ES478718A1 - Procedimiento para la obtencion de lipopeptidos. - Google Patents
Procedimiento para la obtencion de lipopeptidos.Info
- Publication number
- ES478718A1 ES478718A1 ES478718A ES478718A ES478718A1 ES 478718 A1 ES478718 A1 ES 478718A1 ES 478718 A ES478718 A ES 478718A ES 478718 A ES478718 A ES 478718A ES 478718 A1 ES478718 A1 ES 478718A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- group
- compounds
- carboxyl
- free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010028921 Lipopeptides Proteins 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 5
- 108090000765 processed proteins & peptides Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- -1 aliphatic amino acid Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C07K5/06069—Ser-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Procedimiento para la obtención de lipopéptidos de fórmula **fórmula** donde R1 y R2, en cada caso significan un resto hidrocarburo, saturado o insaturado, alifático, o mixto alifático-cicloalifático, en caso dado sustituido por funciones de oxígeno, con 11- 21 átomos de carbono, R3 significa hidrógeno o el resto R1-CO-O-H2- donde R1 tiene el mismo significado y X es un aminoácido alifático natural, peptídicamente enlazado, con carboxilo libre, esterificado o amidado, o una secuencia de aminoácidos de 2-10 aminoácidos alifáticos naturales, cuyo grupo carboxilo terminal se presenta en forma libre, esterificada o amidada o X=OH donde los centros de asimetría designados con * o bién ** tienen la configuración S absoluta o bien la configuración S o R, y en caso dado, las mezclas de los compuestos R y S epímeros en los átomos C** y en caso dado las sales y los complejos, caracterizado porque un compuesto de fórmula **fórmula** donde R2 tiene el significado indicado para la fórmula (I) y R3 significa hidrógeno o el grupo HO-CH2, y Z2 es OH o representa un grupo correspondiente a X en la fórmula (I) donde sin embargo en una secuencia de péptido o en un solo péptido donde sin embargo no estén presentes grupos hidroxi libres, o un derivado de un compuesto de estos, donde Z2 es Oh, pero con grupo protector carboxilo activado, o una sal de uno de estos compuestos, se acila en forma en si conocida, y si se desea, en los compuestos obtenidos con grupo carboxilo terminar éste se transforma en un grupo amida o grupo éster, y/o un grupo protector carboxilo se libera y/o los compuestos se transforman en sus sales o complejos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU77584 | 1977-06-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES478718A1 true ES478718A1 (es) | 1979-12-16 |
Family
ID=19728618
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES470961A Expired ES470961A1 (es) | 1977-06-20 | 1978-06-20 | Procedimiento para la obtencion de lipopeptidos |
| ES478718A Expired ES478718A1 (es) | 1977-06-20 | 1979-03-16 | Procedimiento para la obtencion de lipopeptidos. |
| ES478717A Expired ES478717A1 (es) | 1977-06-20 | 1979-03-16 | Procedimiento para la obtencion de lipopetidos. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES470961A Expired ES470961A1 (es) | 1977-06-20 | 1978-06-20 | Procedimiento para la obtencion de lipopeptidos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES478717A Expired ES478717A1 (es) | 1977-06-20 | 1979-03-16 | Procedimiento para la obtencion de lipopetidos. |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0000330B1 (es) |
