 (en) * 1981-06-17 1986-01-08 Beecham Group Plc Alkylthio derivatives of azabicyclobenzamides, their preparation and pharmaceutical compositions
EP0068700A1 (en) * 1981-06-29 1983-01-05 Beecham Group Plc Azobicycloalkylbenzamides, process for their preparation and pharmaceutical compositions containing them
EP0069482A1 (en) * 1981-06-29 1983-01-12 Beecham Group Plc Azabicycloalkyl benzamides, process for their preparation and pharmaceutical compositions containing them
GB2111479A (en) * 1981-10-01 1983-07-06 Beecham Group Plc Benzamides
EP0083737A1 (en) * 1981-12-15 1983-07-20 Beecham Group Plc N-azabicycloalkane benzamides, process for their preparation and pharmaceutical compositions containing them
EP0095262B1 (en) * 1982-05-11 1986-12-03 Beecham Group Plc Azabicycloalkane derivatives, their preparation and medicaments containing them
FR2531083B1 (fr) * 1982-06-29 1986-11-28 Sandoz Sa Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
WO1984001151A1 (en) * 1982-09-24 1984-03-29 Beecham Group Plc Amino-azabicycloalkyl derivatives as dopamine antagonists
CA1244028A (en) * 1983-04-14 1988-11-01 Hans Maag Pyrimidine derivatives
FR2546169B1 (fr) * 1983-05-20 1986-03-21 Delalande Sa N-oxydes de derives aminocycliques, leur procede de preparation et leur application en therapeutique
WO1985001048A1 (en) * 1983-08-26 1985-03-14 Sandoz Ag Aromatic esters or amides of carboxylic acid and sulfonic acid
FR2557110B1 (fr) * 1983-12-23 1989-11-24 Sandoz Sa Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
US4997956A (en) * 1989-06-14 1991-03-05 Eli Lilly And Company Certain 2,3-dihydro-2;2-dimethyl-benzothiophene carboxylic acids which are intermediates
US5364863A (en) * 1987-09-08 1994-11-15 Eli Lilly And Company Specific 5-HT3 antagonists
US4921982A (en) * 1988-07-21 1990-05-01 Eli Lilly And Company 5-halo-2,3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acids useful as intermediates for 5-HT3 antagonists
US5070094A (en) * 1989-09-05 1991-12-03 G. D. Searle & Co. N-benzyltropaneamides
GB9027487D0 (en) * 1990-12-19 1991-02-06 Beecham Group Plc Pharmaceuticals
FR2831884B1 (fr) 2001-11-02 2003-12-26 Pf Medicament Nouveaux derives amides heteroaromatiques de 3 beta-amino azabicyclooctane, leur procede de preparation et leurs applications en therapeutique
JP2009513491A (ja) 2003-06-24 2009-04-02 ノイロサーチ アクティーゼルスカブ 新規な８−アザ−ビシクロ［３．２．１］オクタン誘導体、及びモノアミン神経伝達物質の再取り込み阻害剤としてのその使用
EP2336125B1 (en) * 2008-04-11 2013-01-09 Janssen Pharmaceutica N.V. Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase
CA2761881C (en) * 2009-05-14 2017-04-04 Janssen Pharmaceutica Nv Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene a4 hydrolase

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3134782A (en) * 1964-05-26 Chjxch-
FR1162129A (fr) * 1954-10-20 1958-09-09 Sandoz Ag Dérivés amidés du tropane et leur préparation
GB774858A (en) * 1954-10-20 1957-05-15 Sandoz Ltd Tropane and -Î-tropane derivatives and process for preparation thereof
CH374679A (de) * 1958-11-26 1964-01-31 Sandoz Ag Verfahren zur Herstellung von neuen Tropan-Derivaten
DE2513136C3 (de) * 1974-03-21 1981-04-30 Anphar S.A., Madrid N-(1-Benzylpiperid-4-yl)-benzamide, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate
GB1593146A (en) * 1976-11-05 1981-07-15 Beecham Group Ltd Octahydro-quinolizinyl benzamide derivatives
US4179567A (en) * 1978-04-10 1979-12-18 Sterling Drug Inc. 2-Aryltropane compounds
IL59004A0 (en) * 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
US4329466A (en) * 1979-01-16 1982-05-11 Delalande S.A. Certain nor-tropan-8-amine-3-aryl or heteroaryl derivatives
US4321378A (en) * 1979-01-16 1982-03-23 Delalande S.A. 8-(5-Pyrimidinecarboxamide)nor-tropane derivatives

