ES429473A1 - Procedimiento para la preparacion de nuevos derivados de isoquinoleina. - Google Patents
Procedimiento para la preparacion de nuevos derivados de isoquinoleina.Info
- Publication number
- ES429473A1 ES429473A1 ES429473A ES429473A ES429473A1 ES 429473 A1 ES429473 A1 ES 429473A1 ES 429473 A ES429473 A ES 429473A ES 429473 A ES429473 A ES 429473A ES 429473 A1 ES429473 A1 ES 429473A1
- Authority
- ES
- Spain
- Prior art keywords
- phenyl
- methoxy
- hydrogen
- salts
- isoquinolines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- -1 methy-pyridyl Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 125000000068 chlorophenyl group Chemical group 0.000 abstract 1
- 125000005805 dimethoxy phenyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 125000003944 tolyl group Chemical group 0.000 abstract 1
- 125000005023 xylyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2345422A DE2345422C2 (de) | 1973-09-08 | 1973-09-08 | Substituierte Isochinolyl-arylpiperazine diese enthaltende Arzneimittel sowie Verfahren zu deren Herstellung |
| DE19732345423 DE2345423A1 (de) | 1973-09-08 | 1973-09-08 | Neue substituierte phenylaethylaminderivate, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu deren herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES429473A1 true ES429473A1 (es) | 1976-09-01 |
Family
ID=25765764
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES429473A Expired ES429473A1 (es) | 1973-09-08 | 1974-08-23 | Procedimiento para la preparacion de nuevos derivados de isoquinoleina. |
| ES433958A Expired ES433958A1 (es) | 1973-09-08 | 1975-01-20 | Procedimiento para la preparacion de nuevos derivados de isoquinoleina. |
| ES433959A Expired ES433959A1 (es) | 1973-09-08 | 1975-01-20 | Procedimiento para la preparacion de nuevos derivados de isoquinoleina. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES433958A Expired ES433958A1 (es) | 1973-09-08 | 1975-01-20 | Procedimiento para la preparacion de nuevos derivados de isoquinoleina. |
| ES433959A Expired ES433959A1 (es) | 1973-09-08 | 1975-01-20 | Procedimiento para la preparacion de nuevos derivados de isoquinoleina. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US3948898A (en, 2012) |
| JP (1) | JPS596868B2 (en, 2012) |
| AT (1) | AT330777B (en, 2012) |
| BG (2) | BG22390A3 (en, 2012) |
| CA (1) | CA1025869A (en, 2012) |
| CH (2) | CH605779A5 (en, 2012) |
| CS (1) | CS185660B2 (en, 2012) |
| DD (1) | DD115122A5 (en, 2012) |
| DK (1) | DK137124C (en, 2012) |
| ES (3) | ES429473A1 (en, 2012) |
| FI (1) | FI52219C (en, 2012) |
| FR (1) | FR2242979B1 (en, 2012) |
| GB (1) | GB1446791A (en, 2012) |
| HK (1) | HK4180A (en, 2012) |
| HU (1) | HU167869B (en, 2012) |
| IE (1) | IE40742B1 (en, 2012) |
| IL (1) | IL45609A (en, 2012) |
| MY (1) | MY8100330A (en, 2012) |
| NL (1) | NL176363C (en, 2012) |
| NO (1) | NO140978C (en, 2012) |
| PH (1) | PH12918A (en, 2012) |
| PL (1) | PL91712B1 (en, 2012) |
| RO (1) | RO63655A (en, 2012) |
| SE (1) | SE424863B (en, 2012) |
| SU (2) | SU545256A3 (en, 2012) |
| YU (1) | YU39928B (en, 2012) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2639718C2 (de) * | 1976-09-03 | 1987-03-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | 1-[6,7-Dimethoxy-3,4-dihydro-2H-isochinolin-1-on-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-äthyl)-amino]-propan, dessen physiologisch verträgliche Säureadditionssalze und diese Verbindungen enthaltende Arzneimittel |
| DE2702600A1 (de) * | 1977-01-22 | 1978-07-27 | Thomae Gmbh Dr K | Neue aminoalkoxyphenyl-derivate |
| US4619930A (en) * | 1985-01-16 | 1986-10-28 | Bristol-Myers Company | Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use |
