FR2300562A1 - 2-Alkyl-thiazolyl-alkanols and their esters - have antilicpolytic activity - Google Patents

2-Alkyl-thiazolyl-alkanols and their esters - have antilicpolytic activity

Info

Publication number
FR2300562A1
FR2300562A1 FR7504627A FR7504627A FR2300562A1 FR 2300562 A1 FR2300562 A1 FR 2300562A1 FR 7504627 A FR7504627 A FR 7504627A FR 7504627 A FR7504627 A FR 7504627A FR 2300562 A1 FR2300562 A1 FR 2300562A1
Authority
FR
France
Prior art keywords
alkyl
activity
antilicpolytic
alkanols
thiazolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7504627A
Other languages
French (fr)
Other versions
FR2300562B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7504627A priority Critical patent/FR2300562A1/en
Priority to AR262223A priority patent/AR208020A1/en
Priority to US05/654,629 priority patent/US4073919A/en
Priority to US05/654,630 priority patent/US4032643A/en
Priority to IL48968A priority patent/IL48968A/en
Priority to IL48970A priority patent/IL48970A/en
Priority to IL48969A priority patent/IL48969A/en
Priority to HU76RO00000874A priority patent/HU171950B/en
Priority to HU76RO00000876A priority patent/HU171952B/en
Priority to HU76RO00000875A priority patent/HU171951B/en
Priority to SU762319296A priority patent/SU634670A3/en
Priority to SU762319297A priority patent/SU651698A3/en
Priority to AR262222A priority patent/AR210485A1/en
Priority to AR262221A priority patent/AR219277A1/en
Priority to SE7601591A priority patent/SE7601591L/en
Priority to BE164262A priority patent/BE838488A/en
Priority to DD191211A priority patent/DD124980A5/xx
Priority to DD191209A priority patent/DD124981A5/xx
Priority to BE164264A priority patent/BE838490A/en
Priority to LU74339A priority patent/LU74339A1/xx
Priority to SE7601590A priority patent/SE7601590L/en
Priority to BE164263A priority patent/BE838489A/en
Priority to LU74340A priority patent/LU74340A1/xx
Priority to SE7601589A priority patent/SE417510B/en
Priority to CA245,873A priority patent/CA1082715A/en
Priority to LU74338A priority patent/LU74338A1/xx
Priority to DD191210A priority patent/DD124979A5/xx
Priority to AT99576A priority patent/AT350557B/en
Priority to CH181176A priority patent/CH609974A5/en
Priority to IE295/76A priority patent/IE42775B1/en
Priority to DK58576*#A priority patent/DK58576A/en
Priority to ES445148A priority patent/ES445148A1/en
Priority to PT64803A priority patent/PT64803B/en
Priority to PT64802A priority patent/PT64802B/en
Priority to DK58476AA priority patent/DK142284B/en
Priority to ZA760879A priority patent/ZA76879B/en
Priority to ZA760880A priority patent/ZA76880B/en
Priority to PT64801A priority patent/PT64801B/en
Priority to DE19762605839 priority patent/DE2605839A1/en
Priority to JP51014120A priority patent/JPS51105058A/ja
Priority to ZA760878A priority patent/ZA76878B/en
Priority to GB5820/76A priority patent/GB1535267A/en
Priority to DE19762605838 priority patent/DE2605838A1/en
Priority to JP51014118A priority patent/JPS51105056A/ja
Priority to ES445150A priority patent/ES445150A1/en
Priority to ES445149A priority patent/ES445149A1/en
Priority to AU11107/76A priority patent/AU498500B2/en
Priority to JP51014119A priority patent/JPS51105057A/ja
Priority to CH180976A priority patent/CH610314A5/xx
Priority to DE19762605840 priority patent/DE2605840A1/en
Priority to AU11105/76A priority patent/AU498142B2/en
Priority to AU11106/76A priority patent/AU494769B2/en
Priority to CH181276A priority patent/CH610315A5/xx
Priority to DK58676*#A priority patent/DK58676A/en
Priority to NL7601563A priority patent/NL7601563A/en
Priority to NL7601561A priority patent/NL7601561A/en
Priority to NL7601562A priority patent/NL7601562A/en
Publication of FR2300562A1 publication Critical patent/FR2300562A1/en
Priority to SU772439825A priority patent/SU596166A3/en
Application granted granted Critical
Publication of FR2300562B1 publication Critical patent/FR2300562B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

Cpds. of formula (I) (where R is 1-5C alkyl; n is 2-7; R1 is H or R2CO-; R2 is 1-5C alkyl). (I) have pharmacological props., they have a marked antilipolytic activity and reduce plasma levels of free fatty acids. They are useful in treatment of acute or chronic hyperlipaemia, coronary insufficiency, atheromatose cardiac insufficiency and chronic angina. Doses are e.g. 0.1-2.5g/day orally, for adult humans.
FR7504627A 1975-02-14 1975-02-14 2-Alkyl-thiazolyl-alkanols and their esters - have antilicpolytic activity Granted FR2300562A1 (en)