Also Published As

Publication number Publication date
CH646969A5 (fr) 1984-12-28
BE881134A (fr) 1980-07-14
IT8024713A0 (it) 1980-09-17
SE8000068L (sv) 1980-07-17
SE444941B (sv) 1986-05-20
FR2476088B2 (es) 1983-11-04
SE431984B (sv) 1984-03-12
DE3001328A1 (de) 1980-07-24
GB2042522B (en) 1983-04-13
GR66499B (es) 1981-03-24
US4471120A (en) 1984-09-11
NL8000277A (nl) 1980-07-18
DE3001328C2 (es) 1989-06-08
IT1235424B (it) 1992-07-09
GB2042522A (en) 1980-09-24
FR2476088A2 (fr) 1981-08-21
CH647520A5 (fr) 1985-01-31
AU5461080A (en) 1980-07-24
US4536580A (en) 1985-08-20
IT1148801B (it) 1986-12-03
DE3049963C2 (de) 1993-11-25
LU82083A1 (fr) 1981-09-10
IT8019071A0 (it) 1980-01-08
CA1130286A (en) 1982-08-24
AU542537B2 (en) 1985-02-28

Similar Documents

Publication Publication Date Title
ES487721A1 (es) Procedimiento de preparacion de nuevos derivados del nor- tropano
AU500514B2 (en) Hydrogenated indeno [5,4-b] furan ( &amp; thiophene) carboxylic acid derivatives
ES8200359A1 (es) Un procedimiento de preparacion de dihidro-2,3-dime- til-2,2-hidroxi-7-benzofurano
PT66779B (fr) Procede pour la preparation de derives de l&#39;acide 5-(2-furoil)-, 5-(2-tenoil)-, 5-(3-furoil)-et 5-(3tenoil)-1,2-dihydro-3h-pirrole/1,2-alpha/ pirrole-1-carboxilique
IT7819222A0 (it) Composizione contenente anidride maleica, ad elevato punto di rammollimento.
JPS522794A (en) Health control table
AU4273078A (en) Substituted 1,5-cyclohexadiene carboxylic acid derivatives
SU691341A1 (ru) Устройство дл заводки гребных валов
AU1146076A (en) 4h-benzo%4,5&lt;-cyclohepta%1,2-6&lt;thiophene derivatives
JPS5322529A (en) Dihydropyrazine derivative and its preparation
JPS53149991A (en) Preparation of 3-heterothiomethyl-1-oxadethia-3-cephem-4-carboxylic acid
JPS5410576A (en) Washer
JPS524546A (en) Polyolefin composition
JPS5377098A (en) Preparation of indoloisoquinoline derivative
JPS5399638A (en) Range hood
JPS5245093A (en) Heat resistant thermit
JPS5451A (en) Polyolefin resin composition
JPS5375589A (en) Throw away chip and drill
JPS5235379A (en) Transfer body for conveyance and connecting mechanism with guide rail thereof
JPS549258A (en) Epidesmosterol derivatives
AU513200B2 (en) 2, 4, 6-Trisubstituted-2, 3-dihydro-benzofuran derivatives
JPS5321169A (en) Novel lactone derivatives
JPS53143647A (en) Hologen-containing resin composition
JPS5295658A (en) Preparation of thienyl acetate derivatives
JPS5261038A (en) Observation elevator