ES484292A1 - Un procedimiento para la obtencion de un preparado de globu-lina inmunizante - Google Patents
Un procedimiento para la obtencion de un preparado de globu-lina inmunizanteInfo
- Publication number
- ES484292A1 ES484292A1 ES484292A ES484292A ES484292A1 ES 484292 A1 ES484292 A1 ES 484292A1 ES 484292 A ES484292 A ES 484292A ES 484292 A ES484292 A ES 484292A ES 484292 A1 ES484292 A1 ES 484292A1
- Authority
- ES
- Spain
- Prior art keywords
- globulin
- immune
- preparing
- polyethylene glycol
- immune globulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Electronic Switches (AREA)
Abstract
1. Un procedimiento para la obtención de un preparado de globulina inmunizante con contenido de anticuerpos, administrables por vía intravenosa, para lo cual se fracciona plasma sanguíneo humano, y se libera una fracción con contenido de globulina inmunizante de impurezas proteicas indeseables, mediante precipitación una o varias veces con polistilenglicol, caracterizado porque la fracción que contiene globulina inmunizante se somete en una primera fase de purificación, con anterioridad a la precipitación con polietilenglicol, a un tratamiento con una solución acuosa de una sal de un ácido inorgánico polivalente, en especial de sulfato amónico, y porque al menos una de las fases de purificación siguientes con polietilenglicol se lleva a cabo en presencia de un hidrato de carbono soluble o de un poliol con al menos tres grupos hidróxilos, a continuación de lo cual se hace precipitar de la solución sobrante la globulina inmunizante liberada de impurezas proteicas, con ayuda de polímeros hidrosolubles, para seguidamente transformarla en un preparado farmacéutico de la manera conocida.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT675378A AT359641B (de) | 1978-09-19 | 1978-09-19 | Verfahren zur herstellung eines intravenoes ver- abreichbaren antikoerperhaeltigen immunglobulin- praeparates |
Publications (1)
Publication Number | Publication Date |
---|---|
ES484292A1 true ES484292A1 (es) | 1980-05-16 |
Family
ID=3589418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES484292A Expired ES484292A1 (es) | 1978-09-19 | 1979-09-19 | Un procedimiento para la obtencion de un preparado de globu-lina inmunizante |
Country Status (17)
Country | Link |
---|---|
US (1) | US4276283A (es) |
JP (1) | JPS5547628A (es) |
AT (1) | AT359641B (es) |
BE (1) | BE878688A (es) |
CA (1) | CA1112166A (es) |
CH (1) | CH646608A5 (es) |
DE (1) | DE2936047A1 (es) |
DK (1) | DK154267C (es) |
ES (1) | ES484292A1 (es) |
FI (1) | FI66534C (es) |
FR (1) | FR2436604A1 (es) |
GB (1) | GB2030150B (es) |
IT (1) | IT1123200B (es) |
NL (1) | NL191670C (es) |
NO (1) | NO154255C (es) |
SE (1) | SE447790B (es) |
YU (1) | YU44151B (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4374763A (en) * | 1979-09-17 | 1983-02-22 | Morishita Pharmaceutical Co., Ltd. | Method for producing gamma-globulin for use in intravenous administration and method for producing a pharmaceutical preparation thereof |
JPS5855432A (ja) * | 1981-09-29 | 1983-04-01 | Fujirebio Inc | 静脈注射用免疫グロブリンの製法 |
JPS58180433A (ja) * | 1982-04-16 | 1983-10-21 | Fujirebio Inc | 免疫グロブリンから抗補体作用物質の除去法 |
US4434093A (en) | 1982-07-26 | 1984-02-28 | Ortho Diagnostic Systems Inc. | Methods for preparation of HBs Ag free gamma globulins |
DE3382394D1 (de) * | 1982-08-30 | 1991-10-02 | Baxter Travenol Lab | Verfahren zur herstellung von gamma-globulin enthaltenden zusammensetzungen. |
US4639513A (en) * | 1984-02-02 | 1987-01-27 | Cuno Inc. | Intravenously injectable immunoglobulin G (IGG) and method for producing same |
