CH609974A5 - Process for the preparation of new thiazole derivatives - Google Patents

Process for the preparation of new thiazole derivatives

Info

Publication number
CH609974A5
CH609974A5 CH181176A CH181176A CH609974A5 CH 609974 A5 CH609974 A5 CH 609974A5 CH 181176 A CH181176 A CH 181176A CH 181176 A CH181176 A CH 181176A CH 609974 A5 CH609974 A5 CH 609974A5
Authority
CH
Switzerland
Prior art keywords
alkyl
gamma
alpha
preparation
acids
Prior art date
Application number
CH181176A
Inventor
Andre Poittevin
Vesperto Torelli
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7504627A external-priority patent/FR2300562A1/en
Priority claimed from FR7538061A external-priority patent/FR2334353A1/en
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of CH609974A5 publication Critical patent/CH609974A5/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

The compounds of formula <IMAGE> in which R represents a C1-C5 alkyl, are obtained by reaction of a thioamide RCSNH2 with an alpha -chloro- or alpha -bromo- gamma , gamma -dialkoxycarbonylbutyraldehyde, hydrolysis of the dialkyl [(2-alkyl-5-thiazolyl)methyl]propanedioate formed and decarboxylation, using a strong acid, of the corresponding dicarboxylic acid. These acids, as well as their salts with strong inorganic or organic acids, their alkali metal, alkaline-earth metal and aluminium salts and their C1-C5 alkyl esters, display an anti-fat-splitting action and lower the level of free fatty acids in the blood. They can thus be used in the treatment of hyperlipemia and of certain coronary or cardiac insufficiencies.
CH181176A 1975-02-14 1976-02-13 Process for the preparation of new thiazole derivatives CH609974A5 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7504627A FR2300562A1 (en) 1975-02-14 1975-02-14 2-Alkyl-thiazolyl-alkanols and their esters - have antilicpolytic activity
FR7538061A FR2334353A1 (en) 1975-12-12 1975-12-12 NEW THIAZOLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
CH609974A5 true CH609974A5 (en) 1979-03-30

Family

ID=26218733

Family Applications (1)

Application Number Title Priority Date Filing Date
CH181176A CH609974A5 (en) 1975-02-14 1976-02-13 Process for the preparation of new thiazole derivatives

Country Status (16)

Country Link
JP (1) JPS51105056A (en)
AR (1) AR219277A1 (en)
AU (1) AU498142B2 (en)
BE (1) BE838488A (en)
CA (1) CA1082715A (en)
CH (1) CH609974A5 (en)
DD (1) DD124981A5 (en)
DE (1) DE2605838A1 (en)
DK (1) DK142284B (en)
ES (1) ES445148A1 (en)
HU (1) HU171950B (en)
IL (1) IL48968A (en)
LU (1) LU74338A1 (en)
NL (1) NL7601561A (en)
PT (1) PT64801B (en)
SE (1) SE417510B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1042362B (en) * 1953-06-20 1958-10-30 Mindener Molkerei E G M B H Milk pasteurizer

Also Published As

Publication number Publication date
DK142284C (en) 1981-03-02
HU171950B (en) 1978-04-28
PT64801A (en) 1976-03-01
DD124981A5 (en) 1977-03-23
PT64801B (en) 1978-02-06
JPS51105056A (en) 1976-09-17
LU74338A1 (en) 1976-12-31
DE2605838A1 (en) 1976-08-26
NL7601561A (en) 1976-08-17
AR219277A1 (en) 1980-08-15
IL48968A0 (en) 1976-04-30
SE417510B (en) 1981-03-23
SE7601589L (en) 1976-08-15
BE838488A (en) 1976-08-12
CA1082715A (en) 1980-07-29
DK58476A (en) 1976-08-15
IL48968A (en) 1978-08-31
ES445148A1 (en) 1977-09-16
AU498142B2 (en) 1979-02-15
AU1110576A (en) 1977-08-18
DK142284B (en) 1980-10-06

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Legal Events

Date Code Title Description
PL Patent ceased