ES474408A1 - Procedimiento para la obtencion de 1,4-dihidropiridinas con agrupaciones ester sulfurosas - Google Patents

Procedimiento para la obtencion de 1,4-dihidropiridinas con agrupaciones ester sulfurosas

Info

Publication number
ES474408A1
ES474408A1 ES474408A ES474408A ES474408A1 ES 474408 A1 ES474408 A1 ES 474408A1 ES 474408 A ES474408 A ES 474408A ES 474408 A ES474408 A ES 474408A ES 474408 A1 ES474408 A1 ES 474408A1
Authority
ES
Spain
Prior art keywords
sulfur
preparation
carboxylic acids
pharmaceutical use
containing esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES474408A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES474408A1 publication Critical patent/ES474408A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)

Abstract

Procedimiento para la obtención de 1,4-dihidropiridinas con agrupaciones éster sulfurosas de formula **(formula)** donde R significa un resto arilo, o un resto tienilo, furilo, pirrilo, pirazolilo, imidazolilo, oxazolilo, isoxazolilo, tiazolilo, piridilo, piridazinilo, pirimidilo, pirazinilo o quinoxalilo, donde el resto arilo, así como los heterociclos, contienen en caso dado 1 hasta 3 sustituyentes, iguales o diferentes, del grupo fenilo, alquilo, alquenilo, alquinilo, alcoxi, alquenoxi, alquinoxi, alquileno, dioxialquileno, halogeno, trifluormetilo, trifluormetoxi, hidroxi, amino, alquilamino, nitro, ciano, azido, carboxi, carbalcoxi, carbonamido, sulfonamido o Som-alquilo (m=0 hasta 2).
ES474408A 1977-10-22 1978-10-20 Procedimiento para la obtencion de 1,4-dihidropiridinas con agrupaciones ester sulfurosas Expired ES474408A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772747513 DE2747513A1 (de) 1977-10-22 1977-10-22 Dihydropyridine mit schwefelhaltigen estergruppierungen

Publications (1)

Publication Number Publication Date
ES474408A1 true ES474408A1 (es) 1979-10-16

Family

ID=6022043

Family Applications (1)

Application Number Title Priority Date Filing Date
ES474408A Expired ES474408A1 (es) 1977-10-22 1978-10-20 Procedimiento para la obtencion de 1,4-dihidropiridinas con agrupaciones ester sulfurosas

Country Status (8)

Country Link
EP (1) EP0001769A1 (es)
JP (1) JPS5470284A (es)
AT (1) AT368135B (es)
CA (1) CA1108615A (es)
DE (1) DE2747513A1 (es)
ES (1) ES474408A1 (es)
IL (1) IL55765A (es)
IT (1) IT7828988A0 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ193167A (en) 1979-03-27 1984-08-24 Boots Co Plc Quinoline derivatives and pharmaceutical compositions
JPS57200364A (en) * 1981-06-04 1982-12-08 Yoshitomi Pharmaceut Ind Ltd 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its salt
GB2111978B (en) * 1981-10-19 1985-05-01 Maruko Pharmaceutical Co 1 4-dihydropyridine compounds
IL68524A0 (en) * 1982-05-21 1983-07-31 Haessle Ab Novel dihydropyridines
DE3247118A1 (de) * 1982-12-20 1984-06-20 Cassella Ag, 6000 Frankfurt Neue substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
FI852359L (fi) * 1984-06-27 1985-12-28 Hoffmann La Roche Dihydropyridinderivat.
WO1986001081A1 (en) * 1984-08-03 1986-02-27 Mitsui & Co., Ltd Method of and apparatus for freezing food
JPS6147477A (ja) * 1984-08-14 1986-03-07 Kowa Co 新規１，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体
JPS61293972A (ja) * 1985-06-24 1986-12-24 Nisshin Flour Milling Co Ltd １，４−ジヒドロピリジンスルホン誘導体およびその製法
AU8154087A (en) * 1986-10-15 1988-05-06 Byk Gulden Lomberg Chemische Fabrik Gmbh 1,4-dihydropyridine
US5177211A (en) * 1988-01-21 1993-01-05 Alter, S.A. 4-alkyl-1,4-dihydropyridines with PAF-antagonist activity
DE3801717C1 (es) * 1988-01-21 1989-05-24 Alter S.A., Madrid, Es
JPH02167262A (ja) * 1988-06-05 1990-06-27 Taisho Pharmaceut Co Ltd １，４―ジヒドロピリジン誘導体
KR940003492B1 (ko) * 1988-10-27 1994-04-23 주식회사 유한양행 1,4-디하이드로피리딘유도체 및 그의 제조방법
US6265417B1 (en) 1997-12-18 2001-07-24 Abbott Laboratories Potassium channel openers
US6593335B1 (en) 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
EP1040097B1 (en) * 1997-12-18 2004-04-14 Abbott Laboratories Potassium channel openers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH607848A5 (es) * 1974-06-04 1978-11-30 Bayer Ag
DE2508181A1 (de) * 1975-02-26 1976-09-09 Bayer Ag 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
DE2616995A1 (de) * 1976-04-17 1977-10-27 Bayer Ag 1.4-dihydropyridine mit schwefelhaltigen substituenten mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
CA1108615A (en) 1981-09-08
IL55765A0 (en) 1978-12-17
ATA755378A (de) 1982-01-15
EP0001769A1 (de) 1979-05-16
JPS5470284A (en) 1979-06-05
IT7828988A0 (it) 1978-10-20
AT368135B (de) 1982-09-10
DE2747513A1 (de) 1979-05-03
IL55765A (en) 1982-08-31

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