DK166763C (da) * | 1983-03-16 | 1993-07-12 | Immuno Ag | Immunoglobulin-g-holdig fraktion |
US5234685A (en) * | 1983-03-16 | 1993-08-10 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Method of determining incompatibility-reaction-causing substances in blood products as well as a method of inactivating said incompatibility-reaction-causing substances |
AT383739B (de) * | 1983-03-16 | 1987-08-10 | Immuno Ag | Verfahren zur inaktivierung von unvertraeglichkeitsreaktionen verursachenden substanzen in immunglobulinhaeltigen blutfraktionen |
US4482483A (en) * | 1983-04-06 | 1984-11-13 | Armour Pharmceutical Company | Composition of intravenous immune globulin |
DE3344656A1 (de) * | 1983-12-09 | 1985-06-13 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Verfahren zur herstellung einer serumproteinloesung |
US4623541A (en) * | 1984-06-26 | 1986-11-18 | Candian Patents And Development Limited | Production of purified porcine immunoglobulins |
EP0256190A1 (en) * | 1986-08-20 | 1988-02-24 | Canadian Patents and Development Limited Société Canadienne des Brevets et d'Exploitation Limitée | Production of purified porcine immunoglobulins |
US4835257A (en) * | 1984-07-07 | 1989-05-30 | Armour Pharma Gmbh | Process for preparing gamma globulin suitable for intravenous administration using peg and a citrate buffer |
EP0168506B2 (en) * | 1984-07-07 | 1998-01-07 | Armour Pharma GmbH | Process for preparing gamma globulin suitable for intravenous administration |
US5019557A (en) * | 1986-09-15 | 1991-05-28 | Pitts Jr Ferris N | Method for the effective treatment of disease conditions in humans associated with HTLV-III infection |
DE3641115A1 (de) * | 1986-12-02 | 1988-06-16 | Lentia Gmbh | Verfahren zur herstellung eines intravenoes anwendbaren und in fluessiger form stabilen immunglobulins |
AT389817B (de) * | 1987-01-22 | 1990-02-12 | Schwab & Co Ges Mbh | Verfahren zur herstellung eines in fluessiger form stabilen immunglobulins zur intravenoesen anwendung |
CA1308023C (en) * | 1988-07-29 | 1992-09-29 | William Austin James Mcauley | Immunoglobulin extraction utilizing properties of colloidal solutions |
JPH0552008U (ja) * | 1991-04-04 | 1993-07-09 | 株式会社日本アルミ | 伸縮継手装置の耐火帯構造 |
DE4344824C1 (de) * | 1993-12-28 | 1995-08-31 | Immuno Ag | Hochkonzentriertes Immunglobulin-Präparat und Verfahren zu seiner Herstellung |
DE4424935C1 (de) * | 1994-07-14 | 1996-03-21 | Immuno Ag | Humanes virussicheres monomeres Immunglobulin A und Verfahren zu seiner Herstellung |
US8703126B2 (en) | 2000-10-12 | 2014-04-22 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
DK1324776T4 (en) | 2000-10-12 | 2018-05-28 | Genentech Inc | CONCENTRATED PROTEIN FORMULATIONS WITH REDUCED VISCOSITY |
AU2002335815A1 (en) * | 2001-10-16 | 2003-04-28 | Rxkinetix, Inc. | High-concentration protein formulations and method of manufacture |
WO2008100578A2 (en) * | 2007-02-14 | 2008-08-21 | Amgen Inc. | Method of isolating antibodies by precipitation |
KR20110128333A (ko) | 2009-03-06 | 2011-11-29 | 제넨테크, 인크. | 항체 제제 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1350895A (fr) * | 1962-01-03 | 1964-01-31 | South African Inventions | Précipitation des colloïdes organiques |
NL286954A (es) * | 1962-01-03 | |||
SE348942B (es) * | 1970-06-02 | 1972-09-18 | Statens Bakteriologiska Labor | |
DE2234069A1 (de) * | 1971-07-16 | 1973-02-08 | South African Inventions | Verfahren zur herstellung eines gereinigten gamma-globulins |
US3763135A (en) * | 1971-11-08 | 1973-10-02 | Baxter Laboratories Inc | Gamma globulin production from cohn fraction iii using polyethylene glycol |