Priority Applications (58)

Application Number Priority Date Filing Date Title
FR7504627A FR2300562A1 (en) 1975-02-14 1975-02-14 2-Alkyl-thiazolyl-alkanols and their esters - have antilicpolytic activity
AR262223A AR208020A1 (en) 1975-02-14 1976-01-01 PROCEDURE FOR THE PREPARATION OF 2-ALKYL-5 - ((N-SUBSTITUTED CARBAMOYLOXY) ALKYL) -THAZOLE
US05/654,629 US4073919A (en) 1975-02-14 1976-02-02 Hypolipemiant compositions and methods
US05/654,630 US4032643A (en) 1975-02-14 1976-02-02 Novel thiazole derivatives
IL48968A IL48968A (en) 1975-02-14 1976-02-04 2-alkyl-5-thiazolylaliphatic carboxylic acid dervatives, process for preparing them and pharmaceutical compositions containing them
IL48970A IL48970A (en) 1975-02-14 1976-02-04 2alkyl-5-thiazolylakyl carbamates, process for preparing them and pharmaceutical compositions containing them
IL48969A IL48969A (en) 1975-02-14 1976-02-04 5-thiazole alkanol derivatives,process for preparing them and pharmaceutical compositions
HU76RO00000874A HU171950B (en) 1975-02-14 1976-02-05 Process for preparing thiazole derivatives
HU76RO00000876A HU171952B (en) 1975-02-14 1976-02-05 Process for producing thiazole derivatives
HU76RO00000875A HU171951B (en) 1975-02-14 1976-02-05 Process for producing thiazol-5-yl-alkanol derivatives
SU762319296A SU634670A3 (en) 1975-02-14 1976-02-10 Method of obtaining thiazole derivatives or their salts with mineral acids or with organic sulfoacids
SU762319297A SU651698A3 (en) 1975-02-14 1976-02-10 Method of obtaining derivatives of 5-thiazoloalkanoles
AR262222A AR210485A1 (en) 1975-02-14 1976-02-11 PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 2-ALCOHYL 5-THIAZOLALCANOL
AR262221A AR219277A1 (en) 1975-02-14 1976-02-11 PROCEDURE TO PREPARE NEW ACID DERIVATIVES 2-ALKYL 5-THIAZOL-PROPANOIC
SE7601591A SE7601591L (en) 1975-02-14 1976-02-12 WAY TO PRODUCE NEW TIAZOLE DERIVATIVES
BE164262A BE838488A (en) 1975-02-14 1976-02-12 NEW THIAZOLIC DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS
DD191211A DD124980A5 (en) 1975-02-14 1976-02-12
DD191209A DD124981A5 (en) 1975-02-14 1976-02-12
BE164264A BE838490A (en) 1975-02-14 1976-02-12 NEW THIAZOLIC DERIVATIVES, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITION
LU74339A LU74339A1 (en) 1975-02-14 1976-02-12
SE7601590A SE7601590L (en) 1975-02-14 1976-02-12 WAY TO PRODUCE NEW 5-ALKANOLTIAZOLE DERIVATIVES
BE164263A BE838489A (en) 1975-02-14 1976-02-12 NEW DERIVATIVES OF 5-THIAZOLE ALCANOLS PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS
LU74340A LU74340A1 (en) 1975-02-14 1976-02-12
SE7601589A SE417510B (en) 1975-02-14 1976-02-12 SET TO PREPARE NEW 2-ALKYL-5-THIAZOLPROPANIC ACID DERIVATIVES
CA245,873A CA1082715A (en) 1975-02-14 1976-02-12 Process for the preparation of novel thiazole derivatives
LU74338A LU74338A1 (en) 1975-02-14 1976-02-12
DD191210A DD124979A5 (en) 1975-02-14 1976-02-12
AT99576A AT350557B (en) 1975-02-14 1976-02-12 PROCESS FOR PRODUCING NEW THIAZOLE DERIVATIVES AND THEIR SALTS
CH181176A CH609974A5 (en) 1975-02-14 1976-02-13 Process for the preparation of new thiazole derivatives
IE295/76A IE42775B1 (en) 1975-02-14 1976-02-13 Thiazole derivatives
DK58576*#A DK58576A (en) 1975-02-14 1976-02-13 PROCEDURE FOR THE PREPARATION OF 5-THIAZOLAL CHANNELS
ES445148A ES445148A1 (en) 1975-02-14 1976-02-13 Procedure for the preparation of new tiazolic derivatives. (Machine-translation by Google Translate, not legally binding)
PT64803A PT64803B (en) 1975-02-14 1976-02-13 PROCESS FOR THE PREPARATION OF NEW THIAZOLIC DERIVATIVES
PT64802A PT64802B (en) 1975-02-14 1976-02-13 PROCESS FOR THE PREPARATION OF NEW 5-THIAZOL-ALCANOLIS DERIVATIVES.
DK58476AA DK142284B (en) 1975-02-14 1976-02-13 Analogous Process for Preparation of Thiazole Derivatives.
ZA760879A ZA76879B (en) 1975-02-14 1976-02-13 New 5-thiazole alkanol derivatives process for preparing them and pharmaceutical compositions
ZA760880A ZA76880B (en) 1975-02-14 1976-02-13 New thiazole derivatives process for preparing them and pharmaceutical compositions
PT64801A PT64801B (en) 1975-02-14 1976-02-13 PROCESS FOR THE PREPARATION OF NEW THIAZOLIC DERIVATIVES
DE19762605839 DE2605839A1 (en) 1975-02-14 1976-02-13 5-HYDROXYALKYLTHIAZOL DERIVATIVES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS
JP51014120A JPS51105058A (en) 1975-02-14 1976-02-13
ZA760878A ZA76878B (en) 1975-02-14 1976-02-13 New thiazole derivatives process for preparing them and pharmaceutical compositions
GB5820/76A GB1535267A (en) 1975-02-14 1976-02-13 Thiazole derivatives
DE19762605838 DE2605838A1 (en) 1975-02-14 1976-02-13 Antilipoltic thiazolyl - alkanoic, -alkenoic, and alkadienoic acid - eg 2- methylthiazol-5-yl propanoic acid
JP51014118A JPS51105056A (en) 1975-02-14 1976-02-13
ES445150A ES445150A1 (en) 1975-02-14 1976-02-13 Novel thiazole derivatives
ES445149A ES445149A1 (en) 1975-02-14 1976-02-13 Hypolipemiant compositions and methods
AU11107/76A AU498500B2 (en) 1975-02-14 1976-02-13 Thiazoles
JP51014119A JPS51105057A (en) 1975-02-14 1976-02-13
CH180976A CH610314A5 (en) 1975-02-14 1976-02-13
DE19762605840 DE2605840A1 (en) 1975-02-14 1976-02-13 NEW THIAZOLE DERIVATIVES, PROCEDURES FOR THEIR MANUFACTURING AND PHARMACEUTICAL COMPOSITIONS
AU11105/76A AU498142B2 (en) 1975-02-14 1976-02-13 Thiazole derivatives
AU11106/76A AU494769B2 (en) 1975-02-14 1976-02-13 Thiazoles
CH181276A CH610315A5 (en) 1975-02-14 1976-02-13
DK58676*#A DK58676A (en) 1975-02-14 1976-02-13 PROCEDURE FOR THE PREPARATION OF THIAZOLE DERIVATIVES
NL7601563A NL7601563A (en) 1975-02-14 1976-02-16 PROCESS FOR PREPARING NEW THIAZOLE COMPOUNDS.
NL7601561A NL7601561A (en) 1975-02-14 1976-02-16 PROCESS FOR PREPARING NEW THIAZOLE COMPOUNDS.
NL7601562A NL7601562A (en) 1975-02-14 1976-02-16 PROCESS FOR PREPARING NEW 5-THIAZOLIC ALKANOL COMPOUNDS.
SU772439825A SU596166A3 (en) 1975-02-14 1977-01-12 Method of preparing thiazole derivatives or their additive salts with mineral acids or organic sulfoacids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7504627A FR2300562A1 (en) 1975-02-14 1975-02-14 2-Alkyl-thiazolyl-alkanols and their esters - have antilicpolytic activity

