ES479667A1 - Un procedimiento para la preparacion de derivados de karra- micina. - Google Patents

Un procedimiento para la preparacion de derivados de karra- micina.

Info

Publication number
ES479667A1
ES479667A1 ES479667A ES479667A ES479667A1 ES 479667 A1 ES479667 A1 ES 479667A1 ES 479667 A ES479667 A ES 479667A ES 479667 A ES479667 A ES 479667A ES 479667 A1 ES479667 A1 ES 479667A1
Authority
ES
Spain
Prior art keywords
kanamycin
derivatives
acyl
formyl
kanamycin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES479667A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp
Original Assignee
Pfizer Corp Belgium
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp filed Critical Pfizer Corp Belgium
Publication of ES479667A1 publication Critical patent/ES479667A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Un procedimiento para la preparación de derivadas de kanamicina de fórmula (II): **(Fórmula)** donde R2 es un grupo formilo, R3 es un grupo alcanoílo C2 a C4 o un grupo benzoílo y R4 es un grupo hidroxi o un grupo NHR3, que consiste en la formilación de dicho compuesto donde R2 es hidrógeno y R3 y R4 son los definidos anteriormente, seguida de hidrólisis selectiva para separar el grupo formilo de la posición 1-amino.
ES479667A 1977-08-18 1979-04-17 Un procedimiento para la preparacion de derivados de karra- micina. Expired ES479667A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3480877 1977-08-18

Publications (1)

Publication Number Publication Date
ES479667A1 true ES479667A1 (es) 1979-08-01

Family

ID=10370176

Family Applications (2)

Application Number Title Priority Date Filing Date
ES472657A Expired ES472657A1 (es) 1977-08-18 1978-08-17 Un procedimiento para la preparacion de aminoglicosidos an- tibioticos
ES479667A Expired ES479667A1 (es) 1977-08-18 1979-04-17 Un procedimiento para la preparacion de derivados de karra- micina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES472657A Expired ES472657A1 (es) 1977-08-18 1978-08-17 Un procedimiento para la preparacion de aminoglicosidos an- tibioticos

Country Status (24)

Country Link
US (1) US4178437A (es)
JP (1) JPS5459256A (es)
AR (1) AR218324A1 (es)
AT (1) AT360154B (es)
BE (1) BE869761A (es)
CA (1) CA1106842A (es)
CS (1) CS201512B2 (es)
DD (2) DD148220A5 (es)
DE (1) DE2835759A1 (es)
DK (1) DK308878A (es)
EG (1) EG13472A (es)
ES (2) ES472657A1 (es)
FI (1) FI782497A (es)
FR (1) FR2400523A1 (es)
GR (1) GR70241B (es)
IE (1) IE47150B1 (es)
IT (1) IT1098281B (es)
LU (1) LU80124A1 (es)
NL (1) NL7808566A (es)
NO (1) NO782796L (es)
PL (2) PL114954B1 (es)
PT (1) PT68427A (es)
SE (1) SE7808702L (es)
SU (1) SU873889A3 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4493831A (en) * 1982-10-25 1985-01-15 Fujisawa Pharmaceutical Co., Ltd. Aminoglycoside derivatives
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
CN103360440B (zh) 2007-11-21 2016-08-31 尔察祯有限公司 抗菌性氨基糖苷类似物
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132757A2 (en) * 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE630462A (es) * 1962-04-03
JPS5644076B2 (es) * 1973-07-12 1981-10-16
US4029882A (en) * 1974-03-19 1977-06-14 Schering Corporation Selective acylation of the C-1 amino group of aminoglycoside antibiotics
US4044123A (en) * 1975-05-02 1977-08-23 Schering Corporation 6'-N-alkyl-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, methods for their use as antibacterial agents and compositions useful therefor
NZ184213A (en) * 1976-06-16 1980-05-27 Pfizer 2-deoxystreptamine aminoglycosides and antibacterial pharmaceutical compositions

Also Published As

Publication number Publication date
CS201512B2 (en) 1980-11-28
FI782497A (fi) 1979-02-19
DD139582A5 (de) 1980-01-09
IT7826812A0 (it) 1978-08-17
US4178437A (en) 1979-12-11
BE869761A (fr) 1979-02-16
ATA590278A (de) 1980-05-15
EG13472A (en) 1981-12-31
CA1106842A (en) 1981-08-11
FR2400523A1 (fr) 1979-03-16
DD148220A5 (de) 1981-05-13
PL114954B1 (en) 1981-03-31
DK308878A (da) 1979-02-19
SE7808702L (sv) 1979-02-19
JPS5459256A (en) 1979-05-12
IE781653L (en) 1979-02-18
PL209082A1 (es) 1980-01-02
NO782796L (no) 1979-02-20
IT1098281B (it) 1985-09-07
GR70241B (es) 1982-09-01
AR218324A1 (es) 1980-05-30
SU873889A3 (ru) 1981-10-15
ES472657A1 (es) 1979-10-16
IE47150B1 (en) 1983-12-28
PT68427A (en) 1978-09-01
AT360154B (de) 1980-12-29
DE2835759A1 (de) 1979-03-08
NL7808566A (nl) 1979-02-20
PL114720B1 (en) 1981-02-28
LU80124A1 (fr) 1980-04-21

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