JPS49101516A (es) * | 1973-01-13 | 1974-09-25 | ||
DE2364792A1 (de) * | 1973-01-15 | 1974-07-18 | South African Inventions | Verfahren zum reinigen von gammaglobulin |
DE2500076C3 (de) * | 1975-01-02 | 1982-11-18 | SCHURA Blutderivate GmbH & Co KG, 4150 Krefeld | Verfahren zur Gewinnung von intravenös-verträglichen Gammaglobulinen |
CA1064396A (en) * | 1975-02-18 | 1979-10-16 | Myer L. Coval | Fractional precipitation of gamma globulin with polyethylene glycol |
US4126605A (en) * | 1975-12-29 | 1978-11-21 | Plasmesco Ag | Process of improving the compatibility of gamma globulins |
US4165370A (en) * | 1976-05-21 | 1979-08-21 | Coval M L | Injectable gamma globulin |
JPS6016406B2 (ja) * | 1976-08-06 | 1985-04-25 | マイヤ−、ル−イス、コ−バル | 静脈内に投与可能なガンマ・グロブリンの製造法ならびにそれにより調製したガンマ・グロブリン |
JPS5347515A (en) * | 1976-10-13 | 1978-04-28 | Green Cross Corp:The | Gamma-globulin pharmaceutical preparation for intravenous injection |
US4124576A (en) * | 1976-12-03 | 1978-11-07 | Coval M L | Method of producing intravenously injectable gamma globulin |
DE2658334B2 (de) * | 1976-12-23 | 1980-06-04 | Behringwerke Ag, 3550 Marburg | Verfahren zum Herstellen von Immunglobulinpraparationen mit verminderter Komplementbindung und ein diese enthaltendes Arzneimittel |
-
1978
- 1978-09-19 AT AT675378A patent/AT359641B/de not_active IP Right Cessation
-
1979
- 1979-08-23 SE SE7907045A patent/SE447790B/sv not_active IP Right Cessation
- 1979-08-31 FR FR7921922A patent/FR2436604A1/fr active Granted
- 1979-09-03 DK DK368579A patent/DK154267C/da not_active IP Right Cessation
- 1979-09-05 FI FI792757A patent/FI66534C/fi not_active IP Right Cessation
- 1979-09-06 NL NL7906685A patent/NL191670C/xx not_active IP Right Cessation
- 1979-09-06 DE DE19792936047 patent/DE2936047A1/de active Granted
- 1979-09-07 CA CA335,211A patent/CA1112166A/en not_active Expired
- 1979-09-10 US US06/074,257 patent/US4276283A/en not_active Expired - Lifetime
- 1979-09-10 BE BE0/197072A patent/BE878688A/xx not_active IP Right Cessation
- 1979-09-13 JP JP11679879A patent/JPS5547628A/ja active Granted
- 1979-09-13 GB GB7931744A patent/GB2030150B/en not_active Expired
- 1979-09-13 CH CH830779A patent/CH646608A5/de not_active IP Right Cessation
- 1979-09-17 YU YU2259/79A patent/YU44151B/xx unknown
- 1979-09-18 IT IT7925778A patent/IT1123200B/it active
- 1979-09-18 NO NO793001A patent/NO154255C/no unknown
- 1979-09-19 ES ES484292A patent/ES484292A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
SE7907045L (sv) | 1980-03-20 |
FR2436604B1 (es) | 1982-11-05 |
DE2936047C2 (es) | 1988-10-27 |
NL7906685A (nl) | 1980-03-21 |
NL191670B (nl) | 1995-10-02 |
JPH0253408B2 (es) | 1990-11-16 |
NO793001L (no) | 1980-03-20 |
JPS5547628A (en) | 1980-04-04 |
DK154267B (da) | 1988-10-31 |
YU225979A (en) | 1983-10-31 |
SE447790B (sv) | 1986-12-15 |
YU44151B (en) | 1990-02-28 |
US4276283A (en) | 1981-06-30 |
FI66534C (fi) | 1984-11-12 |
IT7925778A0 (it) | 1979-09-18 |
DE2936047A1 (de) | 1980-03-27 |
FR2436604A1 (fr) | 1980-04-18 |
ATA675378A (de) | 1980-04-15 |
NO154255C (no) | 1986-08-20 |
DK368579A (da) | 1980-03-20 |
NO154255B (no) | 1986-05-12 |
BE878688A (fr) | 1979-12-31 |
AT359641B (de) | 1980-11-25 |
NL191670C (nl) | 1996-02-05 |
FI792757A (fi) | 1980-03-20 |
GB2030150A (en) | 1980-04-02 |
CH646608A5 (de) | 1984-12-14 |
FI66534B (fi) | 1984-07-31 |
IT1123200B (it) | 1986-04-30 |
GB2030150B (en) | 1982-11-03 |
CA1112166A (en) | 1981-11-10 |
DK154267C (da) | 1989-03-28 |
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