ES412799A1 - Alpha-aminoalkyl-4-hydroxy-3-alkylsulphonylmethylbenzyl alcohols - Google Patents

Alpha-aminoalkyl-4-hydroxy-3-alkylsulphonylmethylbenzyl alcohols

Info

Publication number
ES412799A1
ES412799A1 ES412799A ES412799A ES412799A1 ES 412799 A1 ES412799 A1 ES 412799A1 ES 412799 A ES412799 A ES 412799A ES 412799 A ES412799 A ES 412799A ES 412799 A1 ES412799 A1 ES 412799A1
Authority
ES
Spain
Prior art keywords
formula
alcohols
hydroxy
hydrogen
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES412799A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
GlaxoSmithKline LLC
Original Assignee
Smith Kline and French Laboratories Ltd
GlaxoSmithKline LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd, GlaxoSmithKline LLC filed Critical Smith Kline and French Laboratories Ltd
Publication of ES412799A1 publication Critical patent/ES412799A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for preparing alcohol-sulphonylmethylbenzyl alcohols having the formula **(See formula)** in which; R is straight or branched chain lower alcohol of 1 to 5 carbon atoms; R1 is branched-chain lower alcohol of 3 to 5 carbon atoms, cycloalcohyl or cycloalcohylmethyl, with the cycloalcoyl residue having 3 to 6 carbon atoms; or **(See formula)** R2 is hydrogen, methyl or ethyl; R3 and R4 are hydrogen, hydroxy or methoxy; and R5 is hydrogen or methyl, which comprises catalytically hydrogenating a compound of the formula **(See formula)** where R, R1 and R2 are as defined above; optionally followed by conversion of the product into one of its salts. (Machine-translation by Google Translate, not legally binding)
ES412799A 1972-03-20 1973-03-17 Alpha-aminoalkyl-4-hydroxy-3-alkylsulphonylmethylbenzyl alcohols Expired ES412799A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23617772A 1972-03-20 1972-03-20

Publications (1)

Publication Number Publication Date
ES412799A1 true ES412799A1 (en) 1976-06-01

Family

ID=22888442

Family Applications (1)

Application Number Title Priority Date Filing Date
ES412799A Expired ES412799A1 (en) 1972-03-20 1973-03-17 Alpha-aminoalkyl-4-hydroxy-3-alkylsulphonylmethylbenzyl alcohols

Country Status (22)

Country Link
JP (1) JPS5636188B2 (en)
AR (1) AR196924A1 (en)
AU (1) AU469666B2 (en)
BE (1) BE796894A (en)
BR (1) BR7301986D0 (en)
CA (1) CA1007662A (en)
CH (1) CH576435A5 (en)
DE (1) DE2313625C2 (en)
DK (1) DK145082C (en)
ES (1) ES412799A1 (en)
FI (1) FI58326C (en)
FR (1) FR2183681B1 (en)
GB (2) GB1386029A (en)
HU (1) HU166931B (en)
IE (1) IE38206B1 (en)
IL (1) IL41758A (en)
IT (1) IT1061426B (en)
LU (1) LU67220A1 (en)
NL (1) NL7303715A (en)
PH (1) PH9436A (en)
SE (1) SE403773B (en)
ZA (1) ZA731903B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966770A (en) * 1975-03-25 1976-06-29 Smithkline Corporation 4-Hydroxy-α-[(3,4-methylenedioxyphenyl)isopropylaminoethyl]-3-(methylsulfonylmethyl)benzyl alcohol
ES2054861T3 (en) * 1987-03-26 1994-08-16 Ciba Geigy Ag NEW ALPHA-AMINO ACETOPHENONES AS PHOTO INITIATORS.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE34545B1 (en) * 1969-10-01 1975-06-11 Continental Pharma Amino-alcohols,their salts and process for preparing the same
ZA723611B (en) * 1971-06-01 1973-03-28 Smith Kline French Lab N,n'-bis(2-(3-substituted-4-hydroxyphenyl)-ethyl or-2-hydroxyethyl)-polymethylene-diamines

Also Published As

Publication number Publication date
FI58326C (en) 1981-01-12
FR2183681B1 (en) 1976-10-22
IE38206B1 (en) 1978-01-18
IE38206L (en) 1973-09-20
DK145082C (en) 1983-03-21
SE403773B (en) 1978-09-04
HU166931B (en) 1975-06-28
IL41758A (en) 1976-03-31
IT1061426B (en) 1983-02-28
ZA731903B (en) 1974-01-30
DK145082B (en) 1982-08-23
LU67220A1 (en) 1973-05-22
AU469666B2 (en) 1976-02-19
CA1007662A (en) 1977-03-29
GB1386029A (en) 1975-03-05
JPS4911846A (en) 1974-02-01
GB1386028A (en) 1975-03-05
PH9436A (en) 1975-11-26
CH576435A5 (en) 1976-06-15
FR2183681A1 (en) 1973-12-21
BE796894A (en) 1973-09-17
AU5341073A (en) 1974-09-19
IL41758A0 (en) 1973-05-31
DE2313625C2 (en) 1986-03-13
JPS5636188B2 (en) 1981-08-22
FI58326B (en) 1980-09-30
DE2313625A1 (en) 1973-10-25
BR7301986D0 (en) 1974-07-25
AR196924A1 (en) 1974-02-28
NL7303715A (en) 1973-09-24

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