ES423969A1 - Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES423969A1
ES423969A1 ES423969A ES423969A ES423969A1 ES 423969 A1 ES423969 A1 ES 423969A1 ES 423969 A ES423969 A ES 423969A ES 423969 A ES423969 A ES 423969A ES 423969 A1 ES423969 A1 ES 423969A1
Authority
ES
Spain
Prior art keywords
carbon atoms
radical
signifies
formula
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES423969A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19722251891 external-priority patent/DE2251891C3/en
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES423969A1 publication Critical patent/ES423969A1/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Procedure for the preparation of new benzylamines of the general formula I, **(See formula)** where Hal signifies a chlorine or bromine atom, R1 signifies a hydrogen, chlorine or bromine atom, R2 signifies the morpholinocarbonylmethyl radical, a branched alcohol radical with 3 to 5 carbon atoms optionally substituted with 1 to 3 hydroxyl groups, or a group of the formula **(See formula)** where R3 signifies a hydrogen atom, a hydroxy group or an alcohol group with 1 to 4 carbon atoms, n signifies the numbers 0, 1 or 2 and the two radicals A and B signify hydrogen atoms or together the group **(See formula)** where R5 represents a hydrogen atom or a lower alcohol radical with 1 or 2 carbon atoms and m means the numbers 1 or 2, R4 means a straight chain or branched alcohol radical with 1 to 4 carbon atoms, an alkenyl radical with 2 to 4 carbon atoms, a cycloalkyl radical with 3 or 4 carbon atoms or also a hydrogen atom, if R3 does not represent any hydrogen atom or R2 represents a branched alcoholic radical with 3 to 5 carbon atoms, possibly substituted with 1 to 3 hydroxyl groups, and 1 means the numbers 1 or 2, as well as their physiologically compatible acid addition salts, with organic or inorganic acids, characterized in that an aldehyde of the general formula II is reacted **(See formula)** wherein R1, Hal and I are as initially defined, with an amine of general formula III **(See formula)** wherein R2 and R4 are as initially defined, or with the corresponding formamide, in the presence of formic acid; and a compound of the general formula I, obtained according to the procedure, is subsequently transformed, if desired, into its physiologically compatible salts with organic or inorganic acids. (Machine-translation by Google Translate, not legally binding)
ES423969A 1972-10-23 1974-03-06 Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding) Expired ES423969A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19722251891 DE2251891C3 (en) 1972-10-23 Benzylamines, their physiologically acceptable salts, processes for their preparation and pharmaceuticals containing them
DE19732320967 DE2320967C3 (en) 1973-04-26 New benzylamines, their physiologically acceptable salts, processes for their production and pharmaceuticals containing them
DE2346743A DE2346743C3 (en) 1972-10-23 1973-09-17 2- or 4-Hydroxy-3,5-dihalogenobenzylamines, their physiologically tolerable salts, processes for their preparation and medicaments containing them

Publications (1)

Publication Number Publication Date
ES423969A1 true ES423969A1 (en) 1976-06-16

Family

ID=27184785

Family Applications (3)

Application Number Title Priority Date Filing Date
ES74423971A Expired ES423971A1 (en) 1972-10-23 1974-03-06 Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding)
ES423972A Expired ES423972A1 (en) 1972-10-23 1974-03-06 Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding)
ES423969A Expired ES423969A1 (en) 1972-10-23 1974-03-06 Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES74423971A Expired ES423971A1 (en) 1972-10-23 1974-03-06 Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding)
ES423972A Expired ES423972A1 (en) 1972-10-23 1974-03-06 Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding)

Country Status (7)

Country Link
AT (2) ATA89075A (en)
DE (1) DE2346743C3 (en)
ES (3) ES423971A1 (en)
MX (1) MX3103E (en)
PH (1) PH13986A (en)
PL (2) PL91886B1 (en)
SU (3) SU519123A3 (en)

Also Published As

Publication number Publication date
ES423972A1 (en) 1976-06-16
SU519123A3 (en) 1976-06-25
ATA89375A (en) 1975-07-15
SU517248A3 (en) 1976-06-05
DE2346743B2 (en) 1978-11-09
DE2346743A1 (en) 1975-04-03
ATA89075A (en) 1975-07-15
ES423971A1 (en) 1976-06-16
DE2346743C3 (en) 1979-07-12
MX3103E (en) 1980-04-10
PL96274B1 (en) 1977-12-31
PH13986A (en) 1980-11-20
SU520033A3 (en) 1976-06-30
PL91886B1 (en) 1977-03-31

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