ES433892A1 - Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES433892A1 ES433892A1 ES433892A ES433892A ES433892A1 ES 433892 A1 ES433892 A1 ES 433892A1 ES 433892 A ES433892 A ES 433892A ES 433892 A ES433892 A ES 433892A ES 433892 A1 ES433892 A1 ES 433892A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- radicals
- signifies
- carbon atoms
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/24—Camphidines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Procedure for the preparation of new benzylamines of the general formula I **(See formula)** wherein R1 signifies a hydrogen atom or an optionally substituted aliphatic or aromatic acyl radical; R2 signifies a hydrogen, chlorine or bromine atom; R3 signifies a 1-hydroxyethyl group; R4 and R5, which may be the same or different, represent hydrogen atoms, straight or branched chain alcohol radicals with 1 to 5 carbon atoms, which may be substituted with one or two hydroxy groups, alkenyl radicals with 2 to 4 carbon atoms. carbon, cycloalconyl radicals with 5 to 7 carbon atoms optionally substituted with one or two hydroxy groups, benzyl groups, morpholinocarbonylmethyl or together with the nitrogen atom signify a pyrrolidine, piperidine, hexamethylenamine, morpholine, N-methyl-pipe-razin ring or Camfidine, as well as its acid addition salts physiologically compatible with organic or inorganic acids, characterized in that a compound of the general formula II is reduced **(See formula)** wherein R1, R2, R4 and R5 are as initially defined; and, if desired, a compound of the general formula I obtained, in which R1 represents a hydrogen atom and R2, R3, R4 and R5 with the exception of the radicals containing a hydrogen atom capable of reacting, are as they have been Initially defined, it is acylated if desired subsequently, and/or a compound obtained from the general formula I is transformed if desired into its physiologically compatible salts with organic or inorganic acids. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732318636 DE2318636B2 (en) | 1973-04-13 | 1973-04-13 | NEW BENZYLAMINES, MEDICINAL PRODUCTS AND THE METHOD OF MANUFACTURING THEM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES433892A1 true ES433892A1 (en) | 1976-12-16 |
Family
ID=5877933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES433892A Expired ES433892A1 (en) | 1973-04-13 | 1975-01-17 | Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding) |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE813678A (en) |
| CH (1) | CH592606A5 (en) |
| DE (1) | DE2318636B2 (en) |
| ES (1) | ES433892A1 (en) |
| PL (1) | PL95667B1 (en) |
| SU (1) | SU522790A3 (en) |
| ZA (1) | ZA742298B (en) |
-
1973
- 1973-04-13 DE DE19732318636 patent/DE2318636B2/en active Granted
-
1974
- 1974-04-09 CH CH528577A patent/CH592606A5/xx not_active IP Right Cessation
- 1974-04-10 ZA ZA00742298A patent/ZA742298B/en unknown
- 1974-04-12 BE BE143168A patent/BE813678A/en unknown
- 1974-04-12 PL PL1974181440A patent/PL95667B1/en unknown
-
1975
- 1975-01-17 ES ES433892A patent/ES433892A1/en not_active Expired
- 1975-01-30 SU SU2101048A patent/SU522790A3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| PL95667B1 (en) | 1977-11-30 |
| DE2318636B2 (en) | 1976-07-01 |
| BE813678A (en) | 1974-10-14 |
| DE2318636A1 (en) | 1974-10-31 |
| CH592606A5 (en) | 1977-10-31 |
| SU522790A3 (en) | 1976-07-25 |
| ZA742298B (en) | 1975-12-31 |
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