| JPS6312877U (en, 2012) * | 1986-03-05 | 1988-01-27 | ||
| US4876256A (en) * | 1988-04-29 | 1989-10-24 | Merck & Co., Inc. | Alkylpiperazinylpyridines as hypoglycemic agents |
| US5169948A (en) * | 1991-05-22 | 1992-12-08 | American Home Products Corporation | Process and intermediates for the preparation of spiro[isoquinoline-4(1H),3-pyrrolidine]1,2,3,5 (2H)-tetrones which are useful as aldose reductase inhibitors |
| SE9303274D0 (sv) * | 1993-10-07 | 1993-10-07 | Astra Ab | Novel phenylethyl and phenylproplamines |
| DE69826883T2 (de) | 1997-10-27 | 2005-02-03 | Neurosearch A/S | Heteroaryl diazacycloalkane als cholinergische ligande für nikotin-acetylcholin-rezeptoren |
| US20040152710A1 (en) * | 2002-10-15 | 2004-08-05 | Deecher Darlene Coleman | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms |
| EP1844033B1 (de) * | 2005-01-28 | 2011-07-27 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur herstellung von isochroman und derivaten davon |
| US8927546B2 (en) | 2006-02-28 | 2015-01-06 | Dart Neuroscience (Cayman) Ltd. | Therapeutic piperazines |
| JP2009528363A (ja) | 2006-02-28 | 2009-08-06 | ヘリコン セラピューティクス，インコーポレイテッド | Ｐｄｅ４インヒビターとしての治療用ピペラジン |
| WO2023288039A1 (en) * | 2021-07-16 | 2023-01-19 | Denali Therapeutics Inc. | Compounds, compositions and methods |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1185934A (en) * | 1967-06-28 | 1970-03-25 | Pfizer & Co C | Derivatives of 1,3(2H,4H)-Dioxoisoquinoline and preparation thereof |
| SE368009B (en, 2012) * | 1971-09-16 | 1974-06-17 | Kabi Ab | |
| GB1424348A (en) * | 1972-11-30 | 1976-02-11 | Wyeth John & Brother Ltd | Isoquinoline derivatives |
-
1974
- 1974-08-08 AT AT651474A patent/AT330777B/de active
- 1974-08-21 FI FI742465A patent/FI52219C/fi active
- 1974-08-23 ES ES429473A patent/ES429473A1/es not_active Expired
- 1974-09-04 BG BG027624A patent/BG22390A3/xx unknown
- 1974-09-04 US US05/503,072 patent/US3948898A/en not_active Expired - Lifetime
- 1974-09-04 BG BG028726A patent/BG26195A4/xx unknown
- 1974-09-04 IE IE1838/74A patent/IE40742B1/xx unknown
- 1974-09-05 YU YU2391/74A patent/YU39928B/xx unknown
- 1974-09-06 IL IL45609A patent/IL45609A/en unknown
- 1974-09-06 CS CS7400006150A patent/CS185660B2/cs unknown
- 1974-09-06 PH PH16248A patent/PH12918A/en unknown
- 1974-09-06 HU HUTO980A patent/HU167869B/hu unknown
- 1974-09-06 DD DD180966A patent/DD115122A5/xx unknown
- 1974-09-06 FR FR7430387A patent/FR2242979B1/fr not_active Expired
- 1974-09-06 SE SE7411312A patent/SE424863B/xx not_active IP Right Cessation
- 1974-09-06 CH CH1601477A patent/CH605779A5/xx not_active IP Right Cessation
- 1974-09-06 NO NO743220A patent/NO140978C/no unknown
- 1974-09-06 CA CA208,607A patent/CA1025869A/en not_active Expired
- 1974-09-06 JP JP49102862A patent/JPS596868B2/ja not_active Expired
- 1974-09-06 GB GB3908374A patent/GB1446791A/en not_active Expired
- 1974-09-06 CH CH1218974A patent/CH605778A5/xx not_active IP Right Cessation
- 1974-09-06 DK DK472774A patent/DK137124C/da not_active IP Right Cessation
- 1974-09-06 NL NLAANVRAGE7411843,A patent/NL176363C/xx not_active IP Right Cessation
- 1974-09-06 RO RO7400079932A patent/RO63655A/ro unknown
- 1974-09-07 PL PL1974173958A patent/PL91712B1/pl unknown
-
1975
- 1975-01-20 ES ES433958A patent/ES433958A1/es not_active Expired
- 1975-01-20 ES ES433959A patent/ES433959A1/es not_active Expired
- 1975-06-20 SU SU2145935A patent/SU545256A3/ru active
- 1975-06-20 SU SU2145942A patent/SU538664A3/ru active
-
1980
- 1980-01-31 HK HK41/80A patent/HK4180A/xx unknown
-
1981
- 1981-12-30 MY MY330/81A patent/MY8100330A/xx unknown
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