ES445148A1 - Procedure for the preparation of new tiazolic derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new tiazolic derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES445148A1
ES445148A1 ES445148A ES445148A ES445148A1 ES 445148 A1 ES445148 A1 ES 445148A1 ES 445148 A ES445148 A ES 445148A ES 445148 A ES445148 A ES 445148A ES 445148 A1 ES445148 A1 ES 445148A1
Authority
ES
Spain
Prior art keywords
formula
carbon atoms
radical containing
product
alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES445148A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7504627A external-priority patent/FR2300562A1/en
Priority claimed from FR7538061A external-priority patent/FR2334353A1/en
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES445148A1 publication Critical patent/ES445148A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

Procedure for the preparation of new thiazolic derivatives of general formula I: **(See formula)** in which R represents an alcohol radical containing from 1 to 5 carbon atoms, z represents a linear, saturated, aliphatic hydrocarbon chain of the formula: - (CH2) n- where n is an integer from 1 to 6, or an unsaturated aliphatic hydrocarbon chain of the formula: -CH = CH- or -CH = CH-CH = CH- and R1 represents a hydrogen atom or an alcohol radical containing from 1 to 5 carbon atoms, and its addition salts with strong mineral or organic acids or its alkaline, alkaline earth and aluminum salts, characterized in that: either, to obtain the products of formula I, in which Z represents: - (CH2) n- An alcoholylthioamide of formula II is reacted: **(See formula)** in which R represents an alcohol radical containing from 1 to 5 carbon atoms, with a product of formula III: **(See formula)** in which hal represents a chlorine or bromine atom, Z has the meaning given above and represents an alcohol radical containing from 1 to 5 carbon atoms, obtaining a product of formula I, in which R1 represents a alcohol radical containing from 1 to 5 carbon atoms which, if desired, hydrolyzes to obtain a corresponding product of formula I, in which R1 represents a hydrogen atom which, if desired, is treated with an alcohol of formula : R'1OH in which R'1 represents an alcohol radical containing from 1 to 5 carbon atoms, to obtain the corresponding ester of formula I; either, to obtain the products of formula I, in which Z represents: -CH = CH- or -CH = CH-CH = CH- a product of formula IV is reacted: **(See formula)** in which R has the meaning already given, or with malonic acid in the presence of a basic agent, to obtain a product of formula I, in which Z represents: -CH = CH- and R1 represents a hydrogen atom which, if desired, is treated with an alcohol of the formula: R'1OH in which R'1 represents an alcoholic radical containing from 1 to 5 carbon atoms, to obtain the corresponding ester of formula I, or with an alcoholic dialcohilfosfonocrotonate of formula V: **(See formula)** in which R'1 represents an alcoholic radical containing from 1 to 5 carbon atoms and alc represents an alcoholic radical containing from 1 to 3 carbon atoms, to obtain a product of formula I, in which Z represents: -CH = CH-CH = CH- and R1 represents an alcohol radical containing from 1 to 5 carbon atoms which, if desired, hydrolyzes to obtain a product of formula I, in which R1 represents a hydrogen atom which, if desired, is treated with a formula alcohol: R'1OH in which R'1 represents an alcohol radical containing from 1 to 5 carbon atoms, to obtain the corresponding ester of formula I; and, if desired, the product of formula I is reacted with a strong mineral or organic acid or, when R1 represents a hydrogen atom, with the corresponding base. (Machine-translation by Google Translate, not legally binding)
ES445148A 1975-02-14 1976-02-13 Procedure for the preparation of new tiazolic derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES445148A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7504627A FR2300562A1 (en) 1975-02-14 1975-02-14 2-Alkyl-thiazolyl-alkanols and their esters - have antilicpolytic activity
FR7538061A FR2334353A1 (en) 1975-12-12 1975-12-12 NEW THIAZOLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
ES445148A1 true ES445148A1 (en) 1977-09-16

Family

ID=26218733

Family Applications (1)

Application Number Title Priority Date Filing Date
ES445148A Expired ES445148A1 (en) 1975-02-14 1976-02-13 Procedure for the preparation of new tiazolic derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (16)

Country Link
JP (1) JPS51105056A (en)
AR (1) AR219277A1 (en)
AU (1) AU498142B2 (en)
BE (1) BE838488A (en)
CA (1) CA1082715A (en)
CH (1) CH609974A5 (en)
DD (1) DD124981A5 (en)
DE (1) DE2605838A1 (en)
DK (1) DK142284B (en)
ES (1) ES445148A1 (en)
HU (1) HU171950B (en)
IL (1) IL48968A (en)
LU (1) LU74338A1 (en)
NL (1) NL7601561A (en)
PT (1) PT64801B (en)
SE (1) SE417510B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1042362B (en) * 1953-06-20 1958-10-30 Mindener Molkerei E G M B H Milk pasteurizer

Also Published As

Publication number Publication date
IL48968A0 (en) 1976-04-30
NL7601561A (en) 1976-08-17
JPS51105056A (en) 1976-09-17
CH609974A5 (en) 1979-03-30
HU171950B (en) 1978-04-28
DD124981A5 (en) 1977-03-23
PT64801B (en) 1978-02-06
DK58476A (en) 1976-08-15
CA1082715A (en) 1980-07-29
IL48968A (en) 1978-08-31
AU498142B2 (en) 1979-02-15
DK142284B (en) 1980-10-06
AU1110576A (en) 1977-08-18
BE838488A (en) 1976-08-12
LU74338A1 (en) 1976-12-31
PT64801A (en) 1976-03-01
DK142284C (en) 1981-03-02
SE7601589L (en) 1976-08-15
AR219277A1 (en) 1980-08-15
SE417510B (en) 1981-03-23
DE2605838A1 (en) 1976-08-26

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