| JP (2) | JPS549224A (es) |
| AT (1) | AT364095B (es) |
| AU (1) | AU525005B2 (es) |
| CA (1) | CA1139305A (es) |
| DD (1) | DD139257A5 (es) |
| DE (1) | DE2860893D1 (es) |
| DK (1) | DK275178A (es) |
| ES (3) | ES470961A1 (es) |
| FI (1) | FI781933A7 (es) |
| GR (1) | GR71681B (es) |
| IE (1) | IE46957B1 (es) |
| IL (1) | IL54950A (es) |
| NO (1) | NO148921C (es) |
| NZ (1) | NZ187611A (es) |
| PL (3) | PL207766A1 (es) |
| PT (1) | PT68188A (es) |
| ZA (1) | ZA783504B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0014815A3 (de) * | 1978-12-20 | 1980-10-29 | Ciba-Geigy Ag | Peptidderivate, Verfahren zu deren Herstellung und Zwischenprodukte sowie pharmazeutische Präparate mit einer dieser Verbindungen |
| DE3485094D1 (de) * | 1983-01-25 | 1991-10-31 | Ciba Geigy Ag | Neue peptidderivate. |
| FR2546164B1 (fr) * | 1983-05-16 | 1987-07-17 | Centre Nat Rech Scient | Nouveaux derives de peptides, leur preparation et leur application comme inhibiteurs de l'elastase |
| US6024964A (en) * | 1985-06-24 | 2000-02-15 | Hoechst Aktiengesellschaft | Membrane anchor/active compound conjugate, its preparation and its uses |
| DE3546150A1 (de) * | 1985-06-24 | 1987-01-22 | Hoechst Ag | Membrananker-wirkstoffkonjugat, seine herstellung sowie seine verwendung |
| US6074650A (en) * | 1985-06-24 | 2000-06-13 | Hoechst Aktiengesellschaft | Membrane anchor/active compound conjugate, its preparation and its uses |
| DE3522638A1 (de) * | 1985-06-25 | 1987-01-08 | Diamalt Ag | Neue somatostatin-derivate |
| FR2611205B1 (fr) * | 1987-02-20 | 1990-03-02 | Serbio | Dipeptides, procede de preparation et utilisation dans le dosage de proteases |
| EP0306912A3 (en) * | 1987-09-08 | 1989-07-05 | Albany Medical College | Immunogenic composites capable of selectively inducing antibody production and pharmaceutical compositions employing the same. |
| DE4119856A1 (de) * | 1991-06-17 | 1992-12-24 | Hoechst Ag | N-acyl-s-(2-hydroxyalkyl)-cysteine, deren herstellung sowie deren verwendung als zwischenprodukte zur herstellung von synthetischen immunadjuvantien und synthetischen impfstoffen |
| DE59207848D1 (de) * | 1991-12-19 | 1997-02-20 | Ciba Geigy Ag | Aminosulfonsäurederivate und Verfahren zu ihrer Herstellung |
| AU666789B2 (en) * | 1992-12-28 | 1996-02-22 | Takeda Chemical Industries Ltd. | 2-amino-6,7-dihydroxy-4-thiaheptanoic acid derivatives, production and use thereof |
| EP0604945A1 (en) | 1992-12-28 | 1994-07-06 | Takeda Chemical Industries, Ltd. | TAN-1511, its derivatives, production and use thereof |
| EP0641776A3 (en) * | 1993-09-08 | 1997-05-02 | Takeda Chemical Industries Ltd | Thioglycerol derivatives. |
| GB9930591D0 (en) * | 1999-12-23 | 2000-02-16 | Univ London | Component for vaccine |
| DE10048840A1 (de) * | 2000-10-02 | 2002-04-11 | Biotechnolog Forschung Gmbh | Verwendung von Lipopeptiden oder Lipoproteinen zur Behandlung von Lungeninfektionen und -tumoren |
| FR2816060A1 (fr) * | 2000-10-27 | 2002-05-03 | Pf Medicament | Procede d'identification de nouvelles molecules se liant au recepteur lox et utilisation de ces molecules |
| NZ565063A (en) | 2005-06-13 | 2011-04-29 | Cleveland Biolabs Inc | Methods of protecting against apoptosis using lipopeptides |
| WO2007014193A2 (en) * | 2005-07-25 | 2007-02-01 | Therimunex, Llc | Peptidyl diacylglycerides |
| DE102016005550B4 (de) | 2016-05-09 | 2024-09-26 | Hans-Georg Rammensee | Adjuvans zur lnduzierung einer zellulären lmmunantwort |
| MX2020004742A (es) * | 2017-11-06 | 2020-08-13 | Crown Equip Corp | Sistema de colocacion lateral de vehiculo industrial. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE785933A (fr) * | 1971-07-07 | 1973-01-08 | Ciba Geigy | Procede de preparation de peptides contenant de la cystine |
| ZA735680B (en) * | 1972-09-21 | 1974-07-31 | Hoffmann La Roche | Polypeptides |
| DE2706490A1 (de) | 1976-02-20 | 1977-08-25 | Ciba Geigy Ag | Neue carbonsaeureester |
-
1978
- 1978-06-14 DE DE7878100149T patent/DE2860893D1/de not_active Expired
- 1978-06-14 EP EP78100149A patent/EP0000330B1/de not_active Expired
- 1978-06-16 CA CA000305645A patent/CA1139305A/en not_active Expired
- 1978-06-16 FI FI781933A patent/FI781933A7/fi not_active Application Discontinuation
- 1978-06-19 DK DK275178A patent/DK275178A/da not_active Application Discontinuation
- 1978-06-19 AT AT0445178A patent/AT364095B/de not_active IP Right Cessation
- 1978-06-19 PT PT68188A patent/PT68188A/pt unknown
- 1978-06-19 IL IL54950A patent/IL54950A/xx unknown
- 1978-06-19 NZ NZ187611A patent/NZ187611A/xx unknown
- 1978-06-19 NO NO782138A patent/NO148921C/no unknown
- 1978-06-19 ZA ZA00783504A patent/ZA783504B/xx unknown
- 1978-06-19 AU AU37230/78A patent/AU525005B2/en not_active Expired
- 1978-06-19 DD DD78206107A patent/DD139257A5/xx unknown
- 1978-06-19 IE IE1227/78A patent/IE46957B1/en unknown
- 1978-06-20 GR GR56557A patent/GR71681B/el unknown
- 1978-06-20 PL PL20776678A patent/PL207766A1/xx not_active IP Right Cessation
- 1978-06-20 JP JP7382878A patent/JPS549224A/ja active Granted
- 1978-06-20 PL PL21674078A patent/PL216740A1/xx unknown
- 1978-06-20 ES ES470961A patent/ES470961A1/es not_active Expired
- 1978-06-20 PL PL21673978A patent/PL216739A1/xx unknown
-
1979
- 1979-03-16 ES ES478718A patent/ES478718A1/es not_active Expired
- 1979-03-16 ES ES478717A patent/ES478717A1/es not_active Expired
-
1987
- 1987-05-21 JP JP62122684A patent/JPS6372671A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| ES478717A1 (es) | 1979-12-16 |
| PT68188A (de) | 1978-07-01 |
| NZ187611A (en) | 1981-07-13 |
| ES470961A1 (es) | 1980-03-01 |
| ZA783504B (en) | 1979-06-27 |
| IE46957B1 (en) | 1983-11-16 |
| GR71681B (es) | 1983-06-21 |
| IE781227L (en) | 1978-12-20 |
| DK275178A (da) | 1978-12-21 |
| NO148921C (no) | 1984-01-11 |
| NO782138L (no) | 1978-12-21 |
| DD139257A5 (de) | 1979-12-19 |
| ATA445178A (de) | 1981-02-15 |
| JPS641466B2 (es) | 1989-01-11 |
| AU3723078A (en) | 1980-01-03 |
| JPS6360760B2 (es) | 1988-11-25 |
| IL54950A (en) | 1983-10-31 |
| DE2860893D1 (en) | 1981-11-05 |
| AT364095B (de) | 1981-09-25 |
| PL207766A1 (pl) | 1979-11-19 |
| FI781933A7 (fi) | 1978-12-21 |
| EP0000330A1 (de) | 1979-01-24 |
| IL54950A0 (en) | 1978-08-31 |
| CA1139305A (en) | 1983-01-11 |
| PL216739A1 (es) | 1980-05-19 |
| JPS549224A (en) | 1979-01-24 |
| JPS6372671A (ja) | 1988-04-02 |
| AU525005B2 (en) | 1982-10-14 |
| PL216740A1 (es) | 1980-05-19 |
| NO148921B (no) | 1983-10-03 |
| EP0000330B1 (de) | 1981-08-05 |
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