GB1386028A - Alpha-aminoalkyl-4-hydroxy-3-alkylsulphonylmethylbenzyl alcohols - Google Patents
Alpha-aminoalkyl-4-hydroxy-3-alkylsulphonylmethylbenzyl alcoholsInfo
- Publication number
- GB1386028A GB1386028A GB1076873A GB1076873A GB1386028A GB 1386028 A GB1386028 A GB 1386028A GB 1076873 A GB1076873 A GB 1076873A GB 1076873 A GB1076873 A GB 1076873A GB 1386028 A GB1386028 A GB 1386028A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkylsulphonylmethylbenzyl
- alcohols
- hydroxy
- aminoalkyl
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001298 alcohols Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- LAMHAMBOLINJML-UHFFFAOYSA-N 1-[3-(chloromethyl)-4-hydroxyphenyl]ethanone Chemical compound CC(=O)C1=CC=C(O)C(CCl)=C1 LAMHAMBOLINJML-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003182 bronchodilatating effect Effects 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
- C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1386028 Alkylsulphonylmethylbenzyl alcohols SMITHKLINE CORP 6 March 1973 [20 March 1972] 10768/73 Heading C2C Novel compounds (I) (including salts thereof) where R is straight or branched C 1-5 alkyl, R 1 is branched C 3-5 alkyl, C 3-6 cycloalkyl or C 3-6 cycloalkyl-methyl or a group of Formula (II): R 2 is H, Me or Et, R 3 and R 4 are H, OH or MeO and R 5 is H or Me, are made by hydrogenating compounds (III): 3 - Chloromethyl - 4 - hydroxyacetophenone, 4- hydroxy- and -benzyloxy - 3 - methylsulphonylmethylacetophenones and 4 - benzyloxy - α- bromo - 3 - methylsulphonylmethylacetophenone are also prepared. Pharmaceutical preparations having bronchodilatory action contain (I) as active ingredient. Administration is orally or parenterally.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US359063A US3917704A (en) | 1972-03-20 | 1973-05-10 | Alpha-aminoalkyl-4-hydroxy-3-alkylsulfonylmethylbenzyl alcohols |
IN457/CAL/1974A IN138474B (en) | 1973-03-06 | 1974-03-04 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23617772A | 1972-03-20 | 1972-03-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1386028A true GB1386028A (en) | 1975-03-05 |
Family
ID=22888442
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2471474A Expired GB1386029A (en) | 1972-03-20 | 1973-03-06 | Alpha-benzylamino-4-benzyloxy-3-alkylsulphonylmethyl phenones |
GB1076873A Expired GB1386028A (en) | 1972-03-20 | 1973-03-06 | Alpha-aminoalkyl-4-hydroxy-3-alkylsulphonylmethylbenzyl alcohols |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2471474A Expired GB1386029A (en) | 1972-03-20 | 1973-03-06 | Alpha-benzylamino-4-benzyloxy-3-alkylsulphonylmethyl phenones |
Country Status (22)
Country | Link |
---|---|
JP (1) | JPS5636188B2 (en) |
AR (1) | AR196924A1 (en) |
AU (1) | AU469666B2 (en) |
BE (1) | BE796894A (en) |
BR (1) | BR7301986D0 (en) |
CA (1) | CA1007662A (en) |
CH (1) | CH576435A5 (en) |
DE (1) | DE2313625C2 (en) |
DK (1) | DK145082C (en) |
ES (1) | ES412799A1 (en) |
FI (1) | FI58326C (en) |
FR (1) | FR2183681B1 (en) |
GB (2) | GB1386029A (en) |
HU (1) | HU166931B (en) |
IE (1) | IE38206B1 (en) |
IL (1) | IL41758A (en) |
IT (1) | IT1061426B (en) |
LU (1) | LU67220A1 (en) |
NL (1) | NL7303715A (en) |
PH (1) | PH9436A (en) |
SE (1) | SE403773B (en) |
ZA (1) | ZA731903B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3966770A (en) * | 1975-03-25 | 1976-06-29 | Smithkline Corporation | 4-Hydroxy-α-[(3,4-methylenedioxyphenyl)isopropylaminoethyl]-3-(methylsulfonylmethyl)benzyl alcohol |
ES2054861T3 (en) * | 1987-03-26 | 1994-08-16 | Ciba Geigy Ag | NEW ALPHA-AMINO ACETOPHENONES AS PHOTO INITIATORS. |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE34545B1 (en) * | 1969-10-01 | 1975-06-11 | Continental Pharma | Amino-alcohols,their salts and process for preparing the same |
ZA723611B (en) * | 1971-06-01 | 1973-03-28 | Smith Kline French Lab | N,n'-bis(2-(3-substituted-4-hydroxyphenyl)-ethyl or-2-hydroxyethyl)-polymethylene-diamines |
-
1973
- 1973-03-06 GB GB2471474A patent/GB1386029A/en not_active Expired
- 1973-03-06 GB GB1076873A patent/GB1386028A/en not_active Expired