Publications (2)

Publication Number Publication Date
FR2300562A1 true FR2300562A1 (en) 1976-09-10
FR2300562B1 FR2300562B1 (en) 1978-07-21

Family

ID=9151232

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7504627A Granted FR2300562A1 (en) 1975-02-14 1975-02-14 2-Alkyl-thiazolyl-alkanols and their esters - have antilicpolytic activity

Country Status (3)

Country Link
FR (1) FR2300562A1 (en)
SU (3) SU651698A3 (en)
ZA (3) ZA76880B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2148056A1 (en) * 1971-07-30 1973-03-11 Banyu Pharma Co Ltd Thiazole-2,4-dimethanol dicarbamates - with circulator and cns activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2148056A1 (en) * 1971-07-30 1973-03-11 Banyu Pharma Co Ltd Thiazole-2,4-dimethanol dicarbamates - with circulator and cns activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANNALES PHARMACEUTIQUES FRANCAISES, 23 1965 , PAGES 179-186.) *

Also Published As

Publication number Publication date
ZA76879B (en) 1977-03-30
ZA76880B (en) 1977-03-30
FR2300562B1 (en) 1978-07-21
SU596166A3 (en) 1978-02-28
SU651698A3 (en) 1979-03-05
ZA76878B (en) 1977-05-25
SU634670A3 (en) 1978-11-25

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Legal Events

Date Code Title Description
ST Notification of lapse