- 1973-03-13 IL IL41758A patent/IL41758A/en unknown
- 1973-03-13 IE IE409/73A patent/IE38206B1/en unknown
- 1973-03-14 FI FI778/73A patent/FI58326C/en active
- 1973-03-14 SE SE7303544A patent/SE403773B/en unknown
- 1973-03-14 FR FR7309051A patent/FR2183681B1/fr not_active Expired
- 1973-03-15 CA CA166,212A patent/CA1007662A/en not_active Expired
- 1973-03-15 AR AR247078A patent/AR196924A1/en active
- 1973-03-15 DK DK139673A patent/DK145082C/en active
- 1973-03-15 IT IT21683/73A patent/IT1061426B/en active
- 1973-03-15 JP JP3048873A patent/JPS5636188B2/ja not_active Expired
- 1973-03-15 HU HUSI1298A patent/HU166931B/hu unknown
- 1973-03-15 LU LU67220A patent/LU67220A1/xx unknown
- 1973-03-16 PH PH14433*UA patent/PH9436A/en unknown
- 1973-03-16 AU AU53410/73A patent/AU469666B2/en not_active Expired
- 1973-03-16 NL NL7303715A patent/NL7303715A/xx unknown
- 1973-03-16 BE BE128895A patent/BE796894A/en not_active IP Right Cessation
- 1973-03-17 ES ES412799A patent/ES412799A1/en not_active Expired
- 1973-03-19 ZA ZA731903A patent/ZA731903B/en unknown
- 1973-03-19 DE DE2313625A patent/DE2313625C2/en not_active Expired
- 1973-03-19 CH CH396473A patent/CH576435A5/xx not_active IP Right Cessation
- 1973-03-20 BR BR731986A patent/BR7301986D0/en unknown
Also Published As
Publication number | Publication date |
---|---|
JPS4911846A (en) | 1974-02-01 |
HU166931B (en) | 1975-06-28 |
IE38206L (en) | 1973-09-20 |
JPS5636188B2 (en) | 1981-08-22 |
DK145082B (en) | 1982-08-23 |
DE2313625A1 (en) | 1973-10-25 |
AU5341073A (en) | 1974-09-19 |
ZA731903B (en) | 1974-01-30 |
PH9436A (en) | 1975-11-26 |
DK145082C (en) | 1983-03-21 |
FR2183681A1 (en) | 1973-12-21 |
IE38206B1 (en) | 1978-01-18 |
BE796894A (en) | 1973-09-17 |
CH576435A5 (en) | 1976-06-15 |
CA1007662A (en) | 1977-03-29 |
LU67220A1 (en) | 1973-05-22 |
IT1061426B (en) | 1983-02-28 |
DE2313625C2 (en) | 1986-03-13 |
FI58326C (en) | 1981-01-12 |
SE403773B (en) | 1978-09-04 |
NL7303715A (en) | 1973-09-24 |
BR7301986D0 (en) | 1974-07-25 |
ES412799A1 (en) | 1976-06-01 |
FR2183681B1 (en) | 1976-10-22 |
GB1386029A (en) | 1975-03-05 |
AR196924A1 (en) | 1974-02-28 |
IL41758A0 (en) | 1973-05-31 |
IL41758A (en) | 1976-03-31 |
FI58326B (en) | 1980-09-30 |
AU469666B2 (en) | 1976-02-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1413892A (en) | 2-pyrimidinyl-thio-acetic acids and their derivatives | |
GB1355147A (en) | Oxoprostanoic acid derivatives | |
GB1142066A (en) | New diphenyl-ureas and process for preparing them | |
GB1386028A (en) | Alpha-aminoalkyl-4-hydroxy-3-alkylsulphonylmethylbenzyl alcohols | |
GB1171670A (en) | Derivatives of 4-Aryl-3-Hydroxybutyric Acid | |
GB1350710A (en) | Ureas and thioureas | |
GB1370066A (en) | N,n1-bis-2-3-substituted-4-hydroxyphenyl-ethyl or 2-hydroxyethyl- polymethylenediamines | |
GB1434139A (en) | 3-substituted-4-hydroxyphenyl-2-piperidylcarbinols | |
GB1314899A (en) | Thiosemicarbazones processes for their preparations and compositions incorporating them | |
GB1394184A (en) | 4,5-dihydropyridazine-3 2h- ones | |
GB1503626A (en) | Substituted piperazine derivative its preparation and compositions containing it | |
GB1331161A (en) | Amino-s-triazolylbenzenesulphonamides | |
SE7408868L (en) | ||
GB1195319A (en) | Alkyl Sulfate Salts of 1-(p-Chlorobenzhydryl)-4-Methylhomopiperazines | |
GB1436505A (en) | -omega-i-imidazolyl-alkyl-hydrogen monothiosulphates and salts thereof | |
GB1393228A (en) | 2-2-2-methyl-5-nitro-1-imidazolyl-ethyl-2-thiopseudoureas and related compounds | |
GB1388041A (en) | Benzimidazolyl sulphides and sulphones | |
GB1298057A (en) | Bis(aminoalkylsulphamoyl)anthraquinones | |
GB1168302A (en) | Aluminium N-Acetylglycinate and Pharmaceutical Compositions containing the same | |
GB1342643A (en) | Thioacetanilide derivatives | |
GB1364318A (en) | Laurotetanine derivatives | |
GB1363508A (en) | Thiolcarbamates | |
GB1299037A (en) | Dithiocarbamic acid esters | |
GB1444558A (en) | Pyridylthioureas | |
GB1378964A (en) | Pyridine derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |